{"id":"https://openalex.org/W4281656540","doi":"https://doi.org/10.1111/dom.14785","title":"C\u2010peptide determination in the diagnosis of type of diabetes and its management: A clinical perspective","display_name":"C\u2010peptide determination in the diagnosis of type of diabetes and its management: A clinical perspective","publication_year":2022,"publication_date":"2022-06-09","ids":{"openalex":"https://openalex.org/W4281656540","doi":"https://doi.org/10.1111/dom.14785","pmid":"https://pubmed.ncbi.nlm.nih.gov/35676794","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9543865"},"language":"en","primary_location":{"id":"doi:10.1111/dom.14785","doi":"https://doi.org/10.1111/dom.14785","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dom.14785","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.14785","source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.14785","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082570327","display_name":"Ernesto Maddaloni","orcid":"https://orcid.org/0000-0003-3844-9463","observed_orcids":["https://orcid.org/0000-0003-3844-9463"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ernesto Maddaloni","raw_affiliation_strings":["Experimental Medicine Department, Sapienza University of Rome, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3844-9463","affiliations":[{"raw_affiliation_string":"Experimental Medicine Department, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057323309","display_name":"Geremia B. Bolli","orcid":"https://orcid.org/0000-0003-4966-4003","observed_orcids":["https://orcid.org/0000-0003-4966-4003"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Geremia B. Bolli","raw_affiliation_strings":["Department of Medicine and Surgery, Section of Endocrinology and Metabolism, University of Perugia, Perugia, Italy"],"raw_orcid":"https://orcid.org/0000-0003-4966-4003","affiliations":[{"raw_affiliation_string":"Department of Medicine and Surgery, Section of Endocrinology and Metabolism, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010285104","display_name":"Brian M. Frier","orcid":"https://orcid.org/0000-0002-9590-9473","observed_orcids":["https://orcid.org/0000-0002-9590-9473"]},"institutions":[{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian M. Frier","raw_affiliation_strings":["The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK","institution_ids":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036167780","display_name":"Randie R. Little","orcid":"https://orcid.org/0000-0001-6450-8012","observed_orcids":["https://orcid.org/0000-0001-6450-8012"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randie R. Little","raw_affiliation_strings":["Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039395009","display_name":"Richard David Leslie","orcid":"https://orcid.org/0000-0002-1786-1531","observed_orcids":["https://orcid.org/0000-0002-1786-1531"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard D. Leslie","raw_affiliation_strings":["Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087265840","display_name":"Paolo Pozzilli","orcid":"https://orcid.org/0000-0001-5090-636X","observed_orcids":["https://orcid.org/0000-0001-5090-636X"]},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB","IT"],"is_corresponding":true,"raw_author_name":"Paolo Pozzilli","raw_affiliation_strings":["Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK","Department of Medicine, Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5090-636X","affiliations":[{"raw_affiliation_string":"Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"Department of Medicine, Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I155125353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016239812","display_name":"Raffaella Buzzetti","orcid":"https://orcid.org/0000-0003-1490-6041","observed_orcids":["https://orcid.org/0000-0003-1490-6041"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaela Buzzetti","raw_affiliation_strings":["Experimental Medicine Department, Sapienza University of Rome, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1490-6041","affiliations":[{"raw_affiliation_string":"Experimental Medicine Department, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5087265840"],"corresponding_institution_ids":["https://openalex.org/I155125353","https://openalex.org/I166337079","https://openalex.org/I4405263501"],"apc_list":{"value":4800,"currency":"USD","value_usd":4800},"apc_paid":{"value":4800,"currency":"USD","value_usd":4800},"fwci":3.8651,"has_fulltext":true,"cited_by_count":153,"citation_normalized_percentile":{"value":0.96788385,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"24","issue":"10","first_page":"1912","last_page":"1926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8569999933242798},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/autoimmune-diabetes","display_name":"autoimmune diabetes","score":0.7080000042915344},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.9470000267028809},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.871999979019165},{"id":"https://openalex.org/keywords/diabetes-classification","display_name":"diabetes classification","score":0.5619999766349792},{"id":"https://openalex.org/keywords/diabetes-management","display_name":"diabetes management","score":0.531000018119812},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7490000128746033},{"id":"https://openalex.org/keywords/assay-standardization","display_name":"assay standardization","score":0.8619999885559082},{"id":"https://openalex.org/keywords/clinical-biomarkers","display_name":"clinical biomarkers","score":0.6320000290870667},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.723106324672699},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.702050507068634},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6125206351280212},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5244672298431396},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5161424875259399},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.483218789100647},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47390472888946533},{"id":"https://openalex.org/C2776217022","wikidata":"https://www.wikidata.org/wiki/Q1100933","display_name":"Diabetes management","level":4,"score":0.4457995295524597},{"id":"https://openalex.org/C188087704","wikidata":"https://www.wikidata.org/wiki/Q369577","display_name":"Standardization","level":2,"score":0.4383585453033447},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37485331296920776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2687491178512573},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2077367603778839},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11361446976661682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09811204671859741},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/dom.14785","doi":"https://doi.org/10.1111/dom.14785","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dom.14785","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.14785","source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9543865","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9543865","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Obes Metab","raw_type":"Text"},{"id":"pmid:35676794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35676794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, obesity & metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1650097","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/1650097","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/dom.14785","doi":"https://doi.org/10.1111/dom.14785","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dom.14785","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.14785","source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281656540.pdf","grobid_xml":"https://content.openalex.org/works/W4281656540.grobid-xml"},"referenced_works_count":131,"referenced_works":["https://openalex.org/W1050125050","https://openalex.org/W1488133193","https://openalex.org/W1493207176","https://openalex.org/W1531029954","https://openalex.org/W1894478766","https://openalex.org/W1968897306","https://openalex.org/W1974554536","https://openalex.org/W1978195880","https://openalex.org/W1982948566","https://openalex.org/W1988519907","https://openalex.org/W1991909333","https://openalex.org/W1998995830","https://openalex.org/W2001072123","https://openalex.org/W2001534544","https://openalex.org/W2001834753","https://openalex.org/W2003089807","https://openalex.org/W2004129431","https://openalex.org/W2005132190","https://openalex.org/W2013663820","https://openalex.org/W2019717131","https://openalex.org/W2021584674","https://openalex.org/W2028749119","https://openalex.org/W2032622596","https://openalex.org/W2041551639","https://openalex.org/W2042485158","https://openalex.org/W2042850859","https://openalex.org/W2044234363","https://openalex.org/W2044780703","https://openalex.org/W2046562480","https://openalex.org/W2046609891","https://openalex.org/W2049583719","https://openalex.org/W2051313176","https://openalex.org/W2052007524","https://openalex.org/W2059172107","https://openalex.org/W2060267055","https://openalex.org/W2063952869","https://openalex.org/W2072309323","https://openalex.org/W2099682683","https://openalex.org/W2100086068","https://openalex.org/W2101947332","https://openalex.org/W2110009838","https://openalex.org/W2111023063","https://openalex.org/W2114260033","https://openalex.org/W2116054282","https://openalex.org/W2118174270","https://openalex.org/W2121251837","https://openalex.org/W2122413504","https://openalex.org/W2135741828","https://openalex.org/W2137638424","https://openalex.org/W2142903571","https://openalex.org/W2147072756","https://openalex.org/W2147139493","https://openalex.org/W2149248906","https://openalex.org/W2154711384","https://openalex.org/W2156470388","https://openalex.org/W2158338802","https://openalex.org/W2164825249","https://openalex.org/W2166730792","https://openalex.org/W2170019319","https://openalex.org/W2170472882","https://openalex.org/W2171472795","https://openalex.org/W2184500611","https://openalex.org/W2236465528","https://openalex.org/W2267897056","https://openalex.org/W2467561455","https://openalex.org/W2472022302","https://openalex.org/W2514658869","https://openalex.org/W2549213286","https://openalex.org/W2562627364","https://openalex.org/W2595991351","https://openalex.org/W2599593177","https://openalex.org/W2613460974","https://openalex.org/W2620867946","https://openalex.org/W2696753613","https://openalex.org/W2752336761","https://openalex.org/W2752569040","https://openalex.org/W2760883322","https://openalex.org/W2761164368","https://openalex.org/W2761909812","https://openalex.org/W2790501791","https://openalex.org/W2793451448","https://openalex.org/W2793668441","https://openalex.org/W2795350597","https://openalex.org/W2884950815","https://openalex.org/W2887294293","https://openalex.org/W2894993577","https://openalex.org/W2896006385","https://openalex.org/W2904693701","https://openalex.org/W2907891321","https://openalex.org/W2915983396","https://openalex.org/W2929026664","https://openalex.org/W2945252747","https://openalex.org/W2969557623","https://openalex.org/W2977126534","https://openalex.org/W2980359524","https://openalex.org/W2981213371","https://openalex.org/W2989794873","https://openalex.org/W2991077754","https://openalex.org/W2998261787","https://openalex.org/W3005063061","https://openalex.org/W3005511727","https://openalex.org/W3011936912","https://openalex.org/W3012508049","https://openalex.org/W3016370459","https://openalex.org/W3022083761","https://openalex.org/W3028422533","https://openalex.org/W3044223210","https://openalex.org/W3045471137","https://openalex.org/W3080476633","https://openalex.org/W3084335726","https://openalex.org/W3086776832","https://openalex.org/W3087292339","https://openalex.org/W3087448187","https://openalex.org/W3097445394","https://openalex.org/W3100185039","https://openalex.org/W3107494639","https://openalex.org/W3111471920","https://openalex.org/W3116973135","https://openalex.org/W3126232165","https://openalex.org/W3133424156","https://openalex.org/W3134999461","https://openalex.org/W3139973230","https://openalex.org/W3161420092","https://openalex.org/W3161458931","https://openalex.org/W3173416428","https://openalex.org/W3204080639","https://openalex.org/W3205932037","https://openalex.org/W3209121959","https://openalex.org/W4200148796","https://openalex.org/W4235093819","https://openalex.org/W4253996779"],"related_works":["https://openalex.org/W7128768232","https://openalex.org/W2049583719","https://openalex.org/W4406285535","https://openalex.org/W4384339635","https://openalex.org/W2404914751","https://openalex.org/W2612702080","https://openalex.org/W1986037800","https://openalex.org/W7221241337","https://openalex.org/W3144862997","https://openalex.org/W2060253508"],"abstract_inverted_index":{"Impaired":[0],"beta-cell":[1,39],"function":[2],"is":[3,78],"a":[4,45,79],"recognized":[5],"cornerstone":[6],"of":[7,11,25,61,68,94,103,114,138,153,158,164,189],"diabetes":[8,52,165,168],"pathophysiology.":[9],"Estimates":[10],"insulin":[12,76],"secretory":[13],"capacity":[14],"are":[15,122],"useful":[16],"to":[17,22,31,172,183,191],"inform":[18,126],"clinical":[19,47,66,120,180],"practice,":[20],"helping":[21],"classify":[23],"types":[24],"diabetes,":[26,74,115],"complication":[27],"risk":[28],"stratification":[29],"and":[30,53,112,118,131,134,140,169,182,187],"guide":[32],"treatment":[33],"decisions.":[34],"Because":[35],"C-peptide":[36,69,154],"secretion":[37],"mirrors":[38],"function,":[40],"it":[41],"has":[42],"emerged":[43],"as":[44],"valuable":[46],"biomarker,":[48],"mainly":[49],"in":[50,55,71,85,91,155],"autoimmune":[51,170],"especially":[54],"adult-onset":[56],"diabetes.":[57],"Nonetheless,":[58],"the":[59,65,92,95,110,145,150,156,159],"lack":[60],"robust":[62],"evidence":[63,147],"about":[64,101,128,149],"utility":[67],"measurement":[70,176],"type":[72],"2":[73,167],"where":[75],"resistance":[77],"major":[80],"confounder,":[81],"limits":[82],"its":[83,175],"use":[84],"such":[86],"cases.":[87],"Furthermore,":[88],"problems":[89],"remain":[90],"standardization":[93],"assay":[96],"for":[97],"C-peptide,":[98],"raising":[99],"concerns":[100],"comparability":[102],"measurements":[104],"between":[105],"different":[106],"laboratories.":[107],"To":[108],"approach":[109],"heterogeneity":[111],"complexity":[113],"reliable,":[116],"simple":[117],"inexpensive":[119],"markers":[121],"required":[123],"that":[124],"can":[125],"clinicians":[127],"probable":[129],"pathophysiology":[130],"disease":[132],"progression,":[133],"so":[135],"enable":[136],"personalization":[137],"management":[139,157],"therapy.":[141],"This":[142],"review":[143],"summarizes":[144],"current":[146,185],"base":[148],"potential":[151],"value":[152],"two":[160],"most":[161],"prevalent":[162],"forms":[163],"(type":[166],"diabetes)":[171],"address":[173],"how":[174],"may":[177],"assist":[178],"daily":[179],"practice":[181],"highlight":[184],"limitations":[186],"areas":[188],"uncertainties":[190],"be":[192],"covered":[193],"by":[194],"future":[195],"research.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":44},{"year":2025,"cited_by_count":48},{"year":2024,"cited_by_count":34},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-06-13T00:00:00"}
