{"id":"https://openalex.org/W4281840414","doi":"https://doi.org/10.1002/prp2.974","title":"Are thyrotropin\u2010releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid\u2010induced respiratory depression?","display_name":"Are thyrotropin\u2010releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid\u2010induced respiratory depression?","publication_year":2022,"publication_date":"2022-05-27","ids":{"openalex":"https://openalex.org/W4281840414","doi":"https://doi.org/10.1002/prp2.974","pmid":"https://pubmed.ncbi.nlm.nih.gov/35621218","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9137104"},"language":"en","primary_location":{"id":"doi:10.1002/prp2.974","doi":"https://doi.org/10.1002/prp2.974","is_oa":true,"landing_page_url":"https://doi.org/10.1002/prp2.974","pdf_url":null,"source":{"id":"https://openalex.org/S2764487716","display_name":"Pharmacology Research & Perspectives","issn_l":"2052-1707","issn":["2052-1707"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology Research &amp; Perspectives","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/prp2.974","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008517872","display_name":"Marijke Hyke Algera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marieke Hyke Algera","raw_affiliation_strings":["Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007052039","display_name":"Joseph Frank Cotten","orcid":"https://orcid.org/0000-0002-3526-0908","observed_orcids":["https://orcid.org/0000-0002-3526-0908"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph F. Cotten","raw_affiliation_strings":["Department of Anesthesia Critical Care, and Pain Medicine Massachusetts General Hospital Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia Critical Care, and Pain Medicine Massachusetts General Hospital Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041229784","display_name":"Monique van Velzen","orcid":"https://orcid.org/0000-0002-0289-6432","observed_orcids":["https://orcid.org/0000-0002-0289-6432","https://orcid.org/0000-0001-8428-7317"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Monique van Velzen","raw_affiliation_strings":["Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078916012","display_name":"Marieke Niesters","orcid":"https://orcid.org/0009-0002-2822-7509","observed_orcids":["https://orcid.org/0009-0002-2822-7509"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marieke Niesters","raw_affiliation_strings":["Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042412836","display_name":"Martijn Boon","orcid":"https://orcid.org/0000-0002-2724-9581","observed_orcids":["https://orcid.org/0000-0002-2724-9581"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martijn Boon","raw_affiliation_strings":["Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2724-9581","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078101631","display_name":"Daniel S. Shoham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Shoham","raw_affiliation_strings":["Department of Anesthesia Critical Care, and Pain Medicine Massachusetts General Hospital Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia Critical Care, and Pain Medicine Massachusetts General Hospital Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037503569","display_name":"Kaye E. Dandrea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaye E. Dandrea","raw_affiliation_strings":["Department of Anesthesia Critical Care, and Pain Medicine Massachusetts General Hospital Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia Critical Care, and Pain Medicine Massachusetts General Hospital Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047934112","display_name":"Rutger M. van der Schrier","orcid":"https://orcid.org/0000-0003-1422-3830","observed_orcids":["https://orcid.org/0000-0003-1422-3830"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rutger van der Schrier","raw_affiliation_strings":["Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077603374","display_name":"Albert Dahan","orcid":"https://orcid.org/0000-0003-3161-3945","observed_orcids":["https://orcid.org/0000-0003-3161-3945"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Albert Dahan","raw_affiliation_strings":["Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-3161-3945","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077603374"],"corresponding_institution_ids":["https://openalex.org/I2800006345"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.1802,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.1426087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"3","first_page":"e00974","last_page":"e00974"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.5737000107765198,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.5737000107765198,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.13369999825954437,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-induced-respiratory-depression","display_name":"opioid-induced respiratory depression","score":0.9350000023841858},{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/reversal-agents","display_name":"reversal agents","score":0.6940000057220459},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.8330000042915344},{"id":"https://openalex.org/keywords/prebotzinger-complex","display_name":"pre-B\u00f6tzinger complex","score":0.968999981880188},{"id":"https://openalex.org/keywords/brainstem-respiratory-network","display_name":"brainstem respiratory network","score":0.7239999771118164},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.6069999933242798},{"id":"https://openalex.org/keywords/sufentanil","display_name":"sufentanil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/remifentanil","display_name":"remifentanil","score":0.9950000047683716},{"id":"https://openalex.org/keywords/rapid-shallow-breathing","display_name":"rapid shallow breathing","score":0.6650000214576721},{"id":"https://openalex.org/keywords/brain-penetration","display_name":"brain penetration","score":0.6029999852180481},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.7116022109985352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5607662200927734},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5501360893249512},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5225816965103149},{"id":"https://openalex.org/C2775962371","wikidata":"https://www.wikidata.org/wiki/Q908096","display_name":"Opioid antagonist","level":5,"score":0.4966145157814026},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.4905676245689392},{"id":"https://openalex.org/C3019590667","wikidata":"https://www.wikidata.org/wiki/Q908096","display_name":"Narcotic antagonist","level":5,"score":0.41034409403800964},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4060843288898468},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.3791978657245636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2842346131801605},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.24004977941513062},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1740439534187317}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017409","descriptor_name":"Sufentanil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1002/prp2.974","doi":"https://doi.org/10.1002/prp2.974","is_oa":true,"landing_page_url":"https://doi.org/10.1002/prp2.974","pdf_url":null,"source":{"id":"https://openalex.org/S2764487716","display_name":"Pharmacology Research & Perspectives","issn_l":"2052-1707","issn":["2052-1707"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology Research &amp; Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9137104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9137104","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacol Res Perspect","raw_type":"Text"},{"id":"pmid:35621218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35621218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology research & perspectives","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthmed_docs-1857","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthmed_docs/869","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3572104","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/3572104","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacology Research and Perspectives, 10(3). JOHN WILEY &amp; SONS LTD","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940745091402711","doi":null,"is_oa":false,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/3572104","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacology Research and Perspectives, No. 3","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:92891bef7a3246019c37120717556227","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/92891bef7a3246019c37120717556227","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacology Research & Perspectives, Vol 10, Iss 3, Pp n/a-n/a (2022)","raw_type":"article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3572104","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/3572104","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacology Research and Perspectives","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1002/prp2.974","doi":"https://doi.org/10.1002/prp2.974","is_oa":true,"landing_page_url":"https://doi.org/10.1002/prp2.974","pdf_url":null,"source":{"id":"https://openalex.org/S2764487716","display_name":"Pharmacology Research & Perspectives","issn_l":"2052-1707","issn":["2052-1707"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology Research &amp; Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2038129014","display_name":"Safer, Non-addicting Pain Management: Identification and Expression of Cyclic Peptides with Analgesic and Breathing Stimulant Properties","funder_award_id":"R21DA045231","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3785610240","display_name":"Preventing and Tackling the Opioid Epidemic","funder_award_id":"NWA.1160.18.300","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W154769866","https://openalex.org/W250885317","https://openalex.org/W1485977809","https://openalex.org/W1876211719","https://openalex.org/W1920209237","https://openalex.org/W1969651411","https://openalex.org/W1976314063","https://openalex.org/W1977481764","https://openalex.org/W1978192203","https://openalex.org/W1983393001","https://openalex.org/W1986551515","https://openalex.org/W1987170270","https://openalex.org/W1990744785","https://openalex.org/W1992443864","https://openalex.org/W1999393604","https://openalex.org/W2000709146","https://openalex.org/W2003462078","https://openalex.org/W2004997082","https://openalex.org/W2009683448","https://openalex.org/W2016037437","https://openalex.org/W2017771093","https://openalex.org/W2021541323","https://openalex.org/W2024707384","https://openalex.org/W2027287625","https://openalex.org/W2032182831","https://openalex.org/W2035046154","https://openalex.org/W2035415038","https://openalex.org/W2035456382","https://openalex.org/W2048799749","https://openalex.org/W2052250637","https://openalex.org/W2058737530","https://openalex.org/W2071913782","https://openalex.org/W2076992047","https://openalex.org/W2080452867","https://openalex.org/W2084825834","https://openalex.org/W2085330168","https://openalex.org/W2090171096","https://openalex.org/W2091404718","https://openalex.org/W2094820308","https://openalex.org/W2105831178","https://openalex.org/W2121049369","https://openalex.org/W2128918211","https://openalex.org/W2132468342","https://openalex.org/W2132844065","https://openalex.org/W2136904223","https://openalex.org/W2138085242","https://openalex.org/W2143995568","https://openalex.org/W2161059199","https://openalex.org/W2164406177","https://openalex.org/W2184736235","https://openalex.org/W2271165668","https://openalex.org/W2410345616","https://openalex.org/W2412796442","https://openalex.org/W2586801440","https://openalex.org/W2771328536","https://openalex.org/W2781479251","https://openalex.org/W2794081746","https://openalex.org/W2795355519","https://openalex.org/W2802756903","https://openalex.org/W2895281105","https://openalex.org/W2896525391","https://openalex.org/W2980219486","https://openalex.org/W2987002164","https://openalex.org/W2995224783","https://openalex.org/W2999133444","https://openalex.org/W3005042045","https://openalex.org/W3013708506","https://openalex.org/W3163800561","https://openalex.org/W3189454392","https://openalex.org/W3195893440","https://openalex.org/W4200103896","https://openalex.org/W4200362978","https://openalex.org/W4224324916","https://openalex.org/W4240558127"],"related_works":["https://openalex.org/W4224324916","https://openalex.org/W2802756903","https://openalex.org/W2412796442","https://openalex.org/W3163800561","https://openalex.org/W3163391196","https://openalex.org/W4200103896","https://openalex.org/W2048799749","https://openalex.org/W1986551515","https://openalex.org/W3165909459","https://openalex.org/W6999452534"],"abstract_inverted_index":{"Opioid-induced":[0],"respiratory":[1,97,103,107,129,174],"depression":[2],"(OIRD)":[3],"is":[4,26,177,211],"a":[5,22,44,156,213,249],"potentially":[6],"life-threatening":[7],"complication":[8],"of":[9,28,56,68,138,143,159,182,217,232],"opioid":[10,16],"consumption.":[11],"Apart":[12],"from":[13,204],"naloxone,":[14],"an":[15,89,95],"antagonist":[17],"that":[18,80,209],"has":[19],"various":[20],"disadvantages,":[21],"possible":[23],"reversal":[24,67,215,252],"strategy":[25],"treatment":[27],"OIRD":[29,69,218],"with":[30,162],"the":[31,54,66,92,101,141,185,228],"hypothalamic":[32],"hormone":[33,37],"and":[34,49,58,62,72,82,119,123,127,149,153,206,230,236],"neuromodulator":[35],"thyrotropin-releasing":[36],"(TRH).":[38],"In":[39,117,151,201],"this":[40,244],"review,":[41],"we":[42],"performed":[43],"search":[45],"in":[46,65,70,219],"electronic":[47],"databases":[48],"retrieved":[50],"52":[51],"papers":[52],"on":[53,60,197,227],"effect":[55,90,109],"TRH":[57,81,122,161,183,210],"TRH-analogs":[59],"respiration":[61],"their":[63],"efficacy":[64,229],"awake":[71,118,152,220],"anesthetized":[73,120,154,222],"mammals,":[74],"including":[75],"humans.":[76,223],"Animal":[77],"studies":[78,226],"show":[79],"its":[83],"analog":[84,239],"taltirelin":[85,124,198,240],"stimulate":[86],"breathing":[87,139],"via":[88],"at":[91],"preB\u00f6tzinger":[93],"complex,":[94],"important":[96],"rhythm":[98],"generator":[99],"within":[100],"brainstem":[102],"network.":[104],"An":[105],"additional":[106],"excitatory":[108],"may":[110],"be":[111,248],"related":[112,178],"to":[113,165,179,247],"TRH's":[114,233],"analeptic":[115],"effect.":[116],"rodents,":[121],"improved":[125],"morphine-":[126],"sufentanil-induced":[128],"depression,":[130],"by":[131],"causing":[132],"rapid":[133],"shallow":[134],"breathing.":[135],"This":[136,176],"pattern":[137],"increases":[140],"work":[142],"breathing,":[144],"dead":[145],"space":[146],"ventilation,":[147],"atelectasis,":[148],"hypoxia.":[150],"humans,":[155],"continuous":[157],"infusion":[158],"intravenous":[160],"doses":[163],"up":[164],"8":[166],"mg,":[167],"did":[168],"not":[169,212],"reverse":[170],"sufentanil-":[171],"or":[172,221],"remifentanil-induced":[173],"depression.":[175],"poor":[180],"penetration":[181],"into":[184],"brain":[186],"compartment":[187],"but":[188],"also":[189],"other":[190],"causes":[191],"are":[192,199,241],"discussed.":[193],"No":[194],"human":[195,207,225],"data":[196,203],"available.":[200],"conclusion,":[202],"animals":[205],"indicate":[208],"viable":[214],"agent":[216,245],"Further":[224],"safety":[231],"more":[234,250],"potent":[235],"longer":[237],"lasting":[238],"needed":[242],"as":[243],"seems":[246],"promising":[251],"drug.":[253]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-06-13T00:00:00"}
