{"id":"https://openalex.org/W4281730640","doi":"https://doi.org/10.1016/j.cbpa.2022.102160","title":"Natural and engineered precision antibiotics in the context of resistance","display_name":"Natural and engineered precision antibiotics in the context of resistance","publication_year":2022,"publication_date":"2022-05-31","ids":{"openalex":"https://openalex.org/W4281730640","doi":"https://doi.org/10.1016/j.cbpa.2022.102160","pmid":"https://pubmed.ncbi.nlm.nih.gov/35660248"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbpa.2022.102160","doi":"https://doi.org/10.1016/j.cbpa.2022.102160","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2022.102160","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.cbpa.2022.102160","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022831807","display_name":"Chad W. Johnston","orcid":"https://orcid.org/0000-0002-1988-709X","observed_orcids":["https://orcid.org/0000-0002-1988-709X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chad W. Johnston","raw_affiliation_strings":["Department of Pharmacology & Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: chad.johnston@bcm.edu","Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX 77030, USA","Department of Pharmacology & Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":"https://orcid.org/0000-0002-1988-709X","affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: chad.johnston@bcm.edu","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Pharmacology & Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060537679","display_name":"Ahmed H. Badran","orcid":"https://orcid.org/0000-0002-8105-1883","observed_orcids":["https://orcid.org/0000-0002-8105-1883"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ahmed H. Badran","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: ahbadran@scripps.edu","Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA","Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":"https://orcid.org/0000-0002-8105-1883","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: ahbadran@scripps.edu","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022831807","https://openalex.org/A5060537679"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I181547552"],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":0.3228,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.2905353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"69","issue":null,"first_page":"102160","last_page":"102160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.9340000152587891},{"id":"https://openalex.org/keywords/microbiota-stability","display_name":"microbiome stability","score":0.6740000247955322},{"id":"https://openalex.org/keywords/broad-spectrum-antibiotics","display_name":"broad-spectrum antibiotics","score":0.6949999928474426},{"id":"https://openalex.org/keywords/natural-product-scaffolds","display_name":"natural product scaffolds","score":0.6000000238418579},{"id":"https://openalex.org/keywords/antibacterial-mechanism","display_name":"antibacterial mechanism","score":0.7200000286102295},{"id":"https://openalex.org/keywords/biosynthetic-pathway","display_name":"biosynthetic pathway","score":0.7739999890327454},{"id":"https://openalex.org/keywords/antibiotic-design","display_name":"antibiotic design","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7811322808265686},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6263529658317566},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.6111413240432739},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5957167148590088},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5109269022941589},{"id":"https://openalex.org/C3020442560","wikidata":"https://www.wikidata.org/wiki/Q4971815","display_name":"Broad spectrum","level":2,"score":0.48369795083999634},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4747993052005768},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44274401664733887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43197470903396606},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.41136717796325684},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3894732892513275},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.32130545377731323},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.29667019844055176},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2536126971244812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25327005982398987},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2239823341369629},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2168162763118744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16934281587600708},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15419980883598328},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.09069287776947021},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cbpa.2022.102160","doi":"https://doi.org/10.1016/j.cbpa.2022.102160","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2022.102160","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},{"id":"pmid:35660248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35660248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in chemical biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cbpa.2022.102160","doi":"https://doi.org/10.1016/j.cbpa.2022.102160","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2022.102160","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1085249139","display_name":"Functional Interrogation Of Ribosomal Biology Using Continuous Evolution","funder_award_id":"DP5OD024590","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4179875059","display_name":"Recruitment of First-Time, Tenure-Track Faculty Members","funder_award_id":"RR210066","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G7050354141","display_name":null,"funder_award_id":"DP5-OD024590","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320312995","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W1796900355","https://openalex.org/W1827916032","https://openalex.org/W1853559395","https://openalex.org/W1885633068","https://openalex.org/W1964895549","https://openalex.org/W1975156465","https://openalex.org/W1982793579","https://openalex.org/W1990562658","https://openalex.org/W1993689968","https://openalex.org/W1994921867","https://openalex.org/W1995808283","https://openalex.org/W1998078889","https://openalex.org/W2011357172","https://openalex.org/W2011934361","https://openalex.org/W2013383995","https://openalex.org/W2016256427","https://openalex.org/W2032546148","https://openalex.org/W2033196044","https://openalex.org/W2034401306","https://openalex.org/W2050673229","https://openalex.org/W2059773467","https://openalex.org/W2063212143","https://openalex.org/W2064744296","https://openalex.org/W2067120481","https://openalex.org/W2069812362","https://openalex.org/W2074696084","https://openalex.org/W2077957449","https://openalex.org/W2079251921","https://openalex.org/W2087367101","https://openalex.org/W2088966853","https://openalex.org/W2099886897","https://openalex.org/W2101760102","https://openalex.org/W2114839447","https://openalex.org/W2115717127","https://openalex.org/W2116279935","https://openalex.org/W2122113142","https://openalex.org/W2125157276","https://openalex.org/W2133170921","https://openalex.org/W2134985690","https://openalex.org/W2135786672","https://openalex.org/W2138298207","https://openalex.org/W2138408777","https://openalex.org/W2139119508","https://openalex.org/W2139241849","https://openalex.org/W2142498662","https://openalex.org/W2152553790","https://openalex.org/W2152598367","https://openalex.org/W2166972934","https://openalex.org/W2172734967","https://openalex.org/W2194023039","https://openalex.org/W2252937219","https://openalex.org/W2266633395","https://openalex.org/W2271565196","https://openalex.org/W2301336437","https://openalex.org/W2316756060","https://openalex.org/W2331458239","https://openalex.org/W2331960585","https://openalex.org/W2399451660","https://openalex.org/W2413697458","https://openalex.org/W2520542585","https://openalex.org/W2520989670","https://openalex.org/W2528897472","https://openalex.org/W2574382050","https://openalex.org/W2587315940","https://openalex.org/W2590317180","https://openalex.org/W2593189583","https://openalex.org/W2596432041","https://openalex.org/W2621442359","https://openalex.org/W2746313608","https://openalex.org/W2766707489","https://openalex.org/W2769554577","https://openalex.org/W2782107316","https://openalex.org/W2782456186","https://openalex.org/W2787886853","https://openalex.org/W2799469700","https://openalex.org/W2888421328","https://openalex.org/W2889984933","https://openalex.org/W2895564901","https://openalex.org/W2898908856","https://openalex.org/W2911011185","https://openalex.org/W2914792159","https://openalex.org/W2921257516","https://openalex.org/W2922696371","https://openalex.org/W2941148099","https://openalex.org/W2943639827","https://openalex.org/W2950608592","https://openalex.org/W2951089481","https://openalex.org/W2953584423","https://openalex.org/W2955224282","https://openalex.org/W2978513174","https://openalex.org/W2979595179","https://openalex.org/W2982225348","https://openalex.org/W2982415196","https://openalex.org/W2990344250","https://openalex.org/W2998838505","https://openalex.org/W3004618361","https://openalex.org/W3006342711","https://openalex.org/W3008901682","https://openalex.org/W3011366455","https://openalex.org/W3020914529","https://openalex.org/W3022320185","https://openalex.org/W3025082178","https://openalex.org/W3027325047","https://openalex.org/W3036723549","https://openalex.org/W3042302441","https://openalex.org/W3044043637","https://openalex.org/W3087348949","https://openalex.org/W3088036532","https://openalex.org/W3091268297","https://openalex.org/W3107629351","https://openalex.org/W3118565791","https://openalex.org/W3122611304","https://openalex.org/W3125149014","https://openalex.org/W3131356111","https://openalex.org/W3139375672","https://openalex.org/W3156544690","https://openalex.org/W3177302655","https://openalex.org/W3186191610","https://openalex.org/W3198152865","https://openalex.org/W3207744615","https://openalex.org/W3208116526","https://openalex.org/W3209878801","https://openalex.org/W3217491883","https://openalex.org/W4200140585","https://openalex.org/W4214826609","https://openalex.org/W4224286658","https://openalex.org/W4235106149","https://openalex.org/W4246067865","https://openalex.org/W6680039556","https://openalex.org/W6804607579"],"related_works":["https://openalex.org/W2773844300","https://openalex.org/W3047190446","https://openalex.org/W2756935148","https://openalex.org/W2802179142","https://openalex.org/W7168759588","https://openalex.org/W2995221434","https://openalex.org/W3048615579","https://openalex.org/W1171942363","https://openalex.org/W7140441686","https://openalex.org/W2556672658"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-13T00:00:00"}
