{"id":"https://openalex.org/W4281673081","doi":"https://doi.org/10.1136/thoraxjnl-2021-218577","title":"Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis","display_name":"Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis","publication_year":2022,"publication_date":"2022-06-10","ids":{"openalex":"https://openalex.org/W4281673081","doi":"https://doi.org/10.1136/thoraxjnl-2021-218577","pmid":"https://pubmed.ncbi.nlm.nih.gov/35688625","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9329250"},"language":"en","primary_location":{"id":"doi:10.1136/thoraxjnl-2021-218577","doi":"https://doi.org/10.1136/thoraxjnl-2021-218577","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thoraxjnl-2021-218577","pdf_url":null,"source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1136/thoraxjnl-2021-218577","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066779629","display_name":"Richard J. Allen","orcid":"https://orcid.org/0000-0002-8450-3056","observed_orcids":["https://orcid.org/0000-0002-8450-3056"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Richard J Allen","raw_affiliation_strings":["Department of Health Sciences, University of Leicester, Leicester, UK rja34@leicester.ac.uk","Department of Health Sciences","University of Leicester"],"raw_orcid":"https://orcid.org/0000-0002-8450-3056","affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University of Leicester, Leicester, UK rja34@leicester.ac.uk","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"Department of Health Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063351606","display_name":"Amy Stockwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Stockwell","raw_affiliation_strings":["Genentech Inc, South San Francisco, California, USA","Genentech Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech Inc, South San Francisco, California, USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech Inc","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009091055","display_name":"Justin M. Oldham","orcid":"https://orcid.org/0000-0003-4957-8869","observed_orcids":["https://orcid.org/0000-0003-4957-8869"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin M Oldham","raw_affiliation_strings":["Department of Internal Medicine, University of California Davis, Davis, California, USA","Department of Internal Medicine","University of California Davis"],"raw_orcid":"https://orcid.org/0000-0003-4957-8869","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of California Davis, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"University of California Davis","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090565569","display_name":"Beatriz Guill\u00e9n\u2010Gu\u00edo","orcid":"https://orcid.org/0000-0002-3703-1738","observed_orcids":["https://orcid.org/0000-0002-3703-1738"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Beatriz Guillen-Guio","raw_affiliation_strings":["Department of Health Sciences, University of Leicester, Leicester, UK","Department of Health Sciences","University of Leicester"],"raw_orcid":"https://orcid.org/0000-0002-3703-1738","affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University of Leicester, Leicester, UK","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"Department of Health Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376759","display_name":"David A. Schwartz","orcid":"https://orcid.org/0000-0001-6743-8443","observed_orcids":["https://orcid.org/0000-0001-6743-8443"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Schwartz","raw_affiliation_strings":["Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA","Department of Immunology, University of Colorado Denver, Denver, Colorado, USA","Department of Medicine, University of Colorado Denver, Denver, Colorado, USA","Center for Genes, Environment and Health","Department of Immunology","Department of Medicine","National Jewish Health","University of Colorado Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"Department of Immunology, University of Colorado Denver, Denver, Colorado, USA","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Medicine, University of Colorado Denver, Denver, Colorado, USA","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Center for Genes, Environment and Health","institution_ids":[]},{"raw_affiliation_string":"Department of Immunology","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"National Jewish Health","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"University of Colorado Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058325633","display_name":"Toby M. Maher","orcid":"https://orcid.org/0000-0001-7192-9149","observed_orcids":["https://orcid.org/0000-0001-7192-9149"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I2800036501","display_name":"Royal Brompton & Harefield NHS Foundation Trust","ror":"https://ror.org/02218z997","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501"]},{"id":"https://openalex.org/I2802782613","display_name":"Harefield Hospital","ror":"https://ror.org/04fwa4t58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I2802782613"]},{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Toby M Maher","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, California, USA","National Heart and Lung Institute, Imperial College, London, UK","Royal Brompton and Harefield Hospitals, London, UK","Division of Pulmonary and Critical Care Medicine","Imperial College","National Heart and Lung Institute","Royal Brompton and Harefield Hospitals","University of Southern California"],"raw_orcid":"https://orcid.org/0000-0001-7192-9149","affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Royal Brompton and Harefield Hospitals, London, UK","institution_ids":["https://openalex.org/I2802782613","https://openalex.org/I4210096640"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine","institution_ids":[]},{"raw_affiliation_string":"Imperial College","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"National Heart and Lung Institute","institution_ids":[]},{"raw_affiliation_string":"Royal Brompton and Harefield Hospitals","institution_ids":["https://openalex.org/I2800036501","https://openalex.org/I2802782613","https://openalex.org/I4210096640"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056138948","display_name":"Carlos Flores","orcid":"https://orcid.org/0000-0001-5352-069X","observed_orcids":["https://orcid.org/0000-0001-5352-069X"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210088232","display_name":"Hospital Universitario Nuestra Se\u00f1ora de Candelaria","ror":"https://ror.org/005a3p084","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210088232"]},{"id":"https://openalex.org/I4210099160","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias","ror":"https://ror.org/0119pby33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210099160","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210101737","display_name":"Instituto Tecnol\u00f3gico y de Energ\u00edas Renovables","ror":"https://ror.org/015g99884","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210101737"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Flores","raw_affiliation_strings":["CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain","Genomics Division, Instituto Tecnol\u00f3gico y de Energ\u00edas Renovables SA, Santa Cruz de Tenerife, Spain","Research Unit, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Santa Cruz de Tenerife, Spain","CIBER de Enfermedades Respiratorias","Genomics Division","Hospital Universitario Nuestra Se\u00f1ora de la Candelaria","Instituto Tecnol\u00f3gico y de Energ\u00edas Renovables SA","Instituto de Salud Carlos III","Research Unit"],"raw_orcid":"https://orcid.org/0000-0001-5352-069X","affiliations":[{"raw_affiliation_string":"CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210099160"]},{"raw_affiliation_string":"Genomics Division, Instituto Tecnol\u00f3gico y de Energ\u00edas Renovables SA, Santa Cruz de Tenerife, Spain","institution_ids":["https://openalex.org/I4210101737"]},{"raw_affiliation_string":"Research Unit, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Santa Cruz de Tenerife, Spain","institution_ids":["https://openalex.org/I4210088232"]},{"raw_affiliation_string":"CIBER de Enfermedades Respiratorias","institution_ids":["https://openalex.org/I4210099160"]},{"raw_affiliation_string":"Genomics Division","institution_ids":[]},{"raw_affiliation_string":"Hospital Universitario Nuestra Se\u00f1ora de la Candelaria","institution_ids":["https://openalex.org/I4210088232"]},{"raw_affiliation_string":"Instituto Tecnol\u00f3gico y de Energ\u00edas Renovables SA","institution_ids":["https://openalex.org/I4210101737"]},{"raw_affiliation_string":"Instituto de Salud Carlos III","institution_ids":["https://openalex.org/I2801357902"]},{"raw_affiliation_string":"Research Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006650120","display_name":"Imre Noth","orcid":"https://orcid.org/0000-0001-9846-5030","observed_orcids":["https://orcid.org/0000-0001-9846-5030"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Imre Noth","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA","Division of Pulmonary and Critical Care Medicine","University of Virginia"],"raw_orcid":"https://orcid.org/0000-0001-9846-5030","affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055928722","display_name":"Brian L. Yaspan","orcid":"https://orcid.org/0000-0002-3787-2510","observed_orcids":["https://orcid.org/0000-0002-3787-2510"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian L Yaspan","raw_affiliation_strings":["Genentech Inc, South San Francisco, California, USA","Genentech Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech Inc, South San Francisco, California, USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech Inc","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025077014","display_name":"Gisli R. Jenkins","orcid":"https://orcid.org/0000-0002-7929-2119","observed_orcids":["https://orcid.org/0000-0002-7929-2119"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Gisli Jenkins","raw_affiliation_strings":["National Heart and Lung Institute, Imperial College, London, UK","Imperial College","National Heart and Lung Institute"],"raw_orcid":"https://orcid.org/0000-0002-7929-2119","affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Imperial College","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"National Heart and Lung Institute","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060565935","display_name":"Louise V. Wain","orcid":"https://orcid.org/0000-0003-4951-1867","observed_orcids":["https://orcid.org/0000-0003-4951-1867"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210166781","display_name":"NIHR Leicester Biomedical Research Centre","ror":"https://ror.org/05xqxa525","country_code":"GB","type":"facility","lineage":["https://openalex.org/I143804889","https://openalex.org/I153648349","https://openalex.org/I2802445252","https://openalex.org/I34931013","https://openalex.org/I4210166781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise V Wain","raw_affiliation_strings":["Department of Health Sciences, University of Leicester, Leicester, UK","National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK","Department of Health Sciences","National Institute for Health Research Leicester Biomedical Research Centre","University of Leicester"],"raw_orcid":"https://orcid.org/0000-0003-4951-1867","affiliations":[{"raw_affiliation_string":"Department of Health Sciences, University of Leicester, Leicester, UK","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK","institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210166781"]},{"raw_affiliation_string":"Department of Health Sciences","institution_ids":[]},{"raw_affiliation_string":"National Institute for Health Research Leicester Biomedical Research Centre","institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210166781"]},{"raw_affiliation_string":"University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5066779629"],"corresponding_institution_ids":["https://openalex.org/I153648349"],"apc_list":null,"apc_paid":null,"fwci":15.1505,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.99472423,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"77","issue":"8","first_page":"829","last_page":"833"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":1.0},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.753000020980835},{"id":"https://openalex.org/keywords/novel-genetic-loci","display_name":"novel genetic loci","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/telomere-maintenance","display_name":"telomere maintenance","score":0.9610000252723694},{"id":"https://openalex.org/keywords/spindle-assembly","display_name":"spindle assembly","score":0.8019999861717224},{"id":"https://openalex.org/keywords/effect-size-heterogeneity","display_name":"effect size heterogeneity","score":0.734000027179718},{"id":"https://openalex.org/keywords/replicability","display_name":"replicability","score":0.6610000133514404},{"id":"https://openalex.org/keywords/lung-disease-genetics","display_name":"lung disease genetics","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.7952397465705872},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7506011724472046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.676349401473999},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.6106777191162109},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.49333158135414124},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.41876399517059326},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38724762201309204},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35484495759010315},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3520470857620239},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.34533315896987915},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3352741301059723},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3195834457874298},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2701922059059143},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2548527121543884},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2001621127128601},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19708094000816345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1809934377670288}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1136/thoraxjnl-2021-218577","doi":"https://doi.org/10.1136/thoraxjnl-2021-218577","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thoraxjnl-2021-218577","pdf_url":null,"source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},{"id":"doi:10.1101/2021.12.06.21266509","doi":"https://doi.org/10.1101/2021.12.06.21266509","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.12.06.21266509","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2021/12/07/2021.12.06.21266509.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:35688625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35688625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9329250","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9329250","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Thorax","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/20072192","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Genome-wide_association_study_across_five_cohorts_identifies_five_novel_loci_associated_with_idiopathic_pulmonary_fibrosis/20072192","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:https://hull-repository.worktribe.com/:4044374","doi":null,"is_oa":true,"landing_page_url":"https://hull-repository.worktribe.com/output/4044374","pdf_url":null,"source":{"id":"https://openalex.org/S4306400827","display_name":"Repository@Hull (Worktribe) (University of Hull)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I191240316","host_organization_name":"University of Hull","host_organization_lineage":["https://openalex.org/I191240316"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/thoraxjnl-2021-218577","doi":"https://doi.org/10.1136/thoraxjnl-2021-218577","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thoraxjnl-2021-218577","pdf_url":null,"source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1135971225","display_name":"Architectural structure and regulation of TOLLIP in IPF","funder_award_id":"R01HL130796","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1207450233","display_name":"Improving Pulmonary Fibrosis Classification with Genomics Informed Phenotypic Clusters","funder_award_id":"K23HL146942","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2154954666","display_name":"Elucidating the Genomic Determinants of Outcomes in Idiopathic Pulmonary Fibrosis","funder_award_id":"K23HL138190","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2707037546","display_name":"Genomic epidemiology of acute respiratory distress syndrome and fibrosis in patients with COVID-19","funder_award_id":"221680/Z/20/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2904642737","display_name":null,"funder_award_id":"I01 BX005295","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3229355252","display_name":"Derivation and validation of a clinical-molecular signature to predict fibrotic progression and treatment response in patients with autoimmune interstitial lung disease","funder_award_id":"R56HL158935","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3351175380","display_name":"MICA: Defining Endotypes of Pulmonary Fibrosis by Understanding the Functional Consequences of Known, and Novel, Genetic Associations with Disease","funder_award_id":"MR/V00235X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3447358814","display_name":"Developing a biomarker guided strategy to treat patients with pulmonary fibrosis","funder_award_id":"RP-2017-08-ST2-014","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G3777853095","display_name":"A randomized, double blind controlled trial comparing rituximab against intravenous  cyclophosphamide in connective tissue disease associated interstitial lung disease","funder_award_id":"11/116/03","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G4045737173","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0617-10096","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G664983364","display_name":"Improving clinical phenotyping of interstitial lung disease for better diagnosis and disease management","funder_award_id":"CS-2013-13-017","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336903","display_name":"NIHR Leicester Biomedical Research Centre","ror":"https://ror.org/05xqxa525"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281673081.pdf","grobid_xml":"https://content.openalex.org/works/W4281673081.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2133520037","https://openalex.org/W2152885121","https://openalex.org/W2153860431","https://openalex.org/W2167383172","https://openalex.org/W2417483443","https://openalex.org/W2474747771","https://openalex.org/W2511515754","https://openalex.org/W2799479598","https://openalex.org/W2805074752","https://openalex.org/W2889197569","https://openalex.org/W2907407196","https://openalex.org/W2983449145","https://openalex.org/W3098244848","https://openalex.org/W3120392574","https://openalex.org/W3150268191","https://openalex.org/W3162254480","https://openalex.org/W3212862486","https://openalex.org/W6725775959","https://openalex.org/W6757311756"],"related_works":["https://openalex.org/W2983449145","https://openalex.org/W2988877917","https://openalex.org/W4407074039","https://openalex.org/W4388714602","https://openalex.org/W4377012829","https://openalex.org/W2100190218","https://openalex.org/W3024117683","https://openalex.org/W3206860155","https://openalex.org/W4304695003","https://openalex.org/W2037645843"],"abstract_inverted_index":{"Idiopathic":[0],"pulmonary":[1],"fibrosis":[2],"(IPF)":[3],"is":[4],"a":[5,16,48],"chronic":[6],"lung":[7],"condition":[8],"with":[9,25],"poor":[10],"survival":[11],"times.":[12],"We":[13,64],"previously":[14],"published":[15],"genome-wide":[17,49,61],"meta-analysis":[18,50],"of":[19,28,68,79,94],"IPF":[20,59,104],"risk":[21,60],"across":[22,51,71],"three":[23],"studies":[24,54,74],"independent":[26],"replication":[27],"associated":[29],"variants":[30],"in":[31,56,103],"two":[32],"additional":[33],"studies.":[34,63],"To":[35],"maximise":[36],"power":[37],"and":[38,82,99],"to":[39,75],"generate":[40],"more":[41],"accurate":[42],"effect":[43,69],"size":[44],"estimates,":[45],"we":[46],"performed":[47],"all":[52],"five":[53,73,84],"included":[55],"the":[57,66,72,77,80],"previous":[58],"association":[62,88],"used":[65],"distribution":[67],"sizes":[70],"assess":[76],"replicability":[78],"results":[81],"identified":[83],"robust":[85],"novel":[86],"genetic":[87],"signals":[89],"implicating":[90],"mTOR":[91],"(mammalian":[92],"target":[93],"rapamycin)":[95],"signalling,":[96],"telomere":[97],"maintenance":[98],"spindle":[100],"assembly":[101],"genes":[102],"risk.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":34},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":36},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-13T00:00:00"}
