{"id":"https://openalex.org/W4281806822","doi":"https://doi.org/10.1038/s41598-022-12992-x","title":"Cryopreservation Does Not Affect the Clinical Pregnancy Rate of Blastocysts Derived from Vitrified Oocytes","display_name":"Cryopreservation Does Not Affect the Clinical Pregnancy Rate of Blastocysts Derived from Vitrified Oocytes","publication_year":2022,"publication_date":"2022-05-27","ids":{"openalex":"https://openalex.org/W4281806822","doi":"https://doi.org/10.1038/s41598-022-12992-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/35624188","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9142575"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-022-12992-x","doi":"https://doi.org/10.1038/s41598-022-12992-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-12992-x","pdf_url":"https://www.nature.com/articles/s41598-022-12992-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-022-12992-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080523696","display_name":"Hadi Ramadan","orcid":"https://orcid.org/0000-0002-0380-7235","observed_orcids":["https://orcid.org/0000-0002-0380-7235"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hadi Ramadan","raw_affiliation_strings":["Eastern Virginia Medical School, 825 Fairfax Ave, Norfolk, VA, 23507, USA. hadiramadan1989@gmail.com","Eastern Virginia Medical School, 825 Fairfax Ave, Norfolk, VA, 23507, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, 825 Fairfax Ave, Norfolk, VA, 23507, USA. hadiramadan1989@gmail.com","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Eastern Virginia Medical School, 825 Fairfax Ave, Norfolk, VA, 23507, USA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067314114","display_name":"Tarita Pakrashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tarita Pakrashi","raw_affiliation_strings":["Shady Grove Fertility Jones Institute, 601 Colley Ave, Norfolk, VA, 23507, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shady Grove Fertility Jones Institute, 601 Colley Ave, Norfolk, VA, 23507, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031286794","display_name":"Andrea Ries Thurman","orcid":"https://orcid.org/0000-0001-9826-6664","observed_orcids":["https://orcid.org/0000-0001-9826-6664"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea R. Thurman","raw_affiliation_strings":["Eastern Virginia Medical School, 825 Fairfax Ave, Norfolk, VA, 23507, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, 825 Fairfax Ave, Norfolk, VA, 23507, USA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034062195","display_name":"Kimball O. Pomeroy","orcid":"https://orcid.org/0000-0002-7661-707X","observed_orcids":["https://orcid.org/0000-0002-7661-707X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimball O. Pomeroy","raw_affiliation_strings":["The World Egg and Sperm Bank US, 7826 East Evans Road, Scottsdale, AZ, 85260, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The World Egg and Sperm Bank US, 7826 East Evans Road, Scottsdale, AZ, 85260, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110150799","display_name":"Gerard Celia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard Celia","raw_affiliation_strings":["Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA, 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA, 23298, USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080523696"],"corresponding_institution_ids":["https://openalex.org/I156802259"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":0.8828,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.70681675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"8970","last_page":"8970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oocyte-vitrification","display_name":"oocyte vitrification","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cryopreservation","display_name":"cryopreservation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/frozen-embryo-transfer","display_name":"frozen embryo transfer","score":0.8339999914169312},{"id":"https://openalex.org/keywords/clinical-pregnancy-rate","display_name":"clinical pregnancy rate","score":0.828000009059906},{"id":"https://openalex.org/keywords/blastocyst","display_name":"blastocyst","score":0.8799999952316284},{"id":"https://openalex.org/keywords/single-embryo-transfer","display_name":"single embryo transfer","score":0.7509999871253967},{"id":"https://openalex.org/keywords/embryonic-age","display_name":"embryo age","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.8113552331924438},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.6893354058265686},{"id":"https://openalex.org/C2776537878","wikidata":"https://www.wikidata.org/wiki/Q7239894","display_name":"Pregnancy rate","level":3,"score":0.6761527061462402},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.670814037322998},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6435126066207886},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.639517068862915},{"id":"https://openalex.org/C59843425","wikidata":"https://www.wikidata.org/wiki/Q5370216","display_name":"Embryo cryopreservation","level":4,"score":0.6247003078460693},{"id":"https://openalex.org/C2778022349","wikidata":"https://www.wikidata.org/wiki/Q1072553","display_name":"Vitrification","level":2,"score":0.5352075695991516},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5099090337753296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44290781021118164},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.4377974569797516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3032568693161011},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0827452540397644}],"mesh":[{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015925","descriptor_name":"Cryopreservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018873","descriptor_name":"Pregnancy Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058989","descriptor_name":"Vitrification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-022-12992-x","doi":"https://doi.org/10.1038/s41598-022-12992-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-12992-x","pdf_url":"https://www.nature.com/articles/s41598-022-12992-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9142575","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9142575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:35624188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35624188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:60aef3ed31334b1fadcc1021e43455fc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/60aef3ed31334b1fadcc1021e43455fc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 12, Iss 1, Pp 1-4 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-022-12992-x","doi":"https://doi.org/10.1038/s41598-022-12992-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-12992-x","pdf_url":"https://www.nature.com/articles/s41598-022-12992-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281806822.pdf","grobid_xml":"https://content.openalex.org/works/W4281806822.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2012394364","https://openalex.org/W2336688692","https://openalex.org/W2407257601","https://openalex.org/W2621213480","https://openalex.org/W2746282189","https://openalex.org/W2766266818","https://openalex.org/W3107012035"],"related_works":["https://openalex.org/W2107555815","https://openalex.org/W2745597409","https://openalex.org/W3092767912","https://openalex.org/W3092853513","https://openalex.org/W2793756501","https://openalex.org/W2079265629","https://openalex.org/W2095340460","https://openalex.org/W2393133678","https://openalex.org/W2101016616","https://openalex.org/W2000402801"],"abstract_inverted_index":{"Vitrified,":[0],"or":[1,16],"\"frozen\",":[2],"donor":[3,41],"eggs":[4],"can":[5],"either":[6],"be":[7,172],"fertilized":[8,17],"and":[9,18,87,139],"cultured":[10],"for":[11,20],"fresh":[12],"transfer":[13,21],"(group":[14,28],"1),":[15],"cryopreserved":[19],"in":[22,98,117,154,165,184],"a":[23,160],"\"frozen":[24],"embryo":[25,65,113],"transfer\"":[26],"cycle":[27],"2).":[29],"This":[30],"study":[31,170],"compared":[32],"the":[33,37,50,79,103,147,176],"pregnancy":[34,59,100,155],"rates":[35],"between":[36,102],"two":[38,104,135,148],"groups.":[39],"Frozen":[40],"egg":[42],"cycles":[43,77,86],"(N":[44],"=":[45,110],"1213)":[46],"were":[47],"analyzed":[48],"at":[49],"World":[51],"Egg":[52],"Bank.":[53],"The":[54,127],"outcome":[55],"studied":[56],"was":[57,94,115,159],"clinical":[58,99],"rate.":[60,156],"Cycles":[61],"included":[62,84],"only":[63],"single":[64],"transfers":[66],"(ET)":[67],"without":[68],"preimplantation":[69],"genetic":[70],"testing":[71],"(PGT).":[72],"A":[73,168],"total":[74],"of":[75,130,178],"600":[76],"met":[78],"inclusion":[80],"criteria.":[81],"Group":[82],"1":[83],"409":[85],"group":[88,118,166],"2":[89,119],"had":[90],"191":[91],"cycles.":[92],"There":[93],"no":[95,152],"statistical":[96],"significance":[97],"rate":[101],"groups":[105],"(38.63%":[106],"vs":[107],"32.46%,":[108],"p":[109,124],"0.14).":[111],"Mean":[112],"age":[114],"higher":[116],"(5.1":[120],"vs.":[121],"5.4":[122],"days,":[123],"<":[125],"0.01).":[126],"compounding":[128],"effect":[129],"vitrification":[131],"when":[132],"applied":[133],"to":[134,174],"distinct":[136],"stages":[137],"(oocyte":[138],"embryo),":[140],"has":[141],"not":[142],"been":[143],"studied.":[144],"When":[145],"comparing":[146],"groups,":[149],"we":[150],"found":[151],"difference":[153],"However,":[157],"there":[158],"trend":[161],"towards":[162],"fewer":[163],"pregnancies":[164],"2.":[167],"larger":[169],"should":[171],"done":[173],"determine":[175],"validity":[177],"this":[179],"result":[180],"(Ramadan":[181],"et":[182],"al.":[183],"Fertil":[185],"Steril,":[186],"2020).":[187]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-13T00:00:00"}
