{"id":"https://openalex.org/W4281822232","doi":"https://doi.org/10.1098/rstb.2020.0514","title":"Extensive simulations assess the performance of genome-wide association mapping in various Saccharomyces cerevisiae subpopulations","display_name":"Extensive simulations assess the performance of genome-wide association mapping in various Saccharomyces cerevisiae subpopulations","publication_year":2022,"publication_date":"2022-05-30","ids":{"openalex":"https://openalex.org/W4281822232","doi":"https://doi.org/10.1098/rstb.2020.0514","pmid":"https://pubmed.ncbi.nlm.nih.gov/35634920","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9149792"},"language":"en","primary_location":{"id":"doi:10.1098/rstb.2020.0514","doi":"https://doi.org/10.1098/rstb.2020.0514","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rstb.2020.0514","pdf_url":null,"source":{"id":"https://openalex.org/S91660768","display_name":"Philosophical Transactions of the Royal Society B Biological Sciences","issn_l":"0962-8436","issn":["0962-8436","1471-2970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philosophical Transactions of the Royal Society B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1098/rstb.2020.0514","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043931148","display_name":"Jackson Peter","orcid":"https://orcid.org/0000-0002-4094-5258","observed_orcids":["https://orcid.org/0000-0002-4094-5258"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210148000","display_name":"G\u00e9n\u00e9tique Mol\u00e9culaire G\u00e9nomique Microbiologie","ror":"https://ror.org/05n4nmn13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210148000","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jackson Peter","raw_affiliation_strings":["CNRS, GMGM UMR 7156, Strasbourg, France 1 ,","Universit\u00e9 de Strasbourg 1 ,","Universit\u00e9 de Strasbourg, CNRS, GMGM UMR 7156, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, GMGM UMR 7156, Strasbourg, France 1 ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210148000"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg 1 ,","institution_ids":["https://openalex.org/I68947357"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, GMGM UMR 7156, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210148000","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051713747","display_name":"Anne Friedrich","orcid":"https://orcid.org/0000-0003-3558-9356","observed_orcids":["https://orcid.org/0000-0003-3558-9356"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210148000","display_name":"G\u00e9n\u00e9tique Mol\u00e9culaire G\u00e9nomique Microbiologie","ror":"https://ror.org/05n4nmn13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210148000","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Friedrich","raw_affiliation_strings":["CNRS, GMGM UMR 7156, Strasbourg, France 1 ,","Universit\u00e9 de Strasbourg 1 ,","Universit\u00e9 de Strasbourg, CNRS, GMGM UMR 7156, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, GMGM UMR 7156, Strasbourg, France 1 ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210148000"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg 1 ,","institution_ids":["https://openalex.org/I68947357"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, GMGM UMR 7156, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210148000","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029927126","display_name":"Gianni Liti","orcid":"https://orcid.org/0000-0002-2318-0775","observed_orcids":["https://orcid.org/0000-0002-2318-0775"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210119200","display_name":"Institut de Recherche sur le Cancer et le Vieillissement de Nice","ror":"https://ror.org/01td3kv81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210119200"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gianni Liti","raw_affiliation_strings":["CNRS, INSERM, IRCAN, Nice, France 2 ,","Universit\u00e9 C\u00f4te d'Azur 2 ,","Universit\u00e9 C\u00f4te d'Azur, CNRS, INSERM, IRCAN, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, INSERM, IRCAN, Nice, France 2 ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210119200"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur 2 ,","institution_ids":["https://openalex.org/I201841394"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, CNRS, INSERM, IRCAN, Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210119200"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091722749","display_name":"Joseph Schacherer","orcid":"https://orcid.org/0000-0002-6606-6884","observed_orcids":["https://orcid.org/0000-0002-6606-6884"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I185839726","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266","country_code":"FR","type":"education","lineage":["https://openalex.org/I185839726"]},{"id":"https://openalex.org/I4210148000","display_name":"G\u00e9n\u00e9tique Mol\u00e9culaire G\u00e9nomique Microbiologie","ror":"https://ror.org/05n4nmn13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210148000","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Joseph Schacherer","raw_affiliation_strings":["CNRS, GMGM UMR 7156, Strasbourg, France 1 ,","Institut Universitaire de France (IUF) 3 ,","Paris, France 3 ,","Universit\u00e9 de Strasbourg 1 ,","Institut Universitaire de France (IUF), Paris, France","Universit\u00e9 de Strasbourg, CNRS, GMGM UMR 7156, Strasbourg, France"],"raw_orcid":"https://orcid.org/0000-0002-6606-6884","affiliations":[{"raw_affiliation_string":"CNRS, GMGM UMR 7156, Strasbourg, France 1 ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210148000"]},{"raw_affiliation_string":"Institut Universitaire de France (IUF) 3 ,","institution_ids":["https://openalex.org/I185839726"]},{"raw_affiliation_string":"Paris, France 3 ,","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg 1 ,","institution_ids":["https://openalex.org/I68947357"]},{"raw_affiliation_string":"Institut Universitaire de France (IUF), Paris, France","institution_ids":["https://openalex.org/I185839726"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, GMGM UMR 7156, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210148000","https://openalex.org/I68947357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5091722749"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I185839726","https://openalex.org/I4210148000","https://openalex.org/I68947357"],"apc_list":null,"apc_paid":{"value":2040,"currency":"EUR","value_usd":2200},"fwci":0.6033,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.62520197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"377","issue":"1855","first_page":"20200514","last_page":"20200514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.4595000147819519,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.4595000147819519,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.3073999881744385,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.06629999727010727,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.9380000233650208},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9959999918937683},{"id":"https://openalex.org/keywords/population-structure","display_name":"population structure","score":0.6830000281333923},{"id":"https://openalex.org/keywords/simulation-study","display_name":"simulation study","score":0.5640000104904175},{"id":"https://openalex.org/keywords/linear-mixed-models","display_name":"linear mixed models","score":0.6940000057220459},{"id":"https://openalex.org/keywords/mendelian-traits","display_name":"Mendelian traits","score":0.8370000123977661},{"id":"https://openalex.org/keywords/complex-traits","display_name":"complex traits","score":0.9900000095367432},{"id":"https://openalex.org/keywords/false-positive-and-false-negative-rates","display_name":"false positive and false negative rates","score":0.8059999942779541},{"id":"https://openalex.org/keywords/sample-size","display_name":"sample size","score":0.8479999899864197},{"id":"https://openalex.org/keywords/relatedness","display_name":"relatedness","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.8000079393386841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6727704405784607},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.6055439114570618},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5797350406646729},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5374366044998169},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.5301488637924194},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.527905285358429},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4959896504878998},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4542754590511322},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.4457102417945862},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.44541481137275696},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3732870817184448},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2325703203678131},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22460490465164185},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14559966325759888},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13421925902366638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06510299444198608},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1098/rstb.2020.0514","doi":"https://doi.org/10.1098/rstb.2020.0514","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rstb.2020.0514","pdf_url":null,"source":{"id":"https://openalex.org/S91660768","display_name":"Philosophical Transactions of the Royal Society B Biological Sciences","issn_l":"0962-8436","issn":["0962-8436","1471-2970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philosophical Transactions of the Royal Society B","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9149792","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9149792","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philos Trans R Soc Lond B Biol Sci","raw_type":"Text"},{"id":"pmid:35634920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35634920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04895349v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04895349","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://royalsocietypublishing.org/doi/10.1098/rstb.2020.0514","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:univoak.eu:islandora_173858","doi":null,"is_oa":true,"landing_page_url":"https://royalsocietypublishing.org/doi/10.1098/rstb.2020.0514","pdf_url":null,"source":{"id":"https://openalex.org/S4306402449","display_name":"univOAK (4 institutions : Universit\u00e9 de Strasbourg, Universit\u00e9 de Haute Alsace, INSA Strasbourg, Biblioth\u00e8que Nationale et Universitaire de Strasbourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210100283","host_organization_name":"Laboratoire des Sciences de l'Ing\u00e9nieur, de l'Informatique et de l'Imagerie","host_organization_lineage":["https://openalex.org/I4210100283"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1098/rstb.2020.0514","doi":"https://doi.org/10.1098/rstb.2020.0514","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rstb.2020.0514","pdf_url":null,"source":{"id":"https://openalex.org/S91660768","display_name":"Philosophical Transactions of the Royal Society B Biological Sciences","issn_l":"0962-8436","issn":["0962-8436","1471-2970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philosophical Transactions of the Royal Society B","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1828054788","https://openalex.org/W1907868928","https://openalex.org/W1979914496","https://openalex.org/W1980386768","https://openalex.org/W1983654804","https://openalex.org/W2033151532","https://openalex.org/W2079927753","https://openalex.org/W2084482326","https://openalex.org/W2099085143","https://openalex.org/W2104549677","https://openalex.org/W2109667697","https://openalex.org/W2119180969","https://openalex.org/W2144939475","https://openalex.org/W2149992227","https://openalex.org/W2163938253","https://openalex.org/W2253002676","https://openalex.org/W2419574648","https://openalex.org/W2466720169","https://openalex.org/W2508506323","https://openalex.org/W2529752014","https://openalex.org/W2766784689","https://openalex.org/W2798064943","https://openalex.org/W2812634658","https://openalex.org/W2901303766","https://openalex.org/W2915402738","https://openalex.org/W2951733089","https://openalex.org/W2982084346","https://openalex.org/W3133859624","https://openalex.org/W3142233419"],"related_works":["https://openalex.org/W2163938253","https://openalex.org/W2109667697","https://openalex.org/W2794826005","https://openalex.org/W2611671612","https://openalex.org/W4415196206","https://openalex.org/W7202013122","https://openalex.org/W2621386604","https://openalex.org/W3088213436","https://openalex.org/W3011135393","https://openalex.org/W2333021083"],"abstract_inverted_index":{"Abstract":[0],"With":[1],"the":[2,20,24,32,47,50,66,74,78,108,112,119,160,175,204],"advent":[3],"of":[4,23,34,52,69,122,147,177,182,203,209],"high":[5,116],"throughput":[6],"sequencing":[7],"technologies,":[8],"genome-wide":[9],"association":[10],"studies":[11],"(GWAS)":[12],"have":[13],"become":[14],"a":[15,40,90,123,142,165],"powerful":[16],"paradigm":[17],"for":[18,43,104],"dissecting":[19],"genetic":[21,80,120],"origins":[22],"observed":[25],"phenotypic":[26],"variation.":[27],"We":[28,72],"recently":[29],"completely":[30],"sequenced":[31],"genome":[33],"1011":[35,70],"Saccharomyces":[36],"cerevisiae":[37],"isolates,":[38],"laying":[39],"strong":[41],"foundation":[42],"GWAS.":[44],"To":[45],"assess":[46],"feasibility":[48,176],"and":[49,85,105,151,173,195,211],"limits":[51],"this":[53,178],"approach,":[54],"we":[55,156],"performed":[56,157],"extensive":[57],"simulations":[58],"using":[59,89,164],"five":[60],"selected":[61],"subpopulations":[62,163],"as":[63,65,191],"well":[64,102],"total":[67],"set":[68],"genomes.":[71],"measured":[73],"ability":[75],"to":[76,170,215],"detect":[77],"causal":[79],"variants":[81],"involved":[82],"in":[83,129,145],"Mendelian":[84,124],"more":[86],"complex":[87,143],"traits":[88],"linear":[91],"mixed":[92],"model":[93],"approach.":[94,179],"The":[95,180],"results":[96],"showed":[97,174],"that":[98],"population":[99,196],"structure":[100],"is":[101,106,115,126,201],"accounted":[103],"not":[107],"main":[109],"problem":[110],"when":[111,138],"sample":[113,192],"size":[114],"enough.":[117],"While":[118],"determinant":[121],"trait":[125,144,168],"easily":[127],"mapped":[128],"all":[130],"studied":[131],"subpopulations,":[132],"discrepancies":[133],"are":[134],"seen":[135],"between":[136],"datasets":[137],"performing":[139],"GWAS":[140,158],"on":[141,159,187],"terms":[146],"detection,":[148],"false":[149,152],"positive":[150],"negative":[153],"rate.":[154],"Finally,":[155],"different":[161],"defined":[162],"real":[166],"quantitative":[167],"(resistance":[169],"copper":[171],"sulfate)":[172],"performance":[181],"each":[183],"dataset":[184],"depends":[185],"simultaneously":[186],"several":[188],"factors":[189],"such":[190],"size,":[193],"relatedness":[194],"evolutionary":[197],"history.":[198],"This":[199],"article":[200],"part":[202],"theme":[205],"issue":[206],"\u2018Genetic":[207],"basis":[208],"adaptation":[210],"speciation:":[212],"from":[213],"loci":[214],"causative":[216],"mutations\u2019.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-13T00:00:00"}