{"id":"https://openalex.org/W4281761237","doi":"https://doi.org/10.1002/term.3324","title":"Hypoxia facilitates proliferation of smooth muscle cells derived from pluripotent stem cells for vascular tissue engineering","display_name":"Hypoxia facilitates proliferation of smooth muscle cells derived from pluripotent stem cells for vascular tissue engineering","publication_year":2022,"publication_date":"2022-05-28","ids":{"openalex":"https://openalex.org/W4281761237","doi":"https://doi.org/10.1002/term.3324","pmid":"https://pubmed.ncbi.nlm.nih.gov/35633489"},"language":"en","primary_location":{"id":"doi:10.1002/term.3324","doi":"https://doi.org/10.1002/term.3324","is_oa":false,"landing_page_url":"https://doi.org/10.1002/term.3324","pdf_url":null,"source":{"id":"https://openalex.org/S68700368","display_name":"Journal of Tissue Engineering and Regenerative Medicine","issn_l":"1932-6254","issn":["1932-6254","1932-7005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tissue Engineering and Regenerative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048549621","display_name":"Lijun Fang","orcid":"https://orcid.org/0000-0003-2190-4888","observed_orcids":["https://orcid.org/0000-0003-2190-4888"]},"institutions":[{"id":"https://openalex.org/I4210089285","display_name":"Ji Hua Laboratory","ror":"https://ror.org/006aydy55","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210089285"]},{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijun Fang","raw_affiliation_strings":["Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","institution_ids":["https://openalex.org/I4210089285"]},{"raw_affiliation_string":"School of Medicine, South China University of Technology, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112844211","display_name":"Jingyi Mei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089285","display_name":"Ji Hua Laboratory","ror":"https://ror.org/006aydy55","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210089285"]},{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Mei","raw_affiliation_strings":["Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","institution_ids":["https://openalex.org/I4210089285"]},{"raw_affiliation_string":"School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083362940","display_name":"Boqian Yao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boqian Yao","raw_affiliation_strings":["Songshan Lake Central Hospital of Dongguan City, Dongguan, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Songshan Lake Central Hospital of Dongguan City, Dongguan, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325221","display_name":"Jiang Liu","orcid":"https://orcid.org/0000-0002-0654-707X","observed_orcids":["https://orcid.org/0000-0002-0654-707X"]},"institutions":[{"id":"https://openalex.org/I4210089285","display_name":"Ji Hua Laboratory","ror":"https://ror.org/006aydy55","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210089285"]},{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang Liu","raw_affiliation_strings":["Department of Pharmacy, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guanzhou, China","Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guanzhou, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","institution_ids":["https://openalex.org/I4210089285"]},{"raw_affiliation_string":"School of Medicine, South China University of Technology, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100346882","display_name":"Peng Liu","orcid":"https://orcid.org/0000-0003-2370-7810","observed_orcids":["https://orcid.org/0000-0003-2370-7810"]},"institutions":[{"id":"https://openalex.org/I4210089285","display_name":"Ji Hua Laboratory","ror":"https://ror.org/006aydy55","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210089285"]},{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Liu","raw_affiliation_strings":["Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","institution_ids":["https://openalex.org/I4210089285"]},{"raw_affiliation_string":"School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066933299","display_name":"Xichun Wang","orcid":"https://orcid.org/0000-0001-5096-3970","observed_orcids":["https://orcid.org/0000-0001-5096-3970"]},"institutions":[{"id":"https://openalex.org/I4210089285","display_name":"Ji Hua Laboratory","ror":"https://ror.org/006aydy55","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210089285"]},{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xichun Wang","raw_affiliation_strings":["Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","institution_ids":["https://openalex.org/I4210089285"]},{"raw_affiliation_string":"School of Medicine, South China University of Technology, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101301061","display_name":"Jiahui Zhou","orcid":"https://orcid.org/0009-0008-5185-1602","observed_orcids":["https://orcid.org/0009-0008-5185-1602"]},"institutions":[{"id":"https://openalex.org/I4210089285","display_name":"Ji Hua Laboratory","ror":"https://ror.org/006aydy55","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210089285"]},{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiahui Zhou","raw_affiliation_strings":["Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","institution_ids":["https://openalex.org/I4210089285"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018974634","display_name":"Zhanyi Lin","orcid":"https://orcid.org/0000-0002-0961-2009","observed_orcids":["https://orcid.org/0000-0002-0961-2009"]},"institutions":[{"id":"https://openalex.org/I4210089285","display_name":"Ji Hua Laboratory","ror":"https://ror.org/006aydy55","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210089285"]},{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhanyi Lin","raw_affiliation_strings":["Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0002-0961-2009","affiliations":[{"raw_affiliation_string":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Ji Hua Institute of Biomedical Engineering Technology, Ji Hua Laboratory, Foshan, Guangdong, China","institution_ids":["https://openalex.org/I4210089285"]},{"raw_affiliation_string":"School of Medicine, South China University of Technology, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I90610280"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018974634","https://openalex.org/A5101301061"],"corresponding_institution_ids":["https://openalex.org/I4210089285","https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I90610280"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":null,"fwci":0.3264,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.45006654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"8","first_page":"744","last_page":"756"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/human-induced-pluripotent-stem-cells","display_name":"human induced pluripotent stem cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/tissue-engineered-blood-vessels","display_name":"tissue-engineered blood vessels","score":0.9440000057220459},{"id":"https://openalex.org/keywords/embryoid-body-differentiation","display_name":"embryoid body differentiation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/seed-cells","display_name":"seed cells","score":0.6100000143051147},{"id":"https://openalex.org/keywords/biodegradable-scaffolds","display_name":"biodegradable scaffolds","score":0.9679999947547913},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7287039756774902},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7095964550971985},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.5946546792984009},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5802124738693237},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5676890015602112},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5481722950935364},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5377203822135925},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46813592314720154},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.44133108854293823},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.40092137455940247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37551528215408325},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.21715638041496277},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15499302744865417},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09162959456443787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/term.3324","doi":"https://doi.org/10.1002/term.3324","is_oa":false,"landing_page_url":"https://doi.org/10.1002/term.3324","pdf_url":null,"source":{"id":"https://openalex.org/S68700368","display_name":"Journal of Tissue Engineering and Regenerative Medicine","issn_l":"1932-6254","issn":["1932-6254","1932-7005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tissue Engineering and Regenerative Medicine","raw_type":"journal-article"},{"id":"pmid:35633489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35633489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of tissue engineering and regenerative medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1550989298","https://openalex.org/W1819324525","https://openalex.org/W1965827991","https://openalex.org/W1972782503","https://openalex.org/W1987285745","https://openalex.org/W1988357840","https://openalex.org/W1991874179","https://openalex.org/W2004505453","https://openalex.org/W2008847140","https://openalex.org/W2008946188","https://openalex.org/W2021741218","https://openalex.org/W2025738240","https://openalex.org/W2030536669","https://openalex.org/W2071076164","https://openalex.org/W2095528497","https://openalex.org/W2098972920","https://openalex.org/W2116557605","https://openalex.org/W2119559705","https://openalex.org/W2124066511","https://openalex.org/W2125987139","https://openalex.org/W2126775351","https://openalex.org/W2143815602","https://openalex.org/W2151934024","https://openalex.org/W2156954449","https://openalex.org/W2159561039","https://openalex.org/W2178356665","https://openalex.org/W2362125499","https://openalex.org/W2472010266","https://openalex.org/W2562173220","https://openalex.org/W2743461578","https://openalex.org/W2745489261","https://openalex.org/W2982449660","https://openalex.org/W2989571549","https://openalex.org/W3014331892","https://openalex.org/W3016567236","https://openalex.org/W3091955098","https://openalex.org/W3109707805","https://openalex.org/W3193278380","https://openalex.org/W3200637417","https://openalex.org/W3203179399","https://openalex.org/W3206590108","https://openalex.org/W4205380287"],"related_works":["https://openalex.org/W2420925260","https://openalex.org/W3203179399","https://openalex.org/W2333785329","https://openalex.org/W7202189941","https://openalex.org/W3109707805","https://openalex.org/W3095065003","https://openalex.org/W2982449660","https://openalex.org/W2156954449","https://openalex.org/W4283826666","https://openalex.org/W2154791520"],"abstract_inverted_index":{"Tissue-engineered":[0],"blood":[1,11],"vessels":[2],"(TEBVs)":[3],"show":[4],"significant":[5,119],"therapeutic":[6],"potential":[7],"for":[8,122,142],"replacing":[9],"diseased":[10],"vessels.":[12],"Vascular":[13],"smooth":[14],"muscle":[15],"cells":[16,24,34,46,107],"(VSMCs)":[17],"derived":[18],"from":[19,66],"human":[20],"induced":[21],"pluripotent":[22],"stem":[23],"(hiPSCs)":[25],"via":[26],"embryoid":[27],"body":[28],"(EB)-based":[29],"differentiation,":[30,95],"are":[31,47],"promising":[32],"seed":[33,139],"to":[35,71],"construct":[36],"TEBVs.":[37],"However,":[38],"obtaining":[39],"sufficient":[40],"high-quality":[41,138],"hiPSC-VSMCs":[42,96],"remains":[43],"challenging.":[44],"Stem":[45],"located":[48],"in":[49],"a":[50],"niche":[51],"characterized":[52],"by":[53],"hypoxia.":[54],"Hence,":[55,125],"we":[56,126],"explored":[57],"molecular":[58],"and":[59,79,88,114],"cellular":[60],"functions":[61],"at":[62],"different":[63],"induction":[64],"stages":[65],"the":[67,72,85],"EB":[68],"formation":[69],"commencement":[70],"end":[73],"of":[74,91],"directed":[75,94],"differentiation":[76,132],"under":[77,101],"normoxic":[78],"hypoxic":[80,102,129],"conditions,":[81],"respectively.":[82],"Hypoxia":[83],"enhanced":[84],"formation,":[86],"adhesion":[87],"amplification":[89],"rates":[90],"EBs.":[92],"During":[93],"exhibited":[97],"increased":[98],"cell":[99,140],"viability":[100],"conditions.":[103],"Moreover,":[104],"seeding":[105],"hypoxia-pretreated":[106],"on":[108],"biodegradable":[109],"scaffolds,":[110],"facilitated":[111],"collagen":[112],"I":[113],"elastin":[115],"secretion,":[116],"which":[117],"has":[118],"application":[120],"value":[121],"TEBV":[123,143],"development.":[124],"proposed":[127],"that":[128],"treatment":[130],"during":[131],"effectively":[133],"induces":[134],"proliferative":[135],"hiPSC-VSMCs,":[136],"expanding":[137],"sources":[141],"construction.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-13T00:00:00"}