{"id":"https://openalex.org/W4281556483","doi":"https://doi.org/10.21608/ejchem.2022.132222.5856","title":"Sulforaphane can intensify the antitumor effect of gemcitabine by targeting cancer stem cells in non-small cell lung cancer via suppressing TGF-\u03b21/TNF-\u03b1 factor","display_name":"Sulforaphane can intensify the antitumor effect of gemcitabine by targeting cancer stem cells in non-small cell lung cancer via suppressing TGF-\u03b21/TNF-\u03b1 factor","publication_year":2022,"publication_date":"2022-05-22","ids":{"openalex":"https://openalex.org/W4281556483","doi":"https://doi.org/10.21608/ejchem.2022.132222.5856"},"language":"en","primary_location":{"id":"doi:10.21608/ejchem.2022.132222.5856","doi":"https://doi.org/10.21608/ejchem.2022.132222.5856","is_oa":false,"landing_page_url":"https://doi.org/10.21608/ejchem.2022.132222.5856","pdf_url":null,"source":{"id":"https://openalex.org/S4210174320","display_name":"Egyptian Journal of Chemistry","issn_l":"0449-2285","issn":["0449-2285","2357-0245"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Journal of Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ibrahim Zahran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ibrahim Zahran","raw_affiliation_strings":["Chemistry Department, Faculty of Science, \nHelwan University, Ain Helwan, 11795\nCairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, \nHelwan University, Ain Helwan, 11795\nCairo, Egypt","institution_ids":["https://openalex.org/I84058292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048069255","display_name":"Enas Mahmoud Moustafa","orcid":"https://orcid.org/0000-0003-0484-5759","observed_orcids":["https://orcid.org/0000-0003-0484-5759"]},"institutions":[{"id":"https://openalex.org/I3089115","display_name":"Egyptian Atomic Energy Authority","ror":"https://ror.org/04hd0yz67","country_code":"EG","type":"government","lineage":["https://openalex.org/I3089115"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Enas Moustafa","raw_affiliation_strings":["Radiation Biology Department\nNational Center for Radiation Research and Technology\nEgyptian Atomic Energy Authority, Nasr City,11787\nCairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Biology Department\nNational Center for Radiation Research and Technology\nEgyptian Atomic Energy Authority, Nasr City,11787\nCairo, Egypt","institution_ids":["https://openalex.org/I3089115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032471597","display_name":"Manar Seleem Fouda","orcid":"https://orcid.org/0000-0002-8315-2143","observed_orcids":["https://orcid.org/0000-0002-8315-2143"]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Manar Fouda","raw_affiliation_strings":["Chemistry Department, Faculty of Science, \nHelwan University, Ain Helwan, 11795\nCairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, \nHelwan University, Ain Helwan, 11795\nCairo, Egypt","institution_ids":["https://openalex.org/I84058292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085425199","display_name":"Fatma Elzahraa H. Salem","orcid":"https://orcid.org/0000-0002-4334-2081","observed_orcids":["https://orcid.org/0000-0002-4334-2081"]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Fatma Salem","raw_affiliation_strings":["Chemistry Department, Faculty of Science, \nHelwan University, Ain Helwan, 11795\nCairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, \nHelwan University, Ain Helwan, 11795\nCairo, Egypt","institution_ids":["https://openalex.org/I84058292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038247948","display_name":"Mohamed M. Omran","orcid":"https://orcid.org/0000-0001-8557-3104","observed_orcids":["https://orcid.org/0000-0001-8557-3104"]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed Omran","raw_affiliation_strings":["Chemistry Department, Faculty of Science, \nHelwan University, Ain Helwan, 11795\nCairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, \nHelwan University, Ain Helwan, 11795\nCairo, Egypt","institution_ids":["https://openalex.org/I84058292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"0","issue":"0","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulforaphane","display_name":"sulforaphane","score":1.0},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.9729999899864197},{"id":"https://openalex.org/keywords/aldh1a1","display_name":"ALDH1A1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8610000014305115},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7300000190734863},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2780841255","wikidata":"https://www.wikidata.org/wiki/Q424489","display_name":"Sulforaphane","level":2,"score":0.9720155000686646},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.710881233215332},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.6441415548324585},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6259256601333618},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5962938070297241},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.515340268611908},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4764459431171417},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4720628559589386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4616284668445587},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4254933297634125},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40549495816230774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35073208808898926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24579468369483948},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10279673337936401}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21608/ejchem.2022.132222.5856","doi":"https://doi.org/10.21608/ejchem.2022.132222.5856","is_oa":false,"landing_page_url":"https://doi.org/10.21608/ejchem.2022.132222.5856","pdf_url":null,"source":{"id":"https://openalex.org/S4210174320","display_name":"Egyptian Journal of Chemistry","issn_l":"0449-2285","issn":["0449-2285","2357-0245"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Journal of Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2568391148","https://openalex.org/W3133266120","https://openalex.org/W2004215099","https://openalex.org/W4321496399","https://openalex.org/W4247857637","https://openalex.org/W4297347915","https://openalex.org/W3048232459","https://openalex.org/W4415231334","https://openalex.org/W4318196629","https://openalex.org/W2745004068"],"abstract_inverted_index":{"Cancer":[0],"stem":[1],"cells":[2,5,26,136],"(CSCs)":[3],"are":[4,27],"in":[6,18,57,103,149,165,177],"a":[7,19,42,114,158],"malignancy":[8],"that":[9,109,172],"have":[10],"the":[11,58,120,155,167],"potential":[12],"to":[13,30,32,137,154],"self-renew":[14],"and":[15,45,52,80,89,181],"differentiate,":[16],"resulting":[17],"diverse":[20],"population":[21],"of":[22,122,145,169],"cancer":[23,62,151],"cells.":[24,124],"These":[25],"increasingly":[28],"linked":[29],"resistance":[31,180],"traditional":[33],"therapies,":[34],"as":[35,37],"well":[36],"tumour":[38],"recurrence.":[39,182],"Sulforaphane":[40],"(SFN),":[41],"strong":[43],"anti-cancer":[44],"well-tolerated":[46],"nutritional":[47],"substance,":[48],"reduces":[49],"CSC":[50,94,147],"characteristics":[51],"improves":[53],"gemcitabine":[54],"therapeutic":[55],"effectiveness":[56],"non-small":[59],"cell":[60],"lung":[61,150],"(NSCLC)":[63],"rat":[64],"model.":[65],"Gemcitabine":[66],"(GEM)":[67],"and/or":[68,111],"SFN":[69,112,133],"enhance":[70],"these":[71],"capabilities":[72],"by":[73,101,143],"reducing":[74],"transforming":[75],"growth":[76],"factor":[77,83],"beta1":[78],"(TGF-\u03b21)":[79],"tumor":[81],"necrosis":[82],"alpha":[84],"(TNF-\u03b1),":[85],"which":[86,140],"target":[87],"CD133":[88],"aldehyde":[90],"dehydrogenase":[91],"1A1":[92],"(ALDH1A1)":[93],"markers.":[95],"This":[96],"discovery":[97],"was":[98,141],"supported":[99],"further":[100],"changes":[102],"histological":[104],"findings.":[105,156],"Furthermore,":[106],"we":[107],"demonstrated":[108,162],"GEM":[110,138],"had":[113],"highly":[115],"substantial":[116],"inhibitory":[117],"effect":[118],"on":[119],"viability":[121],"A549":[123],"In":[125],"vitro,":[126],"combination":[127,159],"treatment":[128],"increased":[129],"chemotherapeutic":[130],"drug":[131],"cytotoxicity.":[132],"sensitized":[134],"NSCLC":[135,179],"effectiveness,":[139],"accompanied":[142],"suppression":[144],"GEM-induced":[146],"formation":[148],"tissues":[152],"according":[153],"GEM+SFN,":[157],"therapy,":[160],"has":[161],"promising":[163],"results":[164],"restricting":[166],"availability":[168],"CSCs,":[170],"suggesting":[171],"it":[173],"might":[174],"be":[175],"effective":[176],"combating":[178]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-27T00:00:00"}
