{"id":"https://openalex.org/W4281384635","doi":"https://doi.org/10.3390/jcm11112951","title":"Cytokine Profiles as Potential Prognostic and Therapeutic Markers in SARS-CoV-2-Induced ARDS","display_name":"Cytokine Profiles as Potential Prognostic and Therapeutic Markers in SARS-CoV-2-Induced ARDS","publication_year":2022,"publication_date":"2022-05-24","ids":{"openalex":"https://openalex.org/W4281384635","doi":"https://doi.org/10.3390/jcm11112951","pmid":"https://pubmed.ncbi.nlm.nih.gov/35683340"},"language":"en","primary_location":{"id":"doi:10.3390/jcm11112951","doi":"https://doi.org/10.3390/jcm11112951","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm11112951","pdf_url":"https://www.mdpi.com/2077-0383/11/11/2951/pdf?version=1653371902","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/11/11/2951/pdf?version=1653371902","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063327497","display_name":"Francesco Salton","orcid":"https://orcid.org/0000-0002-0864-9766","observed_orcids":["https://orcid.org/0000-0002-0864-9766"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Salton","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0864-9766","affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048338051","display_name":"Paola Confalonieri","orcid":"https://orcid.org/0000-0002-7284-5016","observed_orcids":["https://orcid.org/0000-0002-7284-5016"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Confalonieri","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7284-5016","affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066423919","display_name":"Giuseppina Campisciano","orcid":"https://orcid.org/0000-0002-2307-5537","observed_orcids":["https://orcid.org/0000-0002-2307-5537"]},"institutions":[{"id":"https://openalex.org/I2799929701","display_name":"IRCCS Materno Infantile Burlo Garofolo","ror":"https://ror.org/03t1jzs40","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2799929701","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppina Campisciano","raw_affiliation_strings":["Department of Advanced Translational Microbiology, Institute for Maternal and Child Health-IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy","Department of Advanced Translational Microbiology, Institute for Maternal and Child Health-IRCCS \"Burlo Garofolo\", 34137 Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2307-5537","affiliations":[{"raw_affiliation_string":"Department of Advanced Translational Microbiology, Institute for Maternal and Child Health-IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy","institution_ids":["https://openalex.org/I2799929701"]},{"raw_affiliation_string":"Department of Advanced Translational Microbiology, Institute for Maternal and Child Health-IRCCS \"Burlo Garofolo\", 34137 Trieste, Italy","institution_ids":["https://openalex.org/I2799929701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032896994","display_name":"Rossella Cifaldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossella Cifaldi","raw_affiliation_strings":["Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040066504","display_name":"Clara Rizzardi","orcid":"https://orcid.org/0000-0003-2018-9835","observed_orcids":["https://orcid.org/0000-0003-2018-9835"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Clara Rizzardi","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Department of Pathology, University Hospital of Trieste, 34149 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Department of Pathology, University Hospital of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014990363","display_name":"Daniele Generali","orcid":"https://orcid.org/0000-0001-6002-1530","observed_orcids":["https://orcid.org/0000-0001-6002-1530","https://orcid.org/0000-0003-2480-3855"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele Generali","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Department of Pathology, University Hospital of Trieste, 34149 Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6002-1530","affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Department of Pathology, University Hospital of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068676235","display_name":"Riccardo Pozzan","orcid":"https://orcid.org/0000-0003-4114-8776","observed_orcids":["https://orcid.org/0000-0003-4114-8776"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Pozzan","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038500797","display_name":"Stefano Tavano","orcid":"https://orcid.org/0000-0003-0833-8711","observed_orcids":["https://orcid.org/0000-0003-0833-8711"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Tavano","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002407702","display_name":"Chiara Bozzi","orcid":"https://orcid.org/0000-0002-8412-8356","observed_orcids":["https://orcid.org/0000-0002-8412-8356"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Bozzi","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089500387","display_name":"Giulia Lapadula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Lapadula","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019278117","display_name":"Gianfranco Umberto Meduri","orcid":"https://orcid.org/0000-0002-4848-8928","observed_orcids":["https://orcid.org/0000-0002-4848-8928"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gianfranco Umberto Meduri","raw_affiliation_strings":["Department of Medicine, Pulmonary, Critical Care, and Sleep Medicine Division, University of Tennessee Health Science Center, Memphis, TN 38163, USA"],"raw_orcid":"https://orcid.org/0000-0002-4848-8928","affiliations":[{"raw_affiliation_string":"Department of Medicine, Pulmonary, Critical Care, and Sleep Medicine Division, University of Tennessee Health Science Center, Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025917999","display_name":"Marco Confalonieri","orcid":"https://orcid.org/0000-0002-4791-768X","observed_orcids":["https://orcid.org/0000-0002-4791-768X"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Confalonieri","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4791-768X","affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003472379","display_name":"Manola Comar","orcid":"https://orcid.org/0000-0002-9487-861X","observed_orcids":["https://orcid.org/0000-0002-9487-861X"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]},{"id":"https://openalex.org/I2799929701","display_name":"IRCCS Materno Infantile Burlo Garofolo","ror":"https://ror.org/03t1jzs40","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2799929701","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Manola Comar","raw_affiliation_strings":["Department of Advanced Translational Microbiology, Institute for Maternal and Child Health-IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy","Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Department of Advanced Translational Microbiology, Institute for Maternal and Child Health-IRCCS \"Burlo Garofolo\", 34137 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Translational Microbiology, Institute for Maternal and Child Health-IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy","institution_ids":["https://openalex.org/I2799929701"]},{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Department of Advanced Translational Microbiology, Institute for Maternal and Child Health-IRCCS \"Burlo Garofolo\", 34137 Trieste, Italy","institution_ids":["https://openalex.org/I2799929701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006969095","display_name":"Selene Lerda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Selene Lerda","raw_affiliation_strings":["24ore Business School, Via Monte Rosa 91, 20149 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"24ore Business School, Via Monte Rosa 91, 20149 Milano, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043876077","display_name":"Barbara Ruaro","orcid":"https://orcid.org/0000-0001-8990-859X","observed_orcids":["https://orcid.org/0000-0001-8990-859X"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Ruaro","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8990-859X","affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"Pulmonology Unit, University Hospital of Trieste, University of Trieste, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063327497"],"corresponding_institution_ids":["https://openalex.org/I142444530"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":9.0728,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.98708857,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"11","issue":"11","first_page":"2951","last_page":"2951"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.6166999936103821,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.6166999936103821,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.37450000643730164,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cytokine-profile","display_name":"cytokine profile","score":0.7319999933242798},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.902999997138977},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-invasive-ventilation","display_name":"non-invasive ventilation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/invasive-mechanical-ventilation","display_name":"invasive mechanical ventilation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7099999785423279},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.3580000102519989},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7490000128746033},{"id":"https://openalex.org/keywords/therapeutic-biomarkers","display_name":"therapeutic biomarkers","score":0.5210000276565552},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.963997483253479},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.9162566065788269},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6729683876037598},{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.6155941486358643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5118679404258728},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.5044196844100952},{"id":"https://openalex.org/C2778716859","wikidata":"https://www.wikidata.org/wiki/Q939018","display_name":"Intubation","level":2,"score":0.48429054021835327},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.4636956453323364},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3982101082801819},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3700653314590454},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33420121669769287},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3049054741859436},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/jcm11112951","doi":"https://doi.org/10.3390/jcm11112951","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm11112951","pdf_url":"https://www.mdpi.com/2077-0383/11/11/2951/pdf?version=1653371902","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmid:35683340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35683340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"},{"id":"pmh:oai:arts.units.it:11368/3024653","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9180983","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9180983/pdf/jcm-11-02951.pdf","source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9180983","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9180983","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8b68a05fbd074b399ed4b6519e626cae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8b68a05fbd074b399ed4b6519e626cae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Medicine, Vol 11, Iss 2951, p 2951 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jcm11112951","doi":"https://doi.org/10.3390/jcm11112951","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm11112951","pdf_url":"https://www.mdpi.com/2077-0383/11/11/2951/pdf?version=1653371902","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8899999856948853,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281384635.pdf","grobid_xml":"https://content.openalex.org/works/W4281384635.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1803784511","https://openalex.org/W2014249234","https://openalex.org/W2042000189","https://openalex.org/W2065764124","https://openalex.org/W2104968736","https://openalex.org/W2140229413","https://openalex.org/W2150691073","https://openalex.org/W2342581347","https://openalex.org/W2620241325","https://openalex.org/W3042270788","https://openalex.org/W3044132961","https://openalex.org/W3082355253","https://openalex.org/W3085008014","https://openalex.org/W3087377819","https://openalex.org/W3089936348","https://openalex.org/W3093261446","https://openalex.org/W3097806887","https://openalex.org/W3137854570","https://openalex.org/W3176631387","https://openalex.org/W3192649037","https://openalex.org/W3197653778","https://openalex.org/W4220998927","https://openalex.org/W4254133364"],"related_works":["https://openalex.org/W3217749975","https://openalex.org/W2406153264","https://openalex.org/W3032528766","https://openalex.org/W3108633277","https://openalex.org/W4362670593","https://openalex.org/W2797453375","https://openalex.org/W4213320550","https://openalex.org/W2360492777","https://openalex.org/W2121348586","https://openalex.org/W2379971878"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glucocorticoids":[1],"(GCs)":[2],"have":[3,211],"been":[4,26],"shown":[5],"to":[6,71,87,96,197,227],"reduce":[7],"mortality":[8],"and":[9,53,157,219,242],"the":[10,49,89,133,144,178,188,229],"need":[11],"for":[12,213],"invasive":[13],"mechanical":[14],"ventilation":[15,83],"(IMV)":[16],"in":[17,37,56,77,85,91,132,143,177,207,235],"SARS-CoV-2-induced":[18,59],"acute":[19],"respiratory":[20],"distress":[21],"syndrome":[22],"(ARDS).":[23],"It":[24],"has":[25],"suggested":[27],"that":[28],"serum":[29],"cytokines":[30,139],"levels":[31,76,184],"are":[32,225],"markers":[33],"of":[34,45,217,232,237,245],"disease":[35],"severity":[36],"ARDS,":[38],"although":[39],"there":[40],"is":[41],"only":[42],"limited":[43],"evidence":[44],"a":[46,67,194,203,214,220],"relationship":[47],"between":[48,170],"longitudinal":[50],"cytokine":[51,75,233],"profile":[52],"clinical":[54,115],"outcomes":[55],"patients":[57,79,93,100,107,126,209],"with":[58,62,81,103],"ARDS":[60],"treated":[61],"GC.":[63],"METHODS:":[64],"We":[65],"conducted":[66],"single-center":[68],"observational":[69],"study":[70,119],"investigate":[72],"serial":[73],"plasma":[74],"17":[78],"supported":[80],"non-invasive":[82],"(NIV)":[84],"order":[86],"compare":[88],"response":[90],"five":[92],"who":[94,101],"progressed":[95],"IMV":[97,145,179],"versus":[98],"12":[99],"continued":[102],"NIV":[104,134,189],"alone.":[105],"All":[106,125],"received":[108],"methylprednisolone":[109],"80":[110],"mg/day":[111],"continuous":[112],"infusion":[113],"until":[114],"improvement.":[116],"RESULTS:":[117],"The":[118],"groups":[120,171],"were":[121,140,168],"comparable":[122],"at":[123,136,185],"baseline.":[124],"survived.":[127],"Although":[128],"IL-6":[129],"was":[130],"higher":[131,142,182,195],"group":[135,146,180],"baseline,":[137],"several":[138],"significantly":[141],"on":[147,172],"day":[148,173],"7":[149],"(IL-6,":[150,159],"IL-8,":[151,160],"IL-9,":[152],"G-CSF,":[153,162],"IP-10,":[154],"MCP-1,":[155],"MIP-1\u03b1)":[156],"14":[158],"IL-17,":[161],"MIP-1\u03b1,":[163],"RANTES).":[164],"No":[165],"significant":[166],"differences":[167],"observed":[169],"28.":[174],"CONCLUSIONS:":[175],"Patients":[176],"had":[181],"inflammation":[183,218],"intubation":[186],"than":[187],"group,":[190],"which":[191],"may":[192],"indicate":[193],"resistance":[196],"glucocorticoids.":[198],"Higher":[199],"GC":[200,239],"doses":[201],"or":[202],"longer":[204],"treatment":[205,240],"duration":[206],"these":[208],"might":[210],"allowed":[212],"better":[215,221],"control":[216],"outcome.":[222],"Further":[223],"studies":[224],"required":[226],"define":[228],"prognostic":[230],"value":[231],"patterns,":[234],"terms":[236],"both":[238],"tailoring":[241],"timely":[243],"initiation":[244],"IMV.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":15},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
