{"id":"https://openalex.org/W4281485602","doi":"https://doi.org/10.1016/j.alit.2022.04.003","title":"Peripheral itch sensitization in atopic dermatitis","display_name":"Peripheral itch sensitization in atopic dermatitis","publication_year":2022,"publication_date":"2022-05-25","ids":{"openalex":"https://openalex.org/W4281485602","doi":"https://doi.org/10.1016/j.alit.2022.04.003","pmid":"https://pubmed.ncbi.nlm.nih.gov/35624035"},"language":"en","primary_location":{"id":"doi:10.1016/j.alit.2022.04.003","doi":"https://doi.org/10.1016/j.alit.2022.04.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.alit.2022.04.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1323893022000417/pdf","source":{"id":"https://openalex.org/S116585092","display_name":"Allergology International","issn_l":"1323-8930","issn":["1323-8930","1440-1592"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology International","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1323893022000417/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012980973","display_name":"Mitsutoshi Tominaga","orcid":"https://orcid.org/0000-0002-1254-1803","observed_orcids":["https://orcid.org/0000-0002-1254-1803"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mitsutoshi Tominaga","raw_affiliation_strings":["Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan; Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, Chiba, Japan. Electronic address: tominaga@juntendo.ac.jp","Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, Chiba, Japan","Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1254-1803","affiliations":[{"raw_affiliation_string":"Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan; Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, Chiba, Japan. Electronic address: tominaga@juntendo.ac.jp","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048504310","display_name":"Kenji Takamori","orcid":"https://orcid.org/0000-0002-0644-0504","observed_orcids":["https://orcid.org/0000-0002-0644-0504"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]},{"id":"https://openalex.org/I4210137488","display_name":"Juntendo University Urayasu Hospital","ror":"https://ror.org/03gxkq182","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137488"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Takamori","raw_affiliation_strings":["Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan; Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, Chiba, Japan; Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan","Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, Chiba, Japan","Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan","Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan; Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, Chiba, Japan; Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I34077901","https://openalex.org/I4210137488"]},{"raw_affiliation_string":"Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4210137488"]},{"raw_affiliation_string":"Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I34077901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012980973"],"corresponding_institution_ids":["https://openalex.org/I34077901"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":{"value":0,"currency":"USD","value_usd":0},"fwci":5.5428,"has_fulltext":true,"cited_by_count":171,"citation_normalized_percentile":{"value":0.98449167,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"71","issue":"3","first_page":"265","last_page":"277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":1.0},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.8180000185966492},{"id":"https://openalex.org/keywords/itch-scratch-cycle","display_name":"itch-scratch cycle","score":0.7839999794960022},{"id":"https://openalex.org/keywords/skin-barrier-dysfunction","display_name":"skin barrier dysfunction","score":0.8870000243186951},{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":0.7730000019073486},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/intraepidermal-nerve-fibers","display_name":"intraepidermal nerve fibers","score":0.906000018119812},{"id":"https://openalex.org/keywords/type-2-cytokines","display_name":"type 2 cytokines","score":0.7369999885559082},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.7990000247955322},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":1.0},{"id":"https://openalex.org/keywords/il-31","display_name":"IL-31","score":0.9990000128746033},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/house-dust-mite-allergens","display_name":"house dust mite allergens","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neuroimmune-interactions","display_name":"neuroimmune interactions","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.8443301916122437},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6966399550437927},{"id":"https://openalex.org/C2780196728","wikidata":"https://www.wikidata.org/wiki/Q1413166","display_name":"Scratching","level":2,"score":0.688935399055481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6868370771408081},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6283499598503113},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5202226042747498},{"id":"https://openalex.org/C2777464272","wikidata":"https://www.wikidata.org/wiki/Q5309747","display_name":"Dryness","level":2,"score":0.4889339506626129},{"id":"https://openalex.org/C2777035695","wikidata":"https://www.wikidata.org/wiki/Q1929023","display_name":"Dry skin","level":2,"score":0.4517780840396881},{"id":"https://openalex.org/C2776056826","wikidata":"https://www.wikidata.org/wiki/Q16242752","display_name":"Allergic contact dermatitis","level":3,"score":0.42977476119995117},{"id":"https://openalex.org/C2779824493","wikidata":"https://www.wikidata.org/wiki/Q5315925","display_name":"Dupilumab","level":3,"score":0.41679179668426514},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.35324734449386597},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011537","descriptor_name":"Pruritus","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011537","descriptor_name":"Pruritus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.alit.2022.04.003","doi":"https://doi.org/10.1016/j.alit.2022.04.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.alit.2022.04.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1323893022000417/pdf","source":{"id":"https://openalex.org/S116585092","display_name":"Allergology International","issn_l":"1323-8930","issn":["1323-8930","1440-1592"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology International","raw_type":"journal-article"},{"id":"pmid:35624035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35624035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology international : official journal of the Japanese Society of Allergology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a67e50b1a1ef43acae471a7f43a5d7ab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a67e50b1a1ef43acae471a7f43a5d7ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Allergology International, Vol 71, Iss 3, Pp 265-277 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.alit.2022.04.003","doi":"https://doi.org/10.1016/j.alit.2022.04.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.alit.2022.04.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1323893022000417/pdf","source":{"id":"https://openalex.org/S116585092","display_name":"Allergology International","issn_l":"1323-8930","issn":["1323-8930","1440-1592"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1639728832","display_name":null,"funder_award_id":"22H02956","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2787539732","display_name":"Elucidation of the mechanism of itch control by targeting skin-distributed mu-opioid receptors and development of new antipruritic topical agents","funder_award_id":"23K20320","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4928619991","display_name":null,"funder_award_id":"S1311011","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5103065146","display_name":"Elucidation of the mechanisms of alloknesis (itch hypersensitivity) and development of treatment","funder_award_id":"18K07396","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5712049267","display_name":null,"funder_award_id":"20H03568","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6364325561","display_name":"Development of oral antipruritic drugs by elucidating the spinal alloknesis circuitry","funder_award_id":"23K24217","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320323513","display_name":"Cosmetology Research Foundation","ror":"https://ror.org/013n55y95"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281485602.pdf","grobid_xml":"https://content.openalex.org/works/W4281485602.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W1528306168","https://openalex.org/W1555167286","https://openalex.org/W1808158484","https://openalex.org/W1945577104","https://openalex.org/W1951576969","https://openalex.org/W1964444312","https://openalex.org/W1965915954","https://openalex.org/W1969655931","https://openalex.org/W1970404910","https://openalex.org/W1972780851","https://openalex.org/W1974895367","https://openalex.org/W1979126820","https://openalex.org/W1981003526","https://openalex.org/W1988011157","https://openalex.org/W1993502009","https://openalex.org/W1997380538","https://openalex.org/W2001603256","https://openalex.org/W2002935694","https://openalex.org/W2004248084","https://openalex.org/W2016979573","https://openalex.org/W2018203891","https://openalex.org/W2018905766","https://openalex.org/W2020279617","https://openalex.org/W2021468215","https://openalex.org/W2033072655","https://openalex.org/W2035459676","https://openalex.org/W2039990838","https://openalex.org/W2040780713","https://openalex.org/W2041515888","https://openalex.org/W2042298303","https://openalex.org/W2045026834","https://openalex.org/W2045634023","https://openalex.org/W2055706749","https://openalex.org/W2060891980","https://openalex.org/W2062447716","https://openalex.org/W2065094796","https://openalex.org/W2065246339","https://openalex.org/W2067510223","https://openalex.org/W2069573332","https://openalex.org/W2070803915","https://openalex.org/W2071359561","https://openalex.org/W2072653944","https://openalex.org/W2074043272","https://openalex.org/W2074547900","https://openalex.org/W2074926332","https://openalex.org/W2076734646","https://openalex.org/W2077529892","https://openalex.org/W2082144986","https://openalex.org/W2083380164","https://openalex.org/W2084634816","https://openalex.org/W2084675187","https://openalex.org/W2084935555","https://openalex.org/W2087004322","https://openalex.org/W2092625551","https://openalex.org/W2093102705","https://openalex.org/W2096194006","https://openalex.org/W2101428179","https://openalex.org/W2105176852","https://openalex.org/W2121392603","https://openalex.org/W2128598867","https://openalex.org/W2137990000","https://openalex.org/W2155146800","https://openalex.org/W2155260685","https://openalex.org/W2156511362","https://openalex.org/W2158259619","https://openalex.org/W2160702994","https://openalex.org/W2163039776","https://openalex.org/W2164578214","https://openalex.org/W2165413281","https://openalex.org/W2165537285","https://openalex.org/W2166917684","https://openalex.org/W2169192341","https://openalex.org/W2199728488","https://openalex.org/W2324698448","https://openalex.org/W2518740409","https://openalex.org/W2546339689","https://openalex.org/W2549478702","https://openalex.org/W2552845751","https://openalex.org/W2588005135","https://openalex.org/W2588876255","https://openalex.org/W2589947839","https://openalex.org/W2615030262","https://openalex.org/W2615818071","https://openalex.org/W2750013446","https://openalex.org/W2752127863","https://openalex.org/W2752706812","https://openalex.org/W2767316178","https://openalex.org/W2788371497","https://openalex.org/W2788787807","https://openalex.org/W2801072880","https://openalex.org/W2883360817","https://openalex.org/W2885251099","https://openalex.org/W2890283911","https://openalex.org/W2893631054","https://openalex.org/W2900664323","https://openalex.org/W2901397443","https://openalex.org/W2914010879","https://openalex.org/W2936303415","https://openalex.org/W2952923709","https://openalex.org/W2956549677","https://openalex.org/W2968691478","https://openalex.org/W2969959484","https://openalex.org/W2970348403","https://openalex.org/W2971579095","https://openalex.org/W2971778691","https://openalex.org/W2979582832","https://openalex.org/W2983063065","https://openalex.org/W2997548580","https://openalex.org/W2999398470","https://openalex.org/W2999716574","https://openalex.org/W3003757612","https://openalex.org/W3008228715","https://openalex.org/W3014914329","https://openalex.org/W3035094346","https://openalex.org/W3046835420","https://openalex.org/W3080211491","https://openalex.org/W3115550390","https://openalex.org/W3119038672","https://openalex.org/W3128292268","https://openalex.org/W3137327640","https://openalex.org/W3165536054","https://openalex.org/W3175125488","https://openalex.org/W3177578813","https://openalex.org/W3188488714","https://openalex.org/W3197805702","https://openalex.org/W3200769092","https://openalex.org/W3205217240","https://openalex.org/W3212704133","https://openalex.org/W3213054806","https://openalex.org/W3213057710","https://openalex.org/W3213141717","https://openalex.org/W3215181486","https://openalex.org/W3215635193","https://openalex.org/W3215707863","https://openalex.org/W4211013257","https://openalex.org/W4214773221","https://openalex.org/W4229049133","https://openalex.org/W4249098321"],"related_works":["https://openalex.org/W2045634023","https://openalex.org/W2016780116","https://openalex.org/W3096642903","https://openalex.org/W4406942591","https://openalex.org/W2997259035","https://openalex.org/W4394695130","https://openalex.org/W4387564181","https://openalex.org/W2809640877","https://openalex.org/W7163325167","https://openalex.org/W2078153362"],"abstract_inverted_index":{"Atopic":[0],"dermatitis":[1,26],"is":[2,27,49,76,106,213],"a":[3,33,152,194,202],"skin":[4,8,15,75,117,122,241],"disorder":[5],"caused":[6],"by":[7,32,66,72,108,164],"dryness":[9],"and":[10,17,61,70,90,110,159,167,226],"barrier":[11,123],"dysfunction,":[12],"resulting":[13],"in":[14,57,187,229,236],"inflammation":[16],"chronic":[18],"itch":[19,37,47,80,94,102,105,176,212,234],"(or":[20],"pruritus).":[21],"The":[22],"pathogenesis":[23],"of":[24,35,45,63,88,120,129,146,180,218,232],"atopic":[25,99,190,219,237],"thought":[28,183],"to":[29,40,54,79,82,142,184,193,207],"be":[30],"initiated":[31],"lowering":[34,44],"the":[36,46,55,111,116,121,127,216,230],"threshold":[38,48],"due":[39,53,81],"dry":[41],"skin.":[42],"This":[43,198],"at":[50],"least":[51],"partially":[52],"increase":[56],"intraepidermal":[58],"nerve":[59,172],"fibers":[60,173],"sensitization":[62,235],"sensory":[64,171],"nerves":[65],"interleukin":[67],"(IL)-33":[68],"produced":[69],"secreted":[71,163],"keratinocytes.":[73],"Such":[74],"easily":[77],"prone":[78],"mechanical":[83],"stimuli,":[84],"such":[85,133],"as":[86,134],"rubbing":[87],"clothing":[89],"chemical":[91],"stimuli":[92],"from":[93,137],"mediators.":[95],"In":[96,221],"patients":[97,188],"with":[98,189],"dermatitis,":[100,191,238],"once":[101],"occurs,":[103],"further":[104,175],"induced":[107],"scratching,":[109],"associated":[112],"scratching":[113],"breaks":[114],"down":[115],"barrier.":[118],"Disruption":[119],"allows":[124],"entry":[125],"into":[126],"epidermis":[128],"external":[130],"foreign":[131],"substances,":[132],"allergens":[135],"derived":[136],"house":[138],"dust":[139],"mites,":[140],"leading":[141,192],"an":[143],"increased":[144],"induction":[145],"type":[147,154],"2":[148,155],"inflammatory":[149],"responses.":[150],"As":[151],"result,":[153],"cytokines":[156],"IL-4,":[157],"IL-13,":[158],"IL-31":[160],"are":[161,182],"mainly":[162],"Th2":[165],"cells,":[166],"their":[168],"action":[169],"on":[170,240],"causes":[174],"sensitization.":[177],"These":[178],"sequences":[179],"events":[181],"occur":[185],"simultaneously":[186],"vicious":[195,199],"itch-scratch":[196],"cycle.":[197],"cycle":[200],"becomes":[201],"negative":[203],"spiral":[204],"that":[205],"leads":[206],"disease":[208],"burden.":[209],"Therefore,":[210],"controlling":[211],"essential":[214],"for":[215],"treatment":[217],"dermatitis.":[220],"this":[222],"review,":[223],"we":[224],"summarize":[225],"discuss":[227],"advances":[228],"mechanisms":[231],"peripheral":[233],"focusing":[239],"barrier-neuro-immune":[242],"triadic":[243],"connectivity.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":43},{"year":2025,"cited_by_count":60},{"year":2024,"cited_by_count":33},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-05-26T00:00:00"}