{"id":"https://openalex.org/W4281668092","doi":"https://doi.org/10.3389/fcvm.2022.872498","title":"Angiographic Lesion Morphology Provides Incremental Value to Generalize Quantitative Flow Ratio for Predicting Myocardial Ischemia","display_name":"Angiographic Lesion Morphology Provides Incremental Value to Generalize Quantitative Flow Ratio for Predicting Myocardial Ischemia","publication_year":2022,"publication_date":"2022-06-06","ids":{"openalex":"https://openalex.org/W4281668092","doi":"https://doi.org/10.3389/fcvm.2022.872498","pmid":"https://pubmed.ncbi.nlm.nih.gov/35734275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9207314"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2022.872498","doi":"https://doi.org/10.3389/fcvm.2022.872498","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.872498","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcvm.2022.872498","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jie Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652243","display_name":"Na Zhao","orcid":"https://orcid.org/0000-0003-3655-7145","observed_orcids":["https://orcid.org/0000-0003-3655-7145"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Zhao","raw_affiliation_strings":["Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439925","display_name":"Bo Xu","orcid":"https://orcid.org/0000-0002-1165-7302","observed_orcids":["https://orcid.org/0000-0002-1165-7302","https://orcid.org/0000-0002-2985-7468"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Xu","raw_affiliation_strings":["Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101573540","display_name":"Lihua Xie","orcid":"https://orcid.org/0000-0002-4573-8215","observed_orcids":["https://orcid.org/0000-0002-4573-8215"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lihua Xie","raw_affiliation_strings":["Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101693211","display_name":"Weihua Yin","orcid":"https://orcid.org/0000-0001-8932-5554","observed_orcids":["https://orcid.org/0000-0001-8932-5554"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihua Yin","raw_affiliation_strings":["Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056813093","display_name":"Yunqiang An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunqiang An","raw_affiliation_strings":["Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019201683","display_name":"Hankun Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hankun Yan","raw_affiliation_strings":["Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109461551","display_name":"Yitong Yu","orcid":"https://orcid.org/0009-0004-4761-9545","observed_orcids":["https://orcid.org/0009-0004-4761-9545"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yitong Yu","raw_affiliation_strings":["Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021356388","display_name":"Bin L\u00fc","orcid":"https://orcid.org/0000-0002-1744-7584","observed_orcids":["https://orcid.org/0000-0002-1744-7584"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Lu","raw_affiliation_strings":["Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021356388"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.3497,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.54814187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"9","issue":null,"first_page":"872498","last_page":"872498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12018","display_name":"Coronary Artery Anomalies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-flow-ratio","display_name":"quantitative flow ratio","score":0.9800000190734863},{"id":"https://openalex.org/keywords/coronary-stenosis","display_name":"coronary artery stenosis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/lesion-morphology","display_name":"lesion morphology","score":0.7900000214576721},{"id":"https://openalex.org/keywords/coronary-ct-angiography","display_name":"coronary CT angiography","score":0.8460000157356262},{"id":"https://openalex.org/keywords/fractional-flow-reserve","display_name":"fractional flow reserve","score":0.7329999804496765},{"id":"https://openalex.org/keywords/left-anterior-descending-artery","display_name":"left anterior descending artery","score":0.7250000238418579},{"id":"https://openalex.org/keywords/multiple-lesions","display_name":"multiple lesions","score":0.6610000133514404},{"id":"https://openalex.org/keywords/minimum-lumen-diameter","display_name":"minimal lumen diameter","score":0.8960000276565552},{"id":"https://openalex.org/keywords/lesion-length","display_name":"lesion length","score":0.5770000219345093},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.5989999771118164},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.6880000233650208},{"id":"https://openalex.org/keywords/incremental-diagnostic-value","display_name":"incremental diagnostic value","score":0.43799999356269836},{"id":"https://openalex.org/keywords/hemodynamically-significant-stenosis","display_name":"hemodynamically significant stenosis","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2777987666","wikidata":"https://www.wikidata.org/wiki/Q1440572","display_name":"Fractional flow reserve","level":4,"score":0.9318140149116516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8797531723976135},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.6803997755050659},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6732338666915894},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.6678266525268555},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.6427772045135498},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5833169221878052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5820496082305908},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5259283185005188},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.49654585123062134},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.44792720675468445},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.43172454833984375},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.41446390748023987},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4128345847129822},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.40310004353523254},{"id":"https://openalex.org/C3019004856","wikidata":"https://www.wikidata.org/wiki/Q42297149","display_name":"Coronary angiography","level":3,"score":0.37123680114746094},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.16893833875656128},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13992094993591309}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcvm.2022.872498","doi":"https://doi.org/10.3389/fcvm.2022.872498","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.872498","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9207314","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9207314/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9207314/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmid:35734275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35734275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cd12611432444d08905873020e1fdf5e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cd12611432444d08905873020e1fdf5e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2022.872498","doi":"https://doi.org/10.3389/fcvm.2022.872498","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.872498","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3561399067","display_name":null,"funder_award_id":"2019XK320065","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G6039287816","display_name":null,"funder_award_id":"2016YFC1300402","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G701537270","display_name":null,"funder_award_id":"82000444","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281668092.pdf","grobid_xml":"https://content.openalex.org/works/W4281668092.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W42615294","https://openalex.org/W123601357","https://openalex.org/W127494906","https://openalex.org/W147178430","https://openalex.org/W152819705","https://openalex.org/W1513605821","https://openalex.org/W1989397955","https://openalex.org/W1994374856","https://openalex.org/W2001110351","https://openalex.org/W2029533088","https://openalex.org/W2039392638","https://openalex.org/W2084768640","https://openalex.org/W2095680098","https://openalex.org/W2115416118","https://openalex.org/W2124659021","https://openalex.org/W2127649313","https://openalex.org/W2133924558","https://openalex.org/W2145318712","https://openalex.org/W2161812533","https://openalex.org/W2173487411","https://openalex.org/W2328176404","https://openalex.org/W2335916523","https://openalex.org/W2528991729","https://openalex.org/W2579717673","https://openalex.org/W2598990095","https://openalex.org/W2679854800","https://openalex.org/W2782546695","https://openalex.org/W2784126947","https://openalex.org/W2798237365","https://openalex.org/W2810133839","https://openalex.org/W2867290565","https://openalex.org/W2885757423","https://openalex.org/W2888711527","https://openalex.org/W2904183515","https://openalex.org/W2916912835","https://openalex.org/W2939157708","https://openalex.org/W2950205356","https://openalex.org/W2951643640","https://openalex.org/W2984113419","https://openalex.org/W2998573716","https://openalex.org/W3005631733","https://openalex.org/W3014850286","https://openalex.org/W3015866482","https://openalex.org/W3027871254","https://openalex.org/W3097300653","https://openalex.org/W3127859932","https://openalex.org/W3134827211","https://openalex.org/W3135721060","https://openalex.org/W3141829582","https://openalex.org/W3170598984","https://openalex.org/W4231358771"],"related_works":["https://openalex.org/W3116170636","https://openalex.org/W3204664215","https://openalex.org/W2888965005","https://openalex.org/W3110083728","https://openalex.org/W7027051945","https://openalex.org/W2888711527","https://openalex.org/W4400936634","https://openalex.org/W2784126947","https://openalex.org/W4226033355","https://openalex.org/W2982189609"],"abstract_inverted_index":{"Aim":[0],"The":[1,22,170,232,263],"quantitative":[2],"flow":[3,80],"ratio":[4],"(QFR)":[5],"is":[6],"favorable":[7],"for":[8,40,73,203,361],"functional":[9],"assessment":[10],"of":[11,20,24,158,172,179,188,219,227,241,256,322],"coronary":[12,66,70,76,199],"artery":[13,67],"stenosis":[14,143],"without":[15,346],"pressure":[16],"wires":[17],"and":[18,148,252,260,281,329],"induction":[19],"hyperemia.":[21],"aim":[23],"this":[25],"study":[26,49],"was":[27,50,83,93,152,243,333],"to":[28,37,53,108,154],"explore":[29],"whether":[30],"angiographic":[31,354],"lesion":[32,110,128,145,165,355],"morphology":[33],"provides":[34],"incremental":[35],"value":[36,255],"generalize":[38],"QFR":[39,92,180,215,242,271,276,282,288,330,357],"predicting":[41,362],"myocardial":[42,363],"ischemia":[43,364],"in":[44,85,95,101,365],"unselected":[45,366],"patients.":[46,367],"Methods":[47],"This":[48],"a":[51,102,182,225,246],"substudy":[52],"the":[54,168,220,235,320,323],"CT-FFR":[55],"CHINA":[56],"trial,":[57],"referring":[58],"345":[59],"participants":[60,100,190],"from":[61,98],"five":[62],"centers":[63],"with":[64,88,167,177,197,224,245,289,318,353],"suspected":[65],"disease":[68],"on":[69,181],"CT":[71],"angiography":[72,77],"diagnostic":[74],"invasive":[75],"(ICA).":[78],"Fractional":[79],"reserve":[81],"(FFR)":[82],"measured":[84],"all":[86],"vessels":[87,210,221],"30\u201390%":[89],"diameter":[90,135,139,142],"stenosis.":[91],"calculated":[94],"186":[96],"lesions":[97,131],"159":[99],"blinded":[103],"manner.":[104],"In":[105,206],"addition,":[106],"parameters":[107,166],"characterize":[109],"features":[111],"were":[112,175,201,211],"recorded":[113],"or":[114,163,349],"measured,":[115],"including":[116],"left":[117],"anterior":[118],"descending":[119],"arteries":[120,200],"(LADs)-involved":[121],"lesions,":[122],"side":[123],"branch":[124],"located":[125],"at":[126],"stenotic":[127],"(BL),":[129],"multiple":[130],"(ML),":[132],"minimal":[133],"lumen":[134,138],"(MLD),":[136],"reference":[137,230],"(RLD),":[140],"percent":[141],"(%DS),":[144],"length":[146],"(LL),":[147],"LL/MLD4.":[149],"Logistic":[150],"regression":[151],"used":[153],"construct":[155],"two":[156,164],"kinds":[157],"models":[159,174,265,325],"by":[160],"combining":[161],"single":[162],"QFR.":[169],"performances":[171],"these":[173],"compared":[176],"that":[178],"per-vessel":[183],"level.":[184],"Results":[185],"A":[186],"total":[187],"148":[189],"(mean":[191],"age:":[192],"59.5":[193],"years;":[194],"101":[195],"men)":[196],"175":[198],"included":[202],"final":[204],"analysis.":[205],"total,":[207],"81":[208],"(46%)":[209],"considered":[212],"hemodynamically":[213],"significant.":[214],"correctly":[216],"classified":[217],"82.29%":[218],"using":[222],"FFR":[223],"cutoff":[226],"0.80":[228],"as":[229],"standard.":[231],"area":[233],"under":[234],"receiver":[236],"operating":[237],"characteristic":[238],"curve":[239],"(AUC)":[240],"0.86":[244],"sensitivity,":[247],"specificity,":[248],"positive":[249],"predictive":[250,254],"value,":[251],"negative":[253],"80.25,":[257],"84.04,":[258],"81.25,":[259],"83.16%,":[261],"respectively.":[262],"combined":[264,324],"(QFR":[266,326],"+":[267,269,272,274,277,279,283,285,327,331],"LAD":[268,273],"MLD,":[270,280],"%DS,":[275],"BL":[278,284,328],"%DS)":[286],"outperformed":[287],"higher":[290],"AUCs":[291],"(0.91":[292],"vs.":[293,299,305,311,336,339],"0.86,":[294,300,306,312],"P":[295,301,307,313,343],"=":[296,302,308,314],"0.02;":[297,303,309],"0.91":[298,304],"0.90":[310],"0.03,":[315],"respectively).":[316],"Compared":[317],"QFR,":[319],"sensitivity":[321],"MLD)":[332],"improved":[334],"(91.36":[335],"80.25%,":[337,340],"91.36":[338],"respectively,":[341],"both":[342],"<":[344],"0.05)":[345],"compromised":[347],"specificity":[348],"accuracy.":[350],"Conclusion":[351],"Combined":[352],"parameters,":[356],"can":[358],"be":[359],"optimized":[360]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-06-13T00:00:00"}