{"id":"https://openalex.org/W4281786571","doi":"https://doi.org/10.1021/jacs.2c03454","title":"Microenvironment-Sensitive Fluorescent Nucleotide Probes from Benzofuran, Benzothiophene, and Selenophene as Substrates for DNA Polymerases","display_name":"Microenvironment-Sensitive Fluorescent Nucleotide Probes from Benzofuran, Benzothiophene, and Selenophene as Substrates for DNA Polymerases","publication_year":2022,"publication_date":"2022-06-06","ids":{"openalex":"https://openalex.org/W4281786571","doi":"https://doi.org/10.1021/jacs.2c03454","pmid":"https://pubmed.ncbi.nlm.nih.gov/35666775"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.2c03454","doi":"https://doi.org/10.1021/jacs.2c03454","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.2c03454","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://kops.uni-konstanz.de/server/api/core/bitstreams/34dcdfdb-b86f-4556-b016-5e0023d40bdb/content","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023150701","display_name":"Pulak Ghosh","orcid":"https://orcid.org/0000-0002-3784-0252","observed_orcids":["https://orcid.org/0000-0002-3784-0252"]},"institutions":[{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pulak Ghosh","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune Dr. Homi Bhabha Road, Pune 411008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune Dr. Homi Bhabha Road, Pune 411008, India","institution_ids":["https://openalex.org/I181996519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010133877","display_name":"H.M. Kropp","orcid":"https://orcid.org/0000-0002-8723-7347","observed_orcids":["https://orcid.org/0000-0002-8723-7347"]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heike M. Kropp","raw_affiliation_strings":["Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany","institution_ids":["https://openalex.org/I189712700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087057452","display_name":"Karin Betz","orcid":"https://orcid.org/0000-0002-5111-7730","observed_orcids":["https://orcid.org/0000-0002-5111-7730"]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karin Betz","raw_affiliation_strings":["Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany","institution_ids":["https://openalex.org/I189712700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074323356","display_name":"Samra Ludmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Samra Ludmann","raw_affiliation_strings":["Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany","institution_ids":["https://openalex.org/I189712700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011269879","display_name":"Kay Diederichs","orcid":"https://orcid.org/0000-0001-5360-0905","observed_orcids":["https://orcid.org/0000-0001-5360-0905"]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kay Diederichs","raw_affiliation_strings":["Department of Biology and Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany","institution_ids":["https://openalex.org/I189712700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035525469","display_name":"Andreas Marx","orcid":"https://orcid.org/0000-0002-6471-3689","observed_orcids":["https://orcid.org/0000-0002-6471-3689"]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Marx","raw_affiliation_strings":["Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6471-3689","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany","institution_ids":["https://openalex.org/I189712700"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066827195","display_name":"Seergazhi G. Srivatsan","orcid":"https://orcid.org/0000-0001-5765-3967","observed_orcids":["https://orcid.org/0000-0001-5765-3967"]},"institutions":[{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Seergazhi G. Srivatsan","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune Dr. Homi Bhabha Road, Pune 411008, India"],"raw_orcid":"https://orcid.org/0000-0001-5765-3967","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune Dr. Homi Bhabha Road, Pune 411008, India","institution_ids":["https://openalex.org/I181996519"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035525469","https://openalex.org/A5066827195"],"corresponding_institution_ids":["https://openalex.org/I181996519","https://openalex.org/I189712700"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.5001,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.91580862,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"144","issue":"23","first_page":"10556","last_page":"10569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenophene","display_name":"selenophene","score":0.8199999928474426},{"id":"https://openalex.org/keywords/benzofurans","display_name":"benzofurans","score":0.996999979019165},{"id":"https://openalex.org/keywords/benzothiophene","display_name":"benzothiophene","score":1.0},{"id":"https://openalex.org/keywords/oligonucleotide-labeling","display_name":"oligonucleotide labeling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/site-specific-labeling","display_name":"site-specific labeling","score":0.6150000095367432},{"id":"https://openalex.org/keywords/ternary-complex-crystal-structure","display_name":"ternary complex crystal structure","score":0.6840000152587891},{"id":"https://openalex.org/keywords/nucleotide-analogues","display_name":"nucleotide analogues","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.727601170539856},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.7024190425872803},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.7018454074859619},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.6754475235939026},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.44817930459976196},{"id":"https://openalex.org/C2776589655","wikidata":"https://www.wikidata.org/wiki/Q410089","display_name":"Benzofuran","level":2,"score":0.4449825882911682},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4385393261909485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4319505989551544},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.4312632381916046},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3552989959716797},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3319017291069031},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.057442277669906616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003857","descriptor_name":"Deoxyuridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/jacs.2c03454","doi":"https://doi.org/10.1021/jacs.2c03454","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.2c03454","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:35666775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35666775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:kops.uni-konstanz.de:123456789/57764","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:352-2-xianvgtwrusb1","pdf_url":"https://kops.uni-konstanz.de/server/api/core/bitstreams/34dcdfdb-b86f-4556-b016-5e0023d40bdb/content","source":{"id":"https://openalex.org/S4306401487","display_name":"KOPS (University of Konstanz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189712700","host_organization_name":"University of Konstanz","host_organization_lineage":["https://openalex.org/I189712700"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Chemical Society. American Chemical Society. 2022, 144(23), S. 10556-10569. ISSN 0002-7863. eISSN 1520-5126. Verf\u00fcgbar unter: doi: 10.1021/jacs.2c03454","raw_type":"doc-type:article"},{"id":"pmh:oai:dora:psi_43307","doi":null,"is_oa":false,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:43307","pdf_url":null,"source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Chemical Society","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:kops.uni-konstanz.de:123456789/57764","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:352-2-xianvgtwrusb1","pdf_url":"https://kops.uni-konstanz.de/server/api/core/bitstreams/34dcdfdb-b86f-4556-b016-5e0023d40bdb/content","source":{"id":"https://openalex.org/S4306401487","display_name":"KOPS (University of Konstanz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189712700","host_organization_name":"University of Konstanz","host_organization_lineage":["https://openalex.org/I189712700"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Chemical Society. American Chemical Society. 2022, 144(23), S. 10556-10569. ISSN 0002-7863. eISSN 1520-5126. Verf\u00fcgbar unter: doi: 10.1021/jacs.2c03454","raw_type":"doc-type:article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2329739092","display_name":null,"funder_award_id":"IA/S/16/1/502360","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G8932922373","display_name":"Innovative Nucleoside Probes as Multifunctional Toolbox to Study RNA Structure, Dynamics and Function","funder_award_id":"IA/S/16/1/502360","funder_id":"https://openalex.org/F4320325580","funder_display_name":"The Wellcome Trust DBT India Alliance"}],"funders":[{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320322463","display_name":"Paul Scherrer Institut","ror":"https://ror.org/03eh3y714"},{"id":"https://openalex.org/F4320324168","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13"},{"id":"https://openalex.org/F4320325580","display_name":"The Wellcome Trust DBT India Alliance","ror":"https://ror.org/04reqzt68"},{"id":"https://openalex.org/F4320327182","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281786571.pdf","grobid_xml":"https://content.openalex.org/works/W4281786571.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1431005611","https://openalex.org/W1530890935","https://openalex.org/W1765730586","https://openalex.org/W1908796392","https://openalex.org/W1967323519","https://openalex.org/W1978298790","https://openalex.org/W1981802577","https://openalex.org/W1986594702","https://openalex.org/W1988496377","https://openalex.org/W2005365616","https://openalex.org/W2006882392","https://openalex.org/W2008987165","https://openalex.org/W2009596051","https://openalex.org/W2010430643","https://openalex.org/W2012016911","https://openalex.org/W2012797635","https://openalex.org/W2024738869","https://openalex.org/W2026758416","https://openalex.org/W2029443955","https://openalex.org/W2036229671","https://openalex.org/W2038578123","https://openalex.org/W2047491311","https://openalex.org/W2049180098","https://openalex.org/W2057141789","https://openalex.org/W2057666290","https://openalex.org/W2064850497","https://openalex.org/W2074713448","https://openalex.org/W2086476153","https://openalex.org/W2091984642","https://openalex.org/W2103272211","https://openalex.org/W2110416817","https://openalex.org/W2117882102","https://openalex.org/W2122464209","https://openalex.org/W2124026197","https://openalex.org/W2126526871","https://openalex.org/W2127960534","https://openalex.org/W2133093457","https://openalex.org/W2134166196","https://openalex.org/W2139631118","https://openalex.org/W2141731346","https://openalex.org/W2144081223","https://openalex.org/W2150650428","https://openalex.org/W2152342221","https://openalex.org/W2153508349","https://openalex.org/W2153792822","https://openalex.org/W2154714625","https://openalex.org/W2164389987","https://openalex.org/W2178439483","https://openalex.org/W2180229411","https://openalex.org/W2287122233","https://openalex.org/W2291221808","https://openalex.org/W2316902933","https://openalex.org/W2323583668","https://openalex.org/W2325531676","https://openalex.org/W2328478424","https://openalex.org/W2330574937","https://openalex.org/W2474361678","https://openalex.org/W2514433423","https://openalex.org/W2554786884","https://openalex.org/W2560251639","https://openalex.org/W2565179363","https://openalex.org/W2583906387","https://openalex.org/W2626565560","https://openalex.org/W2751065990","https://openalex.org/W2766432068","https://openalex.org/W2774557158","https://openalex.org/W2891482074","https://openalex.org/W2891977888","https://openalex.org/W2901966955","https://openalex.org/W2909317900","https://openalex.org/W2914377858","https://openalex.org/W2919497789","https://openalex.org/W2921321364","https://openalex.org/W2934740702","https://openalex.org/W2945525411","https://openalex.org/W2948384417","https://openalex.org/W2948934927","https://openalex.org/W2949020667","https://openalex.org/W2988130192","https://openalex.org/W3003689821","https://openalex.org/W3007709539","https://openalex.org/W3015182592","https://openalex.org/W3025651409","https://openalex.org/W3040637873","https://openalex.org/W3042079661","https://openalex.org/W3048454004","https://openalex.org/W3081849720","https://openalex.org/W3094102798","https://openalex.org/W3094352085","https://openalex.org/W3133563112","https://openalex.org/W3153641383","https://openalex.org/W3163782710","https://openalex.org/W4248872320","https://openalex.org/W4254945764"],"related_works":["https://openalex.org/W4403615384","https://openalex.org/W2291221808","https://openalex.org/W2558307411","https://openalex.org/W2092013032","https://openalex.org/W3027745876","https://openalex.org/W2110416817","https://openalex.org/W1983572399","https://openalex.org/W2006882392","https://openalex.org/W2069228169","https://openalex.org/W1978807042"],"abstract_inverted_index":{"DNA":[0,43,88,96,165,231],"polymerases":[1,44],"can":[2],"process":[3],"a":[4,57,143,150,155,213,226,239],"wide":[5],"variety":[6],"of":[7,31,42,67,82,103,136,149,216,225,229,242,245,247],"structurally":[8],"diverse":[9],"nucleotide":[10,35,54,112,123,132,145,187],"substrates,":[11],"but":[12],"the":[13,18,29,39,50,64,80,83,87,101,104,114,121,130,137,147,169,174,185,205,209,217,243],"molecular":[14],"basis":[15],"by":[16,194],"which":[17,77,152],"analogs":[19,55],"are":[20,69],"processed":[21],"is":[22,98],"not":[23],"completely":[24],"understood.":[25],"Here,":[26],"we":[27],"demonstrate":[28],"utility":[30],"environment-sensitive":[32],"heterocycle-modified":[33,248],"fluorescent":[34],"substrates":[36],"in":[37,45,129,208],"probing":[38],"incorporation":[40,133,218,246],"mechanism":[41,244],"real":[46],"time":[47],"and":[48,86,163,178,203,222],"at":[49,63,125,146],"atomic":[51],"level.":[52],"The":[53],"containing":[56],"selenophene,":[58],"benzofuran,":[59],"or":[60],"benzothiophene":[61],"moiety":[62],"C5":[65],"position":[66],"2'-deoxyuridine":[68],"incorporated":[70],"into":[71,113],"oligonucleotides":[72],"(ONs)":[73],"with":[74,181,233],"varying":[75],"efficiency,":[76],"depends":[78],"on":[79],"size":[81,102],"heterocycle":[84,138],"modification":[85,105],"polymerase":[89,232],"sequence":[90],"family":[91,95],"used.":[92],"KlenTaq":[93,230],"(A":[94],"polymerase)":[97],"sensitive":[99],"to":[100,168,199],"as":[106,190],"it":[107,118,140],"incorporates":[108,120],"only":[109],"one":[110],"heterobicycle-modified":[111],"growing":[115],"polymer,":[116],"whereas":[117],"efficiently":[119],"selenophene-modified":[122],"analog":[124],"multiple":[126,182],"positions.":[127],"Notably,":[128],"single":[131,144],"assay,":[134],"irrespective":[135],"size,":[139],"exclusively":[141],"adds":[142],"3'-end":[148],"primer,":[151],"enabled":[153],"devising":[154],"simple":[156],"two-step":[157],"site-specific":[158],"ON":[159],"labeling":[160],"technique.":[161],"KOD":[162],"Vent(exo-)":[164],"polymerases,":[166],"belonging":[167],"B":[170],"family,":[171],"tolerate":[172],"all":[173],"three":[175],"modified":[176],"nucleotides":[177],"produce":[179],"ONs":[180],"labels.":[183],"Importantly,":[184],"benzofuran-modified":[186],"(BFdUTP)":[188],"serves":[189],"an":[191],"excellent":[192],"reporter":[193],"providing":[195],"real-time":[196],"fluorescence":[197,220],"readouts":[198],"monitor":[200],"enzyme":[201],"activity":[202],"estimate":[204],"binding":[206],"events":[207],"catalytic":[210],"cycle.":[211],"Further,":[212],"direct":[214],"comparison":[215],"profiles,":[219],"data,":[221],"crystal":[223],"structure":[224],"ternary":[227],"complex":[228],"BFdUTP":[234],"poised":[235],"for":[236],"catalysis":[237],"provides":[238],"detailed":[240],"understanding":[241],"nucleotides.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-06-13T00:00:00"}
