{"id":"https://openalex.org/W4281715729","doi":"https://doi.org/10.3390/gels8060337","title":"Poly(curcumin \u03b2-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin","display_name":"Poly(curcumin \u03b2-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin","publication_year":2022,"publication_date":"2022-05-30","ids":{"openalex":"https://openalex.org/W4281715729","doi":"https://doi.org/10.3390/gels8060337","pmid":"https://pubmed.ncbi.nlm.nih.gov/35735681","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9222275"},"language":"en","primary_location":{"id":"doi:10.3390/gels8060337","doi":"https://doi.org/10.3390/gels8060337","is_oa":true,"landing_page_url":"https://doi.org/10.3390/gels8060337","pdf_url":"https://www.mdpi.com/2310-2861/8/6/337/pdf?version=1653901080","source":{"id":"https://openalex.org/S2737559645","display_name":"Gels","issn_l":"2310-2861","issn":["2310-2861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gels","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2310-2861/8/6/337/pdf?version=1653901080","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086251144","display_name":"Vinod S. Patil","orcid":"https://orcid.org/0000-0003-4093-8979","observed_orcids":["https://orcid.org/0000-0003-4093-8979"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinod S. Patil","raw_affiliation_strings":["Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA"],"raw_orcid":"https://orcid.org/0000-0003-4093-8979","affiliations":[{"raw_affiliation_string":"Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014429181","display_name":"Benjamin C. Burdette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin C. Burdette","raw_affiliation_strings":["Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086644569","display_name":"J. Zach Hilt","orcid":"https://orcid.org/0000-0001-5780-6847","observed_orcids":["https://orcid.org/0000-0001-5780-6847"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Zach Hilt","raw_affiliation_strings":["Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018981577","display_name":"Douglass S. Kalika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglass S. Kalika","raw_affiliation_strings":["Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051709163","display_name":"Thomas D. Dziubla","orcid":"https://orcid.org/0000-0003-2518-3926","observed_orcids":["https://orcid.org/0000-0003-2518-3926"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas D. Dziubla","raw_affiliation_strings":["Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051709163"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1675},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1675},"fwci":0.6021,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.54452954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"6","first_page":"337","last_page":"337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.44679999351501465,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.44679999351501465,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.42969998717308044,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.06830000132322311,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9049999713897705},{"id":"https://openalex.org/keywords/poly-beta-amino-ester","display_name":"poly(\u03b2-amino ester)","score":0.9049999713897705},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.6880000233650208},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7120000123977661},{"id":"https://openalex.org/keywords/oral-tablet-formulation","display_name":"oral tablet formulation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hydrolytic-degradation","display_name":"hydrolytic degradation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/storage-stability","display_name":"storage stability","score":0.6539999842643738},{"id":"https://openalex.org/keywords/moisture-sensitivity","display_name":"moisture sensitivity","score":0.9070000052452087},{"id":"https://openalex.org/keywords/drug-solubility","display_name":"drug solubility","score":0.6100000143051147},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cross-linked-polymer-networks","display_name":"crosslinked polymer networks","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9346843957901001},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.763574481010437},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.7602353096008301},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.6212306022644043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5379711985588074},{"id":"https://openalex.org/C186399102","wikidata":"https://www.wikidata.org/wiki/Q903517","display_name":"Chemical stability","level":2,"score":0.5254718065261841},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4963608384132385},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4441814422607422},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4121502637863159},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.41119492053985596},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.39966678619384766},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33429181575775146},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1959245502948761},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1422085165977478},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09785613417625427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.053205013275146484}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/gels8060337","doi":"https://doi.org/10.3390/gels8060337","is_oa":true,"landing_page_url":"https://doi.org/10.3390/gels8060337","pdf_url":"https://www.mdpi.com/2310-2861/8/6/337/pdf?version=1653901080","source":{"id":"https://openalex.org/S2737559645","display_name":"Gels","issn_l":"2310-2861","issn":["2310-2861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gels","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9222275","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9222275","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gels","raw_type":"Text"},{"id":"pmid:35735681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35735681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gels (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a7dc78796fe54569b4bf2934405e5973","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a7dc78796fe54569b4bf2934405e5973","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gels, Vol 8, Iss 6, p 337 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/gels8060337","doi":"https://doi.org/10.3390/gels8060337","is_oa":true,"landing_page_url":"https://doi.org/10.3390/gels8060337","pdf_url":"https://www.mdpi.com/2310-2861/8/6/337/pdf?version=1653901080","source":{"id":"https://openalex.org/S2737559645","display_name":"Gels","issn_l":"2310-2861","issn":["2310-2861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gels","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281715729.pdf","grobid_xml":"https://content.openalex.org/works/W4281715729.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W97938539","https://openalex.org/W106969692","https://openalex.org/W199821208","https://openalex.org/W1148393218","https://openalex.org/W1162689138","https://openalex.org/W1549826455","https://openalex.org/W1967687007","https://openalex.org/W1968060230","https://openalex.org/W1972573571","https://openalex.org/W1976194786","https://openalex.org/W1977084624","https://openalex.org/W1981162694","https://openalex.org/W1981728432","https://openalex.org/W1990516056","https://openalex.org/W1999481222","https://openalex.org/W2015203678","https://openalex.org/W2036396946","https://openalex.org/W2038833316","https://openalex.org/W2049805949","https://openalex.org/W2059766794","https://openalex.org/W2068686072","https://openalex.org/W2071051059","https://openalex.org/W2074677423","https://openalex.org/W2077008353","https://openalex.org/W2077364459","https://openalex.org/W2078116888","https://openalex.org/W2081365179","https://openalex.org/W2125799301","https://openalex.org/W2125930252","https://openalex.org/W2130813452","https://openalex.org/W2138508372","https://openalex.org/W2141116781","https://openalex.org/W2142519131","https://openalex.org/W2147931681","https://openalex.org/W2152240524","https://openalex.org/W2153190211","https://openalex.org/W2154748960","https://openalex.org/W2156899992","https://openalex.org/W2318545873","https://openalex.org/W2322953677","https://openalex.org/W2330570895","https://openalex.org/W2335434301","https://openalex.org/W2346320316","https://openalex.org/W2499872298","https://openalex.org/W2570486811","https://openalex.org/W2600393318","https://openalex.org/W2726872980","https://openalex.org/W2904150488","https://openalex.org/W2952528349","https://openalex.org/W3086311472"],"related_works":["https://openalex.org/W2598097837","https://openalex.org/W4306160736","https://openalex.org/W3206441881","https://openalex.org/W7127884532","https://openalex.org/W4307496388","https://openalex.org/W4317733167","https://openalex.org/W2015634504","https://openalex.org/W2076720077","https://openalex.org/W2913437999","https://openalex.org/W7144300941"],"abstract_inverted_index":{"Oral":[0],"drug":[1,12,23,98,111],"delivery":[2],"remains":[3],"the":[4,31,37,62,69,73,84,159,171],"most":[5],"common":[6],"and":[7,25,33,54,71,101,137,150,181],"well":[8],"tolerated":[9],"method":[10,132],"for":[11,61,155],"administration.":[13],"However,":[14],"its":[15],"applicability":[16],"is":[17,36,188],"often":[18],"limited":[19],"due":[20],"to":[21,29,170,195,198],"low":[22,106,108],"solubility":[24,32,74],"stability.":[26,103],"One":[27],"approach":[28],"overcome":[30],"stability":[34,70,109,176,183,192],"limitations":[35],"use":[38,86],"of":[39,65,75,87,162],"amorphous":[40,124],"polymeric":[41],"prodrug":[42],"formulations,":[43],"such":[44],"as":[45,114],"poly(\u03b2-amino":[46],"ester)":[47,120],"(PBAE).":[48],"PBAE":[49,88],"hydrogels,":[50],"which":[51],"are":[52],"biodegradable":[53],"pH":[55],"responsive,":[56],"have":[57,82],"shown":[58],"promising":[59],"results":[60],"controlled":[63],"release":[64,99,154,172],"drugs":[66],"by":[67,128],"improving":[68],"increasing":[72],"these":[76],"drugs.":[77],"In":[78,168],"this":[79],"work,":[80],"we":[81],"evaluated":[83],"potential":[85,100],"prodrugs":[89],"in":[90,141],"an":[91],"oral":[92],"tablet":[93,191],"formulation,":[94],"studying":[95],"their":[96],"sustained":[97,153],"storage":[102,175],"Curcumin,":[104],"a":[105,115,122,129,134,138,152],"solubility,":[107],"antioxidant":[110],"was":[112,126,177,193],"used":[113],"model":[116],"compound.":[117],"Poly(curcumin":[118],"\u03b2-amino":[119],"(PCBAE),":[121],"crosslinked":[123],"network,":[125],"synthesized":[127],"previously":[130],"published":[131],"using":[133,179],"commercial":[135],"diacrylate":[136],"primary":[139],"diamine,":[140],"combination":[142],"with":[143],"acrylate-functionalized":[144],"curcumin.":[145,167],"PCBAE-based":[146],"tablets":[147],"were":[148],"made":[149],"exhibited":[151],"16":[156],"h,":[157],"following":[158],"hydrolytic":[160],"degradation":[161,187],"PCBAE":[163,186],"particles":[164],"into":[165],"native":[166],"addition":[169],"studies,":[173],"preliminary":[174],"assessed":[178],"standard":[180],"accelerated":[182],"conditions.":[184],"As":[185],"hydrolysis":[189],"driven,":[190],"found":[194],"be":[196],"sensitive":[197],"moisture.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-13T00:00:00"}
