{"id":"https://openalex.org/W4281565387","doi":"https://doi.org/10.1038/s41590-022-01210-5","title":"Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3","display_name":"Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3","publication_year":2022,"publication_date":"2022-05-26","ids":{"openalex":"https://openalex.org/W4281565387","doi":"https://doi.org/10.1038/s41590-022-01210-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/35618829","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9179227"},"language":"en","primary_location":{"id":"doi:10.1038/s41590-022-01210-5","doi":"https://doi.org/10.1038/s41590-022-01210-5","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41590-022-01210-5","pdf_url":null,"source":{"id":"https://openalex.org/S41063453","display_name":"Nature Immunology","issn_l":"1529-2908","issn":["1529-2908","1529-2916"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9179227","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021817696","display_name":"Stephanie Grebinoski","orcid":"https://orcid.org/0000-0002-3562-3190","observed_orcids":["https://orcid.org/0000-0002-3562-3190"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Grebinoski","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3562-3190","affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035183199","display_name":"Qianxia Zhang","orcid":"https://orcid.org/0000-0002-2885-2147","observed_orcids":["https://orcid.org/0000-0002-2885-2147","https://orcid.org/0000-0002-6229-6711"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qianxia Zhang","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Program in Cellular and Molecular Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA","Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2885-2147","affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Program in Cellular and Molecular Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091187053","display_name":"Anthony Richard Cillo","orcid":"https://orcid.org/0000-0002-3213-3129","observed_orcids":["https://orcid.org/0000-0002-3213-3129"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony R. Cillo","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3213-3129","affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088868602","display_name":"Sasikanth Manne","orcid":"https://orcid.org/0000-0001-9856-0871","observed_orcids":["https://orcid.org/0000-0001-9856-0871"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasikanth Manne","raw_affiliation_strings":["Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008871759","display_name":"Hanxi Xiao","orcid":"https://orcid.org/0000-0003-3849-1696","observed_orcids":["https://orcid.org/0000-0003-3849-1696"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanxi Xiao","raw_affiliation_strings":["CMU-Pitt Joint Computational Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA","Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CMU-Pitt Joint Computational Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I74973139"]},{"raw_affiliation_string":"Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046890572","display_name":"Erin A. Brunazzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin A. Brunazzi","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008361623","display_name":"Tracy Tabib","orcid":"https://orcid.org/0000-0003-4053-988X","observed_orcids":["https://orcid.org/0000-0003-4053-988X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy Tabib","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075852714","display_name":"Carly Cardello","orcid":"https://orcid.org/0000-0002-2810-7681","observed_orcids":["https://orcid.org/0000-0002-2810-7681"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carly Cardello","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085108299","display_name":"Christine Guo Lian","orcid":"https://orcid.org/0000-0003-4626-1612","observed_orcids":["https://orcid.org/0000-0003-4626-1612"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine G. Lian","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101526499","display_name":"George F. Murphy","orcid":"https://orcid.org/0000-0002-3909-1160","observed_orcids":["https://orcid.org/0000-0002-3909-1160"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George F. Murphy","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032437502","display_name":"Robert Lafyatis","orcid":"https://orcid.org/0000-0002-9398-5034","observed_orcids":["https://orcid.org/0000-0002-9398-5034"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Lafyatis","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057824723","display_name":"E. John Wherry","orcid":"https://orcid.org/0000-0003-0477-1956","observed_orcids":["https://orcid.org/0000-0003-0477-1956"]},"institutions":[{"id":"https://openalex.org/I4210109986","display_name":"Parker Institute for Cancer Immunotherapy","ror":"https://ror.org/0184qbg02","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210109986"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. John Wherry","raw_affiliation_strings":["Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","Parker Institute for Cancer Immunotherapy at University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0003-0477-1956","affiliations":[{"raw_affiliation_string":"Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Parker Institute for Cancer Immunotherapy at University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I4210109986","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073031182","display_name":"Jishnu Das","orcid":"https://orcid.org/0000-0002-5747-064X","observed_orcids":["https://orcid.org/0000-0002-5747-064X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jishnu Das","raw_affiliation_strings":["Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5747-064X","affiliations":[{"raw_affiliation_string":"Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008106149","display_name":"Creg J. Workman","orcid":"https://orcid.org/0000-0002-9964-9509","observed_orcids":["https://orcid.org/0000-0002-9964-9509"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Creg J. Workman","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-9964-9509","affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001000053","display_name":"Dario A.A. Vignali","orcid":"https://orcid.org/0000-0002-2771-5992","observed_orcids":["https://orcid.org/0000-0002-2771-5992"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dario A. A. Vignali","raw_affiliation_strings":["Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu","Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. dvignali@pitt.edu","Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu","Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2771-5992","affiliations":[{"raw_affiliation_string":"Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. dvignali@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5001000053"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526","https://openalex.org/I4210134769"],"apc_list":{"value":11390,"currency":"USD","value_usd":11390},"apc_paid":null,"fwci":8.261,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.98848392,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"23","issue":"6","first_page":"868","last_page":"877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.07400000095367432,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cell-exhaustion","display_name":"CD8+ T cell exhaustion","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.7870000004768372},{"id":"https://openalex.org/keywords/t-cell-metabolism","display_name":"T cell metabolism","score":0.6159999966621399},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.7829999923706055},{"id":"https://openalex.org/keywords/inhibitory-receptors","display_name":"inhibitory receptors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nonobese-diabetic-mouse","display_name":"nonobese diabetic mouse","score":0.7350000143051147},{"id":"https://openalex.org/keywords/t-cell-fate","display_name":"T cell fate","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5041102170944214},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4263358414173126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3323918879032135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10661441087722778},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41590-022-01210-5","doi":"https://doi.org/10.1038/s41590-022-01210-5","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41590-022-01210-5","pdf_url":null,"source":{"id":"https://openalex.org/S41063453","display_name":"Nature Immunology","issn_l":"1529-2908","issn":["1529-2908","1529-2916"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Immunology","raw_type":"journal-article"},{"id":"pmid:35618829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35618829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9179227","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9179227","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9179227","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9179227","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1083274936","display_name":"Testing the role of BATF as a pioneer transcription factor in effector T cells","funder_award_id":"R01AI115712","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1112520145","display_name":"Special BD LSRFortessaTM","funder_award_id":"1s10od011925-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1644865181","display_name":null,"funder_award_id":"AI105343","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G1796164619","display_name":null,"funder_award_id":"CA210944","funder_id":"https://openalex.org/F4320338333","funder_display_name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute"},{"id":"https://openalex.org/G1837697345","display_name":"Cellular and transcriptional control of exhausted CD8 T cells lineage dynamics","funder_award_id":"R01AI105343","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2350643484","display_name":null,"funder_award_id":"DK089125","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2513989095","display_name":null,"funder_award_id":"LF-OC-19-000256","funder_id":"https://openalex.org/F4320327561","funder_display_name":"LEO Fondet"},{"id":"https://openalex.org/G2567148758","display_name":"Investigating a disintegrin and metalloproteinase-mediated Neuropilin 1 cleavage in autoimmune diabetes","funder_award_id":"F31AI147638","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3176075876","display_name":null,"funder_award_id":"CA210944","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3473713368","display_name":"Parameters that Underlie Treg Insufficiency in Autoimmune Diabetes","funder_award_id":"R01DK089125","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3892873189","display_name":null,"funder_award_id":"AI108545","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G4553951973","display_name":null,"funder_award_id":"AI117950","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G4834714497","display_name":null,"funder_award_id":"AI112521","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G4848079573","display_name":null,"funder_award_id":"AI147638","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6558287505","display_name":null,"funder_award_id":"AI089443","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6565101551","display_name":"Engineering T cells to Provide Durable Control of HIV-1 Replication","funder_award_id":"U19AI117950","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7381222316","display_name":null,"funder_award_id":"AI082630","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7432795147","display_name":"Mechanisms and Immunological Consequences of Host-Virus Interactions","funder_award_id":"P01AI112521","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7742850247","display_name":null,"funder_award_id":"AI115712","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7977681622","display_name":"Autoimmunity and Immunopathology Training Program","funder_award_id":"T32AI089443","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8463110223","display_name":null,"funder_award_id":"AI144422","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G9000856425","display_name":"Linking genome variation to transcriptional network dynamics in human B cells","funder_award_id":"U01HG012041","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000885173","display_name":"Durable Alteration of the Human Immune system after Infection or Immunotherapy","funder_award_id":"U19AI082630","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000897317","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA047904","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000901638","display_name":"Synergies among inhibitory receptors in tolerance and disease","funder_award_id":"P01AI108545","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000905043","display_name":"Structure, Function and Mechanistic Analysis of LAG3","funder_award_id":"R01AI144422","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000920869","display_name":"Using three-dimensional protein networks to uncover immuno-modulatory molecular phenotypes in infectious disease","funder_award_id":"DP2AI164325","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G912950369","display_name":"Radiation and checkpoint blockade for cancer immune therapy","funder_award_id":"P01CA210944","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320327561","display_name":"LEO Fondet","ror":"https://ror.org/02rgsr590"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320338333","display_name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","ror":"https://ror.org/00vkwep27"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W255554239","https://openalex.org/W1521451515","https://openalex.org/W1599208480","https://openalex.org/W1795707064","https://openalex.org/W1850631646","https://openalex.org/W1965031244","https://openalex.org/W1966644185","https://openalex.org/W1981165130","https://openalex.org/W1984883254","https://openalex.org/W1988928779","https://openalex.org/W2019552331","https://openalex.org/W2049740824","https://openalex.org/W2076936076","https://openalex.org/W2077116159","https://openalex.org/W2077997913","https://openalex.org/W2081098333","https://openalex.org/W2098855695","https://openalex.org/W2101372260","https://openalex.org/W2103056503","https://openalex.org/W2104966044","https://openalex.org/W2112604002","https://openalex.org/W2113217592","https://openalex.org/W2119308655","https://openalex.org/W2123106337","https://openalex.org/W2126274788","https://openalex.org/W2130410032","https://openalex.org/W2133465414","https://openalex.org/W2134122465","https://openalex.org/W2137526110","https://openalex.org/W2139591061","https://openalex.org/W2140883620","https://openalex.org/W2146512944","https://openalex.org/W2155893219","https://openalex.org/W2158333823","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2169456326","https://openalex.org/W2232693424","https://openalex.org/W2478467838","https://openalex.org/W2503407514","https://openalex.org/W2509957998","https://openalex.org/W2541574334","https://openalex.org/W2554850815","https://openalex.org/W2577066650","https://openalex.org/W2588544503","https://openalex.org/W2600304928","https://openalex.org/W2746133516","https://openalex.org/W2766745368","https://openalex.org/W2785085486","https://openalex.org/W2792081113","https://openalex.org/W2795386665","https://openalex.org/W2807157442","https://openalex.org/W2888344630","https://openalex.org/W2897805491","https://openalex.org/W2902652978","https://openalex.org/W2903754922","https://openalex.org/W2913558101","https://openalex.org/W2919147181","https://openalex.org/W2943668434","https://openalex.org/W2946173685","https://openalex.org/W2947617159","https://openalex.org/W2949177718","https://openalex.org/W2951520325","https://openalex.org/W2951598503","https://openalex.org/W2952815301","https://openalex.org/W2969718750","https://openalex.org/W2975736685","https://openalex.org/W2990427812","https://openalex.org/W2993390900","https://openalex.org/W2999410311","https://openalex.org/W3013298623","https://openalex.org/W3014673551","https://openalex.org/W3020888809","https://openalex.org/W3039660273","https://openalex.org/W3042559121","https://openalex.org/W3116165322","https://openalex.org/W3119279345","https://openalex.org/W3131540301","https://openalex.org/W3133076643","https://openalex.org/W3216791550","https://openalex.org/W4206139053","https://openalex.org/W4220924887","https://openalex.org/W4230096730","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W4319434007","https://openalex.org/W4281643163","https://openalex.org/W4313368498","https://openalex.org/W1850631646","https://openalex.org/W4313369196","https://openalex.org/W4394578579","https://openalex.org/W2953279006","https://openalex.org/W4320481394","https://openalex.org/W4391304159","https://openalex.org/W3128401419"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-05-27T00:00:00"}
