{"id":"https://openalex.org/W4281684847","doi":"https://doi.org/10.2337/db22-1472-p","title":"1472-P: Dual Pancreatic Adrenergic and Dopaminergic Signaling as a Therapeutic Mechanism for Treatment of Dysglycemia by Bromocriptine","display_name":"1472-P: Dual Pancreatic Adrenergic and Dopaminergic Signaling as a Therapeutic Mechanism for Treatment of Dysglycemia by Bromocriptine","publication_year":2022,"publication_date":"2022-05-31","ids":{"openalex":"https://openalex.org/W4281684847","doi":"https://doi.org/10.2337/db22-1472-p"},"language":"en","primary_location":{"id":"doi:10.2337/db22-1472-p","doi":"https://doi.org/10.2337/db22-1472-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db22-1472-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072771208","display_name":"Despoina Aslanoglou","orcid":"https://orcid.org/0000-0002-8444-1385","observed_orcids":["https://orcid.org/0000-0002-8444-1385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DESPOINA ASLANOGLOU","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063384054","display_name":"Suzanne Bertera","orcid":"https://orcid.org/0000-0002-9228-4279","observed_orcids":["https://orcid.org/0000-0002-9228-4279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SUZANNE BERTERA","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002297958","display_name":"Laura Friggeri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LAURA FRIGGERI","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056446196","display_name":"Marta S\u00e1nchez\u2010Soto","orcid":"https://orcid.org/0000-0003-3343-5628","observed_orcids":["https://orcid.org/0000-0003-3343-5628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARTA SANCHEZ SOTO","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069927019","display_name":"Jeongkyung Lee","orcid":"https://orcid.org/0000-0002-0260-7397","observed_orcids":["https://orcid.org/0000-0002-0260-7397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JEONGKYUNG LEE","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057969622","display_name":"Xiangning Xue","orcid":"https://orcid.org/0000-0002-5775-1193","observed_orcids":["https://orcid.org/0000-0002-5775-1193"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"XIANGNING XUE","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041804176","display_name":"Ryan Wellington Logan","orcid":"https://orcid.org/0000-0001-8579-015X","observed_orcids":["https://orcid.org/0000-0001-8579-015X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RYAN LOGAN","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022934543","display_name":"ROB LANE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ROB LANE","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042873368","display_name":"Vijay K. Yechoor","orcid":"https://orcid.org/0000-0002-9981-6784","observed_orcids":["https://orcid.org/0000-0002-9981-6784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"VIJAY YECHOOR","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034202004","display_name":"R. Benjamin Free","orcid":"https://orcid.org/0000-0002-2428-0487","observed_orcids":["https://orcid.org/0000-0002-2428-0487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R BENJAMIN FREE","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076880355","display_name":"David R. Sibley","orcid":"https://orcid.org/0000-0002-0624-962X","observed_orcids":["https://orcid.org/0000-0002-0624-962X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DAVID R. SIBLEY","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053200897","display_name":"Rita Bottino","orcid":"https://orcid.org/0000-0003-1540-2996","observed_orcids":["https://orcid.org/0000-0003-1540-2996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RITA BOTTINO","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013792187","display_name":"Zachary Freyberg","orcid":"https://orcid.org/0000-0001-6460-0118","observed_orcids":["https://orcid.org/0000-0001-6460-0118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ZACHARY FREYBERG","raw_affiliation_strings":["London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London, United Kingdom, Pittsburgh, PA, Nashville, TN, Boston, MA, Nottingham, United Kingdom, Bethesda, MD","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.10889242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"71","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bromocriptine","display_name":"bromocriptine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/dysglycemia","display_name":"dysglycemia","score":0.9589999914169312},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.8709999918937683},{"id":"https://openalex.org/keywords/pancreatic-alpha-cells","display_name":"alpha cells","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.9020000100135803},{"id":"https://openalex.org/keywords/glucagon-secretion","display_name":"glucagon secretion","score":0.9990000128746033},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/g-protein-signaling","display_name":"G protein signaling","score":0.8600000143051147},{"id":"https://openalex.org/keywords/beta-arrestin-2","display_name":"\u03b2-arrestin2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/receptor-docking","display_name":"receptor docking","score":0.5600000023841858},{"id":"https://openalex.org/keywords/pancreatic-hormone-secretion","display_name":"pancreatic hormone secretion","score":0.6800000071525574},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2776856834","wikidata":"https://www.wikidata.org/wiki/Q413581","display_name":"Bromocriptine","level":4,"score":0.9657893180847168},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7483952045440674},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5670065879821777},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5191299319267273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5160712599754333},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.5122529864311218},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4286348521709442},{"id":"https://openalex.org/C2776286997","wikidata":"https://www.wikidata.org/wiki/Q2880966","display_name":"Dopaminergic pathways","level":4,"score":0.41731715202331543},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.38597163558006287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30570363998413086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2809141278266907},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2253868281841278},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.0921487808227539}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db22-1472-p","doi":"https://doi.org/10.2337/db22-1472-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db22-1472-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4285806737","https://openalex.org/W2031057942","https://openalex.org/W86498498","https://openalex.org/W1982784358","https://openalex.org/W3130697753","https://openalex.org/W2196957770","https://openalex.org/W4408865206","https://openalex.org/W2005356839","https://openalex.org/W2997665305","https://openalex.org/W2037452822"],"abstract_inverted_index":{"Dopaminergic":[0],"agonism":[1,139],"effectively":[2],"treats":[3],"dysglycemia,":[4],"with":[5,167],"dopaminergic":[6,58,137,218],"agonist":[7],"bromocriptine":[8,37,50,93,110,150,181,194],"approved":[9],"as":[10,51],"a":[11,52,72,204,230],"type":[12],"2":[13],"diabetes":[14],"therapy.":[15],"Though":[16],"bromocriptine\u2019s":[17,208],"actions":[18,77,125,210,222],"have":[19],"been":[20],"mainly":[21,162],"attributed":[22],"to":[23,54,100,114,152,186,196,234],"stimulation":[24],"of":[25,57,64,134,155,158,259,265,279,286,290],"dopamine":[26],"D2":[27],"receptors":[28],"(D2R)":[29],"in":[30,62,78,108,121,140,237],"the":[31,44,144,271,287,302],"brain,":[32],"we":[33,48,70],"previously":[34],"showed":[35],"that":[36,193],"also":[38,191],"targets":[39],"metabolically-relevant":[40],"peripheral":[41],"tissues":[42],"including":[43],"endocrine":[45],"pancreas.":[46],"Here,":[47],"employ":[49],"tool":[53],"elucidate":[55],"roles":[56,133],"and":[59,81,85,98,128,136,178,214,219,225,274,293],"adrenergic":[60,86,135,220],"signaling":[61,166,184],"regulation":[63],"pancreatic":[65,79],"hormone":[66,227],"secretion.":[67,117],"Using":[68],"bromocriptine,":[69],"demonstrate":[71],"new":[73,231],"mechanism":[74,233],"for":[75,207],"metabolic":[76],"\u03b1-cells":[80],"\u03b2-cells":[82,122],"via":[83,112,123,163],"D2R":[84,97,113,127,173],"\u03b12A":[87],"receptor":[88,138,145,153,221],"(\u03b12A-AR)":[89],"signaling.":[90],"In":[91,171],"\u03b2-cells,":[92],"acts":[94,111],"jointly":[95],"on":[96,126,211,223],"\u03b12A-AR":[99,147,197,213],"reduce":[101,115],"glucose-stimulated":[102],"insulin":[103],"secretion":[104],"(GSIS)":[105],",":[106,262,270,296,301],"while":[107],"\u03b1-cells,":[109],"glucagon":[116],"Bromocriptine":[118],"reduces":[119],"cAMP":[120],"concurrent":[124],"\u03b12A-AR,":[129],"further":[130],"emphasizing":[131],"shared":[132],"GSIS":[141],"regulation.":[142],"At":[143],"level,":[146],"activation":[148],"by":[149],"leads":[151],"recruitment":[154],"an":[156],"ensemble":[157],"G":[159,164,176],"proteins":[160,177],"driven":[161],"protein":[165],"no":[168],"\u03b2-arrestin2":[169,179],"recruitment.":[170],"contrast,":[172],"recruits":[174],"both":[175],"upon":[180],"stimulation,":[182],"demonstrating":[183],"unique":[185],"each":[187],"receptor.":[188],"Docking":[189],"studies":[190],"reveal":[192],"binding":[195],"is":[198],"distinct":[199],"from":[200],"bromocriptine-bound":[201],"D2R,":[202],"providing":[203],"structural":[205],"basis":[206],"dual":[209],"\u03b2-cell":[212,226],"D2R.":[215],"Together,":[216],"joint":[217],"\u03b1-cell":[224],"release":[228],"provide":[229],"therapeutic":[232],"improve":[235],"dysglycemia":[236],"diabetes.":[238],"Disclosure":[239],"S.":[240],"Bertera:":[241],"None.":[242,245,248,251],"L.":[243],"Friggeri:":[244],"R.":[246,249,252],"Logan:":[247],"Free:":[250],"Bottino:":[253],"Employee;":[254],"Imagine":[255],"Pharma.":[256],"Funding":[257],"Department":[258],"Defense":[260],"(PR141292)":[261],"National":[263,288],"Institutes":[264],"Health":[266],"(R01DK124219,":[267],"R01DK097160,":[268],"RDA046138)":[269],"John":[272],"F.":[273],"Nancy":[275],"A.":[276],"Emmerling":[277],"Fund":[278],"The":[280],"Pittsburgh":[281],"Foundation,":[282],"Intramural":[283],"Research":[284],"Program":[285],"Institute":[289],"Neurological":[291],"Disorders":[292],"Stroke":[294],"(ZIA-NS002263)":[295],"Veterans":[297],"Affairs":[298],"VA-ORD-BLR&D":[299],"(I01BX002678)":[300],"Deutsche":[303],"Forschungsgemeinschaft":[304],"(SFB1423,":[305],"project":[306],"number":[307],"421152132)":[308],".":[309]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2022-06-13T00:00:00"}
