{"id":"https://openalex.org/W4281752342","doi":"https://doi.org/10.1016/j.neuroscience.2022.06.011","title":"The Effects of Chronic Variable Stress and Photoperiod Alteration on the Hypothalamic\u2013Pituitary\u2013Adrenal Axis Response and Behavior of Mice","display_name":"The Effects of Chronic Variable Stress and Photoperiod Alteration on the Hypothalamic\u2013Pituitary\u2013Adrenal Axis Response and Behavior of Mice","publication_year":2022,"publication_date":"2022-06-11","ids":{"openalex":"https://openalex.org/W4281752342","doi":"https://doi.org/10.1016/j.neuroscience.2022.06.011","pmid":"https://pubmed.ncbi.nlm.nih.gov/35700818"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroscience.2022.06.011","doi":"https://doi.org/10.1016/j.neuroscience.2022.06.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2022.06.011","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.neuroscience.2022.06.011","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061547587","display_name":"Lauren A. Miller","orcid":"https://orcid.org/0009-0008-2291-1231","observed_orcids":["https://orcid.org/0009-0008-2291-1231"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Miller","raw_affiliation_strings":["Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States","Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States","institution_ids":["https://openalex.org/I1280259254","https://openalex.org/I148314036"]},{"raw_affiliation_string":"Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012698309","display_name":"Mariella Bodemeier Loayza Careaga","orcid":"https://orcid.org/0000-0001-6305-2244","observed_orcids":["https://orcid.org/0000-0001-6305-2244"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariella Bodemeier Loayza Careaga","raw_affiliation_strings":["Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States","Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States","institution_ids":["https://openalex.org/I1280259254","https://openalex.org/I148314036"]},{"raw_affiliation_string":"Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042132328","display_name":"Robert J. Handa","orcid":"https://orcid.org/0000-0001-9131-2808","observed_orcids":["https://orcid.org/0000-0001-9131-2808"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Handa","raw_affiliation_strings":["Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, United States","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057464777","display_name":"T. John Wu","orcid":"https://orcid.org/0000-0002-1505-7662","observed_orcids":["https://orcid.org/0000-0002-1505-7662"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"T. John Wu","raw_affiliation_strings":["Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address: twu@usuhs.edu","Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address: twu@usuhs.edu","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United States","institution_ids":["https://openalex.org/I148314036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057464777"],"corresponding_institution_ids":["https://openalex.org/I148314036"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.7702,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.8229249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"496","issue":null,"first_page":"105","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-variable-stress","display_name":"chronic variable stress","score":0.9660000205039978},{"id":"https://openalex.org/keywords/photoperiod","display_name":"photoperiod","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hpa-axis-reactivity","display_name":"HPA axis reactivity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8930000066757202},{"id":"https://openalex.org/keywords/proopiomelanocortin","display_name":"proopiomelanocortin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8019999861717224},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.984000027179718},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.8019999861717224},{"id":"https://openalex.org/keywords/pituitary-gene-expression","display_name":"pituitary gene expression","score":0.8289999961853027},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.6740000247955322},{"id":"https://openalex.org/keywords/acute-stress-reaction","display_name":"acute stress response","score":0.546999990940094},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2779146795","wikidata":"https://www.wikidata.org/wiki/Q1369123","display_name":"Hypothalamic\u2013pituitary\u2013adrenal axis","level":3,"score":0.7311566472053528},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7159452438354492},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7090637683868408},{"id":"https://openalex.org/C55969652","wikidata":"https://www.wikidata.org/wiki/Q259028","display_name":"photoperiodism","level":2,"score":0.6836612224578857},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.6774700284004211},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.589650571346283},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.5297399759292603},{"id":"https://openalex.org/C2778654844","wikidata":"https://www.wikidata.org/wiki/Q3305232","display_name":"Chronic stress","level":2,"score":0.5088196396827698},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.4283480644226074},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.41264572739601135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4079107344150543},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3886844217777252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18960857391357422},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17377766966819763}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017440","descriptor_name":"Photoperiod","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuroscience.2022.06.011","doi":"https://doi.org/10.1016/j.neuroscience.2022.06.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2022.06.011","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:35700818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35700818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroscience.2022.06.011","doi":"https://doi.org/10.1016/j.neuroscience.2022.06.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2022.06.011","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1566116982","https://openalex.org/W1598021542","https://openalex.org/W1756428141","https://openalex.org/W1757782583","https://openalex.org/W1894445452","https://openalex.org/W1952369006","https://openalex.org/W1979654595","https://openalex.org/W1983728005","https://openalex.org/W1983996585","https://openalex.org/W1984892899","https://openalex.org/W1993866263","https://openalex.org/W2001308670","https://openalex.org/W2003656057","https://openalex.org/W2010564515","https://openalex.org/W2025500109","https://openalex.org/W2027389756","https://openalex.org/W2028003492","https://openalex.org/W2028956297","https://openalex.org/W2031934304","https://openalex.org/W2036047394","https://openalex.org/W2036250429","https://openalex.org/W2037163549","https://openalex.org/W2050836998","https://openalex.org/W2054372128","https://openalex.org/W2055716589","https://openalex.org/W2063024601","https://openalex.org/W2071721757","https://openalex.org/W2076507733","https://openalex.org/W2087846076","https://openalex.org/W2095822659","https://openalex.org/W2110243057","https://openalex.org/W2114120951","https://openalex.org/W2114405517","https://openalex.org/W2116040831","https://openalex.org/W2116629441","https://openalex.org/W2118659222","https://openalex.org/W2122252112","https://openalex.org/W2125517509","https://openalex.org/W2134428950","https://openalex.org/W2140275529","https://openalex.org/W2165178639","https://openalex.org/W2312247291","https://openalex.org/W2314700651","https://openalex.org/W2416984069","https://openalex.org/W2481842417","https://openalex.org/W2541962673","https://openalex.org/W2552003854","https://openalex.org/W2559884158","https://openalex.org/W2583844671","https://openalex.org/W2587941297","https://openalex.org/W2793654854","https://openalex.org/W2794854472","https://openalex.org/W2801172808","https://openalex.org/W2804081205","https://openalex.org/W2805015443","https://openalex.org/W2865698779","https://openalex.org/W2886383246","https://openalex.org/W2920891356","https://openalex.org/W2921046183","https://openalex.org/W2922516799","https://openalex.org/W2956601333","https://openalex.org/W2997637952","https://openalex.org/W2998525532","https://openalex.org/W3008759278","https://openalex.org/W3080856886","https://openalex.org/W3159463361","https://openalex.org/W4200554985"],"related_works":["https://openalex.org/W2956601333","https://openalex.org/W2045668323","https://openalex.org/W3090129853","https://openalex.org/W3159463361","https://openalex.org/W3011395743","https://openalex.org/W3008759278","https://openalex.org/W4392016842","https://openalex.org/W2155922104","https://openalex.org/W2087932681","https://openalex.org/W2071555379"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-13T00:00:00"}
