{"id":"https://openalex.org/W4281802017","doi":"https://doi.org/10.1530/edm-21-0151","title":"Another case of milk\u2013alkali syndrome or a learning opportunity?","display_name":"Another case of milk\u2013alkali syndrome or a learning opportunity?","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4281802017","doi":"https://doi.org/10.1530/edm-21-0151","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9175614"},"language":"en","primary_location":{"id":"doi:10.1530/edm-21-0151","doi":"https://doi.org/10.1530/edm-21-0151","is_oa":true,"landing_page_url":"https://doi.org/10.1530/edm-21-0151","pdf_url":"https://edm.bioscientifica.com/downloadpdf/journals/edm/2022/1/EDM21-0151.pdf","source":{"id":"https://openalex.org/S2738451715","display_name":"Endocrinology Diabetes and Metabolism Case Reports","issn_l":"2052-0573","issn":["2052-0573"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology, Diabetes & Metabolism Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://edm.bioscientifica.com/downloadpdf/journals/edm/2022/1/EDM21-0151.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081771562","display_name":"Sophie Bondje","orcid":"https://orcid.org/0000-0002-4022-5824","observed_orcids":["https://orcid.org/0000-0002-4022-5824"]},"institutions":[{"id":"https://openalex.org/I2801017582","display_name":"Lister Hospital","ror":"https://ror.org/05hrg0j24","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801017582","https://openalex.org/I4210122718"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sophie Bondje","raw_affiliation_strings":["Lister Hospital, Stevenage, UK"],"raw_orcid":"https://orcid.org/0000-0002-4022-5824","affiliations":[{"raw_affiliation_string":"Lister Hospital, Stevenage, UK","institution_ids":["https://openalex.org/I2801017582"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040607750","display_name":"Camilla Boslev B\u00e5rnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801017582","display_name":"Lister Hospital","ror":"https://ror.org/05hrg0j24","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801017582","https://openalex.org/I4210122718"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Camilla Barnes","raw_affiliation_strings":["Lister Hospital, Stevenage, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lister Hospital, Stevenage, UK","institution_ids":["https://openalex.org/I2801017582"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105779992","display_name":"Felicity Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801017582","display_name":"Lister Hospital","ror":"https://ror.org/05hrg0j24","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801017582","https://openalex.org/I4210122718"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Felicity Kaplan","raw_affiliation_strings":["Lister Hospital, Stevenage, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lister Hospital, Stevenage, UK","institution_ids":["https://openalex.org/I2801017582"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081771562"],"corresponding_institution_ids":["https://openalex.org/I2801017582"],"apc_list":{"value":499,"currency":"GBP","value_usd":612},"apc_paid":{"value":499,"currency":"GBP","value_usd":612},"fwci":0.1538,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37886266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2022","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.11330000311136246,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.06459999829530716,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/milk-alkali-syndrome","display_name":"milk-alkali syndrome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/calcium-carbonate","display_name":"calcium carbonate","score":0.640999972820282},{"id":"https://openalex.org/keywords/self-medication","display_name":"self-medication","score":0.8220000267028809},{"id":"https://openalex.org/keywords/osteoporosis-treatment","display_name":"osteoporosis treatment","score":0.7549999952316284},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.800000011920929},{"id":"https://openalex.org/keywords/metabolic-alkalosis","display_name":"metabolic alkalosis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.796999990940094},{"id":"https://openalex.org/keywords/hypocalcemia","display_name":"hypocalcemia","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pamidronate","display_name":"pamidronate","score":0.7139999866485596},{"id":"https://openalex.org/keywords/drug-safety-warnings","display_name":"drug safety warnings","score":0.4309999942779541},{"id":"https://openalex.org/keywords/older-women","display_name":"older women","score":0.5049999952316284},{"id":"https://openalex.org/keywords/dyspepsia","display_name":"dyspepsia","score":0.8859999775886536},{"id":"https://openalex.org/keywords/delirium","display_name":"delirium","score":0.6650000214576721},{"id":"https://openalex.org/keywords/kidney-stones","display_name":"kidney stones","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.803987979888916},{"id":"https://openalex.org/C2779674975","wikidata":"https://www.wikidata.org/wiki/Q1474877","display_name":"Hypercalcaemia","level":3,"score":0.5782530307769775},{"id":"https://openalex.org/C2777260799","wikidata":"https://www.wikidata.org/wiki/Q15637420","display_name":"Lethargy","level":2,"score":0.5633071064949036},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5200738310813904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4963272213935852},{"id":"https://openalex.org/C2778812048","wikidata":"https://www.wikidata.org/wiki/Q936382","display_name":"Hypocalcaemia","level":3,"score":0.4826565384864807},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4690946340560913},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.4430508613586426},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.18090936541557312}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1530/edm-21-0151","doi":"https://doi.org/10.1530/edm-21-0151","is_oa":true,"landing_page_url":"https://doi.org/10.1530/edm-21-0151","pdf_url":"https://edm.bioscientifica.com/downloadpdf/journals/edm/2022/1/EDM21-0151.pdf","source":{"id":"https://openalex.org/S2738451715","display_name":"Endocrinology Diabetes and Metabolism Case Reports","issn_l":"2052-0573","issn":["2052-0573"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology, Diabetes & Metabolism Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9175614","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9175614/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinol Diabetes Metab Case Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8c3bf1bcdea74fe083ec3954cae0d09d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8c3bf1bcdea74fe083ec3954cae0d09d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-3 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1530/edm-21-0151","doi":"https://doi.org/10.1530/edm-21-0151","is_oa":true,"landing_page_url":"https://doi.org/10.1530/edm-21-0151","pdf_url":"https://edm.bioscientifica.com/downloadpdf/journals/edm/2022/1/EDM21-0151.pdf","source":{"id":"https://openalex.org/S2738451715","display_name":"Endocrinology Diabetes and Metabolism Case Reports","issn_l":"2052-0573","issn":["2052-0573"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology, Diabetes & Metabolism Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281802017.pdf","grobid_xml":"https://content.openalex.org/works/W4281802017.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W181114085","https://openalex.org/W1997730835","https://openalex.org/W2020620880","https://openalex.org/W2143914218","https://openalex.org/W2167766578","https://openalex.org/W2291889248","https://openalex.org/W2324111732"],"related_works":["https://openalex.org/W3087105589","https://openalex.org/W7030111320","https://openalex.org/W7100366248","https://openalex.org/W2121915858","https://openalex.org/W2899975980","https://openalex.org/W2986522931","https://openalex.org/W3026026863","https://openalex.org/W3166374758","https://openalex.org/W7011718089","https://openalex.org/W2016498268"],"abstract_inverted_index":{"Summary":[0],"Milk\u2013alkali":[1],"syndrome":[2,23],"(MAS)":[3],"is":[4,219,252,322,365],"a":[5,19,53,96],"triad":[6],"of":[7,21,28,56,83,91,98,130,149,178,184,202,232,275,301,317,360,363],"hypercalcaemia,":[8],"metabolic":[9,290],"alkalosis":[10,291],"and":[11,38,63,89,106,113,120,134,207,234,243,246,260,289,296,308,371,384],"renal":[12,137,287,351],"insufficiency.":[13],"In":[14],"this":[15,355],"study,":[16],"we":[17,155],"present":[18,282],"case":[20,267],"milk\u2013alkali":[22],"secondary":[24],"to":[25,159,188,325,369],"concurrent":[26],"use":[27,177],"over-the-counter":[29,167],"(OTC)":[30],"calcium":[31,39,82,179,226,258,277,302,318],"carbonate-containing":[32],"antacid":[33,364],"tablets":[34],"(Rennie\u00ae)":[35,169],"for":[36,46,172,181,320],"dyspepsia":[37,192],"carbonate":[40,278],"with":[41,52,72,103,166,214,283],"vitamin":[42],"D3":[43],"(Adcal":[44],"D3)":[45],"osteoporosis.":[47],"A":[48,142],"72-year-old":[49],"woman":[50],"presented":[51],"2-day":[54],"history":[55,68],"nausea,":[57],"vomiting,":[58],"epigastric":[59,173],"pain,":[60],"constipation,":[61],"lethargy":[62],"mild":[64],"delirium.":[65],"Past":[66],"medical":[67],"included":[69],"osteoporosis":[70,185,233],"treated":[71],"daily":[73],"Adcal":[74],"D3.":[75],"Initial":[76],"blood":[77],"tests":[78],"showed":[79,136,146],"elevated":[80],"serum-adjusted":[81],"3.77":[84],"mmol/L":[85],"(normal":[86],"range,":[87],"2.2\u20132.6)":[88],"creatinine":[90],"292":[92],"\u00b5mol/L":[93],"(45\u201384)":[94],"from":[95],"baseline":[97],"84.":[99],"This":[100],"was":[101],"corrected":[102],"i.v.":[104,107],"pamidronate":[105],"fluids.":[108],"She":[109],"developed":[110],"asymptomatic":[111],"hypocalcaemia":[112],"rebound":[114],"hyperparathyroidism.":[115],"Myeloma":[116],"screen,":[117],"vasculitis":[118],"screen":[119],"serum":[121],"angiotensin-converting":[122],"enzyme":[123],"(ACE)":[124],"were":[125],"normal,":[126],"while":[127,305],"the":[128,131,152,182,197,211,230,315],"CT":[129],"chest,":[132],"abdomen":[133],"pelvis":[135],"stones":[138],"but":[139],"no":[140,147],"malignancy.":[141,150],"bone":[143],"marrow":[144],"biopsy":[145],"evidence":[148],"Once":[151],"delirium":[153],"resolved,":[154],"established":[156],"that":[157],"prior":[158],"admission,":[160],"she":[161],"had":[162],"been":[163,264,335],"excessively":[164],"self-medicating":[165],"antacids":[168],"as":[170,270,272,339,341],"required":[171,319],"pain.":[174],"The":[175,358],"increasing":[176],"preparations":[180,193,227,237,379],"management":[183,231],"in":[186,229,266,346],"addition":[187],"easily":[189],"available":[190],"OTC":[191,235,377],"has":[194,263],"made":[195],"MAS":[196,321],"third":[198],"most":[199],"common":[200],"cause":[201],"hypercalcaemia":[203,261],"hospitalisations.":[204],"Educating":[205],"patients":[206,280],"healthcare":[208],"professionals":[209],"on":[210,224,376],"risks":[212],"associated":[213],"these":[215],"seemingly":[216],"safe":[217],"medications":[218],"required.":[220],"Appropriate":[221,373],"warning":[222,374],"labels":[223,375],"both":[225],"used":[228],"calcium-containing":[236,378],"would":[238],"prevent":[239,381],"further":[240],"similar":[241],"cases":[242],"unnecessary":[244,382],"morbidity":[245,383],"hospital":[247,385],"admission.":[248,386],"Learning":[249],"points":[250],"What":[251,354],"known?":[253],"An":[254],"association":[255],"between":[256],"high-dose":[257],"supplementation":[259],"crisis":[262],"seen":[265],"studies.":[268],"After":[269],"little":[271],"1":[273,299],"week":[274],"excessive":[276,361],"ingestion,":[279],"can":[281],"symptomatic":[284],"hypercalcemia,":[285],"acute":[286],"failure":[288],"(1).":[292,313],"Women":[293],"aged":[294,306],"50":[295],"younger":[297],"need":[298,310],"g":[300,312,330,343],"per":[303,331,344],"day,":[304,332],"51":[307],"older":[309],"1.2":[311],"Although":[314],"amount":[316],"generally":[323],"thought":[324],"be":[326],"more":[327],"than":[328],"4":[329],"there":[333],"have":[334],"reports":[336],"at":[337],"intakes":[338],"low":[340],"1.0\u20131.5":[342],"day":[345],"pre-existing":[347],"risk":[348],"factors":[349],"including":[350],"impairment":[352],"(2).":[353],"study":[356],"adds?":[357],"danger":[359],"ingestion":[362],"not":[366],"adequately":[367],"highlighted":[368],"prescribers":[370],"patients.":[372],"could":[380]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-06-13T00:00:00"}