{"id":"https://openalex.org/W4281824035","doi":"https://doi.org/10.3389/fchem.2022.894563","title":"Investigations Into Chemically Stabilized Four-Letter DNA for DNA-Encoded Chemistry","display_name":"Investigations Into Chemically Stabilized Four-Letter DNA for DNA-Encoded Chemistry","publication_year":2022,"publication_date":"2022-06-09","ids":{"openalex":"https://openalex.org/W4281824035","doi":"https://doi.org/10.3389/fchem.2022.894563","pmid":"https://pubmed.ncbi.nlm.nih.gov/35755251","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9218945"},"language":"en","primary_location":{"id":"doi:10.3389/fchem.2022.894563","doi":"https://doi.org/10.3389/fchem.2022.894563","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fchem.2022.894563","pdf_url":"https://www.frontiersin.org/articles/10.3389/fchem.2022.894563/pdf","source":{"id":"https://openalex.org/S2764970645","display_name":"Frontiers in Chemistry","issn_l":"2296-2646","issn":["2296-2646"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fchem.2022.894563/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074719719","display_name":"Marco Potowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marco Potowski","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Medicinal Chemistry, TU Dortmund University, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Medicinal Chemistry, TU Dortmund University, Dortmund, Germany","institution_ids":["https://openalex.org/I200332995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045643656","display_name":"Verena B. K. Kunig","orcid":"https://orcid.org/0000-0002-4894-3644","observed_orcids":["https://orcid.org/0000-0002-4894-3644"]},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Verena B. K. Kunig","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Medicinal Chemistry, TU Dortmund University, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Medicinal Chemistry, TU Dortmund University, Dortmund, Germany","institution_ids":["https://openalex.org/I200332995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042256341","display_name":"Lukas Eberlein","orcid":"https://orcid.org/0000-0002-4087-9617","observed_orcids":["https://orcid.org/0000-0002-4087-9617"]},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lukas Eberlein","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Physical Chemistry, TU Dortmund University, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Physical Chemistry, TU Dortmund University, Dortmund, Germany","institution_ids":["https://openalex.org/I200332995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063201478","display_name":"Mateja Klika \u0160kopi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mateja Klika \u0160kopi\u0107","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Medicinal Chemistry, TU Dortmund University, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Medicinal Chemistry, TU Dortmund University, Dortmund, Germany","institution_ids":["https://openalex.org/I200332995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065499236","display_name":"Alexandros Vakalopoulos","orcid":"https://orcid.org/0000-0002-7032-0304","observed_orcids":["https://orcid.org/0000-0002-7032-0304"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandros Vakalopoulos","raw_affiliation_strings":["Bayer AG, Pharmaceuticals, Research and Development, Synthetic Modalities, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer AG, Pharmaceuticals, Research and Development, Synthetic Modalities, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067084150","display_name":"Stefan Michael Kast","orcid":"https://orcid.org/0000-0001-7346-7064","observed_orcids":["https://orcid.org/0000-0001-7346-7064"]},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan M. Kast","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Physical Chemistry, TU Dortmund University, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Physical Chemistry, TU Dortmund University, Dortmund, Germany","institution_ids":["https://openalex.org/I200332995"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070067508","display_name":"Andreas Brunschweiger","orcid":"https://orcid.org/0000-0002-4401-1495","observed_orcids":["https://orcid.org/0000-0002-4401-1495"]},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Brunschweiger","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Medicinal Chemistry, TU Dortmund University, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Medicinal Chemistry, TU Dortmund University, Dortmund, Germany","institution_ids":["https://openalex.org/I200332995"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067084150","https://openalex.org/A5070067508"],"corresponding_institution_ids":["https://openalex.org/I200332995"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.1501,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.31795965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"10","issue":null,"first_page":"894563","last_page":"894563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.10689999908208847,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-barcodes","display_name":"DNA barcodes","score":0.8119999766349792},{"id":"https://openalex.org/keywords/7-deazaadenine","display_name":"7-deazaadenine","score":0.9470000267028809},{"id":"https://openalex.org/keywords/chemical-stability","display_name":"chemical stability","score":0.6320000290870667},{"id":"https://openalex.org/keywords/depurination","display_name":"depurination","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nucleobase-modification","display_name":"nucleobase modification","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6660656929016113},{"id":"https://openalex.org/C34737976","wikidata":"https://www.wikidata.org/wiki/Q903582","display_name":"Depurination","level":3,"score":0.6126111745834351},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5906140804290771},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.5021905899047852},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.49211829900741577},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.45286697149276733},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4465378522872925},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41870829463005066},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38156992197036743},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.36560332775115967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3229295611381531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2884252071380615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1546202003955841}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fchem.2022.894563","doi":"https://doi.org/10.3389/fchem.2022.894563","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fchem.2022.894563","pdf_url":"https://www.frontiersin.org/articles/10.3389/fchem.2022.894563/pdf","source":{"id":"https://openalex.org/S2764970645","display_name":"Frontiers in Chemistry","issn_l":"2296-2646","issn":["2296-2646"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9218945","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9218945","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Chem","raw_type":"Text"},{"id":"pmid:35755251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35755251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3f3462fa863a4435b7ca5f45117ccc74","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3f3462fa863a4435b7ca5f45117ccc74","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Chemistry, Vol 10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fchem.2022.894563","doi":"https://doi.org/10.3389/fchem.2022.894563","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fchem.2022.894563","pdf_url":"https://www.frontiersin.org/articles/10.3389/fchem.2022.894563/pdf","source":{"id":"https://openalex.org/S2764970645","display_name":"Frontiers in Chemistry","issn_l":"2296-2646","issn":["2296-2646"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1718665122","display_name":"EXC 2033: RESOLV (Ruhr Explores Solvation)","funder_award_id":"390677874","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1888550142","display_name":null,"funder_award_id":"FOR1979","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G199205490","display_name":null,"funder_award_id":"EXC2033390677874","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G274347230","display_name":null,"funder_award_id":"EXC2033","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320307771","display_name":"Bayer","ror":"https://ror.org/04hmn8g73"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320329559","display_name":"Technische Universit\u00e4t Dortmund","ror":"https://ror.org/01k97gp34"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281824035.pdf","grobid_xml":"https://content.openalex.org/works/W4281824035.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1568686261","https://openalex.org/W1850648650","https://openalex.org/W1977054069","https://openalex.org/W1978298790","https://openalex.org/W1999415789","https://openalex.org/W2028553114","https://openalex.org/W2029209483","https://openalex.org/W2033358700","https://openalex.org/W2034242326","https://openalex.org/W2046339455","https://openalex.org/W2094085641","https://openalex.org/W2134359289","https://openalex.org/W2286829287","https://openalex.org/W2299985318","https://openalex.org/W2560363454","https://openalex.org/W2615741776","https://openalex.org/W2987242592","https://openalex.org/W2999977264","https://openalex.org/W3010401543","https://openalex.org/W3092211024","https://openalex.org/W3094883686","https://openalex.org/W3158642658","https://openalex.org/W3166642179","https://openalex.org/W3176855369","https://openalex.org/W4205460523"],"related_works":["https://openalex.org/W3176855369","https://openalex.org/W3189272577","https://openalex.org/W4248207149","https://openalex.org/W1984397054","https://openalex.org/W2095037466","https://openalex.org/W2503131032","https://openalex.org/W2061879076","https://openalex.org/W2782995788","https://openalex.org/W4385306065","https://openalex.org/W7216170306"],"abstract_inverted_index":{"DNA-encoded":[0],"libraries":[1],"are":[2,28],"a":[3,73,87],"prime":[4],"technology":[5],"for":[6,39,42],"target-based":[7],"small":[8],"molecule":[9],"screening.":[10],"Native":[11],"DNA":[12,25,93],"used":[13],"as":[14],"genetic":[15],"compound":[16],"barcode":[17],"is":[18],"chemically":[19],"vulnerable":[20],"under":[21],"many":[22],"reaction":[23],"conditions.":[24],"barcodes":[26,51],"that":[27],"composed":[29],"of":[30],"pyrimidine":[31,92],"nucleobases,":[32],"7-deazaadenine,":[33],"and":[34,47,62,94],"7-deaza-8-azaguanine":[35],"have":[36],"been":[37],"investigated":[38],"their":[40],"suitability":[41],"encoded":[43],"chemistry":[44],"both":[45],"experimentally":[46],"computationally.":[48],"These":[49],"four-letter":[50],"were":[52,66],"readily":[53],"ligated":[54],"by":[55,59],"T4":[56],"ligation,":[57],"amplifiable":[58],"Taq":[60],"polymerase,":[61],"the":[63],"resultant":[64],"amplicons":[65],"correctly":[67],"sequenced.":[68],"Chemical":[69],"stability":[70,76],"profiling":[71],"showed":[72],"superior":[74],"chemical":[75],"compared":[77],"to":[78,84],"native":[79],"DNA,":[80],"though":[81],"higher":[82],"susceptibility":[83],"depurination":[85],"than":[86],"three-letter":[88],"code":[89],"based":[90],"on":[91],"7-deazaadenine.":[95]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-06-13T00:00:00"}
