{"id":"https://openalex.org/W4281663106","doi":"https://doi.org/10.1093/cvr/cvac066.212","title":"Analysis of miRNA profile in circulating extracellular vesicles of patients with pulmonary arterial hypertension","display_name":"Analysis of miRNA profile in circulating extracellular vesicles of patients with pulmonary arterial hypertension","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4281663106","doi":"https://doi.org/10.1093/cvr/cvac066.212"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvac066.212","doi":"https://doi.org/10.1093/cvr/cvac066.212","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvac066.212","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075660728","display_name":"Avinash B. Khandagale","orcid":"https://orcid.org/0000-0002-0756-0364","observed_orcids":["https://orcid.org/0000-0002-0756-0364"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A Khandagale","raw_affiliation_strings":["Uppsala University , Uppsala , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala University , Uppsala , Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041439618","display_name":"P\u00e1draic Corcoran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P Corcoran","raw_affiliation_strings":["Uppsala University , Uppsala , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala University , Uppsala , Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Nikpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M Nikpour","raw_affiliation_strings":["Uppsala University , Uppsala , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala University , Uppsala , Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016303786","display_name":"Agneta G Siegbahn","orcid":"https://orcid.org/0000-0003-3955-5671","observed_orcids":["https://orcid.org/0000-0003-3955-5671"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A Siegbahn","raw_affiliation_strings":["Uppsala University , Uppsala , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala University , Uppsala , Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086614840","display_name":"Christina Christersson","orcid":"https://orcid.org/0000-0001-9116-8084","observed_orcids":["https://orcid.org/0000-0001-9116-8084"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"C Christersson","raw_affiliation_strings":["Uppsala University , Uppsala , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala University , Uppsala , Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":{"value":4177,"currency":"EUR","value_usd":4401},"apc_paid":null,"fwci":0.0691,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.26693003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"118","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":1.0},{"id":"https://openalex.org/keywords/circulating-extracellular-vesicles","display_name":"circulating extracellular vesicles","score":0.8870000243186951},{"id":"https://openalex.org/keywords/microrna-expression-profiles","display_name":"microRNA expression profiles","score":0.8489999771118164},{"id":"https://openalex.org/keywords/plasma-mirna","display_name":"plasma microRNA","score":0.5669999718666077},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8820000290870667},{"id":"https://openalex.org/keywords/platelet-free-plasma","display_name":"platelet-free plasma","score":0.8529999852180481},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.48899999260902405},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.7279999852180481},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6770362257957458},{"id":"https://openalex.org/C2779018089","wikidata":"https://www.wikidata.org/wiki/Q17014303","display_name":"Fold change","level":4,"score":0.5503184795379639},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5234776735305786},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5229609608650208},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5100477337837219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47239017486572266},{"id":"https://openalex.org/C112190416","wikidata":"https://www.wikidata.org/wiki/Q2124450","display_name":"RNA extraction","level":4,"score":0.47232264280319214},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.46606379747390747},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.456964910030365},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3664817214012146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35975944995880127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35758110880851746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2805047333240509},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16043579578399658}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/cvr/cvac066.212","doi":"https://doi.org/10.1093/cvr/cvac066.212","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvac066.212","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2796636403","https://openalex.org/W2015700328","https://openalex.org/W2364565895","https://openalex.org/W2911678823","https://openalex.org/W2037892364","https://openalex.org/W2767847608","https://openalex.org/W3138028456","https://openalex.org/W2223549427","https://openalex.org/W1972696957","https://openalex.org/W2160802685"],"abstract_inverted_index":{"Abstract":[0],"Funding":[1],"Acknowledgements":[2],"Type":[3],"of":[4,26,47,75,92,102,113,128,162,193,204,245,257,260],"funding":[5,10],"sources:":[6],"Public":[7],"Institution(s).":[8],"Main":[9],"source(s):":[11],"Swedish":[12],"Research":[13],"Council":[14],"Introduction":[15],"Pulmonary":[16],"arterial":[17],"hypertension":[18],"(PAH)":[19],"is":[20,35,95,263],"characterized":[21],"by":[22],"a":[23,38,241],"progressive":[24],"elevation":[25],"pulmonary":[27],"pressure":[28],"leading":[29],"to":[30,117,167,175,209,269],"right":[31],"ventricular":[32],"dysfunction":[33],"and":[34,68,71,100,133,150,212,239],"associated":[36,96],"with":[37,42,97,135],"poor":[39],"prognosis.":[40],"Patients":[41],"PAH":[43,152,200,217,236,274],"have":[44],"increased":[45],"numbers":[46],"circulating":[48],"extracellular":[49],"vesicles":[50,56],"(EVs),":[51],"which":[52,205],"are":[53,80,233],"small":[54,81],"membrane":[55],"(<1":[57],"\u00b5m)":[58],"released":[59],"from":[60,126,141,145],"different":[61,103],"cells.":[62],"EVs":[63,124,249],"contain":[64],"surface":[65],"antigens,":[66],"proteins":[67],"genetic":[69],"material,":[70],"serve":[72,251],"as":[73,85,108,252],"vectors":[74],"intercellular":[76],"communication.":[77],"MicroRNAs":[78],"(miRs)":[79],"RNAs":[82],"that":[83,248],"act":[84],"post-transcriptional":[86],"regulators":[87],"inhibiting":[88],"gene":[89],"expression.":[90],"Alteration":[91],"miR":[93],"expression":[94,243],"stage,":[98],"progression":[99,275],"severity":[101],"diseases":[104],"making":[105],"them":[106],"suitable":[107],"potential":[109],"biomarker.":[110],"The":[111],"aim":[112],"the":[114,119,258],"study":[115],"was":[116,184],"evaluate":[118],"miRNA":[120,180],"profile":[121,244],"contained":[122],"in":[123,216,266],"derived":[125],"plasma":[127],"both":[129],"control":[130],"healthy":[131,147],"subjects":[132],"patients":[134,153,237],"PAH.":[136],"Methods":[137],"Circulating":[138],"EVs,":[139],"purified":[140],"platelet":[142],"free":[143],"plasma,":[144],"9":[146],"controls":[148],"(HC)":[149],"10":[151],"were":[154,165,172,196,207,214],"analyzed.":[155],"After":[156],"total":[157,163],"RNA":[158,164],"isolation,":[159],"fixed":[160],"volumes":[161],"biotinylated":[166],"generate":[168],"fragmented":[169],"cRNA.":[170],"Samples":[171],"then":[173],"subjected":[174],"Microarray":[176],"analysis":[177,224],"using":[178,187],"GeneChip":[179],"4.0":[181],"Array.":[182],"Data":[183],"further":[185],"analysed":[186],"various":[188,226],"bioinformatics":[189],"tools.":[190],"Results":[191],"Total":[192],"762":[194],"miRs":[195,232,262],"identified":[197,231],"while":[198],"comparing":[199],"vs":[201],"HC":[202],"groups,":[203],"22":[206],"found":[208],"be":[210],"down-regulated":[211],"3":[213],"up-regulated":[215],"group":[218],"(Table":[219],"1).":[220],"Gene":[221],"ontology":[222],"enrichment":[223],"revealed":[225],"cell":[227],"signaling":[228,253],"pathways":[229],"where-in":[230],"involved.":[234],"Conclusions":[235],"pack":[238],"transport":[240],"differentiated":[242],"miRs,":[246],"suggesting":[247],"might":[250],"vectors.":[254],"Further":[255],"analyses":[256],"functionality":[259],"EVs'":[261],"currently":[264],"undergoing":[265],"our":[267],"lab":[268],"understand":[270],"its":[271],"role":[272],"during":[273],"and/or":[276],"inhibition.":[277]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
