{"id":"https://openalex.org/W4281481237","doi":"https://doi.org/10.2174/1574893617666220524123825","title":"The Immune-based Prognostic Score for the Immunogenomic Landscape Aanalysis and Application of Chemotherapy in Breast Cancer","display_name":"The Immune-based Prognostic Score for the Immunogenomic Landscape Aanalysis and Application of Chemotherapy in Breast Cancer","publication_year":2022,"publication_date":"2022-05-25","ids":{"openalex":"https://openalex.org/W4281481237","doi":"https://doi.org/10.2174/1574893617666220524123825"},"language":"en","primary_location":{"id":"doi:10.2174/1574893617666220524123825","doi":"https://doi.org/10.2174/1574893617666220524123825","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1574893617666220524123825","pdf_url":null,"source":{"id":"https://openalex.org/S25854515","display_name":"Current Bioinformatics","issn_l":"1574-8936","issn":["1574-8936","2212-392X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000700883","display_name":"Qianzi Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qianzi Lu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100640302","display_name":"Shiyuan Wang","orcid":"https://orcid.org/0000-0002-5123-9690","observed_orcids":["https://orcid.org/0000-0002-5123-9690"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyuan Wang","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100836093","display_name":"Yi Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Pan","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036118358","display_name":"Yu Yao","orcid":"https://orcid.org/0000-0002-8366-4712","observed_orcids":["https://orcid.org/0000-0002-8366-4712"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Yu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043807380","display_name":"Yuqiang Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqiang Xiong","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089026965","display_name":"Haodong Wei","orcid":"https://orcid.org/0009-0003-0060-826X","observed_orcids":["https://orcid.org/0009-0003-0060-826X"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haodong Wei","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012353128","display_name":"Dongqing Su","orcid":"https://orcid.org/0000-0003-2101-1852","observed_orcids":["https://orcid.org/0000-0003-2101-1852"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongqing Su","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001300435","display_name":"Yongchun Zuo","orcid":"https://orcid.org/0000-0002-6065-7835","observed_orcids":["https://orcid.org/0000-0002-6065-7835","https://orcid.org/0000-0002-4953-2337"]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongchun Zuo","raw_affiliation_strings":["The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia\nUniversity, Hohhot, 010070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia\nUniversity, Hohhot, 010070, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057225835","display_name":"Lei Yang","orcid":"https://orcid.org/0000-0002-1133-9099","observed_orcids":["https://orcid.org/0000-0002-1133-9099"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Yang","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000700883","https://openalex.org/A5001300435","https://openalex.org/A5057225835"],"corresponding_institution_ids":["https://openalex.org/I156144747","https://openalex.org/I2722730"],"apc_list":null,"apc_paid":null,"fwci":0.1744,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.32951644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"17","issue":"7","first_page":"624","last_page":"631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8930000066757202},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.8339999914169312},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.8349999785423279},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8140000104904175},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.6980000138282776},{"id":"https://openalex.org/keywords/tumor-purity","display_name":"tumor purity","score":0.972000002861023},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8480261564254761},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7408649921417236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7229124903678894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6749004125595093},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6496903896331787},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5621225237846375},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4802604019641876},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20655936002731323}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/1574893617666220524123825","doi":"https://doi.org/10.2174/1574893617666220524123825","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1574893617666220524123825","pdf_url":null,"source":{"id":"https://openalex.org/S25854515","display_name":"Current Bioinformatics","issn_l":"1574-8936","issn":["1574-8936","2212-392X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Bioinformatics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3499448240","display_name":null,"funder_award_id":"LH2020C100","funder_id":"https://openalex.org/F4320323085","funder_display_name":"Natural Science Foundation of Heilongjiang Province"},{"id":"https://openalex.org/G6334680532","display_name":null,"funder_award_id":"LBH-Q19118","funder_id":"https://openalex.org/F4320316313","funder_display_name":"Postdoctoral Scientific Research Development Fund of Heilongjiang Province"},{"id":"https://openalex.org/G7685362454","display_name":null,"funder_award_id":"62173117","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8619683445","display_name":null,"funder_award_id":"32000473","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320316313","display_name":"Postdoctoral Scientific Research Development Fund of Heilongjiang Province","ror":"https://ror.org/0462e7n29"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323085","display_name":"Natural Science Foundation of Heilongjiang Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1966107523","https://openalex.org/W1968524627","https://openalex.org/W1985987855","https://openalex.org/W2004630197","https://openalex.org/W2034729689","https://openalex.org/W2035618305","https://openalex.org/W2112648444","https://openalex.org/W2114694330","https://openalex.org/W2130410032","https://openalex.org/W2130430382","https://openalex.org/W2146512944","https://openalex.org/W2157058802","https://openalex.org/W2159707944","https://openalex.org/W2269332562","https://openalex.org/W2466965232","https://openalex.org/W2725858612","https://openalex.org/W2771978163","https://openalex.org/W2774991280","https://openalex.org/W2780385632","https://openalex.org/W2793383346","https://openalex.org/W2889646458","https://openalex.org/W2901950397","https://openalex.org/W2940010972","https://openalex.org/W2949273159","https://openalex.org/W2979291688","https://openalex.org/W2991095295","https://openalex.org/W2999417355","https://openalex.org/W3009386543","https://openalex.org/W3111471842","https://openalex.org/W3119005666","https://openalex.org/W3128646645","https://openalex.org/W4211032970"],"related_works":["https://openalex.org/W3009386543","https://openalex.org/W3111471842","https://openalex.org/W3109470985","https://openalex.org/W3096934235","https://openalex.org/W4388196602","https://openalex.org/W4388419436","https://openalex.org/W3014336999","https://openalex.org/W4311183838","https://openalex.org/W3159154725","https://openalex.org/W3173843839"],"abstract_inverted_index":{"Background:":[0],"Breast":[1],"cancer":[2,5,41,69,106,121,171,202],"is":[3],"one":[4,12],"that":[6,159,180],"develops":[7],"from":[8,71],"breast":[9,40,54,68,105,120,170,201],"tissue":[10],"and":[11,43,51,100,126,149,154,192],"of":[13,20,53,66,112,130,200],"the":[14,18,24,37,49,62,72,113,119,131,138,147,155,160,181],"major":[15],"reasons":[16],"for":[17,145,197],"death":[19],"women":[21],"all":[22],"over":[23],"world.":[25],"The":[26,109],"tumor":[27,31,94],"infiltrating":[28],"lymphocytes":[29],"in":[30,39,48,104,169],"immune":[32,63,98,101],"microenvironment":[33],"are":[34],"correlated":[35,89],"with":[36,90,124],"prognosis":[38],"patients,":[42],"play":[44],"an":[45,75,188],"important":[46],"role":[47],"occurrence":[50],"development":[52],"cancer.":[55],"Method:":[56],"In":[57,136],"this":[58],"study,":[59],"by":[60,118],"integrated":[61],"gene":[64],"expression":[65],"20":[67],"cohorts":[70],"public":[73],"dataset,":[74],"immune-based":[76,82],"prognostic":[77,83,114,132,151,182,190],"score":[78,84,115,133,152,183],"was":[79,85,116,134,141,162],"established.":[80],"This":[81],"found":[86],"to":[87,143,164],"be":[88,185],"prognosis,":[91],"stromal":[92],"score,":[93],"purity,":[95],"three":[96],"famous":[97],"checkpoints,":[99],"escape":[102],"mechanism":[103],"patients.":[107,172],"Results:":[108],"clinical":[110],"application":[111],"verified":[117],"patients":[122,203],"treated":[123],"chemotherapy,":[125],"good":[127],"therapeutic":[128],"benefit":[129],"obtained.":[135],"addition,":[137],"XGBoost":[139,161],"classifier":[140],"used":[142,186],"construct":[144],"predicting":[146],"high":[148],"low":[150],"subtypes,":[153],"predictive":[156],"results":[157],"indicated":[158],"suitable":[163],"predict":[165],"these":[166,176],"two":[167],"subtypes":[168],"Conclusion:":[173],"Based":[174],"on":[175],"results,":[177],"we":[178],"believed":[179],"may":[184,193],"as":[187],"effective":[189],"marker":[191],"provide":[194],"great":[195],"help":[196],"chemotherapy":[198],"treatment":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2022-05-26T00:00:00"}
