{"id":"https://openalex.org/W4281571994","doi":"https://doi.org/10.1016/j.ijrobp.2022.04.044","title":"Mass Transport Model of Radiation Response: Calibration and Application to Chemoradiation for Pancreatic Cancer","display_name":"Mass Transport Model of Radiation Response: Calibration and Application to Chemoradiation for Pancreatic Cancer","publication_year":2022,"publication_date":"2022-05-25","ids":{"openalex":"https://openalex.org/W4281571994","doi":"https://doi.org/10.1016/j.ijrobp.2022.04.044","pmid":"https://pubmed.ncbi.nlm.nih.gov/35643254"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijrobp.2022.04.044","doi":"https://doi.org/10.1016/j.ijrobp.2022.04.044","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2022.04.044","pdf_url":"http://www.redjournal.org/article/S0360301622004059/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.redjournal.org/article/S0360301622004059/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009770704","display_name":"Charles X. Wang","orcid":"https://orcid.org/0000-0002-9695-492X","observed_orcids":["https://orcid.org/0000-0002-9695-492X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles X. Wang","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Radiation Oncology, University of California Davis Medical Center, Sacramento, California","Department of Radiation Oncology, University of California Davis Medical Center, Sacramento, California","Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Radiation Oncology, University of California Davis Medical Center, Sacramento, California","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4210160527"]},{"raw_affiliation_string":"Department of Radiation Oncology, University of California Davis Medical Center, Sacramento, California","institution_ids":["https://openalex.org/I4210160527"]},{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054475669","display_name":"Dalia Elganainy","orcid":"https://orcid.org/0000-0003-4427-986X","observed_orcids":["https://orcid.org/0000-0003-4427-986X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dalia Elganainy","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046059508","display_name":"Mohamed Zaid","orcid":"https://orcid.org/0000-0002-8615-2456","observed_orcids":["https://orcid.org/0000-0002-8615-2456"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed M. Zaid","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054229369","display_name":"Joseph D. Butner","orcid":"https://orcid.org/0000-0003-0608-2580","observed_orcids":["https://orcid.org/0000-0003-0608-2580"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Butner","raw_affiliation_strings":["Mathematics in Medicine Program, Houston Methodist Research Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematics in Medicine Program, Houston Methodist Research Institute, Houston, Texas","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075444735","display_name":"Anshuman Agrawal","orcid":"https://orcid.org/0000-0001-7957-4928","observed_orcids":["https://orcid.org/0000-0001-7957-4928"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anshuman Agrawal","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028264134","display_name":"Sara Nizzero","orcid":"https://orcid.org/0000-0003-4622-5101","observed_orcids":["https://orcid.org/0000-0003-4622-5101"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Nizzero","raw_affiliation_strings":["Mathematics in Medicine Program, Houston Methodist Research Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematics in Medicine Program, Houston Methodist Research Institute, Houston, Texas","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087201995","display_name":"Bruce D. Minsky","orcid":"https://orcid.org/0000-0001-8434-7930","observed_orcids":["https://orcid.org/0000-0001-8434-7930"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce D. Minsky","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011546832","display_name":"Emma Brey Holliday","orcid":"https://orcid.org/0000-0002-4362-461X","observed_orcids":["https://orcid.org/0000-0002-4362-461X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma B. Holliday","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079075847","display_name":"Cullen M. Taniguchi","orcid":"https://orcid.org/0000-0002-8052-3316","observed_orcids":["https://orcid.org/0000-0002-8052-3316"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cullen M. Taniguchi","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059256779","display_name":"Grace L. Smith","orcid":"https://orcid.org/0000-0002-3171-2911","observed_orcids":["https://orcid.org/0000-0002-3171-2911"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace L. Smith","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071185138","display_name":"Albert C. Koong","orcid":"https://orcid.org/0000-0001-9824-1643","observed_orcids":["https://orcid.org/0000-0001-9824-1643"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert C. Koong","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089299130","display_name":"Joseph M. Herman","orcid":"https://orcid.org/0000-0002-9933-5227","observed_orcids":["https://orcid.org/0000-0002-9933-5227"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Herman","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082668053","display_name":"Prajnan Das","orcid":"https://orcid.org/0000-0002-8253-4190","observed_orcids":["https://orcid.org/0000-0002-8253-4190"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prajnan Das","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048073439","display_name":"Anirban Maitra","orcid":"https://orcid.org/0000-0001-7923-9978","observed_orcids":["https://orcid.org/0000-0001-7923-9978","https://orcid.org/0000-0003-0298-9775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anirban Maitra","raw_affiliation_strings":["Departments of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101758546","display_name":"Huamin Wang","orcid":"https://orcid.org/0000-0002-2038-5863","observed_orcids":["https://orcid.org/0000-0002-2038-5863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huamin Wang","raw_affiliation_strings":["Anatomical Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomical Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035371911","display_name":"Robert A. Wolff","orcid":"https://orcid.org/0000-0002-6614-1610","observed_orcids":["https://orcid.org/0000-0002-6614-1610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert A. Wolff","raw_affiliation_strings":["Gastrointestinal Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Medical Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011254389","display_name":"Matthew H. G. Katz","orcid":"https://orcid.org/0000-0003-3870-6968","observed_orcids":["https://orcid.org/0000-0003-3870-6968"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew H.G. Katz","raw_affiliation_strings":["Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016694714","display_name":"Christopher H. Crane","orcid":"https://orcid.org/0000-0001-5143-2784","observed_orcids":["https://orcid.org/0000-0001-5143-2784"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher H. Crane","raw_affiliation_strings":["Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033025983","display_name":"Vittorio Cristini C","orcid":"https://orcid.org/0000-0002-7909-4278","observed_orcids":["https://orcid.org/0000-0002-7909-4278"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vittorio Cristini","raw_affiliation_strings":["Mathematics in Medicine Program, Houston Methodist Research Institute, Houston, Texas; Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas; Physiology, Biophysics, and Systems Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York","Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas","Mathematics in Medicine Program, Houston Methodist Research Institute, Houston, Texas","Physiology, Biophysics, and Systems Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematics in Medicine Program, Houston Methodist Research Institute, Houston, Texas; Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas; Physiology, Biophysics, and Systems Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4387153466","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Mathematics in Medicine Program, Houston Methodist Research Institute, Houston, Texas","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Physiology, Biophysics, and Systems Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026500137","display_name":"Eugene Jon Koay","orcid":"https://orcid.org/0000-0001-7675-3461","observed_orcids":["https://orcid.org/0000-0001-7675-3461"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eugene J. Koay","raw_affiliation_strings":["Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: ekoay@mdanderson.org","Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: ekoay@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5026500137"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":{"value":3600,"currency":"USD","value_usd":3600},"fwci":0.1805,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.45906724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"114","issue":"1","first_page":"163","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.20239999890327454,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mass-transport-model","display_name":"mass transport model","score":0.9599999785423279},{"id":"https://openalex.org/keywords/radiation-response","display_name":"radiation response","score":0.6899999976158142},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ct-perfusion","display_name":"CT perfusion","score":0.7319999933242798},{"id":"https://openalex.org/keywords/blood-volume-fraction","display_name":"blood volume fraction","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/radiosensitizing-chemotherapy","display_name":"radiosensitizing chemotherapy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6970000267028809},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8036273717880249},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6268075108528137},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5561286211013794},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5200833678245544},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.516040563583374},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5062659978866577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4985194206237793},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.49099090695381165},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4842336177825928},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4775451123714447},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.4564947187900543},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41246497631073},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4105028808116913},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.12132629752159119}],"mesh":[{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ijrobp.2022.04.044","doi":"https://doi.org/10.1016/j.ijrobp.2022.04.044","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2022.04.044","pdf_url":"http://www.redjournal.org/article/S0360301622004059/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},{"id":"pmid:35643254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35643254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation oncology, biology, physics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10042520","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10042520","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10042520/pdf/nihms-1879153.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Radiat Oncol Biol Phys","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthgsbs_docs-3595","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthgsbs_docs/2654","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1016/j.ijrobp.2022.04.044","doi":"https://doi.org/10.1016/j.ijrobp.2022.04.044","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2022.04.044","pdf_url":"http://www.redjournal.org/article/S0360301622004059/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6200000047683716,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, justice, and strong institutions"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G111615301","display_name":null,"funder_award_id":"P30 CA-016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G118604582","display_name":null,"funder_award_id":"U01CA196403","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G1247637531","display_name":null,"funder_award_id":"1P50CA221707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1468253849","display_name":null,"funder_award_id":"(CA016672)","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G1582743944","display_name":null,"funder_award_id":"U01CA200468","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G184908018","display_name":null,"funder_award_id":"1R01CA253865","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G186907829","display_name":"Translational Applications in an Animal Model of Pancreatic Cystic Neoplasm and Cancer","funder_award_id":"5r01ca218004-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1901027039","display_name":null,"funder_award_id":"CA 016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2258116482","display_name":"Center for Immunotherapeutic Transport Oncophysics","funder_award_id":"5u54ca210181-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2270192511","display_name":"Targeted therapeutics for ovarian cancer and its microenvironment - treatment and theoretical modeling","funder_award_id":"U01CA213759","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2324600623","display_name":null,"funder_award_id":"1R01CA222007","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2479442754","display_name":"MD Anderson Cancer Center SPORE in Gastrointestinal Cancer","funder_award_id":"1p50ca221707-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2533282170","display_name":null,"funder_award_id":"P50 CA217674","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G3154343865","display_name":null,"funder_award_id":"U01CA214263","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G318954555","display_name":null,"funder_award_id":"R01 CA253865","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3616507840","display_name":null,"funder_award_id":"P50CA221707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3999671780","display_name":"A Clinical Validation Center for Early Detection of Pancreatic Cancer","funder_award_id":"5u01ca200468-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4439653212","display_name":null,"funder_award_id":"1R01CA226537","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4752752128","display_name":null,"funder_award_id":"R01 CA248917","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G493372791","display_name":null,"funder_award_id":"R01 CA218004","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5192847080","display_name":"Circulating Biomarkers and Imaging for Early Detection of Pancreatic Cancer","funder_award_id":"5u01ca214263-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G520338450","display_name":null,"funder_award_id":"P50\u2010CA217674","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5360353628","display_name":null,"funder_award_id":"U54CA210181","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5427789088","display_name":"Digital Nanoplasmonic Quantification of Tumor-derived Extracellular Vesicles in Plasma Microsamples","funder_award_id":"U01CA252965","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5637555674","display_name":null,"funder_award_id":"1U01CA196403","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5932252125","display_name":null,"funder_award_id":"1R01CA253865","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5989595523","display_name":null,"funder_award_id":"U54CA210181","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6392506253","display_name":"Collaborative Research: A New Multiscale Methodology and Application to Tumor Growth Modeling","funder_award_id":"1930583","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6675610623","display_name":null,"funder_award_id":"1U01CA213759","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6736661663","display_name":null,"funder_award_id":"CA- 016672","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6911098835","display_name":"Imaging and Molecular Correlates of Progression in Cystic Neoplasms of the Pancreas","funder_award_id":"U01CA196403","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7237407956","display_name":"A Targeted Nanomedicine Prototype Against Enzalutamide-resistant Prostate Cancer","funder_award_id":"5r01ca226537-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7600357429","display_name":null,"funder_award_id":"1R01CA226537","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7853443128","display_name":null,"funder_award_id":"CA016672","funder_id":"https://openalex.org/F4320332457","funder_display_name":"GE Healthcare"},{"id":"https://openalex.org/G786656454","display_name":"miR-155 targeted therapeutics for precision medicine in lung cancer","funder_award_id":"R01CA222007","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G787001279","display_name":null,"funder_award_id":"R01 CA226537","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8226878744","display_name":"Nanoparticle delivery of miRNA-based therapeutics to overcome clinical challenges in triple negative breast cancer","funder_award_id":"5r01ca253865-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8271303424","display_name":null,"funder_award_id":"CA217674","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8509788571","display_name":null,"funder_award_id":"U54CA210181-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8760581107","display_name":"Center for Transport Oncophysics","funder_award_id":"U54CA143837","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000013129","display_name":null,"funder_award_id":"U54CA210181-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000096192","display_name":null,"funder_award_id":"P50CA217674","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000162200","display_name":null,"funder_award_id":"U54 CA210181","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000298892","display_name":null,"funder_award_id":"R01CA248917","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000310340","display_name":null,"funder_award_id":"1R01CA253865","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000333488","display_name":null,"funder_award_id":"1R01CA226537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"5p30ca016672-49","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000917314","display_name":"Early Detection of Hepatocellular Carcinoma","funder_award_id":"R01CA195524","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332457","display_name":"GE Healthcare","ror":"https://ror.org/03yt24h27"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281571994.pdf","grobid_xml":"https://content.openalex.org/works/W4281571994.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W80665035","https://openalex.org/W1995166397","https://openalex.org/W2008273832","https://openalex.org/W2009579361","https://openalex.org/W2018895767","https://openalex.org/W2032471754","https://openalex.org/W2036861430","https://openalex.org/W2044245267","https://openalex.org/W2055091294","https://openalex.org/W2062007210","https://openalex.org/W2062338927","https://openalex.org/W2063556542","https://openalex.org/W2070252009","https://openalex.org/W2070779203","https://openalex.org/W2102509488","https://openalex.org/W2107441200","https://openalex.org/W2109294354","https://openalex.org/W2117064395","https://openalex.org/W2136614862","https://openalex.org/W2158619067","https://openalex.org/W2217441961","https://openalex.org/W2266995761","https://openalex.org/W2304258614","https://openalex.org/W2346921980","https://openalex.org/W2410611073","https://openalex.org/W2561537919","https://openalex.org/W2624574700","https://openalex.org/W2655262992","https://openalex.org/W2767233816","https://openalex.org/W2781484625","https://openalex.org/W2781525129","https://openalex.org/W2783576981","https://openalex.org/W2797038701","https://openalex.org/W2807569155","https://openalex.org/W2887187316","https://openalex.org/W2887797769","https://openalex.org/W2904444972","https://openalex.org/W2908581327","https://openalex.org/W2912650118","https://openalex.org/W2934913390","https://openalex.org/W2968934833","https://openalex.org/W3108901394","https://openalex.org/W3111140217","https://openalex.org/W4205797298"],"related_works":["https://openalex.org/W3142026086","https://openalex.org/W2028827184","https://openalex.org/W2146312028","https://openalex.org/W2767564966","https://openalex.org/W1983068147","https://openalex.org/W3146277049","https://openalex.org/W4246588393","https://openalex.org/W4200337742","https://openalex.org/W2994686985","https://openalex.org/W4281722959"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1],"benefit":[2],"of":[3,21,38,80,187,239,254],"radiation":[4,24,274,300],"therapy":[5,147],"for":[6,141,217,275,299],"pancreatic":[7],"ductal":[8],"adenocarcinoma":[9],"(PDAC)":[10],"remains":[11],"unclear.":[12],"We":[13,54,96,172],"hypothesized":[14],"that":[15,61,280,288],"a":[16,30,33,119,262,291],"new":[17,263],"mechanistic":[18],"mathematical":[19,264],"model":[20,60,90,136],"chemotherapy":[22,164,272],"and":[23,125,143,156,196,210,241,273,287],"response":[25,270],"could":[26],"predict":[27,268],"clinical":[28,144,269,285],"outcomes":[29],"priori,":[31],"using":[32,85],"previously":[34,68],"described":[35],"baseline":[36],"measurement":[37],"perfusion":[39],"from":[40,75,110,271],"computed":[41,178],"tomography":[42],"scans,":[43],"normalized":[44],"area":[45,249],"under":[46,250],"the":[47,88,99,105,135,174,188,208,246,251],"enhancement":[48],"curve":[49,252],"(nAUC).":[50],"METHODS":[51],"AND":[52],"MATERIALS:":[53],"simplified":[55],"an":[56],"existing":[57],"mass":[58],"transport":[59],"predicted":[62,100],"cancer":[63,101],"cell":[64,102,107,199],"death":[65,103,108,200],"by":[66],"replacing":[67],"unknown":[69],"variables":[70],"with":[71,115,223,248,297],"averaged":[72],"direct":[73],"measurements":[74],"randomly":[76],"selected":[77],"pathologic":[78,142],"sections":[79],"untreated":[81],"PDAC.":[82,276],"This":[83,259],"allowed":[84],"nAUC":[86,180,220,289],"as":[87],"sole":[89],"input":[91],"to":[92,104,137,165,181,256,267,294],"approximate":[93],"tumor":[94,189,198],"perfusion.":[95],"then":[97],"compared":[98],"actual":[106],"measured":[109],"corresponding":[111],"resected":[112],"tumors":[113],"treated":[114],"neoadjuvant":[116],"chemoradiation":[117,158],"in":[118,168,207,226,245],"calibration":[120,209],"cohort":[121,127,148,159],"(n":[122,128,149,160],"=":[123,129,150,161,191,194,202],"80)":[124],"prospective":[126,211],"25).":[130],"After":[131],"calibration,":[132],"we":[133],"applied":[134],"2":[138],"separate":[139],"cohorts":[140,228,247],"associations:":[145],"targeted":[146],"101),":[151],"cetuximab/bevacizumab":[152],"+":[153],"radiosensitizing":[154,163],"chemotherapy,":[155],"standard":[157],"81),":[162],"50.4":[166],"Gy":[167],"28":[169],"fractions.":[170],"RESULTS:":[171],"established":[173],"relationship":[175],"between":[176],"pretreatment":[177],"v":[179],"pathologically":[182],"verified":[183],"blood":[184],"volume":[185],"fraction":[186],"(r":[190,201],"0.65;":[192],"P":[193,204],".009)":[195],"fractional":[197],"0.97-0.99;":[203],"<":[205],".0001)":[206],"cohorts.":[212],"On":[213],"multivariate":[214],"analyses,":[215],"accounting":[216],"traditional":[218],"covariates,":[219],"independently":[221],"associated":[222],"overall":[224],"survival":[225],"all":[227],"(mean":[229],"hazard":[230],"ratios,":[231],"0.14-0.31).":[232],"Receiver":[233],"operator":[234],"characteristic":[235],"analyses":[236],"revealed":[237],"discrimination":[238],"good":[240],"bad":[242],"prognostic":[243],"groups":[244],"values":[253],"0.64":[255],"0.71.":[257],"CONCLUSIONS:":[258],"work":[260],"presents":[261],"modeling":[265],"approach":[266],"Our":[277],"findings":[278],"indicate":[279],"oxygen/drug":[281],"diffusion":[282],"strongly":[283],"influences":[284],"responses":[286],"is":[290],"potential":[292],"tool":[293],"select":[295],"patients":[296],"PDAC":[298],"therapy.":[301]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2025-10-10T00:00:00"}