{"id":"https://openalex.org/W4281492013","doi":"https://doi.org/10.3389/fimmu.2022.872652","title":"Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis","display_name":"Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis","publication_year":2022,"publication_date":"2022-05-25","ids":{"openalex":"https://openalex.org/W4281492013","doi":"https://doi.org/10.3389/fimmu.2022.872652","pmid":"https://pubmed.ncbi.nlm.nih.gov/35693816","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9174537"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.872652","doi":"https://doi.org/10.3389/fimmu.2022.872652","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.872652","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2022.872652","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"P. Spencer Gill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Spencer Gill","raw_affiliation_strings":["Center for Inflammation, Infectious Disease, and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States","Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Inflammation, Infectious Disease, and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040254279","display_name":"Tammy R. Ozment","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy R. Ozment","raw_affiliation_strings":["Center for Inflammation, Infectious Disease, and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States","Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Inflammation, Infectious Disease, and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048649216","display_name":"Nicole H. Lewis","orcid":"https://orcid.org/0000-0001-7699-3684","observed_orcids":["https://orcid.org/0000-0001-7699-3684"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole H. Lewis","raw_affiliation_strings":["Department of Medical Education, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Education, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028649129","display_name":"Edward R. Sherwood","orcid":"https://orcid.org/0000-0002-9505-7178","observed_orcids":["https://orcid.org/0000-0002-9505-7178"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward R. Sherwood","raw_affiliation_strings":["Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, United States","Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033677559","display_name":"David L. Williams","orcid":"https://orcid.org/0000-0002-4586-9290","observed_orcids":["https://orcid.org/0000-0002-4586-9290"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David L. Williams","raw_affiliation_strings":["Center for Inflammation, Infectious Disease, and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States","Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Inflammation, Infectious Disease, and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States","institution_ids":["https://openalex.org/I119443389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033677559"],"corresponding_institution_ids":["https://openalex.org/I119443389"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.8133,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.85266116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"872652","last_page":"872652"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trained-immunity","display_name":"trained immunity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8930000066757202},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9089999794960022},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/beta-glucan","display_name":"\u03b2-glucan","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8600000143051147},{"id":"https://openalex.org/keywords/h3k27-acetylation","display_name":"H3K27 acetylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-surface-markers","display_name":"cell surface markers","score":0.7829999923706055},{"id":"https://openalex.org/keywords/age-related-immune-decline","display_name":"age-related immune decline","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7869186401367188},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7413791418075562},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6830242276191711},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6681813597679138},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.66426682472229},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6363275051116943},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5062097907066345},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4962940812110901},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4742618799209595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4734441936016083},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44798827171325684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3537885248661041},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047071","descriptor_name":"beta-Glucans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2022.872652","doi":"https://doi.org/10.3389/fimmu.2022.872652","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.872652","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9174537","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9174537","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:35693816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35693816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:227ddbaf4cfd4dbfbd351ec7dc33fed6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/227ddbaf4cfd4dbfbd351ec7dc33fed6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.872652","doi":"https://doi.org/10.3389/fimmu.2022.872652","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.872652","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1124746885","display_name":"Cellular and Molecular Mechanisms of Fungal Sepsis in the Critically Ill Patient","funder_award_id":"R01GM122934","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3704674955","display_name":"Macrophage mitochodrial reprogramming and innate immune memory","funder_award_id":"R01AI151210","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5507603376","display_name":"Training Innate Immunity: A new approach to the treatment of Sepsis","funder_award_id":"R01GM119197","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7505768856","display_name":null,"funder_award_id":"C0RR036551","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G94186973","display_name":"Innate Immunity and Cardiovascular Function in Sepsis","funder_award_id":"R01GM083016","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1486303545","https://openalex.org/W1984164811","https://openalex.org/W2017341404","https://openalex.org/W2044687960","https://openalex.org/W2051020804","https://openalex.org/W2058743791","https://openalex.org/W2059403792","https://openalex.org/W2066222426","https://openalex.org/W2067031028","https://openalex.org/W2114749317","https://openalex.org/W2126924404","https://openalex.org/W2129203245","https://openalex.org/W2138694950","https://openalex.org/W2140876277","https://openalex.org/W2141210456","https://openalex.org/W2171144560","https://openalex.org/W2202756526","https://openalex.org/W2223946157","https://openalex.org/W2280404143","https://openalex.org/W2301209689","https://openalex.org/W2341087784","https://openalex.org/W2395545335","https://openalex.org/W2468925656","https://openalex.org/W2540365220","https://openalex.org/W2562443541","https://openalex.org/W2589917023","https://openalex.org/W2604554752","https://openalex.org/W2626120438","https://openalex.org/W2735891807","https://openalex.org/W2773578465","https://openalex.org/W2798053566","https://openalex.org/W2887700639","https://openalex.org/W2901994942","https://openalex.org/W2972334025","https://openalex.org/W3009920944","https://openalex.org/W3035001102","https://openalex.org/W3038535330","https://openalex.org/W3044571009","https://openalex.org/W3047720006","https://openalex.org/W3048153655","https://openalex.org/W3081629575","https://openalex.org/W3106444534","https://openalex.org/W3112419967","https://openalex.org/W3125562442","https://openalex.org/W3208998528"],"related_works":["https://openalex.org/W7043724437","https://openalex.org/W4405792874","https://openalex.org/W2900474461","https://openalex.org/W4406809107","https://openalex.org/W7154660015","https://openalex.org/W4406447365","https://openalex.org/W2918178231","https://openalex.org/W3047982948","https://openalex.org/W7165536246","https://openalex.org/W4285612418"],"abstract_inverted_index":{"Aging":[0],"plays":[1],"a":[2,38,149],"critical":[3],"role":[4],"in":[5,21,45,58,64,111,123,157,188],"the":[6,59,65,71,130],"incidence":[7],"and":[8,31,35,104,175],"severity":[9],"of":[10,19,67,73,106,132,153],"infection,":[11],"with":[12],"age":[13,163],"emerging":[14],"as":[15,37,88,90,191,193],"an":[16],"independent":[17],"predictor":[18],"mortality":[20],"sepsis.":[22,48,68],"Trained":[23,165],"immunity":[24,57,122,147],"reprograms":[25],"immunocytes":[26],"to":[27,33,41,120,129],"respond":[28],"more":[29],"rapidly":[30],"effectively":[32],"pathogens":[34],"serves":[36],"potential":[39],"approach":[40],"improve":[42],"immune":[43,61,77,183],"function":[44],"aging":[46,60,82,116,125,189],"and/or":[47],"However,":[49],"there":[50],"is":[51],"very":[52],"little":[53],"data":[54],"on":[55,79],"trained":[56,112,121,146],"system":[62],"or":[63],"presence":[66],"We":[69,93],"examined":[70],"impact":[72],"\u03b2-glucan":[74],"induced":[75,148,187],"innate":[76],"training":[78,184],"monocytes":[80,113,126,133,158,166,190,194],"from":[81,114,134,167,195],"healthy":[83,115,124],"humans":[84],"(>60":[85],"years":[86],"old)":[87],"well":[89,192],"sepsis":[91,168,198],"patients.":[92,199],"observed":[94],"increased":[95,101,176],"metabolic":[96,173],"capacity,":[97],"upregulated":[98],"cytokine":[99,177],"secretion,":[100],"H3K27":[102],"acetylation,":[103],"upregulation":[105],"crucial":[107],"intracellular":[108],"signaling":[109],"pathways":[110],"subjects.":[117],"The":[118],"response":[119,131],"was":[127,160],"equivalent":[128],"younger,":[135],"i.e.,":[136],"18":[137],"\u2013":[138],"59":[139],"years,":[140],"individuals.":[141],"Additionally,":[142],"we":[143],"found":[144],"that":[145,159,182],"unique":[150],"expression":[151],"pattern":[152],"cell":[154],"surface":[155],"markers":[156],"consistent":[161],"across":[162],"groups.":[164],"patients":[169],"also":[170],"displayed":[171],"enhanced":[172],"capacity":[174],"production.":[178],"These":[179],"results":[180],"indicate":[181],"can":[185],"be":[186],"critically":[196],"ill":[197]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-26T00:00:00"}
