{"id":"https://openalex.org/W4281679946","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e18605","title":"Successful biosimilar adoption in oncology: strategic approach to system standardization.","display_name":"Successful biosimilar adoption in oncology: strategic approach to system standardization.","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4281679946","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e18605"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.16_suppl.e18605","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e18605","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.e18605","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078924974","display_name":"Suwicha Limvorasak","orcid":"https://orcid.org/0000-0003-2360-5099","observed_orcids":["https://orcid.org/0000-0003-2360-5099"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suwicha Limvorasak","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059595849","display_name":"Crystal Leung Dobbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal Leung Dobbs","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719648","display_name":"James Kim","orcid":"https://orcid.org/0000-0002-9257-2801","observed_orcids":["https://orcid.org/0000-0002-9257-2801"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Kim","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036138286","display_name":"Edwin M. Posadas","orcid":"https://orcid.org/0000-0001-8649-1346","observed_orcids":["https://orcid.org/0000-0001-8649-1346"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin Melencio Posadas","raw_affiliation_strings":["Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017429908","display_name":"Hilary R. Teaford","orcid":"https://orcid.org/0000-0002-2120-7380","observed_orcids":["https://orcid.org/0000-0002-2120-7380"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hilary Teaford","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050837115","display_name":"M\u00e1rcio A. Diniz","orcid":"https://orcid.org/0000-0002-2427-7843","observed_orcids":["https://orcid.org/0000-0002-2427-7843"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcio A. Diniz","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090472587","display_name":"Andr\u00e9 Rogatko","orcid":"https://orcid.org/0000-0001-8935-8890","observed_orcids":["https://orcid.org/0000-0001-8935-8890"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andre Rogatko","raw_affiliation_strings":["Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002794807","display_name":"Bruce Vinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Vinson","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015458856","display_name":"Leanne Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leanne Sakamoto","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026390457","display_name":"Vipul J. Patel","orcid":"https://orcid.org/0000-0002-7012-5752","observed_orcids":["https://orcid.org/0000-0002-7012-5752"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vipul Patel","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050649350","display_name":"Robert A. Figlin","orcid":"https://orcid.org/0000-0002-6323-6075","observed_orcids":["https://orcid.org/0000-0002-6323-6075"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Figlin","raw_affiliation_strings":["Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075448530","display_name":"Rita R. Shane","orcid":"https://orcid.org/0009-0000-8560-6244","observed_orcids":["https://orcid.org/0009-0000-8560-6244","https://orcid.org/0000-0002-8719-9571"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita Shane","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051283101","display_name":"Karen L. Reckamp","orcid":"https://orcid.org/0000-0002-9213-0325","observed_orcids":["https://orcid.org/0000-0002-9213-0325"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen L. Reckamp","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"16_suppl","first_page":"e18605","last_page":"e18605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosimilars","display_name":"biosimilars","score":0.9490000009536743},{"id":"https://openalex.org/keywords/therapeutic-substitution","display_name":"therapeutic substitution","score":0.722000002861023},{"id":"https://openalex.org/keywords/oncology","display_name":"oncology","score":0.7440000176429749},{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.7760000228881836},{"id":"https://openalex.org/keywords/clinical-decision-support","display_name":"clinical decision support","score":0.6919999718666077},{"id":"https://openalex.org/keywords/formulary-management","display_name":"formulary management","score":0.5669999718666077},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.746999979019165},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9940000176429749},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":1.0},{"id":"https://openalex.org/keywords/cost-reduction","display_name":"cost reduction","score":0.6690000295639038},{"id":"https://openalex.org/keywords/biosimilar-interchangeability","display_name":"biosimilar interchangeability","score":0.7089999914169312},{"id":"https://openalex.org/keywords/infusion-related-reactions","display_name":"infusion reactions","score":0.5059999823570251},{"id":"https://openalex.org/keywords/cancer-care-costs","display_name":"cancer care costs","score":0.5680000185966492},{"id":"https://openalex.org/keywords/reimbursement-policy","display_name":"reimbursement policy","score":0.3919999897480011},{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.6320000290870667},{"id":"https://openalex.org/keywords/patient-assistance-programs","display_name":"patient assistance programs","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C59491497","wikidata":"https://www.wikidata.org/wiki/Q864715","display_name":"Biosimilar","level":2,"score":0.9290503859519958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8726715445518494},{"id":"https://openalex.org/C100406419","wikidata":"https://www.wikidata.org/wiki/Q3543802","display_name":"Formulary","level":2,"score":0.759131908416748},{"id":"https://openalex.org/C2779703844","wikidata":"https://www.wikidata.org/wiki/Q760125","display_name":"Reimbursement","level":3,"score":0.6458876132965088},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.5543580651283264},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.4376063942909241},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41240304708480835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3890116810798645},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3573596477508545},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.3163653612136841},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10197648406028748},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.16_suppl.e18605","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e18605","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.e18605","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5400000214576721,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379283973","https://openalex.org/W3170963592","https://openalex.org/W4379335235","https://openalex.org/W4410809943","https://openalex.org/W4286297758","https://openalex.org/W3092167507","https://openalex.org/W4312813437","https://openalex.org/W3199522182","https://openalex.org/W4386949989","https://openalex.org/W4281934510"],"abstract_inverted_index":{"e18605":[0],"Background:":[1],"In":[2],"the":[3,15,60,80,89,100,123,133,143,234,240,256,296],"United":[4],"States,":[5],"therapeutic":[6],"substitution":[7,98,212,253],"with":[8,66,163,171,189],"oncologic":[9],"biosimilars":[10,75,215],"offer":[11],"opportunities":[12],"to":[13,24,50,64,95,119,214,220,239,254,287,292,329],"reduce":[14,336],"rising":[16],"costs":[17],"of":[18,88,97,122,152,165,182,196,222,306,323],"cancer":[19,184],"care":[20],"while":[21,349],"improving":[22],"access":[23],"safe":[25],"and":[26,41,70,137,154,177,273,335,352],"effective":[27],"treatment.":[28],"Current":[29],"challenges":[30],"include":[31],"integration":[32],"into":[33,107],"clinical":[34,67],"practice,":[35],"state":[36],"laws":[37],"for":[38,201,343],"biosimilar":[39,52,331,345],"interchangeability":[40],"payer":[42,268],"reimbursement":[43],"policies.":[44],"Methods:":[45],"We":[46],"developed":[47],"an":[48,128,158,312,324],"approach":[49,339],"standardize":[51,330],"utilization":[53,332],"across":[54],"our":[55],"oncology":[56,81,334,348],"enterprise":[57],"by":[58],"leveraging":[59],"electronic":[61,101,326],"health":[62,327],"record":[63,328],"integrate":[65],"algorithm":[68],"pathways":[69],"financial":[71],"information.":[72],"Institutionally":[73],"preferred":[74,269,275],"drugs":[76],"were":[77,93,105,194,199,260,283],"selected":[78],"through":[79],"Pharmacy":[82],"&":[83],"Therapeutics":[84],"committee":[85],"as":[86,111,127],"part":[87],"formulary":[90],"process.":[91],"Physicians":[92],"permitted":[94],"opt-out":[96],"within":[99],"order":[102],"sets.":[103],"Patients":[104],"divided":[106],"two":[108],"groups":[109],"based":[110],"1)":[112],"main":[113,134,235],"medical":[114,135,236],"center":[115,136,237],"2)":[116],"affiliated":[117,241],"sites":[118,242],"assess":[120],"feasibility":[121],"enterprise-wide":[124],"substitution,":[125],"defined":[126],"80%":[129,164],"compliance":[130,140],"rate":[131,141,213,230],"at":[132,142,167,233],"a":[138,148,180,225],"75%":[139],"affiliates":[144],"sites.":[145],"This":[146,318,338],"provided":[147],"minimum":[149],"detectable":[150],"difference":[151],"5.7%":[153],"8.9%,":[155],"respectively":[156],"using":[157],"exact":[159],"one-sided":[160],"Binomial":[161],"test":[162],"power":[166],"2.5%":[168],"significance":[169],"level":[170],"Sidak":[172],"correction.":[173],"Results:":[174],"Between":[175],"January":[176],"December":[178],"2021,":[179],"total":[181],"811":[183],"patients":[185,248,280],"who":[186,249],"initiated":[187],"treatment":[188],"bevacizumab,":[190],"rituximab":[191],"or":[192,311],"trastuzumab":[193],"identified,":[195],"whom":[197],"535":[198],"eligible":[200],"this":[202],"analysis":[203],"(age":[204],"18-96;":[205],"61%":[206],"female,":[207],"39%":[208],"male).":[209],"The":[210,228],"overall":[211],"was":[216,231],"83%":[217],"(76%-97%)":[218],"compared":[219,238],"baseline":[221],"55%,":[223],"representing":[224],"51%":[226],"improvement.":[227],"conversion":[229],"higher":[232],"(85%":[243],"vs.":[244],"81%).":[245],"Among":[246],"92":[247],"did":[250],"not":[251,284],"have":[252],"biosimilars,":[255],"most":[257],"common":[258],"reasons":[259],"off-label":[261],"indication":[262],"(35%),":[263],"patient":[264],"assistance":[265],"program":[266],"(17%),":[267],"alternative":[270],"brand":[271,277],"(15%)":[272],"clinician":[274],"reference":[276],"(12%).":[278],"Four":[279],"(<":[281],"1%)":[282],"converted":[285],"due":[286],"infusion":[288],"reactions":[289],"possibly":[290],"related":[291],"biosimilars.":[293],"Based":[294],"on":[295],"wholesale":[297],"acquisition":[298],"cost,":[299],"we":[300],"estimate":[301],"reduction":[302],"in":[303,333,347],"direct":[304],"spending":[305],"$1.2":[307],"million":[308],"per":[309],"month":[310],"average":[313],"23%":[314],"cost":[315],"savings.":[316],"Conclusions:":[317],"real-world":[319],"data":[320],"suggest":[321],"use":[322],"integrated":[325],"costs.":[337],"leverages":[340],"existing":[341],"infrastructure":[342],"successful":[344],"adoption":[346],"preserving":[350],"quality":[351],"safety.[Table:":[353],"see":[354],"text]":[355]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-06-13T00:00:00"}