{"id":"https://openalex.org/W4308298470","doi":"https://doi.org/10.1186/s12916-022-02583-y","title":"Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease","display_name":"Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease","publication_year":2022,"publication_date":"2022-11-06","ids":{"openalex":"https://openalex.org/W4308298470","doi":"https://doi.org/10.1186/s12916-022-02583-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/36336692","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9639312"},"language":"en","primary_location":{"id":"doi:10.1186/s12916-022-02583-y","doi":"https://doi.org/10.1186/s12916-022-02583-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-022-02583-y","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-022-02583-y","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-022-02583-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028500143","display_name":"Austin King","orcid":"https://orcid.org/0009-0008-5801-9288","observed_orcids":["https://orcid.org/0009-0008-5801-9288"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin King","raw_affiliation_strings":["Department of Statistics, Florida State University, Tallahassee, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Florida State University, Tallahassee, FL, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061079851","display_name":"Lang Wu","orcid":"https://orcid.org/0000-0001-9938-3627","observed_orcids":["https://orcid.org/0000-0001-9938-3627"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lang Wu","raw_affiliation_strings":["Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024194480","display_name":"Hong\u2010Wen Deng","orcid":"https://orcid.org/0000-0002-0387-8818","observed_orcids":["https://orcid.org/0000-0002-0387-8818","https://orcid.org/0000-0003-1933-7095"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong-Wen Deng","raw_affiliation_strings":["Center of Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013518217","display_name":"Hui Shen","orcid":"https://orcid.org/0000-0003-0335-6064","observed_orcids":["https://orcid.org/0000-0003-0335-6064","https://orcid.org/0009-0007-1039-8955"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Shen","raw_affiliation_strings":["Center of Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011295368","display_name":"Chong Wu","orcid":"https://orcid.org/0000-0002-8400-1785","observed_orcids":["https://orcid.org/0000-0002-8400-1785"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chong Wu","raw_affiliation_strings":["Department of Statistics, Florida State University, Tallahassee, FL, USA","Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-8400-1785","affiliations":[{"raw_affiliation_string":"Department of Statistics, Florida State University, Tallahassee, FL, USA","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011295368"],"corresponding_institution_ids":["https://openalex.org/I103163165","https://openalex.org/I1343551460"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":2.7035,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.91277426,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"385","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14212","display_name":"Health Promotion and Cardiovascular Prevention","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9430000185966492},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pooled-cohort-equations","display_name":"Pooled Cohort Equations","score":0.8199999928474426},{"id":"https://openalex.org/keywords/clinical-risk-prediction","display_name":"clinical risk prediction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/risk-reclassification","display_name":"risk reclassification","score":0.9190000295639038},{"id":"https://openalex.org/keywords/model-discrimination","display_name":"model discrimination","score":0.8519999980926514},{"id":"https://openalex.org/keywords/incident-cardiovascular-events","display_name":"incident cardiovascular events","score":0.44999998807907104},{"id":"https://openalex.org/keywords/uk-biobank","display_name":"UK Biobank","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction-models","display_name":"cardiovascular risk prediction models","score":0.6299999952316284},{"id":"https://openalex.org/keywords/net-reclassification-improvement","display_name":"net reclassification improvement","score":0.6819999814033508},{"id":"https://openalex.org/keywords/c-index","display_name":"concordance index","score":0.6169999837875366},{"id":"https://openalex.org/keywords/risk-communication","display_name":"risk communication","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8901010155677795},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.7964959144592285},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.6991591453552246},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.6328048706054688},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5948505401611328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5131374001502991},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.4477703869342804},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.42299801111221313},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.35332298278808594},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3000090718269348},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.060594379901885986},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.057355284690856934},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12916-022-02583-y","doi":"https://doi.org/10.1186/s12916-022-02583-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-022-02583-y","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-022-02583-y","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},{"id":"doi:10.1101/2022.06.02.22275933","doi":"https://doi.org/10.1101/2022.06.02.22275933","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.06.02.22275933","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/06/03/2022.06.02.22275933.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9639312","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9639312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med","raw_type":"Text"},{"id":"pmid:36336692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36336692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medicine","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthgsbs_docs-3310","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthgsbs_docs/2364","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a33ff3dc6a104a99b2fea33c24dd20dc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a33ff3dc6a104a99b2fea33c24dd20dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medicine, Vol 20, Iss 1, Pp 1-14 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12916-022-02583-y","doi":"https://doi.org/10.1186/s12916-022-02583-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-022-02583-y","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-022-02583-y","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1230166947","display_name":null,"funder_award_id":"R01CA263494","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G3558902290","display_name":"Identification of Metabolomic Profiles for Sarcopenia Traits in Older Whites and Blacks","funder_award_id":"R01AG061917","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5331993534","display_name":"UK Biobank (core renewal)","funder_award_id":"MC_PC_17228","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7105272763","display_name":"Novel Statistical Methods for Multi-omics Data Integration in Alzheimer's Disease","funder_award_id":"R03AG070669","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000869976","display_name":"Uncovering causal protein markers to improve prostate cancer etiology understanding and risk prediction in Africans and Europeans","funder_award_id":"R01CA263494","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308298470.pdf","grobid_xml":"https://content.openalex.org/works/W4308298470.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1892943358","https://openalex.org/W2044702943","https://openalex.org/W2055838663","https://openalex.org/W2082704080","https://openalex.org/W2084139018","https://openalex.org/W2097499820","https://openalex.org/W2102899779","https://openalex.org/W2103645914","https://openalex.org/W2104549677","https://openalex.org/W2106597074","https://openalex.org/W2107165713","https://openalex.org/W2112690682","https://openalex.org/W2119910794","https://openalex.org/W2132432664","https://openalex.org/W2133520037","https://openalex.org/W2148092884","https://openalex.org/W2169795969","https://openalex.org/W2238851414","https://openalex.org/W2280070832","https://openalex.org/W2399385044","https://openalex.org/W2506303923","https://openalex.org/W2587257410","https://openalex.org/W2613151407","https://openalex.org/W2618596952","https://openalex.org/W2723723801","https://openalex.org/W2761498056","https://openalex.org/W2781693957","https://openalex.org/W2794819865","https://openalex.org/W2803332630","https://openalex.org/W2805499342","https://openalex.org/W2884616392","https://openalex.org/W2886752110","https://openalex.org/W2895366584","https://openalex.org/W2895486342","https://openalex.org/W2921012991","https://openalex.org/W2923382806","https://openalex.org/W2932671560","https://openalex.org/W2951553270","https://openalex.org/W2952882474","https://openalex.org/W2958550040","https://openalex.org/W2963160524","https://openalex.org/W2965310331","https://openalex.org/W2971685995","https://openalex.org/W2983607182","https://openalex.org/W2999574254","https://openalex.org/W3007698544","https://openalex.org/W3008788084","https://openalex.org/W3010752615","https://openalex.org/W3015631361","https://openalex.org/W3020100939","https://openalex.org/W3022199624","https://openalex.org/W3028713471","https://openalex.org/W3030835293","https://openalex.org/W3033304694","https://openalex.org/W3045441625","https://openalex.org/W3046366876","https://openalex.org/W3090627945","https://openalex.org/W3092849554","https://openalex.org/W3100437030","https://openalex.org/W3134515557","https://openalex.org/W3134600603","https://openalex.org/W3136190300","https://openalex.org/W3172996796","https://openalex.org/W3199099636","https://openalex.org/W3199261654","https://openalex.org/W3205241549","https://openalex.org/W3205525418","https://openalex.org/W3207912190","https://openalex.org/W4317390883"],"related_works":["https://openalex.org/W3007698544","https://openalex.org/W4213133405","https://openalex.org/W4381125734","https://openalex.org/W4415791148","https://openalex.org/W4377010487","https://openalex.org/W4414532239","https://openalex.org/W3134600603","https://openalex.org/W7214177563","https://openalex.org/W4324116630","https://openalex.org/W4313482995"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,121],"value":[2],"of":[3,34,44,62,71,81,89,104,123,141,184,204,226,277],"polygenic":[4,28,83,109,170,207,280,315],"risk":[5,12,29,84,101,110,131,171,208,218,281,299,316,321],"scores":[6],"(PRSs)":[7],"towards":[8],"improving":[9],"guideline-recommended":[10],"clinical":[11,298],"models":[13],"for":[14,77,117,168,201,233,245,283,294],"coronary":[15],"artery":[16],"disease":[17],"(CAD)":[18],"prediction":[19,33,102,322],"is":[20],"controversial.":[21],"Here":[22],"we":[23],"examine":[24,99],"whether":[25],"an":[26,68,313],"integrated":[27,108,169,206,279,314],"score":[30,209,282,317],"improves":[31,290],"the":[32,82,100,139,202,205,211,264,272,278,286,291,302,306,326],"CAD":[35,65,119,157,256,284,296,320],"beyond":[36],"pooled":[37,105,114,173,178,212,287],"cohort":[38,88,106,115,140,174,179,213,288],"equations.":[39],"METHODS:":[40],"An":[41],"observation":[42],"study":[43],"291,305":[45],"unrelated":[46],"White":[47,303,327],"British":[48,304,328],"UK":[49,307],"Biobank":[50],"participants":[51],"enrolled":[52],"from":[53,305],"2006":[54],"to":[55,94,98,149,210,231,242,252,263,271,285],"2010":[56],"was":[57,75,96,126,166],"conducted.":[58],"A":[59,86],"case-control":[60],"sample":[61],"9499":[63],"prevalent":[64],"cases":[66,158,234],"and":[67,79,112,130,176,193,235,267,297,323],"equal":[69],"number":[70],"randomly":[72],"selected":[73],"controls":[74],"used":[76,97,148],"tuning":[78],"integrating":[80],"scores.":[85],"separate":[87],"272,307":[90,142],"individuals":[91,143],"(with":[92],"follow-up":[93,162],"2020)":[95],"performance":[103,122],"equations,":[107],"score,":[111,172],"PRS-enhanced":[113,177],"equation":[116,180,214],"incident":[118,156,255,295],"cases.":[120],"each":[124],"model":[125],"analyzed":[127],"by":[128],"discrimination":[129,165],"reclassification":[132,200,224],"using":[133],"a":[134,160,216,222],"7.5%":[135,217],"threshold.":[136],"RESULTS:":[137],"In":[138],"(mean":[144],"age,":[145],"56.7":[146],"years)":[147],"analyze":[150],"predictive":[151,292],"accuracy,":[152],"there":[153],"were":[154],"7036":[155],"over":[159],"12-year":[161],"period.":[163],"Model":[164],"tested":[167],"equation,":[175],"with":[181],"reported":[182],"C-statistics":[183],"0.640":[185],"(95%":[186,190,195,228,238,249],"CI,":[187,191,196,229,239,250],"0.634-0.646),":[188],"0.718":[189],"0.713-0.723),":[192],"0.753":[194],"0.748-0.758),":[197],"respectively.":[198],"Risk":[199],"addition":[203],"at":[215],"threshold":[219],"resulted":[220],"in":[221,301,325],"net":[223],"improvement":[225],"0.117":[227],"0.102":[230],"0.129)":[232],"-":[236,240,243],"0.023":[237],"0.025":[241],"0.022)":[244],"noncases":[246],"[overall:":[247],"0.093":[248],"0.08":[251],"0.104)].":[253],"For":[254],"cases,":[257],"this":[258],"represented":[259],"14.2%":[260],"correctly":[261],"reclassified":[262,270],"higher-risk":[265],"category":[266],"2.6%":[268],"incorrectly":[269],"lower-risk":[273],"category.":[274],"CONCLUSIONS:":[275],"Addition":[276],"questions":[289],"accuracy":[293],"classification":[300],"Biobank.":[308],"These":[309],"findings":[310],"suggest":[311],"that":[312],"may":[318],"enhance":[319],"screening":[324],"population.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-10T00:00:00"}
