{"id":"https://openalex.org/W4281721799","doi":"https://doi.org/10.3390/nu14112340","title":"Randomised Clinical Trial to Analyse the Efficacy of Eggshell Membrane to Improve Joint Functionality in Knee Osteoarthritis","display_name":"Randomised Clinical Trial to Analyse the Efficacy of Eggshell Membrane to Improve Joint Functionality in Knee Osteoarthritis","publication_year":2022,"publication_date":"2022-06-03","ids":{"openalex":"https://openalex.org/W4281721799","doi":"https://doi.org/10.3390/nu14112340","pmid":"https://pubmed.ncbi.nlm.nih.gov/35684140","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9182852"},"language":"en","primary_location":{"id":"doi:10.3390/nu14112340","doi":"https://doi.org/10.3390/nu14112340","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu14112340","pdf_url":"https://www.mdpi.com/2072-6643/14/11/2340/pdf?version=1654243317","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6643/14/11/2340/pdf?version=1654243317","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070905355","display_name":"Fernando C\u00e1novas","orcid":"https://orcid.org/0000-0002-8837-1927","observed_orcids":["https://orcid.org/0000-0002-8837-1927"]},"institutions":[{"id":"https://openalex.org/I68763199","display_name":"Universidad Cat\u00f3lica de Murcia","ror":"https://ror.org/05b1rsv17","country_code":"ES","type":"education","lineage":["https://openalex.org/I68763199"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fernando C\u00e1novas","raw_affiliation_strings":["Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8837-1927","affiliations":[{"raw_affiliation_string":"Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain","institution_ids":["https://openalex.org/I68763199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041729463","display_name":"Mar\u00eda Salud Abell\u00e1n-Ruiz","orcid":"https://orcid.org/0000-0003-2952-4783","observed_orcids":["https://orcid.org/0000-0003-2952-4783"]},"institutions":[{"id":"https://openalex.org/I68763199","display_name":"Universidad Cat\u00f3lica de Murcia","ror":"https://ror.org/05b1rsv17","country_code":"ES","type":"education","lineage":["https://openalex.org/I68763199"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Salud Abell\u00e1n-Ru\u00edz","raw_affiliation_strings":["Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain"],"raw_orcid":"https://orcid.org/0000-0003-2952-4783","affiliations":[{"raw_affiliation_string":"Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain","institution_ids":["https://openalex.org/I68763199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082016674","display_name":"Ana Mar\u00eda Garc\u00eda\u2010Mu\u00f1oz","orcid":"https://orcid.org/0000-0002-1021-5385","observed_orcids":["https://orcid.org/0000-0002-1021-5385"]},"institutions":[{"id":"https://openalex.org/I68763199","display_name":"Universidad Cat\u00f3lica de Murcia","ror":"https://ror.org/05b1rsv17","country_code":"ES","type":"education","lineage":["https://openalex.org/I68763199"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Mar\u00eda Garc\u00eda-Mu\u00f1oz","raw_affiliation_strings":["Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1021-5385","affiliations":[{"raw_affiliation_string":"Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain","institution_ids":["https://openalex.org/I68763199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055715835","display_name":"Antonio J. Luque-Rubia","orcid":"https://orcid.org/0000-0002-2800-0470","observed_orcids":["https://orcid.org/0000-0002-2800-0470"]},"institutions":[{"id":"https://openalex.org/I68763199","display_name":"Universidad Cat\u00f3lica de Murcia","ror":"https://ror.org/05b1rsv17","country_code":"ES","type":"education","lineage":["https://openalex.org/I68763199"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio Jes\u00fas Luque-Rubia","raw_affiliation_strings":["Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain","institution_ids":["https://openalex.org/I68763199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076070078","display_name":"Desir\u00e9e Victoria\u2010Montesinos","orcid":"https://orcid.org/0000-0003-3968-9477","observed_orcids":["https://orcid.org/0000-0003-3968-9477"]},"institutions":[{"id":"https://openalex.org/I68763199","display_name":"Universidad Cat\u00f3lica de Murcia","ror":"https://ror.org/05b1rsv17","country_code":"ES","type":"education","lineage":["https://openalex.org/I68763199"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Desir\u00e9e Victoria-Montesinos","raw_affiliation_strings":["Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3968-9477","affiliations":[{"raw_affiliation_string":"Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain","institution_ids":["https://openalex.org/I68763199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082353130","display_name":"Silvia P\u00e9rez-Pi\u00f1ero","orcid":"https://orcid.org/0000-0002-2027-9075","observed_orcids":["https://orcid.org/0000-0002-2027-9075"]},"institutions":[{"id":"https://openalex.org/I68763199","display_name":"Universidad Cat\u00f3lica de Murcia","ror":"https://ror.org/05b1rsv17","country_code":"ES","type":"education","lineage":["https://openalex.org/I68763199"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Silvia P\u00e9rez-Pi\u00f1ero","raw_affiliation_strings":["Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain"],"raw_orcid":"https://orcid.org/0000-0002-2027-9075","affiliations":[{"raw_affiliation_string":"Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain","institution_ids":["https://openalex.org/I68763199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017658890","display_name":"Maravillas S\u00e1nchez-Macarro","orcid":"https://orcid.org/0000-0001-7589-1344","observed_orcids":["https://orcid.org/0000-0001-7589-1344"]},"institutions":[{"id":"https://openalex.org/I68763199","display_name":"Universidad Cat\u00f3lica de Murcia","ror":"https://ror.org/05b1rsv17","country_code":"ES","type":"education","lineage":["https://openalex.org/I68763199"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maravilla S\u00e1nchez-Macarro","raw_affiliation_strings":["Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7589-1344","affiliations":[{"raw_affiliation_string":"Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain","institution_ids":["https://openalex.org/I68763199"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013887986","display_name":"Francisco Javier L\u00f3pez-Rom\u00e1n","orcid":"https://orcid.org/0000-0002-2841-5502","observed_orcids":["https://orcid.org/0000-0002-2841-5502"]},"institutions":[{"id":"https://openalex.org/I4210146619","display_name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria","ror":"https://ror.org/053j10c72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210146619"]},{"id":"https://openalex.org/I68763199","display_name":"Universidad Cat\u00f3lica de Murcia","ror":"https://ror.org/05b1rsv17","country_code":"ES","type":"education","lineage":["https://openalex.org/I68763199"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Francisco Javier L\u00f3pez-Rom\u00e1n","raw_affiliation_strings":["Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain","Primary Care Research Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain"],"raw_orcid":"https://orcid.org/0000-0002-2841-5502","affiliations":[{"raw_affiliation_string":"Health Science Department, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica San Antonio de Murcia UCAM, 30107 Murcia, Spain","institution_ids":["https://openalex.org/I68763199"]},{"raw_affiliation_string":"Primary Care Research Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain","institution_ids":["https://openalex.org/I4210146619"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013887986"],"corresponding_institution_ids":["https://openalex.org/I4210146619","https://openalex.org/I68763199"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2722},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2722},"fwci":1.6945,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.83644578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"11","first_page":"2340","last_page":"2340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eggshell-membrane","display_name":"eggshell membrane","score":0.9919999837875366},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.921999990940094},{"id":"https://openalex.org/keywords/knee-pain","display_name":"knee pain","score":0.9440000057220459},{"id":"https://openalex.org/keywords/quadriceps-strength","display_name":"quadriceps strength","score":0.972000002861023},{"id":"https://openalex.org/keywords/isokinetic-strength","display_name":"isokinetic strength","score":0.9070000052452087},{"id":"https://openalex.org/keywords/isometric-strength","display_name":"isometric strength","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.8830000162124634},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.9229999780654907},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.865651547908783},{"id":"https://openalex.org/C2776352850","wikidata":"https://www.wikidata.org/wiki/Q18389506","display_name":"Eggshell membrane","level":3,"score":0.8285900354385376},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.7731320858001709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7620846033096313},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6240264177322388},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.6136051416397095},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.545899510383606},{"id":"https://openalex.org/C2908736133","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee Joint","level":2,"score":0.5225895643234253},{"id":"https://openalex.org/C2781415944","wikidata":"https://www.wikidata.org/wiki/Q559210","display_name":"Joint stiffness","level":3,"score":0.5218302607536316},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5069668292999268},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.45990392565727234},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.399705708026886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22744855284690857},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1754671335220337},{"id":"https://openalex.org/C195973872","wikidata":"https://www.wikidata.org/wiki/Q2731253","display_name":"Eggshell","level":2,"score":0.1688235104084015},{"id":"https://openalex.org/C2779372316","wikidata":"https://www.wikidata.org/wiki/Q569057","display_name":"Stiffness","level":2,"score":0.14771080017089844},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05997350811958313},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004528","descriptor_name":"Egg Shell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018771","descriptor_name":"Arthralgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018771","descriptor_name":"Arthralgia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/nu14112340","doi":"https://doi.org/10.3390/nu14112340","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu14112340","pdf_url":"https://www.mdpi.com/2072-6643/14/11/2340/pdf?version=1654243317","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmid:35684140","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35684140","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9182852","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9182852/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmh:oai:repositorio.ucam.edu:10952/8082","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10952/8082","pdf_url":"https://repositorio.ucam.edu/bitstream/10952/8082/1/nutrients-14-02340%20%284%29.pdf","source":{"id":"https://openalex.org/S7407055189","display_name":"RIUCAM","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:63268d9502bd4332847a7bd7aef46c28","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/63268d9502bd4332847a7bd7aef46c28","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrients, Vol 14, Iss 2340, p 2340 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/nu14112340","doi":"https://doi.org/10.3390/nu14112340","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu14112340","pdf_url":"https://www.mdpi.com/2072-6643/14/11/2340/pdf?version=1654243317","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281721799.pdf","grobid_xml":"https://content.openalex.org/works/W4281721799.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1900956557","https://openalex.org/W1984796570","https://openalex.org/W1989737704","https://openalex.org/W2056036951","https://openalex.org/W2121596147","https://openalex.org/W2127938288","https://openalex.org/W2140513563","https://openalex.org/W2143606807","https://openalex.org/W2151487996","https://openalex.org/W2170177271","https://openalex.org/W2292533926","https://openalex.org/W2297555457","https://openalex.org/W2468978017","https://openalex.org/W2747777164","https://openalex.org/W2752563562","https://openalex.org/W2936843542","https://openalex.org/W2955666772","https://openalex.org/W2965457812","https://openalex.org/W3041115565","https://openalex.org/W3041720930","https://openalex.org/W3046252492","https://openalex.org/W3048257211","https://openalex.org/W3189197737","https://openalex.org/W4239925387"],"related_works":["https://openalex.org/W7054684874","https://openalex.org/W7133531387","https://openalex.org/W7154493965","https://openalex.org/W4402416740","https://openalex.org/W3041115565","https://openalex.org/W4401515264","https://openalex.org/W2965457812","https://openalex.org/W2170177271","https://openalex.org/W7100497950","https://openalex.org/W2555835828"],"abstract_inverted_index":{"Osteoarthritis":[0],"is":[1],"a":[2,16,56,71,98,118,176],"source":[3],"of":[4,50,93,149,161,163,172],"chronic":[5],"pain":[6,32,102,134],"and":[7,33,53,88,91,114,135,147],"disability.":[8],"Dietary":[9],"supplements":[10],"have":[11],"been":[12],"shown":[13],"to":[14,46,55,132,154,190],"be":[15,181],"more":[17],"secure":[18],"option":[19],"than":[20],"NSAIDS.":[21],"Particularly,":[22],"the":[23,110,124,130,140,159,192],"eggshell":[24],"membrane":[25,128],"has":[26],"demonstrated":[27],"efficacy":[28],"in":[29,40,101,109,121,123,158,188],"relieving":[30],"joint":[31,168],"stiffness.":[34],"A":[35],"clinical":[36],"trial":[37],"was":[38,64,68],"designed":[39],"which":[41,67,179],"three":[42],"groups":[43,96],"were":[44,78,107,152],"assigned":[45],"two":[47,143],"different":[48],"doses":[49],"this":[51,173],"supplement":[52],"compared":[54],"placebo":[57],"control":[58],"group.":[59,112,126],"The":[60,170],"primary":[61],"outcome":[62,76],"variable":[63],"knee":[65,79,150,167],"pain,":[66],"assessed":[69],"using":[70],"visual":[72],"analogue":[73],"scale.":[74],"Secondary":[75],"variables":[77,145],"functional":[80],"ability,":[81],"quadriceps":[82],"muscle":[83],"strength":[84,122,148],"(assessed":[85],"by":[86,166],"isometric":[87,115],"isokinetic":[89],"trials),":[90],"quality":[92,160],"sleep.":[94],"All":[95],"showed":[97,117,129],"significant":[99,119],"decrease":[100],"perception,":[103],"although":[104],"maximum":[105],"values":[106],"obtained":[108],"high-dose":[111,125],"Isokinetic":[113],"trials":[116],"increase":[120],"Eggshell":[127],"potential":[131],"reduce":[133],"stiffness":[136],"symptomatology.":[137],"Here,":[138],"for":[139,185],"first":[141],"time,":[142],"quantitative":[144],"(mobility":[146],"joint)":[151],"used":[153],"accurately":[155],"evaluate":[156],"changes":[157],"life":[162],"subjects":[164],"affected":[165],"pain.":[169],"results":[171],"study":[174],"indicate":[175],"dose-dependent":[177],"response,":[178],"should":[180],"taken":[182],"into":[183],"account":[184],"later":[186],"use":[187],"therapeutics":[189],"establish":[191],"correct":[193],"dosage.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-13T00:00:00"}