{"id":"https://openalex.org/W4281484748","doi":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5804","title":"Pink1 Deficiency Enhances Pulmonary Vascular Remodeling and Aggravates Hypoxia-Induced Pulmonary Hypertension","display_name":"Pink1 Deficiency Enhances Pulmonary Vascular Remodeling and Aggravates Hypoxia-Induced Pulmonary Hypertension","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4281484748","doi":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5804"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5804","doi":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5804","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5804","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"D27. CASTRO: CELL SURVIVAL, ORGANELLES, AND VESICLES IN THE PULMONARY CIRCULATION","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017138601","display_name":"Rakhshinda Rehman","orcid":"https://orcid.org/0000-0002-1755-3416","observed_orcids":["https://orcid.org/0000-0002-1755-3416"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Rehman","raw_affiliation_strings":["Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065776968","display_name":"Paul B. Dieffenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.B. Dieffenbach","raw_affiliation_strings":["Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003559322","display_name":"Shamsudheen Karuthedath Vellarikkal","orcid":"https://orcid.org/0000-0002-6384-2948","observed_orcids":["https://orcid.org/0000-0002-6384-2948"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Karuthedath Vellarikkal","raw_affiliation_strings":["Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034554098","display_name":"K.V.Z. Vera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.V.Z. Vera","raw_affiliation_strings":["Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027518721","display_name":"Aoife Corcoran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.M. Corcoran","raw_affiliation_strings":["Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056363500","display_name":"Antonio Jose Luis Arciniegas","orcid":"https://orcid.org/0000-0002-8370-3996","observed_orcids":["https://orcid.org/0000-0002-8370-3996"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Arciniegas","raw_affiliation_strings":["Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101536710","display_name":"Jian Shen","orcid":"https://orcid.org/0000-0002-8889-9449","observed_orcids":["https://orcid.org/0000-0002-8889-9449"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Shen","raw_affiliation_strings":["Center for Neurologic Diseases, Brigham and Womens Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Brigham and Womens Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113569236","display_name":"HC Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.C. Lam","raw_affiliation_strings":["Medicine, Brigham and Womens Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Womens Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034927801","display_name":"L.E. Fredenburgh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.E. Fredenburgh","raw_affiliation_strings":["Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Critical Care Medicine, Brigham and Womens Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A5804","last_page":"A5804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pink1-deficiency","display_name":"PINK1 deficiency","score":0.7059999704360962},{"id":"https://openalex.org/keywords/pulmonary-vascular-remodeling","display_name":"pulmonary vascular remodeling","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.890999972820282},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mitochondrial-quality-control","display_name":"mitochondrial quality control","score":0.5249999761581421},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.375}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7494755983352661},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.6141273379325867},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.559073269367218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5428135991096497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4618808925151825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16626358032226562},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.09658309817314148},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5804","doi":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5804","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5804","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"D27. CASTRO: CELL SURVIVAL, ORGANELLES, AND VESICLES IN THE PULMONARY CIRCULATION","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3184166930","https://openalex.org/W4411797196","https://openalex.org/W6945227610","https://openalex.org/W2329585779","https://openalex.org/W2915762317","https://openalex.org/W2970567057","https://openalex.org/W3109469995","https://openalex.org/W2326789407","https://openalex.org/W2418229430","https://openalex.org/W2339526477"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-05-26T00:00:00"}