{"id":"https://openalex.org/W4281550146","doi":"https://doi.org/10.21608/ejhm.2022.239189","title":"Evaluation of the Effect of Combination Chemotherapy with Five-day Infusion of Fluorouracil plus Vinorelbine in Pretreated Metastatic Breast Cancer Patients","display_name":"Evaluation of the Effect of Combination Chemotherapy with Five-day Infusion of Fluorouracil plus Vinorelbine in Pretreated Metastatic Breast Cancer Patients","publication_year":2022,"publication_date":"2022-05-26","ids":{"openalex":"https://openalex.org/W4281550146","doi":"https://doi.org/10.21608/ejhm.2022.239189"},"language":"en","primary_location":{"id":"doi:10.21608/ejhm.2022.239189","doi":"https://doi.org/10.21608/ejhm.2022.239189","is_oa":true,"landing_page_url":"https://doi.org/10.21608/ejhm.2022.239189","pdf_url":"https://ejhm.journals.ekb.eg/article_239189_00a75b91d49c41fce24aafb992f871ef.pdf","source":{"id":"https://openalex.org/S2764396899","display_name":"The Egyptian Journal of Hospital Medicine","issn_l":"1687-2002","issn":["1687-2002","2090-7125"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2","poland-20"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Hospital Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ejhm.journals.ekb.eg/article_239189_00a75b91d49c41fce24aafb992f871ef.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055657991","display_name":"Mai Ezz El Din","orcid":"https://orcid.org/0000-0002-2109-606X","observed_orcids":["https://orcid.org/0000-0002-2109-606X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mai Ezz El Din","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Rasha Salah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rasha Salah","raw_affiliation_strings":["Department of Clinical Oncology, El Salam Oncology Centre, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, El Salam Oncology Centre, Cairo, Egypt","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025267424","display_name":"Tarek Kamel","orcid":"https://orcid.org/0000-0001-5896-6068","observed_orcids":["https://orcid.org/0000-0001-5896-6068"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Tarek Kamel","raw_affiliation_strings":["Department of Clinical Oncology, Faculty of Medicine, Ain Shams University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Faculty of Medicine, Ain Shams University, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061100413","display_name":"Ahmed Mohamed Nagy","orcid":"https://orcid.org/0000-0002-7960-8347","observed_orcids":["https://orcid.org/0000-0002-7960-8347"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Nagy","raw_affiliation_strings":["Department of Clinical Oncology, Faculty of Medicine, Ain Shams University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Faculty of Medicine, Ain Shams University, Egypt","institution_ids":["https://openalex.org/I107720978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1122,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35208842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"88","issue":"1","first_page":"2554","last_page":"2560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.10409999638795853,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.984000027179718},{"id":"https://openalex.org/keywords/continuous-infusion-chemotherapy","display_name":"continuous infusion chemotherapy","score":0.777999997138977},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9440000057220459},{"id":"https://openalex.org/keywords/vinorelbine","display_name":"vinorelbine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.652999997138977},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9660000205039978},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7820000052452087},{"id":"https://openalex.org/keywords/stomatitis","display_name":"stomatitis","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9858035445213318},{"id":"https://openalex.org/C2780350996","wikidata":"https://www.wikidata.org/wiki/Q420532","display_name":"Vinorelbine","level":4,"score":0.85954749584198},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.8351245522499084},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.7224117517471313},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.619415283203125},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4915390908718109},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4684790372848511},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4647466540336609},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3926602005958557},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21608/ejhm.2022.239189","doi":"https://doi.org/10.21608/ejhm.2022.239189","is_oa":true,"landing_page_url":"https://doi.org/10.21608/ejhm.2022.239189","pdf_url":"https://ejhm.journals.ekb.eg/article_239189_00a75b91d49c41fce24aafb992f871ef.pdf","source":{"id":"https://openalex.org/S2764396899","display_name":"The Egyptian Journal of Hospital Medicine","issn_l":"1687-2002","issn":["1687-2002","2090-7125"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2","poland-20"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Hospital Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21608/ejhm.2022.239189","doi":"https://doi.org/10.21608/ejhm.2022.239189","is_oa":true,"landing_page_url":"https://doi.org/10.21608/ejhm.2022.239189","pdf_url":"https://ejhm.journals.ekb.eg/article_239189_00a75b91d49c41fce24aafb992f871ef.pdf","source":{"id":"https://openalex.org/S2764396899","display_name":"The Egyptian Journal of Hospital Medicine","issn_l":"1687-2002","issn":["1687-2002","2090-7125"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2","poland-20"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Hospital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281550146.pdf","grobid_xml":"https://content.openalex.org/works/W4281550146.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W143502260","https://openalex.org/W1500477185","https://openalex.org/W1811085086","https://openalex.org/W1830813972","https://openalex.org/W1843618725","https://openalex.org/W1895414556","https://openalex.org/W1946638503","https://openalex.org/W1967612488","https://openalex.org/W1973567302","https://openalex.org/W1989499233","https://openalex.org/W1999691599","https://openalex.org/W2013042796","https://openalex.org/W2019607817","https://openalex.org/W2024793633","https://openalex.org/W2039176586","https://openalex.org/W2040527029","https://openalex.org/W2064920797","https://openalex.org/W2074146123","https://openalex.org/W2082803388","https://openalex.org/W2083292321","https://openalex.org/W2087595493","https://openalex.org/W2093589630","https://openalex.org/W2110617366","https://openalex.org/W2133176934","https://openalex.org/W2136536672","https://openalex.org/W2160834915","https://openalex.org/W2165819904","https://openalex.org/W2257973466","https://openalex.org/W2283947545","https://openalex.org/W2364007313","https://openalex.org/W2442771997","https://openalex.org/W3128646645","https://openalex.org/W3212063988","https://openalex.org/W6607362254"],"related_works":["https://openalex.org/W2039176586","https://openalex.org/W2083292321","https://openalex.org/W2008747642","https://openalex.org/W2034901299","https://openalex.org/W2416933833","https://openalex.org/W2149823615","https://openalex.org/W2079681602","https://openalex.org/W2034861222","https://openalex.org/W1946638503","https://openalex.org/W2086949219"],"abstract_inverted_index":{"Background:":[0],"Continuous":[1],"infusion":[2,117],"(CI)":[3],"of":[4,42,63,77,143],"5-fluorouracil":[5],"(5FU)":[6],"and":[7,10,22,39,52,58,71,103,110,130,171,176,202],"vinorelbine,":[8],"individually":[9],"in":[11,16,45,173,190,207,211],"combination,":[12],"has":[13],"been":[14],"proven":[15],"several":[17],"studies":[18],"to":[19,34,86,204],"be":[20,205],"active":[21,189],"well":[23,163],"tolerated":[24],"for":[25,96,138],"advanced":[26],"pretreated":[27,46],"breast":[28,48,194],"cancer.":[29],"Objective:":[30],"This":[31,54,185],"study":[32,56],"sought":[33],"evaluate":[35],"the":[36,60,81,180,208],"clinical":[37,140],"activity":[38],"side":[40],"effects":[41],"their":[43],"combination":[44,187],"metastatic":[47,191],"cancer":[49,195],"patients.":[50],"Patients":[51],"Methods:":[53],"retrospective":[55],"collected":[57],"analysed":[59],"medical":[61],"records":[62],"fifty-four":[64],"patients":[65,196],"who":[66],"attended":[67],"El-Salam":[68],"Oncology":[69,79],"Center":[70],"Ain":[72],"Shams":[73],"University":[74],"Hospitals,":[75],"Department":[76],"Clinical":[78],"during":[80],"period":[82],"from":[83],"July":[84],"2013":[85],"June":[87],"2018.":[88],"Combination":[89],"chemotherapy":[90],"received":[91],"was":[92,150,158,162],"5FU":[93],"600":[94],"mg/m2/d":[95],"5":[97,111],"consecutive":[98],"days":[99,108],"as":[100,112,179],"a":[101,113,139],"CI":[102],"vinorelbine":[104],"25":[105],"mg/m2":[106],"on":[107],"1":[109],"short":[114],"intravenous":[115],"(IV)":[116],"every":[118],"3":[119,167],"weeks.":[120],"Results:":[121],"Eleven":[122],"(20.4%)":[123],"complete":[124],"responses,":[125],"20":[126],"(37%)":[127],"partial":[128],"responses":[129],"14":[131],"(25.9%)":[132],"stable":[133],"disease":[134],"were":[135],"documented,":[136],"accounting":[137],"benefit":[141],"rate":[142],"83.3%.":[144],"The":[145,153],"median":[146,154],"progression":[147],"free":[148],"survival":[149,156],"6.8":[151],"months.":[152,160],"overall":[155],"(mOS)":[157],"25.8":[159],"Treatment":[161],"tolerated,":[164],"with":[165,197],"grade":[166],"anemia,":[168],"febrile":[169],"neutropenia":[170],"stomatitis":[172],"9.3%,":[174],"5.6%":[175],"1.9%":[177],"respectively":[178],"main":[181],"adverse":[182],"reactions.":[183],"Conclusions:":[184],"drug":[186],"is":[188],"previously":[192],"treated":[193],"an":[198],"acceptable":[199],"toxicity":[200],"profile":[201],"continues":[203],"present":[206],"treatment":[209],"armamentarium":[210],"this":[212],"setting.":[213]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-27T00:00:00"}