{"id":"https://openalex.org/W4281617045","doi":"https://doi.org/10.1155/2022/1617229","title":"Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages","display_name":"Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4281617045","doi":"https://doi.org/10.1155/2022/1617229","pmid":"https://pubmed.ncbi.nlm.nih.gov/35694239","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9178412"},"language":"en","primary_location":{"id":"doi:10.1155/2022/1617229","doi":"https://doi.org/10.1155/2022/1617229","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/1617229","pdf_url":"https://downloads.hindawi.com/journals/sci/2022/1617229.pdf","source":{"id":"https://openalex.org/S27922360","display_name":"Stem Cells International","issn_l":"1687-966X","issn":["1687-966X","1687-9678"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/sci/2022/1617229.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014281687","display_name":"Yanxia Fu","orcid":"https://orcid.org/0000-0002-1590-2619","observed_orcids":["https://orcid.org/0000-0002-1590-2619"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanxia Fu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing 100069, China","State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Tsinghua University, Beijing 100084, China"],"raw_orcid":"https://orcid.org/0000-0002-1590-2619","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing 100069, China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I4391768054","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361921","display_name":"Jun Li","orcid":"https://orcid.org/0000-0002-7236-8088","observed_orcids":["https://orcid.org/0000-0002-7236-8088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["TsCell Biotech Inc., Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TsCell Biotech Inc., Beijing 100084, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606503","display_name":"Mengdi Li","orcid":"https://orcid.org/0000-0001-5605-329X","observed_orcids":["https://orcid.org/0000-0001-5605-329X"]},"institutions":[{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengdi Li","raw_affiliation_strings":["State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I4391768054","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101997879","display_name":"Junfeng Xu","orcid":"https://orcid.org/0000-0002-0519-8920","observed_orcids":["https://orcid.org/0000-0002-0519-8920"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210132375","display_name":"First Affiliated Hospital of Chinese PLA General Hospital","ror":"https://ror.org/039713658","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132375"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfeng Xu","raw_affiliation_strings":["Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210132375"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zheng Rong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Rong","raw_affiliation_strings":["Department of Gynaecology and Obstetrics, Jishuitan Hospital, Beijing 100096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, Jishuitan Hospital, Beijing 100096, China","institution_ids":["https://openalex.org/I2802957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109168967","display_name":"Fangli Ren","orcid":"https://orcid.org/0000-0003-1858-6989","observed_orcids":["https://orcid.org/0000-0003-1858-6989"]},"institutions":[{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangli Ren","raw_affiliation_strings":["State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I4391768054","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025651686","display_name":"Yinyin Wang","orcid":"https://orcid.org/0000-0003-1285-0507","observed_orcids":["https://orcid.org/0000-0003-1285-0507","https://orcid.org/0009-0000-0956-0846"]},"institutions":[{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinyin Wang","raw_affiliation_strings":["State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I4391768054","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065187920","display_name":"Jianqiu Sheng","orcid":"https://orcid.org/0000-0002-9455-0198","observed_orcids":["https://orcid.org/0000-0002-9455-0198"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianqiu Sheng","raw_affiliation_strings":["Department of Gastroenterology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China"],"raw_orcid":"https://orcid.org/0000-0002-9455-0198","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100750876","display_name":"Zhijie Chang","orcid":"https://orcid.org/0000-0003-1567-3227","observed_orcids":["https://orcid.org/0000-0003-1567-3227"]},"institutions":[{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhijie Chang","raw_affiliation_strings":["State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Tsinghua University, Beijing 100084, China"],"raw_orcid":"https://orcid.org/0000-0003-1567-3227","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I4391768054","https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5065187920","https://openalex.org/A5100750876"],"corresponding_institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4391768054","https://openalex.org/I99065089"],"apc_list":{"value":2570,"currency":"USD","value_usd":2570},"apc_paid":{"value":2570,"currency":"USD","value_usd":2570},"fwci":1.6483,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.81960867,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"2022","issue":null,"first_page":"1","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/umbilical-cord-mesenchymal-stem-cells","display_name":"human umbilical cord mesenchymal stem cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/macrophage-regulation","display_name":"macrophage regulation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.6069999933242798},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/aom-dss-model","display_name":"AOM/DSS model","score":0.7350000143051147},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7630000114440918},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/stem-cell-safety","display_name":"stem cell safety","score":0.5680000185966492},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.886566162109375},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7914965152740479},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7307910919189453},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6376340985298157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5172730088233948},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48824194073677063},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45389506220817566},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4359334111213684},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.43487048149108887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3127460181713104},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21586152911186218},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18107208609580994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14194878935813904}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2022/1617229","doi":"https://doi.org/10.1155/2022/1617229","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/1617229","pdf_url":"https://downloads.hindawi.com/journals/sci/2022/1617229.pdf","source":{"id":"https://openalex.org/S27922360","display_name":"Stem Cells International","issn_l":"1687-966X","issn":["1687-966X","1687-9678"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells International","raw_type":"journal-article"},{"id":"pmid:35694239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35694239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells international","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9178412","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9178412/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Int","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a4bb1a1479084f64af26856828ec1bae","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a4bb1a1479084f64af26856828ec1bae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cells International, Vol 2022 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2022/1617229","doi":"https://doi.org/10.1155/2022/1617229","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/1617229","pdf_url":"https://downloads.hindawi.com/journals/sci/2022/1617229.pdf","source":{"id":"https://openalex.org/S27922360","display_name":"Stem Cells International","issn_l":"1687-966X","issn":["1687-966X","1687-9678"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2894566173","display_name":null,"funder_award_id":"20201080606","funder_id":"https://openalex.org/F4320322392","funder_display_name":"Tsinghua University"},{"id":"https://openalex.org/G316601253","display_name":null,"funder_award_id":"20201080606","funder_id":"https://openalex.org/F4320325902","funder_display_name":"Beijing Municipal Science and Technology Commission"},{"id":"https://openalex.org/G4034673986","display_name":null,"funder_award_id":"2019THFS01","funder_id":"https://openalex.org/F4320322392","funder_display_name":"Tsinghua University"},{"id":"https://openalex.org/G6191057997","display_name":null,"funder_award_id":"D171100002617001","funder_id":"https://openalex.org/F4320325902","funder_display_name":"Beijing Municipal Science and Technology Commission"},{"id":"https://openalex.org/G7567319181","display_name":null,"funder_award_id":"D171100002617001","funder_id":"https://openalex.org/F4320322392","funder_display_name":"Tsinghua University"},{"id":"https://openalex.org/G8331545515","display_name":null,"funder_award_id":"2019THFS01","funder_id":"https://openalex.org/F4320325902","funder_display_name":"Beijing Municipal Science and Technology Commission"}],"funders":[{"id":"https://openalex.org/F4320322392","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320325902","display_name":"Beijing Municipal Science and Technology Commission","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281617045.pdf","grobid_xml":"https://content.openalex.org/works/W4281617045.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1902806198","https://openalex.org/W1979811980","https://openalex.org/W1985985259","https://openalex.org/W1988830115","https://openalex.org/W1994980398","https://openalex.org/W1996571434","https://openalex.org/W2003566728","https://openalex.org/W2012060637","https://openalex.org/W2030941625","https://openalex.org/W2033336380","https://openalex.org/W2055004642","https://openalex.org/W2063731747","https://openalex.org/W2082626794","https://openalex.org/W2083808914","https://openalex.org/W2089897360","https://openalex.org/W2094771389","https://openalex.org/W2099883038","https://openalex.org/W2103448559","https://openalex.org/W2112527416","https://openalex.org/W2118278569","https://openalex.org/W2118682325","https://openalex.org/W2137571679","https://openalex.org/W2152518717","https://openalex.org/W2153941567","https://openalex.org/W2169367453","https://openalex.org/W2745435532","https://openalex.org/W2772274254","https://openalex.org/W2973291717","https://openalex.org/W2982887586","https://openalex.org/W3109409752"],"related_works":["https://openalex.org/W2061178755","https://openalex.org/W1997923541","https://openalex.org/W1971299685","https://openalex.org/W2917694845","https://openalex.org/W2463617664","https://openalex.org/W4220714678","https://openalex.org/W4396642838","https://openalex.org/W2033336380","https://openalex.org/W4390595621","https://openalex.org/W1683542568"],"abstract_inverted_index":{"Mesenchymal":[0],"stem":[1,73,101],"cells":[2,74],"(MSCs)":[3],"have":[4],"been":[5],"documented":[6],"to":[7,107],"be":[8,41,145],"effective":[9],"for":[10,43],"the":[11,26,44,66,138,148,155,167,175,183,191,207,222,231],"therapy":[12,46],"of":[13,25,48,68,99,140,161,177,194,209,217,224,234],"inflammation-related":[14],"diseases":[15],"but":[16],"raised":[17],"concerns":[18],"on":[19,52,76,142,230],"possible":[20],"tumorigenic":[21],"effects.":[22],"Since":[23],"most":[24],"tumors":[27],"are":[28],"induced":[29],"or":[30,113,117,130],"promoted":[31],"by":[32,201],"chronic":[33],"inflammation,":[34],"one":[35],"could":[36],"expect":[37],"that":[38,80,124,137,169],"MSCs":[39],"might":[40,144],"beneficial":[42],"cancer":[45,133,211],"because":[47],"their":[49],"potent":[50],"roles":[51],"inhibiting":[53,225],"inflammation.":[54],"This":[55,219],"study":[56,220],"is":[57],"aimed":[58],"at":[59],"performing":[60],"a":[61],"safety":[62],"evaluation":[63],"and":[64,97,158,196,212,227],"evaluating":[65],"role":[67,223],"human":[69],"umbilical":[70],"cord":[71],"mesenchymal":[72,100],"(HUC-MSCs)":[75],"tumorigenesis.":[77,238],"We":[78,135,165],"found":[79],"HUC-MSCs":[81,104,125,141,152,170,235],"cultured":[82],"within":[83],"20":[84],"generations":[85],"had":[86],"no":[87],"significant":[88],"changes":[89,160],"in":[90,111,128,182,206,236],"proliferation,":[91],"cell":[92,102],"cycle,":[93],"cellular":[94],"senescence,":[95],"apoptosis,":[96],"expression":[98,192],"markers.":[103],"were":[105,180,199,203],"unable":[106],"form":[108],"any":[109],"tumor":[110],"immunodeficiency":[112],"normal":[114],"mice":[115,184,214],"with":[116],"without":[118],"inflammatory":[119,149],"stimulation.":[120],"Intriguingly,":[121],"we":[122],"observed":[123],"inhibited":[126,171],"tumorigenesis":[127,143,172],"B16-derived":[129],"AOM/DSS-induced":[131,187],"colon":[132,188,210],"models.":[134],"reasoned":[136],"effect":[139],"through":[146,173],"regulating":[147],"response.":[150],"Indeed,":[151],"dramatically":[153],"ameliorated":[154],"disease":[156],"symptoms":[157],"pathological":[159],"DSS-induced":[162],"colitis":[163,213],"mice.":[164],"deciphered":[166],"mechanism":[168],"reducing":[174],"proportion":[176],"macrophages,":[178,202],"which":[179,198],"decreased":[181,205],"suffered":[185],"from":[186],"cancer.":[189],"Correspondingly,":[190],"levels":[193],"TNF-\u03b1":[195],"IL-6,":[197],"secreted":[200],"significantly":[204],"plasma":[208],"after":[215],"injection":[216],"HUC-MSCs.":[218],"revealed":[221],"macrophages":[226],"shed":[228],"light":[229],"therapeutic":[232],"application":[233],"inflammation-induced":[237]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-06-13T00:00:00"}