{"id":"https://openalex.org/W4281477696","doi":"https://doi.org/10.3389/fphys.2022.898508","title":"The Less Well-Known Little Brothers: The SLC9B/NHA Sodium Proton Exchanger Subfamily\u2014Structure, Function, Regulation and Potential Drug-Target Approaches","display_name":"The Less Well-Known Little Brothers: The SLC9B/NHA Sodium Proton Exchanger Subfamily\u2014Structure, Function, Regulation and Potential Drug-Target Approaches","publication_year":2022,"publication_date":"2022-05-25","ids":{"openalex":"https://openalex.org/W4281477696","doi":"https://doi.org/10.3389/fphys.2022.898508","pmid":"https://pubmed.ncbi.nlm.nih.gov/35694410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9174904"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2022.898508","doi":"https://doi.org/10.3389/fphys.2022.898508","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2022.898508","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.898508/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.898508/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072314683","display_name":"Manuel A. Anderegg","orcid":"https://orcid.org/0000-0002-8449-0232","observed_orcids":["https://orcid.org/0000-0002-8449-0232"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Manuel A. Anderegg","raw_affiliation_strings":["Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076163204","display_name":"Gergely Gyimesi","orcid":"https://orcid.org/0000-0002-2054-4633","observed_orcids":["https://orcid.org/0000-0002-2054-4633"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gergely Gyimesi","raw_affiliation_strings":["Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","Membrane Transport Discovery Lab, Department for BioMedical Research, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Membrane Transport Discovery Lab, Department for BioMedical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076878740","display_name":"Manh Tin Ho","orcid":"https://orcid.org/0000-0003-1608-2234","observed_orcids":["https://orcid.org/0000-0003-1608-2234"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tin Manh Ho","raw_affiliation_strings":["Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078842111","display_name":"Matthias A. Hediger","orcid":"https://orcid.org/0000-0003-1946-027X","observed_orcids":["https://orcid.org/0000-0003-1946-027X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthias A. Hediger","raw_affiliation_strings":["Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","Membrane Transport Discovery Lab, Department for BioMedical Research, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Membrane Transport Discovery Lab, Department for BioMedical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048960429","display_name":"Daniel Guido Fuster","orcid":"https://orcid.org/0000-0001-7220-1803","observed_orcids":["https://orcid.org/0000-0001-7220-1803"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel G. Fuster","raw_affiliation_strings":["Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072314683"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.3885,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.36536851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"898508","last_page":"898508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/na-h-exchanger","display_name":"Na+/H+ exchanger","score":0.8389999866485596},{"id":"https://openalex.org/keywords/membrane-transporters","display_name":"membrane transporters","score":0.6940000057220459},{"id":"https://openalex.org/keywords/ph-control","display_name":"pH control","score":0.5950000286102295},{"id":"https://openalex.org/keywords/acid-base-balance","display_name":"acid-base balance","score":0.902999997138977},{"id":"https://openalex.org/keywords/cell-volume-regulation","display_name":"cell volume regulation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/polycystic-kidney-disease","display_name":"polycystic kidney disease","score":0.9359999895095825},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7200000286102295},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/renal-blood-pressure","display_name":"renal blood pressure","score":0.6179999709129333},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.7739999890327454},{"id":"https://openalex.org/keywords/male-fertility","display_name":"male fertility","score":0.9779999852180481},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.8790911436080933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.547433614730835},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5367822051048279},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40997910499572754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3741871118545532},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3539147973060608}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fphys.2022.898508","doi":"https://doi.org/10.3389/fphys.2022.898508","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2022.898508","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.898508/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9174904","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9174904","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:35694410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35694410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:doi:10.48350/170361","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/85353","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:170361","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/170361/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401747","display_name":"BORIS (University Library Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210103840","host_organization_name":"Nakuru County Council","host_organization_lineage":["https://openalex.org/I4210103840"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anderegg, Manuel A; Gyimesi, Gergely; Ho, Manh Tin; Hediger, Matthias A; Fuster, Daniel G (2022). The Less Well-Known Little Brothers: The SLC9B/NHA Sodium Proton Exchanger Subfamily\u2014Structure, Function, Regulation and Potential Drug-Target Approaches. Frontiers in physiology, 13, p. 898508. Frontiers Research Foundation 10.3389/fphys.2022.898508 &lt;http://dx.doi.org/10.3389/fphys.2022.898508&gt;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3a4d224ddee94a589c4f07ffcc77b1d7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3a4d224ddee94a589c4f07ffcc77b1d7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 13 (2022)","raw_type":"article"},{"id":"doi:10.48350/170361","doi":"https://doi.org/10.48350/170361","is_oa":true,"landing_page_url":"https://doi.org/10.48350/170361","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.3389/fphys.2022.898508","doi":"https://doi.org/10.3389/fphys.2022.898508","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2022.898508","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.898508/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2245949445","display_name":"Sodium/hydrogen exchanger NHA2 - quest for biological function","funder_award_id":"135503","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G3016735795","display_name":null,"funder_award_id":"31003A_152829","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3359803800","display_name":null,"funder_award_id":"33IC30_166785/1","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4995928200","display_name":"Physiological role of the sodium/hydrogen exchanger NHE6","funder_award_id":"152829","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G5912266461","display_name":"NCCR TransCure - From transport physiology to identification of therapeutic targets","funder_award_id":"185544","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6231567155","display_name":null,"funder_award_id":"33IC30_166785/1","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8493365221","display_name":"Randomized double-blind placebo-controlled trial assessing the efficacy of standard and low dose hydrochlorothiazide treatment in the prevention of recurrent calcium nephrolithiasis","funder_award_id":"166785","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320318017","display_name":"Inselspital, Universit\u00e4tsspital Bern","ror":"https://ror.org/01q9sj412"},{"id":"https://openalex.org/F4320318039","display_name":"Insel Gruppe","ror":null},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320336554","display_name":"Swiss National Centre of Competence in Research Kidney Control of Homeostasis","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281477696.pdf","grobid_xml":"https://content.openalex.org/works/W4281477696.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W1491276894","https://openalex.org/W1963623990","https://openalex.org/W1964483243","https://openalex.org/W1964572828","https://openalex.org/W1965191256","https://openalex.org/W1966343281","https://openalex.org/W1982651256","https://openalex.org/W1983379765","https://openalex.org/W1985581534","https://openalex.org/W1990667548","https://openalex.org/W1992756120","https://openalex.org/W1999613945","https://openalex.org/W2007792424","https://openalex.org/W2008708467","https://openalex.org/W2010498001","https://openalex.org/W2012034410","https://openalex.org/W2012315737","https://openalex.org/W2016799157","https://openalex.org/W2018952387","https://openalex.org/W2030630673","https://openalex.org/W2033265499","https://openalex.org/W2034224320","https://openalex.org/W2036937508","https://openalex.org/W2037562571","https://openalex.org/W2039492547","https://openalex.org/W2041061715","https://openalex.org/W2044504624","https://openalex.org/W2046767100","https://openalex.org/W2046927137","https://openalex.org/W2048719584","https://openalex.org/W2055371177","https://openalex.org/W2055703635","https://openalex.org/W2057706200","https://openalex.org/W2059167397","https://openalex.org/W2065199938","https://openalex.org/W2066150108","https://openalex.org/W2070739957","https://openalex.org/W2074870839","https://openalex.org/W2083699738","https://openalex.org/W2085008263","https://openalex.org/W2091324720","https://openalex.org/W2093796467","https://openalex.org/W2098219009","https://openalex.org/W2098314472","https://openalex.org/W2098448352","https://openalex.org/W2099909014","https://openalex.org/W2100945678","https://openalex.org/W2105690070","https://openalex.org/W2108820109","https://openalex.org/W2110609540","https://openalex.org/W2111211467","https://openalex.org/W2112390692","https://openalex.org/W2112643254","https://openalex.org/W2119529392","https://openalex.org/W2120772351","https://openalex.org/W2124577658","https://openalex.org/W2125806973","https://openalex.org/W2127295087","https://openalex.org/W2127322768","https://openalex.org/W2133866155","https://openalex.org/W2137015675","https://openalex.org/W2144944670","https://openalex.org/W2146713449","https://openalex.org/W2148820240","https://openalex.org/W2149336336","https://openalex.org/W2152130162","https://openalex.org/W2152317018","https://openalex.org/W2153720690","https://openalex.org/W2154055479","https://openalex.org/W2156212384","https://openalex.org/W2157018146","https://openalex.org/W2159666908","https://openalex.org/W2160163420","https://openalex.org/W2160571412","https://openalex.org/W2161378561","https://openalex.org/W2162195477","https://openalex.org/W2162715392","https://openalex.org/W2166518300","https://openalex.org/W2172151601","https://openalex.org/W2221809773","https://openalex.org/W2256410766","https://openalex.org/W2293609472","https://openalex.org/W2304210406","https://openalex.org/W2326032252","https://openalex.org/W2334314775","https://openalex.org/W2340550980","https://openalex.org/W2342127666","https://openalex.org/W2347044211","https://openalex.org/W2410402179","https://openalex.org/W2472763914","https://openalex.org/W2520169735","https://openalex.org/W2524186737","https://openalex.org/W2558252046","https://openalex.org/W2585509352","https://openalex.org/W2603623482","https://openalex.org/W2610994034","https://openalex.org/W2620048357","https://openalex.org/W2750791471","https://openalex.org/W2753391286","https://openalex.org/W2765289931","https://openalex.org/W2765795120","https://openalex.org/W2766042443","https://openalex.org/W2825528787","https://openalex.org/W2839224564","https://openalex.org/W2883755802","https://openalex.org/W2911907516","https://openalex.org/W2949890117","https://openalex.org/W2969497424","https://openalex.org/W2973215115","https://openalex.org/W2982521190","https://openalex.org/W2999919126","https://openalex.org/W3006363050","https://openalex.org/W3008574468","https://openalex.org/W3009746164","https://openalex.org/W3034966156","https://openalex.org/W3042457858","https://openalex.org/W3081979328","https://openalex.org/W3087437520","https://openalex.org/W3094008131","https://openalex.org/W3095515890","https://openalex.org/W3105613748","https://openalex.org/W3109958717","https://openalex.org/W3117672821","https://openalex.org/W3124627334","https://openalex.org/W3128501658","https://openalex.org/W3166963116","https://openalex.org/W3171008193","https://openalex.org/W3184729641","https://openalex.org/W3201400965","https://openalex.org/W4200043949","https://openalex.org/W4211232835","https://openalex.org/W4213252248"],"related_works":["https://openalex.org/W4306685152","https://openalex.org/W2065199938","https://openalex.org/W2973215115","https://openalex.org/W4313503448","https://openalex.org/W2073411380","https://openalex.org/W2034224320","https://openalex.org/W4409113144","https://openalex.org/W7056244977","https://openalex.org/W2400485608","https://openalex.org/W3095515890"],"abstract_inverted_index":{"exchangers":[0],"(NHEs),":[1],"a":[2,157],"group":[3],"of":[4,13,29,53,110,159,165,167,186],"membrane":[5],"transport":[6],"proteins":[7],"critically":[8],"involved":[9],"in":[10,40,86,120,130],"the":[11,30,50,54,68,108,114,160,168,175,184,187],"regulation":[12,164],"cytoplasmic":[14],"and":[15,25,43,58,79,90,95,132,138,163],"organellar":[16],"pH,":[17],"cell":[18],"volume,":[19],"as":[20,22,74,125,190],"well":[21],"systemic":[23,96],"acid-base":[24],"volume":[26],"homeostasis.":[27,98],"NHEs":[28,66],"SLC9A":[31,69],"subfamily":[32,170,189],"(NHE":[33],"1-9)":[34],"are":[35],"well-known":[36],"for":[37,135],"their":[38],"roles":[39],"human":[41,148],"physiology":[42],"disease.":[44],"Much":[45],"less":[46],"is":[47,76,127,133],"known":[48,73,124],"about":[49],"two":[51],"members":[52],"SLC9B":[55,169,177,188],"subfamily,":[56],"NHA1":[57,122],"NHA2,":[59],"which":[60],"share":[61],"higher":[62],"similarity":[63],"to":[64,84,105,107],"prokaryotic":[65],"than":[67],"paralogs.":[70],"NHA2":[71,101],"(also":[72,123],"SLC9B2)":[75],"ubiquitously":[77],"expressed":[78,129],"has":[80,102,143],"recently":[81],"been":[82,103,145],"shown":[83],"participate":[85],"renal":[87],"blood":[88],"pressure":[89],"electrolyte":[91],"regulation,":[92],"insulin":[93],"secretion":[94],"glucose":[97],"In":[99,152],"addition,":[100],"proposed":[104],"contribute":[106],"pathogenesis":[109],"polycystic":[111],"kidney":[112,118],"disease,":[113],"most":[115],"common":[116],"inherited":[117],"disease":[119,149],"humans.":[121],"SLC9B1)":[126],"mainly":[128],"testis":[131],"important":[134],"sperm":[136],"motility":[137],"thus":[139,150],"male":[140],"fertility,":[141],"but":[142],"not":[144],"associated":[146],"with":[147],"far.":[151],"this":[153],"review,":[154],"we":[155,181],"present":[156],"summary":[158],"structure,":[161],"function":[162],"expression":[166],"members,":[171],"focusing":[172],"primarily":[173],"on":[174],"better-studied":[176],"paralog,":[178],"NHA2.":[179],"Furthermore,":[180],"will":[182],"review":[183],"potential":[185],"drug":[191],"targets.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-05-26T00:00:00"}
