{"id":"https://openalex.org/W4281720629","doi":"https://doi.org/10.2337/db22-304-or","title":"304-OR: Proteomic Profile and Inflammatory Response of Islet Stressomes Released during Isolation","display_name":"304-OR: Proteomic Profile and Inflammatory Response of Islet Stressomes Released during Isolation","publication_year":2022,"publication_date":"2022-05-31","ids":{"openalex":"https://openalex.org/W4281720629","doi":"https://doi.org/10.2337/db22-304-or"},"language":"en","primary_location":{"id":"doi:10.2337/db22-304-or","doi":"https://doi.org/10.2337/db22-304-or","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db22-304-or","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088153574","display_name":"Prathab Balaji Saravanan","orcid":"https://orcid.org/0000-0001-5361-6472","observed_orcids":["https://orcid.org/0000-0001-5361-6472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PRATHAB BALAJI SARAVANAN","raw_affiliation_strings":["Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Richmond, VA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072806310","display_name":"Jagan Kalivarathan","orcid":"https://orcid.org/0000-0001-7108-1029","observed_orcids":["https://orcid.org/0000-0001-7108-1029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JAGAN KALIVARATHAN","raw_affiliation_strings":["Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Richmond, VA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078861466","display_name":"Marlon F. Levy","orcid":"https://orcid.org/0000-0002-3320-0493","observed_orcids":["https://orcid.org/0000-0002-3320-0493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARLON F. LEVY","raw_affiliation_strings":["Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Richmond, VA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086978977","display_name":"Mazhar A. Kanak","orcid":"https://orcid.org/0000-0003-3058-4687","observed_orcids":["https://orcid.org/0000-0003-3058-4687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MAZHAR A. KANAK","raw_affiliation_strings":["Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Richmond, VA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11063587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.24240000545978546,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.878000020980835},{"id":"https://openalex.org/keywords/autologous-islet-transplantation","display_name":"autologous islet transplantation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9570000171661377},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8679999709129333},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.8259999752044678},{"id":"https://openalex.org/keywords/histones","display_name":"histones","score":0.9900000095367432},{"id":"https://openalex.org/keywords/macrophage-uptake","display_name":"macrophage uptake","score":0.9070000052452087},{"id":"https://openalex.org/keywords/insulitis","display_name":"insulitis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/graft-loss","display_name":"graft loss","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.8050000071525574},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9319999814033508},{"id":"https://openalex.org/keywords/insulin-requirement","display_name":"insulin requirement","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.7961641550064087},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5279970169067383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48747968673706055},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47701072692871094},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.47556987404823303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45999419689178467},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44138023257255554},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4384780526161194},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.427751749753952},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.35448676347732544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2767246961593628},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17219439148902893}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db22-304-or","doi":"https://doi.org/10.2337/db22-304-or","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db22-304-or","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387877426","https://openalex.org/W3217089229","https://openalex.org/W4391840573","https://openalex.org/W2332334694","https://openalex.org/W2026793752","https://openalex.org/W1984288914","https://openalex.org/W4411227205","https://openalex.org/W2318188273","https://openalex.org/W3089097691","https://openalex.org/W3188697976"],"abstract_inverted_index":{"Purpose:":[0],"Islets":[1],"undergo":[2],"enormous":[3],"stress":[4,61,156],"during":[5,19,51],"isolation":[6,52],"and":[7,35,46,72,84,124,130,150,220,240,253,261],"peri-transplant":[8],"periods":[9],"which":[10],"causes":[11],"a":[12,159],"significant":[13],"release":[14],"of":[15,26,48,97,121,165,191,234],"stressomes":[16,49,87,115,142,167,213],"(exosomes":[17],"released":[18],"stress)":[20],".":[21,58,75,101,152,171,204],"Uncovering":[22],"the":[23,42,92,140,163,175,184,218,227,247],"biological":[24],"role":[25,161],"such":[27],"vesicles":[28],"is":[29],"vital":[30],"for":[31],"long-term":[32],"graft":[33,262],"function":[34],"survival.":[36],"Here,":[37],"we":[38],"sought":[39],"to":[40,70,118,126,257],"identify":[41],"global":[43,250],"protein":[44,77,104,251],"content":[45,252],"significance":[47],"isolated":[50,90,173],"in":[53,64,162,183,264],"autologous":[54],"islet":[55,93,114,141,166,248,259],"transplantation":[56],"(AIT)":[57],"Methods:":[59],"Post-transplant":[60],"was":[62],"mimicked":[63],"vitro":[65],"by":[66,81,169,217],"exposing":[67],"human":[68],"islets":[69,123,230],"hypoxia":[71],"cytokines":[73],"(Cyt+Hyp)":[74,170],"Stressome":[76],"contents":[78],"were":[79,88,106,116,194,214],"characterized":[80],"mass":[82,135],"spectrometry":[83,136],"immunoblotting.":[85],"Similar":[86],"also":[89,221],"from":[91,174],"infusion":[94,176],"bag":[95],"samples":[96],"AIT":[98,110],"recipients":[99,200],"(N=20)":[100],"The":[102,134,153,205,243],"stressome":[103,228,249],"levels":[105,190],"correlated":[107,196],"with":[108,197],"1-year":[109],"outcomes.":[111],"Finally,":[112],"these":[113,212],"treated":[117,229],"another":[119],"set":[120],"purified":[122],"macrophages":[125,219],"find":[127],"their":[128],"uptake":[129],"immune":[131,236],"response.":[132],"Results:":[133],"analysis":[137,209],"has":[138,210,245],"revealed":[139,211],"contain":[143],"DAMP":[144,192],"proteins":[145,193],"like":[146,238],"histones":[147],"(H2B,":[148],"H3,":[149],"H4)":[151],"canonical":[154],"ER":[155],"signal":[157],"plays":[158],"crucial":[160],"biogenesis":[164],"induced":[168],"Exosomes":[172],"bags":[177],"showed":[178,231],"an":[179,223],"elevated":[180,232],"histone":[181],"level":[182],"insulin-dependent":[185],"(ID)":[186],"group.":[187],"Moreover,":[188],"high":[189],"positively":[195],"increased":[198],"post-transplant":[199],"insulin":[201],"requirements":[202],"(p=0.029)":[203],"fluorescent":[206],"confocal":[207],"microscopy":[208],"easily":[215],"uptaken":[216],"conferred":[222],"inflammatory":[224],"phenotype.":[225],"Instead,":[226],"expression":[233],"innate":[235],"receptors":[237],"TLR2":[239],"AGTR1.":[241],"Conclusion:":[242],"study":[244],"identified":[246],"briefs":[254],"its":[255],"prospective":[256],"induce":[258],"inflammation":[260],"loss":[263],"AIT.":[265],"Disclosure":[266],"P.Saravanan:":[267],"None.":[268,270,284],"J.Kalivarathan:":[269],"M.F.Levy:":[271],"Research":[272],"Support;":[273],"Vertex":[274],"Pharmaceuticals":[275],"Incorporated,":[276],"Speaker's":[277],"Bureau;":[278],"AbbVie":[279],"Inc.,":[280],"Sanofi":[281],"Genzyme.":[282],"M.A.Kanak:":[283]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-06-13T00:00:00"}
