{"id":"https://openalex.org/W4281784086","doi":"https://doi.org/10.1021/acsbiomedchemau.2c00016","title":"Unanticipated Characteristics of a Selective, Potent Neuromedin-U Receptor 2 Agonist","display_name":"Unanticipated Characteristics of a Selective, Potent Neuromedin-U Receptor 2 Agonist","publication_year":2022,"publication_date":"2022-05-27","ids":{"openalex":"https://openalex.org/W4281784086","doi":"https://doi.org/10.1021/acsbiomedchemau.2c00016","pmid":"https://pubmed.ncbi.nlm.nih.gov/37102164","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10125376"},"language":"en","primary_location":{"id":"doi:10.1021/acsbiomedchemau.2c00016","doi":"https://doi.org/10.1021/acsbiomedchemau.2c00016","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsbiomedchemau.2c00016","pdf_url":null,"source":{"id":"https://openalex.org/S4210197417","display_name":"ACS Bio & Med Chem Au","issn_l":"2694-2437","issn":["2694-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Bio &amp; Med Chem Au","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1021/acsbiomedchemau.2c00016","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044664189","display_name":"Suneet Mehrotra","orcid":"https://orcid.org/0000-0003-1756-5254","observed_orcids":["https://orcid.org/0000-0003-1756-5254"]},"institutions":[{"id":"https://openalex.org/I4210106615","display_name":"Novo Nordisk (United States)","ror":"https://ror.org/011y67d23","country_code":"US","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210106615","https://openalex.org/I4210159963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suneet Mehrotra","raw_affiliation_strings":["Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States","institution_ids":["https://openalex.org/I4210106615"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sebastian Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106615","display_name":"Novo Nordisk (United States)","ror":"https://ror.org/011y67d23","country_code":"US","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210106615","https://openalex.org/I4210159963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian Lam","raw_affiliation_strings":["Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States","institution_ids":["https://openalex.org/I4210106615"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elizabeth Glenn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106615","display_name":"Novo Nordisk (United States)","ror":"https://ror.org/011y67d23","country_code":"US","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210106615","https://openalex.org/I4210159963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Glenn","raw_affiliation_strings":["Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States","institution_ids":["https://openalex.org/I4210106615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038811333","display_name":"David Hymel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106615","display_name":"Novo Nordisk (United States)","ror":"https://ror.org/011y67d23","country_code":"US","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210106615","https://openalex.org/I4210159963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Hymel","raw_affiliation_strings":["Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States","institution_ids":["https://openalex.org/I4210106615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017913691","display_name":"Christina Akers Sanford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106615","display_name":"Novo Nordisk (United States)","ror":"https://ror.org/011y67d23","country_code":"US","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210106615","https://openalex.org/I4210159963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina A. Sanford","raw_affiliation_strings":["Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States","institution_ids":["https://openalex.org/I4210106615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100691425","display_name":"Qingyuan Liu","orcid":"https://orcid.org/0009-0008-6284-2963","observed_orcids":["https://orcid.org/0009-0008-6284-2963"]},"institutions":[{"id":"https://openalex.org/I4210106615","display_name":"Novo Nordisk (United States)","ror":"https://ror.org/011y67d23","country_code":"US","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210106615","https://openalex.org/I4210159963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingyuan Liu","raw_affiliation_strings":["Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States","institution_ids":["https://openalex.org/I4210106615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058338934","display_name":"John P. Herich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106615","display_name":"Novo Nordisk (United States)","ror":"https://ror.org/011y67d23","country_code":"US","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210106615","https://openalex.org/I4210159963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Herich","raw_affiliation_strings":["Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Research Center, 530 Fairview Avenue North #5000, Seattle, Washington 98109, United States","institution_ids":["https://openalex.org/I4210106615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023892780","display_name":"Birgitte S. Wulff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Birgitte S. Wulff","raw_affiliation_strings":["Novo Nordisk Global Obesity and Liver Disease Research, Novo Nordisk Park 1, 2760 M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Global Obesity and Liver Disease Research, Novo Nordisk Park 1, 2760 M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042249966","display_name":"Thomas H. Meek","orcid":"https://orcid.org/0000-0002-4922-7009","observed_orcids":["https://orcid.org/0000-0002-4922-7009"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas H. Meek","raw_affiliation_strings":["Transformational Research Unit, Novo Nordisk Research Center Oxford, Roosevelt Drive, Oxford OX3 7FZ, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4922-7009","affiliations":[{"raw_affiliation_string":"Transformational Research Unit, Novo Nordisk Research Center Oxford, Roosevelt Drive, Oxford OX3 7FZ, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042249966"],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":0.2208,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.39135403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"2","issue":"4","first_page":"370","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromedin-u","display_name":"neuromedin U","score":0.9300000071525574},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.7570000290870667},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.5339999794960022},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.878000020980835},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/receptor-cross-reactivity","display_name":"receptor cross-reactivity","score":0.621999979019165},{"id":"https://openalex.org/keywords/orphan-receptors","display_name":"orphan receptors","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7713892459869385},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7622125148773193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5177825689315796},{"id":"https://openalex.org/C43587935","wikidata":"https://www.wikidata.org/wiki/Q1258877","display_name":"Functional selectivity","level":4,"score":0.49121397733688354},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4856530427932739},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.4659522473812103},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.46136823296546936},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4516540765762329},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41419684886932373},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39448317885398865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2636738419532776},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19792062044143677}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsbiomedchemau.2c00016","doi":"https://doi.org/10.1021/acsbiomedchemau.2c00016","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsbiomedchemau.2c00016","pdf_url":null,"source":{"id":"https://openalex.org/S4210197417","display_name":"ACS Bio & Med Chem Au","issn_l":"2694-2437","issn":["2694-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Bio &amp; Med Chem Au","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10125376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10125376","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10125376/pdf/bg2c00016.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Bio Med Chem Au","raw_type":"Text"},{"id":"pmid:37102164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37102164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS bio & med chem Au","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f58b38b72dbf4650b7df29ab0c9fd09d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f58b38b72dbf4650b7df29ab0c9fd09d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Bio & Med Chem Au, Vol 2, Iss 4, Pp 370-375 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acsbiomedchemau.2c00016","doi":"https://doi.org/10.1021/acsbiomedchemau.2c00016","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsbiomedchemau.2c00016","pdf_url":null,"source":{"id":"https://openalex.org/S4210197417","display_name":"ACS Bio & Med Chem Au","issn_l":"2694-2437","issn":["2694-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Bio &amp; Med Chem Au","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1985820234","https://openalex.org/W1992741666","https://openalex.org/W2018241808","https://openalex.org/W2055169903","https://openalex.org/W2071281071","https://openalex.org/W2074051586","https://openalex.org/W2075522667","https://openalex.org/W2085272854","https://openalex.org/W2086687315","https://openalex.org/W2132603015","https://openalex.org/W2133562965","https://openalex.org/W2141292442","https://openalex.org/W2147180007","https://openalex.org/W2159392554","https://openalex.org/W2168299684","https://openalex.org/W2314688160","https://openalex.org/W2726168754","https://openalex.org/W2739858130","https://openalex.org/W2753580694","https://openalex.org/W2760830224","https://openalex.org/W2765562729","https://openalex.org/W2771864401","https://openalex.org/W2799554534","https://openalex.org/W2879212235","https://openalex.org/W3184352735"],"related_works":["https://openalex.org/W2799554534","https://openalex.org/W2015812683","https://openalex.org/W1992741666","https://openalex.org/W2753580694","https://openalex.org/W2153858224","https://openalex.org/W2020306375","https://openalex.org/W2618689137","https://openalex.org/W7096401631","https://openalex.org/W4398777423","https://openalex.org/W2092784745"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Neuromedin-U":[7],"(NMU)":[8],"mediates":[9],"several":[10],"physiological":[11,229],"functions":[12],"via":[13],"its":[14,54,131],"two":[15,45],"cognate":[16],"receptors,":[17],"NMUR1":[18],"and":[19,86,136,143,190,216],"NMUR2.":[20],"Disentangling":[21],"the":[22,33,44,67,79,99,112,219,228],"individual":[23],"roles":[24,85],"of":[25,35,43,66,82,90,101,114,184,210,222,231],"each":[26],"receptor":[27,69,84,196,233],"has":[28],"largely":[29],"been":[30],"undertaken":[31],"through":[32],"use":[34],"transgenic":[36],"mice":[37],"bearing":[38],"a":[39,59,122,178],"deletion":[40],"in":[41,58,62,97,132,144,226],"one":[42],"receptors":[46,193],"or":[47,53],"by":[48],"testing":[49],"native":[50],"molecules":[51],"(NMU":[52],"truncated":[55],"version":[56],"NMU-8)":[57],"tissue-specific":[60],"manner,":[61],"effect,":[63],"taking":[64],"advantage":[65],"distinct":[68],"expression":[70],"profiles.":[71],"These":[72,201],"strategies":[73],"have":[74,164],"proved":[75],"quite":[76],"useful":[77],"despite":[78],"inherent":[80],"limitations":[81],"overlapping":[83],"potential":[87],"compensatory":[88],"influences":[89],"germline":[91],"gene":[92],"deletion.":[93],"With":[94],"these":[95],"considerations":[96],"mind,":[98],"availability":[100],"potent,":[102],"selective":[103],"NMU":[104,232],"compounds":[105],"with":[106],"appropriate":[107],"pharmacokinetic":[108,141],"profiles":[109],"would":[110],"advance":[111],"capabilities":[113],"investigators":[115],"undertaking":[116],"such":[117],"efforts.":[118],"Here,":[119],"we":[120],"evaluate":[121],"recently":[123],"reported":[124],"NMUR2-selective":[125],"peptide":[126],"(compound":[127],"17":[128,158,186],")":[129],"for":[130,207],"vitro":[133],"potency":[134],"(mouse":[135],"human),":[137],"binding":[138],"affinity,":[139],"murine":[140],"properties,":[142],"vivo":[145],"effects.":[146],"Despite":[147],"being":[148,177],"designed":[149],"as":[150,171],"an":[151,172],"NMUR2":[152,180],"agonist,":[153],"our":[154],"results":[155,211],"show":[156],"compound":[157,185],"unexpectedly":[159],"binds":[160],"but":[161],"does":[162],"not":[163],"functional":[165],"activity":[166],"on":[167],"NMUR1,":[168],"thereby":[169],"acting":[170],"R1":[173],"antagonist":[174],"while":[175],"simultaneously":[176],"potent":[179],"agonist.":[181],"Furthermore,":[182],"evaluation":[183],"across":[187],"all":[188],"known":[189],"orphan":[191],"G-protein-coupled":[192],"demonstrates":[194],"multiple":[195],"partners":[197],"beyond":[198],"NMUR2/R1":[199],"binding.":[200],"properties":[202],"need":[203],"to":[204],"be":[205],"appreciated":[206],"accurate":[208],"interpretation":[209],"generated":[212],"using":[213],"this":[214,223],"molecule":[215],"may":[217],"limit":[218],"broader":[220],"ability":[221],"particular":[224],"entity":[225],"disentangling":[227],"role":[230],"biology.":[234]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2022-06-13T00:00:00"}
