{"id":"https://openalex.org/W4281724322","doi":"https://doi.org/10.3389/fnins.2022.811528","title":"Effects of Treatment With Hypnotics on Reduced Sleep Duration and Behavior Abnormalities in a Mouse Model of Fragile X Syndrome","display_name":"Effects of Treatment With Hypnotics on Reduced Sleep Duration and Behavior Abnormalities in a Mouse Model of Fragile X Syndrome","publication_year":2022,"publication_date":"2022-06-02","ids":{"openalex":"https://openalex.org/W4281724322","doi":"https://doi.org/10.3389/fnins.2022.811528","pmid":"https://pubmed.ncbi.nlm.nih.gov/35720683","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9202518"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2022.811528","doi":"https://doi.org/10.3389/fnins.2022.811528","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.811528","pdf_url":null,"source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fnins.2022.811528","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070318396","display_name":"Rachel Michelle Sar\u00e9","orcid":"https://orcid.org/0000-0003-0605-5697","observed_orcids":["https://orcid.org/0000-0003-0605-5697"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Michelle Sar\u00e9","raw_affiliation_strings":["Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036751583","display_name":"Abigail H. S. Lemons","orcid":"https://orcid.org/0000-0002-9431-0573","observed_orcids":["https://orcid.org/0000-0002-9431-0573"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail Lemons","raw_affiliation_strings":["Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000550919","display_name":"Carolyn Beebe Smith","orcid":"https://orcid.org/0000-0002-2722-0180","observed_orcids":["https://orcid.org/0000-0002-2722-0180"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carolyn Beebe Smith","raw_affiliation_strings":["Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000550919"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.905,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.70621798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"811528","last_page":"811528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.06310000270605087,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fragile-x-syndrome","display_name":"fragile X syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fmr1-knockout-mice","display_name":"Fmr1 knockout mice","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hypnotics","display_name":"hypnotics","score":0.925000011920929},{"id":"https://openalex.org/keywords/sleep-duration","display_name":"sleep duration","score":0.8859999775886536},{"id":"https://openalex.org/keywords/sleep-restriction","display_name":"sleep restriction","score":0.5860000252723694},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.6899999976158142},{"id":"https://openalex.org/keywords/ramelteon","display_name":"ramelteon","score":0.996999979019165},{"id":"https://openalex.org/keywords/zolpidem","display_name":"zolpidem","score":1.0},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.9769999980926514},{"id":"https://openalex.org/keywords/social-behavior","display_name":"social behavior","score":0.9290000200271606},{"id":"https://openalex.org/keywords/open-field-behavior","display_name":"open field behavior","score":0.7080000042915344},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.5839999914169312},{"id":"https://openalex.org/keywords/behavioral-abnormalities","display_name":"behavioral abnormalities","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2779063550","wikidata":"https://www.wikidata.org/wiki/Q905435","display_name":"FMR1","level":4,"score":0.8531527519226074},{"id":"https://openalex.org/C2777630245","wikidata":"https://www.wikidata.org/wiki/Q221472","display_name":"Fragile X syndrome","level":2,"score":0.7014681100845337},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.6821851134300232},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.5948468446731567},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5160784125328064},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4797321856021881},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43654370307922363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42654553055763245},{"id":"https://openalex.org/C2777123777","wikidata":"https://www.wikidata.org/wiki/Q218842","display_name":"Zolpidem","level":3,"score":0.42063143849372864},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.41038978099823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39918842911720276},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.25551125407218933},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2325548231601715},{"id":"https://openalex.org/C3020422209","wikidata":"https://www.wikidata.org/wiki/Q221472","display_name":"Fragile x","level":3,"score":0.10976415872573853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09924134612083435},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnins.2022.811528","doi":"https://doi.org/10.3389/fnins.2022.811528","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.811528","pdf_url":null,"source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9202518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9202518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:35720683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35720683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b862f6b86b2a4b578a8f340b7ff93677","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b862f6b86b2a4b578a8f340b7ff93677","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 16 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2022.811528","doi":"https://doi.org/10.3389/fnins.2022.811528","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.811528","pdf_url":null,"source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5299999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3282665189","display_name":"Dysregulation of Protein Synthesis in Fragile X Syndrome and Other Developmental Disorders","funder_award_id":"ZIAMH000889","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3313643045","display_name":null,"funder_award_id":"MH000889","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306123","display_name":"FRAXA Research Foundation","ror":"https://ror.org/050apvm78"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1481250329","https://openalex.org/W1647335857","https://openalex.org/W1674182966","https://openalex.org/W1839123200","https://openalex.org/W1973373025","https://openalex.org/W1988065740","https://openalex.org/W2001855838","https://openalex.org/W2009998678","https://openalex.org/W2013544601","https://openalex.org/W2027596401","https://openalex.org/W2030260413","https://openalex.org/W2051361436","https://openalex.org/W2054086319","https://openalex.org/W2065008291","https://openalex.org/W2067929669","https://openalex.org/W2071075776","https://openalex.org/W2072126194","https://openalex.org/W2095001602","https://openalex.org/W2107880079","https://openalex.org/W2147496694","https://openalex.org/W2152837277","https://openalex.org/W2162926808","https://openalex.org/W2217368851","https://openalex.org/W2309843623","https://openalex.org/W2323107141","https://openalex.org/W2482285130","https://openalex.org/W2753664457","https://openalex.org/W2783012184","https://openalex.org/W2802026353","https://openalex.org/W2803407338","https://openalex.org/W2897772489","https://openalex.org/W2943169282","https://openalex.org/W2971899999","https://openalex.org/W3028558656","https://openalex.org/W3087454523","https://openalex.org/W3100295528","https://openalex.org/W3127896523","https://openalex.org/W3194426179"],"related_works":["https://openalex.org/W4283590019","https://openalex.org/W2753664457","https://openalex.org/W4384696184","https://openalex.org/W4398252437","https://openalex.org/W3158993605","https://openalex.org/W4407837147","https://openalex.org/W2803407338","https://openalex.org/W4414767240","https://openalex.org/W1995223777","https://openalex.org/W2095001602"],"abstract_inverted_index":{"Many":[0],"patients":[1],"with":[2,78],"fragile":[3],"X":[4],"syndrome":[5],"(FXS)":[6],"have":[7,19],"sleep":[8,21,36,51,63,101,127],"disturbances,":[9],"and":[10,34,60,74,86,88,93,103,116,124,139],"Fmr1":[11,72],"knockout":[12],"(KO)":[13],"mice":[14,76],"(a":[15],"model":[16],"of":[17,82,98,150],"FXS)":[18],"reduced":[20,143],"duration":[22,64,102,128],"compared":[23],"to":[24,57,110],"wild":[25],"type":[26],"(WT).":[27],"Sleep":[28],"is":[29],"important":[30],"for":[31],"brain":[32],"development,":[33],"chronic":[35],"restriction":[37],"during":[38],"development":[39],"has":[40],"long-lasting":[41],"behavioral":[42,58],"effects":[43,97,153],"in":[44,53,129,133,145],"WT":[45,75],"mice.":[46],"We":[47,68],"hypothesized":[48],"that":[49,61],"the":[50,96,130,146],"abnormalities":[52],"FXS":[54],"may":[55],"contribute":[56],"impairments":[59],"increasing":[62],"might":[65],"improve":[66],"behavior.":[67,104,118],"treated":[69],"adult":[70],"male":[71],"KO":[73],"subacutely":[77],"three":[79],"different":[80],"classes":[81],"hypnotics":[83,122],"(DORA-22,":[84],"ramelteon,":[85],"zolpidem)":[87],"caffeine,":[89],"a":[90,111],"methylxanthine":[91],"stimulant,":[92],"we":[94],"tested":[95],"treatments":[99],"on":[100],"Behavior":[105],"tests":[106],"included":[107],"activity":[108,144],"response":[109],"novel":[112],"environment,":[113],"anxiety-like":[114],"behavior,":[115],"social":[117],"As":[119],"expected,":[120],"all":[121],"increased,":[123],"caffeine":[125],"decreased":[126],"circadian":[131],"phase":[132],"which":[134],"drugs":[135],"were":[136,154],"administered.":[137],"Caffeine":[138],"DORA-22":[140],"treatment":[141],"significantly":[142],"open":[147],"field":[148],"regardless":[149],"genotype.":[151],"Other":[152],"not":[155],"as":[156],"apparent.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-06-13T00:00:00"}