{"id":"https://openalex.org/W4281743445","doi":"https://doi.org/10.1159/000525267","title":"Caffeine: Some of the Evidence behind Its Use and Abuse in the Preterm Infant","display_name":"Caffeine: Some of the Evidence behind Its Use and Abuse in the Preterm Infant","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4281743445","doi":"https://doi.org/10.1159/000525267","pmid":"https://pubmed.ncbi.nlm.nih.gov/35691280"},"language":"en","primary_location":{"id":"doi:10.1159/000525267","doi":"https://doi.org/10.1159/000525267","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000525267","pdf_url":null,"source":{"id":"https://openalex.org/S168252155","display_name":"Neonatology","issn_l":"1661-7800","issn":["1661-7800","1661-7819"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neonatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Laura Chavez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laura Chavez","raw_affiliation_strings":["Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida, USA","Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086575273","display_name":"Eduardo H. Bancalari","orcid":"https://orcid.org/0000-0002-1115-8845","observed_orcids":["https://orcid.org/0000-0002-1115-8845"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eduardo Bancalari","raw_affiliation_strings":["Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida, USA","Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086575273"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":2.8997,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.92099386,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"119","issue":"4","first_page":"428","last_page":"432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.22470000386238098,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.04960000142455101,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/apnea-of-prematurity","display_name":"apnea of prematurity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.9480000138282776},{"id":"https://openalex.org/keywords/neurodevelopmental-outcomes","display_name":"neurodevelopmental outcomes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hypoxemia","display_name":"hypoxemia","score":0.7950000166893005},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2779832335","wikidata":"https://www.wikidata.org/wiki/Q4780036","display_name":"Apnea of prematurity","level":4,"score":0.9490860104560852},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7779594659805298},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.7063499093055725},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.6783233880996704},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.6667616963386536},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6235111951828003},{"id":"https://openalex.org/C2776779939","wikidata":"https://www.wikidata.org/wiki/Q1479485","display_name":"Hypoxemia","level":2,"score":0.5349326133728027},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45810508728027344},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4547637104988098},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.44877517223358154},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3728148937225342},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1585376262664795},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1563720405101776},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13530921936035156},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.1069284975528717},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007235","descriptor_name":"Infant, Premature, Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007235","descriptor_name":"Infant, Premature, Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000525267","doi":"https://doi.org/10.1159/000525267","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000525267","pdf_url":null,"source":{"id":"https://openalex.org/S168252155","display_name":"Neonatology","issn_l":"1661-7800","issn":["1661-7800","1661-7819"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neonatology","raw_type":"journal-article"},{"id":"pmid:35691280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35691280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neonatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4339394874","display_name":"Oxygenation instability and maturation of control of breathing in evolving BPD.","funder_award_id":"U01HL133689","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6444720519","display_name":"Prematurity-Related Ventilatory Control: Leadership Data and Coordination Center (LDCC)","funder_award_id":"U01HL133708","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2001420919","https://openalex.org/W2027837397","https://openalex.org/W2045159124","https://openalex.org/W2053058340","https://openalex.org/W2068294255","https://openalex.org/W2068861236","https://openalex.org/W2103565963","https://openalex.org/W2106692198","https://openalex.org/W2119429678","https://openalex.org/W2147778078","https://openalex.org/W2168129634","https://openalex.org/W2254739046","https://openalex.org/W2433618972","https://openalex.org/W2737051102","https://openalex.org/W2753006012","https://openalex.org/W2786360527","https://openalex.org/W2794539359","https://openalex.org/W2821168934"],"related_works":["https://openalex.org/W2089052896","https://openalex.org/W4393306817","https://openalex.org/W4411473032","https://openalex.org/W2076825420","https://openalex.org/W2581583266","https://openalex.org/W1964228249","https://openalex.org/W2981984035","https://openalex.org/W3095066845","https://openalex.org/W4364362702","https://openalex.org/W4398783770"],"abstract_inverted_index":{"Apnea":[0],"of":[1,14,16,51,53,64,72,117,134,149,157,162,166],"prematurity":[2,17],"is":[3,41,121],"a":[4,69,122],"developmental":[5],"disorder":[6],"affecting":[7],"most":[8],"extremely":[9],"preterm":[10,101],"infants.":[11],"The":[12],"consequences":[13],"apnea":[15,29,52],"on":[18,82,138,193],"neurodevelopment":[19],"are":[20,91],"not":[21,191],"well":[22],"established,":[23],"but":[24,198],"several":[25],"reports":[26],"suggest":[27],"that":[28],"and":[30,49,74,98,146,151,155,178,184],"hypoxemia":[31],"episodes":[32],"may":[33],"be":[34],"associated":[35,77],"with":[36,78],"worse":[37],"neurological":[38],"outcome.":[39,85],"Caffeine":[40],"the":[42,47,62,87,135,158,167],"only":[43,192],"FDA-approved":[44],"drug":[45],"for":[46],"prevention":[48],"treatment":[50],"prematurity.":[54],"Besides":[55],"its":[56,144,194,200],"clear":[57],"effectiveness":[58],"to":[59,67,176,187],"reduce":[60],"apnea,":[61],"use":[63,127,140],"caffeine":[65,109,126,139,163],"appears":[66],"have":[68],"wide":[70,123],"margin":[71],"safety":[73],"has":[75],"been":[76],"possible":[79,159],"beneficial":[80,196],"effects":[81,107,161,197],"later":[83],"neurodevelopmental":[84],"At":[86],"same":[88],"time,":[89],"there":[90,120],"also":[92,199],"many":[93,168],"studies":[94,186],"in":[95,100,125,141,170],"experimental":[96],"animals":[97],"some":[99,133,156],"infants":[102],"suggesting":[103],"potential":[104,195],"serious":[105],"adverse":[106,160],"from":[108],"administration,":[110],"especially":[111,172],"when":[112],"using":[113],"higher":[114],"doses.":[115],"Because":[116,165],"these":[118],"uncertainties,":[119],"variation":[124],"across":[128],"institutions.":[129],"This":[130],"review":[131],"summarizes":[132],"available":[136],"evidence":[137],"this":[142],"population,":[143],"indications":[145],"best":[147],"timing":[148],"initiation":[150],"discontinuation,":[152],"appropriate":[153],"dosing,":[154],"administration.":[164],"gaps":[169],"knowledge,":[171],"as":[173],"it":[174],"relates":[175],"efficacy":[177],"safety,":[179],"we":[180],"encourage":[181],"further":[182],"basic":[183],"clinical":[185],"provide":[188],"stronger":[189],"evidence,":[190],"side":[201],"effects.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-13T00:00:00"}