{"id":"https://openalex.org/W4281386567","doi":"https://doi.org/10.3389/fnut.2022.823723","title":"Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3","display_name":"Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3","publication_year":2022,"publication_date":"2022-05-23","ids":{"openalex":"https://openalex.org/W4281386567","doi":"https://doi.org/10.3389/fnut.2022.823723","pmid":"https://pubmed.ncbi.nlm.nih.gov/35685876","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9171434"},"language":"en","primary_location":{"id":"doi:10.3389/fnut.2022.823723","doi":"https://doi.org/10.3389/fnut.2022.823723","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2022.823723","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.823723/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.823723/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033500828","display_name":"Hung\u2010Tsung Wu","orcid":"https://orcid.org/0000-0002-0611-8427","observed_orcids":["https://orcid.org/0000-0002-0611-8427"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hung-Tsung Wu","raw_affiliation_strings":["Department of Internal Medicine, School of Medicine, College of Medicine, National Cheng Kung University, Tainan City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, School of Medicine, College of Medicine, National Cheng Kung University, Tainan City, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055729809","display_name":"Ching\u2010Han Lin","orcid":"https://orcid.org/0000-0002-3743-9733","observed_orcids":["https://orcid.org/0000-0002-3743-9733"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ching-Han Lin","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan","institution_ids":["https://openalex.org/I4210158999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020346394","display_name":"Hsiu-Ling Pai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsiu-Ling Pai","raw_affiliation_strings":["Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei City, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769173","display_name":"Yicheng Chen","orcid":"https://orcid.org/0000-0002-7255-2176","observed_orcids":["https://orcid.org/0000-0002-7255-2176"]},"institutions":[{"id":"https://openalex.org/I4210113809","display_name":"Chia-Yi Christian Hospital","ror":"https://ror.org/01em2mv62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210113809"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Cheng Chen","raw_affiliation_strings":["Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan","institution_ids":["https://openalex.org/I4210113809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027551287","display_name":"Kai\u2010Pi Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kai-Pi Cheng","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan","institution_ids":["https://openalex.org/I4210158999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087446063","display_name":"Hsin\u2010Yu Kuo","orcid":"https://orcid.org/0000-0002-6413-7669","observed_orcids":["https://orcid.org/0000-0002-6413-7669"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Yu Kuo","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan","Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan City, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000798594","display_name":"Chung\u2010Hao Li","orcid":"https://orcid.org/0000-0001-5062-8128","observed_orcids":["https://orcid.org/0000-0001-5062-8128"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210093006","display_name":"An-Nan Hospital","ror":"https://ror.org/00ew3x319","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093006"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chung-Hao Li","raw_affiliation_strings":["Department of Family Medicine, Tainan Municipal An-Nan Hospital, China Medical University, Tainan City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Tainan Municipal An-Nan Hospital, China Medical University, Tainan City, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210093006"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010437672","display_name":"Horng\u2010Yih Ou","orcid":"https://orcid.org/0000-0002-3350-6548","observed_orcids":["https://orcid.org/0000-0002-3350-6548"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Horng-Yih Ou","raw_affiliation_strings":["Department of Internal Medicine, School of Medicine, College of Medicine, National Cheng Kung University, Tainan City, Taiwan","Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, School of Medicine, College of Medicine, National Cheng Kung University, Tainan City, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan","institution_ids":["https://openalex.org/I4210158999"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010437672"],"corresponding_institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":4.3736,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.95590208,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"823723","last_page":"823723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sucralose","display_name":"sucralose","score":1.0},{"id":"https://openalex.org/keywords/artificial-sweeteners","display_name":"artificial sweeteners","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8199999928474426},{"id":"https://openalex.org/keywords/t1r3","display_name":"T1R3","score":0.9039999842643738},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9789999723434448},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.968999981880188},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5809999704360962},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2776480571","wikidata":"https://www.wikidata.org/wiki/Q410209","display_name":"Sucralose","level":2,"score":0.9873510003089905},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.8684898614883423},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.8286997079849243},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5922313928604126},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5615473389625549},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.522185742855072},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.4418129324913025},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.35035109519958496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25240081548690796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2400786578655243},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.18939033150672913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1616310179233551}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnut.2022.823723","doi":"https://doi.org/10.3389/fnut.2022.823723","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2022.823723","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.823723/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9171434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9171434","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Nutr","raw_type":"Text"},{"id":"pmid:35685876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35685876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b31ec41b037e4173b05abc6b29486991","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b31ec41b037e4173b05abc6b29486991","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Nutrition, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnut.2022.823723","doi":"https://doi.org/10.3389/fnut.2022.823723","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2022.823723","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.823723/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4778972910","display_name":"Role of Myozenin 2 in Diabetic Sarcopenia","funder_award_id":"MOST108-2314-B006-032-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G7132580886","display_name":"Role of Non-Nutritive Sweeteners in the Development of Gestational Diabetes( II )","funder_award_id":"MOST110-2314-B006-115","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G8055747892","display_name":"Investigation of the Role of Taste Receptors in Glucose Homeostasis","funder_award_id":"MOST110-2314-B006-116-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281386567.pdf","grobid_xml":"https://content.openalex.org/works/W4281386567.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1966054577","https://openalex.org/W1967632513","https://openalex.org/W1982365101","https://openalex.org/W1989947363","https://openalex.org/W1992463553","https://openalex.org/W2002529150","https://openalex.org/W2030645331","https://openalex.org/W2030901818","https://openalex.org/W2032584297","https://openalex.org/W2040451666","https://openalex.org/W2057142712","https://openalex.org/W2061662539","https://openalex.org/W2067797550","https://openalex.org/W2079431196","https://openalex.org/W2084329579","https://openalex.org/W2087813511","https://openalex.org/W2094683694","https://openalex.org/W2121836743","https://openalex.org/W2144535719","https://openalex.org/W2267903298","https://openalex.org/W2276537905","https://openalex.org/W2338037107","https://openalex.org/W2520834148","https://openalex.org/W2617442709","https://openalex.org/W2739328078","https://openalex.org/W2791512987","https://openalex.org/W2803942685","https://openalex.org/W2886166028","https://openalex.org/W2939856018","https://openalex.org/W2946363643","https://openalex.org/W2994672341","https://openalex.org/W2998209057","https://openalex.org/W3009220429","https://openalex.org/W3013485229","https://openalex.org/W3037337371","https://openalex.org/W3050342321","https://openalex.org/W3076496382","https://openalex.org/W3091779411","https://openalex.org/W3139012013","https://openalex.org/W3160407865","https://openalex.org/W3170394737","https://openalex.org/W4250223817"],"related_works":["https://openalex.org/W2781774768","https://openalex.org/W4297229779","https://openalex.org/W4381661657","https://openalex.org/W2479811934","https://openalex.org/W2381178960","https://openalex.org/W2890615970","https://openalex.org/W4381337606","https://openalex.org/W2582635416","https://openalex.org/W4361205244","https://openalex.org/W7111506361"],"abstract_inverted_index":{"Non-alcoholic":[0],"fatty":[1],"liver":[2,10],"disease":[3,11],"(NAFLD)":[4],"is":[5,15,34],"the":[6,37,57,109,154],"most":[7,38],"common":[8],"chronic":[9],"globally,":[12],"and":[13,32,53,92,144,148,150],"it":[14],"strongly":[16],"associated":[17],"with":[18],"obesity.":[19],"To":[20],"combat":[21],"obesity,":[22],"artificial":[23],"sweeteners":[24],"are":[25],"often":[26],"used":[27,40],"to":[28,141,153],"replace":[29],"natural":[30],"sugars,":[31],"sucralose":[33,46,60,75,85,112,137],"one":[35],"of":[36,59,74,84,102,111,117,156],"extensively":[39],"sweeteners.":[41],"It":[42],"was":[43],"known":[44],"that":[45,72],"exerted":[47],"effects":[48,58,110],"on":[49,61,113],"lipid":[50],"metabolism":[51],"dysregulation,":[52],"hepatic":[54,62,79,157],"inflammation;":[55],"however,":[56],"steatosis":[63],"were":[64],"still":[65],"obscure.":[66],"In":[67,81],"this":[68],"study,":[69],"we":[70],"found":[71],"supplements":[73],"enhanced":[76],"high-fat-diet":[77],"(HFD)-induced":[78],"steatosis.":[80,158],"addition,":[82],"treatment":[83],"increased":[86],"reactive":[87],"oxygen":[88],"species":[89],"(ROS)":[90],"generation":[91],"induced":[93],"endoplasmic":[94],"reticulum":[95],"(ER)":[96],"stress":[97,106,147],"in":[98,132],"HepG2":[99,133],"cells.":[100,134],"Pretreatment":[101],"ROS":[103,143],"or":[104,126],"ER":[105,146],"inhibitors":[107],"reversed":[108,129],"lipogenesis.":[114],"Furthermore,":[115],"pretreatment":[116],"taste":[118],"receptor":[119],"type":[120],"1":[121],"membrane":[122],"3":[123],"(T1R3)":[124],"inhibitor":[125],"T1R3":[127,140],"knockdown":[128],"sucralose-induced":[130],"lipogenesis":[131],"Taken":[135],"together,":[136],"might":[138],"activate":[139],"generate":[142],"promote":[145],"lipogenesis,":[149],"further":[151],"accelerate":[152],"development":[155]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-05-25T00:00:00"}
