{"id":"https://openalex.org/W4281745542","doi":"https://doi.org/10.3389/fgene.2022.908113","title":"A Novel Defined Hypoxia-Related Gene Signature for Prognostic Prediction of Patients With Ewing Sarcoma","display_name":"A Novel Defined Hypoxia-Related Gene Signature for Prognostic Prediction of Patients With Ewing Sarcoma","publication_year":2022,"publication_date":"2022-06-02","ids":{"openalex":"https://openalex.org/W4281745542","doi":"https://doi.org/10.3389/fgene.2022.908113","pmid":"https://pubmed.ncbi.nlm.nih.gov/35719404"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2022.908113","doi":"https://doi.org/10.3389/fgene.2022.908113","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2022.908113","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fgene.2022.908113","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074772624","display_name":"Runyi Jiang","orcid":"https://orcid.org/0000-0002-2441-3091","observed_orcids":["https://orcid.org/0000-0002-2441-3091"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runyi Jiang","raw_affiliation_strings":["Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061427483","display_name":"Jinbo Hu","orcid":"https://orcid.org/0000-0002-5256-5287","observed_orcids":["https://orcid.org/0000-0002-5256-5287"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinbo Hu","raw_affiliation_strings":["Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067141609","display_name":"Hongfei Zhou","orcid":"https://orcid.org/0000-0002-4655-3837","observed_orcids":["https://orcid.org/0000-0002-4655-3837"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongfei Zhou","raw_affiliation_strings":["Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China","The Third Convalescent Department, Hangzhou Sanatorium, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]},{"raw_affiliation_string":"The Third Convalescent Department, Hangzhou Sanatorium, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014651913","display_name":"Haifeng Wei","orcid":"https://orcid.org/0000-0001-5923-6155","observed_orcids":["https://orcid.org/0000-0001-5923-6155"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haifeng Wei","raw_affiliation_strings":["Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058692857","display_name":"Shaohui He","orcid":"https://orcid.org/0000-0003-3569-0059","observed_orcids":["https://orcid.org/0000-0003-3569-0059"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaohui He","raw_affiliation_strings":["Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100620187","display_name":"Jianru Xiao","orcid":"https://orcid.org/0000-0003-1547-851X","observed_orcids":["https://orcid.org/0000-0003-1547-851X"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianru Xiao","raw_affiliation_strings":["Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Tumor Center, Department of Orthopaedic Oncology, No.905 Hospital of PLA Navy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014651913","https://openalex.org/A5058692857","https://openalex.org/A5100620187"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.1241,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.77730676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"908113","last_page":"908113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":1.0},{"id":"https://openalex.org/keywords/hypoxia-related-genes","display_name":"hypoxia-related genes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/patient-survival-prediction","display_name":"patient survival prediction","score":0.7699999809265137},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6520000100135803},{"id":"https://openalex.org/keywords/wsb1","display_name":"WSB1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/rora","display_name":"RORA","score":1.0},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.8169999718666077},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.6650000214576721},{"id":"https://openalex.org/keywords/t-cell-co-inhibition","display_name":"T cell co-inhibition","score":0.9200000166893005},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6129859089851379},{"id":"https://openalex.org/C2777586341","wikidata":"https://www.wikidata.org/wiki/Q1138580","display_name":"Ewing's sarcoma","level":3,"score":0.5959891080856323},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.577187716960907},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5707213282585144},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4903411865234375},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.43908724188804626},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.433829665184021},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41037940979003906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40440845489501953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3921174705028534},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.380409836769104},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36858880519866943},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23856908082962036},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21130144596099854},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17177733778953552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1370002031326294},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10711207985877991},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fgene.2022.908113","doi":"https://doi.org/10.3389/fgene.2022.908113","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2022.908113","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmid:35719404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35719404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9201760","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9201760","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Genet","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:31f6bef58a9d479988e130401c79d907","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/31f6bef58a9d479988e130401c79d907","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2022.908113","doi":"https://doi.org/10.3389/fgene.2022.908113","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2022.908113","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4605837985","display_name":null,"funder_award_id":"82072971","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W177380973","https://openalex.org/W1833079848","https://openalex.org/W1978301900","https://openalex.org/W1985987855","https://openalex.org/W1987001093","https://openalex.org/W2007624262","https://openalex.org/W2015850802","https://openalex.org/W2024903578","https://openalex.org/W2041004059","https://openalex.org/W2072909107","https://openalex.org/W2074357332","https://openalex.org/W2109299543","https://openalex.org/W2117692326","https://openalex.org/W2121376728","https://openalex.org/W2129824771","https://openalex.org/W2136787567","https://openalex.org/W2143900980","https://openalex.org/W2151679423","https://openalex.org/W2344746583","https://openalex.org/W2345528206","https://openalex.org/W2374415404","https://openalex.org/W2514410552","https://openalex.org/W2530711020","https://openalex.org/W2532917317","https://openalex.org/W2550208774","https://openalex.org/W2605993275","https://openalex.org/W2617569755","https://openalex.org/W2762797139","https://openalex.org/W2781923253","https://openalex.org/W2790530558","https://openalex.org/W2911997073","https://openalex.org/W3005777426","https://openalex.org/W3083391098","https://openalex.org/W3113308784","https://openalex.org/W3120488242","https://openalex.org/W3134985057","https://openalex.org/W3161232073","https://openalex.org/W3168156019","https://openalex.org/W3182094520","https://openalex.org/W3194173434","https://openalex.org/W4211227438"],"related_works":["https://openalex.org/W2182789434","https://openalex.org/W2078405839","https://openalex.org/W2347767060","https://openalex.org/W4379537877","https://openalex.org/W2040042473","https://openalex.org/W2414589069","https://openalex.org/W4223579060","https://openalex.org/W4377157499","https://openalex.org/W2163925767","https://openalex.org/W2129907328"],"abstract_inverted_index":{"The":[0,77,183,229],"therapeutic":[1,33],"strategy":[2],"of":[3,100,120,140,195,211,249],"Ewing":[4],"sarcoma":[5],"(EWS)":[6],"remains":[7],"largely":[8],"unchanged":[9],"over":[10],"the":[11,57,105,115,138,190,208,214,223,234,246,292],"past":[12],"few":[13],"decades.":[14],"Hypoxia":[15],"is":[16,27],"reported":[17],"to":[18,283],"have":[19],"an":[20,240,278],"impact":[21],"on":[22,48,144,165,233],"tumor":[23,36,71,126],"cell":[24,254,260],"progression":[25],"and":[26,66,72,84,88,127,171,180,186,201,258],"regarded":[28],"as":[29,62,114,239,299],"a":[30,43,63,161,300],"novel":[31,301],"potential":[32],"target":[34],"in":[35,56,95,213,222,265,272,291,307],"treatment.":[37],"This":[38,295],"study":[39,296],"aimed":[40],"at":[41],"developing":[42],"prognostic":[44,162,302],"gene":[45],"signature":[46,163,197],"based":[47,164,232],"hypoxia-related":[49],"genes":[50],"(HRGs).":[51],"EWS":[52,102,141,147,176,250,285,308],"patients":[53,103,148,177,212],"from":[54,104],"GSE17674":[55],"GEO":[58],"database":[59,111],"were":[60,75,93,112,130,135,149,217,262,289],"analyzed":[61],"training":[64],"cohort,":[65],"differently":[67,122,263],"expressed":[68,123],"HRGs":[69,124,167],"between":[70,125],"normal":[73,128],"samples":[74],"identified.":[76],"univariate":[78],"Cox":[79,90],"regression,":[80],"Least":[81],"Absolute":[82],"Shrinkage":[83],"Selection":[85],"Operator":[86],"(LASSO)":[87],"multivariate":[89],"regression":[91],"analyses":[92],"used":[94],"this":[96,196],"study.":[97],"A":[98,118],"total":[99,119],"57":[101],"International":[106],"Cancer":[107],"Genome":[108],"Consortium":[109],"(ICGC)":[110],"set":[113],"validation":[116,293],"cohort.":[117,294],"506":[121],"tissues":[129],"identified,":[131],"among":[132],"which":[133,269],"52":[134,145],"associated":[136],"with":[137,155],"prognoses":[139],"patients.":[142,251,286,309],"Based":[143],"HRGs,":[146],"divided":[150],"into":[151,178],"two":[152,266],"molecular":[153],"subgroups":[154],"different":[156,273],"survival":[157,209,247,306],"statuses.":[158],"In":[159],"addition,":[160],"4":[166],"(WSB1,":[168],"RXYLT1,":[169],"GLCE":[170],"RORA)":[172],"was":[173,198,205],"constructed,":[174],"dividing":[175],"low-":[179],"high-risk":[181,215],"groups.":[182],"2-,":[184],"3-":[185],"5-years":[187],"area":[188],"under":[189],"receiver":[191],"operator":[192],"characteristic":[193],"curve":[194],"0.913,":[199],"0.97":[200],"0.985,":[202],"respectively.":[203],"It":[204],"found":[206],"that":[207],"rates":[210],"group":[216,225],"significantly":[218],"lower":[219],"than":[220],"those":[221],"low-risk":[224],"(p":[226],"<":[227],"0.001).":[228],"risk":[230,235,267],"level":[231],"score":[236],"could":[237],"serve":[238],"independent":[241],"clinical":[242],"factor":[243],"for":[244,304],"predicting":[245,305],"probabilities":[248],"Additionally,":[252],"antigen-presenting":[253],"(APC)":[255],"related":[256],"pathways":[257],"T":[259],"co-inhibition":[261],"activated":[264],"groups,":[268],"may":[270,276],"result":[271],"prognoses.":[274],"CTLA4":[275],"be":[277],"effective":[279],"immune":[280],"checkpoint":[281],"inhibitor":[282],"treat":[284],"All":[287],"results":[288],"verified":[290],"constructed":[297],"4-HRGs":[298],"marker":[303]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}