{"id":"https://openalex.org/W428134470","doi":"https://doi.org/10.1016/j.vaccine.2014.12.082","title":"Beyond adjuvants: Immunomodulation strategies to enhance T cell immunity","display_name":"Beyond adjuvants: Immunomodulation strategies to enhance T cell immunity","publication_year":2015,"publication_date":"2015-05-26","ids":{"openalex":"https://openalex.org/W428134470","doi":"https://doi.org/10.1016/j.vaccine.2014.12.082","mag":"428134470","pmid":"https://pubmed.ncbi.nlm.nih.gov/26022562","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449453"},"language":"en","primary_location":{"id":"doi:10.1016/j.vaccine.2014.12.082","doi":"https://doi.org/10.1016/j.vaccine.2014.12.082","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2014.12.082","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449453","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013801897","display_name":"Alice Oliffson Kamphorst","orcid":"https://orcid.org/0000-0002-9230-9501","observed_orcids":["https://orcid.org/0000-0002-9230-9501"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice O. Kamphorst","raw_affiliation_strings":["Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Rd Rm G211, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Rd Rm G211, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038996345","display_name":"Koichi Araki","orcid":"https://orcid.org/0000-0003-3478-6315","observed_orcids":["https://orcid.org/0000-0003-3478-6315"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koichi Araki","raw_affiliation_strings":["Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Rd Rm G211, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Rd Rm G211, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016808814","display_name":"Rafi Ahmed","orcid":"https://orcid.org/0000-0002-9591-2621","observed_orcids":["https://orcid.org/0000-0002-9591-2621"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rafi Ahmed","raw_affiliation_strings":["Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Rd Rm G211, Atlanta, GA 30322, USA. Electronic address: rahmed@emory.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Rd Rm G211, Atlanta, GA 30322, USA. Electronic address: rahmed@emory.edu","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016808814"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":0.5027,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.43714556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"33","issue":null,"first_page":"B21","last_page":"B28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4771000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cell-immunity","display_name":"CD8+ T cell immunity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.8009999990463257},{"id":"https://openalex.org/keywords/t-cell-memory","display_name":"T cell memory","score":0.5820000171661377},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.8159999847412109},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.7710000276565552},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6701273322105408},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5992029905319214},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5491797924041748},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5132129192352295},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.49777916073799133},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.493354469537735},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.43561309576034546},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4297983944416046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.320201575756073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.vaccine.2014.12.082","doi":"https://doi.org/10.1016/j.vaccine.2014.12.082","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2014.12.082","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},{"id":"pmid:26022562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26022562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3862133","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449453","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4449453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449453","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Vaccine","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3862133","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449453","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1988398368","display_name":"Translational Regulation of CD8 T-Cell Immunity - Transfer of R01AI139675 from Emory","funder_award_id":"R01AI139675","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3773681860","display_name":"PD-1 Function, Signaling, and Regulation During Viral Infection","funder_award_id":"P01AI080192","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4035462528","display_name":null,"funder_award_id":"P01 A1080192","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G8050863362","display_name":"T Cell Costimulatory Pathways:  Functions and Interactions","funder_award_id":"P01AI056299","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8819355461","display_name":"T cell Memory to Viruses","funder_award_id":"R01AI030048","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W1525262466","https://openalex.org/W1575585006","https://openalex.org/W1613239888","https://openalex.org/W1845038035","https://openalex.org/W1903749320","https://openalex.org/W1963530370","https://openalex.org/W1967067685","https://openalex.org/W1967687807","https://openalex.org/W1967889234","https://openalex.org/W1968183881","https://openalex.org/W1971595657","https://openalex.org/W1974842026","https://openalex.org/W1976355501","https://openalex.org/W1977534471","https://openalex.org/W1978436252","https://openalex.org/W1984781939","https://openalex.org/W1990555844","https://openalex.org/W1993617345","https://openalex.org/W1994257755","https://openalex.org/W1999324987","https://openalex.org/W2013043293","https://openalex.org/W2015085911","https://openalex.org/W2016732129","https://openalex.org/W2016789384","https://openalex.org/W2016983859","https://openalex.org/W2029348880","https://openalex.org/W2029884055","https://openalex.org/W2034412853","https://openalex.org/W2035852466","https://openalex.org/W2036383793","https://openalex.org/W2039855270","https://openalex.org/W2040353461","https://openalex.org/W2041672829","https://openalex.org/W2043579427","https://openalex.org/W2044835625","https://openalex.org/W2046715962","https://openalex.org/W2047703405","https://openalex.org/W2052998574","https://openalex.org/W2053677639","https://openalex.org/W2054738595","https://openalex.org/W2056052081","https://openalex.org/W2057968168","https://openalex.org/W2059689009","https://openalex.org/W2059854063","https://openalex.org/W2061071534","https://openalex.org/W2063264144","https://openalex.org/W2064876347","https://openalex.org/W2066369312","https://openalex.org/W2066951766","https://openalex.org/W2070014391","https://openalex.org/W2072116490","https://openalex.org/W2073310925","https://openalex.org/W2074888413","https://openalex.org/W2075330371","https://openalex.org/W2076067786","https://openalex.org/W2076111644","https://openalex.org/W2077116159","https://openalex.org/W2081047275","https://openalex.org/W2081420986","https://openalex.org/W2087482409","https://openalex.org/W2089401318","https://openalex.org/W2093276391","https://openalex.org/W2097855813","https://openalex.org/W2097995306","https://openalex.org/W2101581360","https://openalex.org/W2101653483","https://openalex.org/W2102458026","https://openalex.org/W2104966044","https://openalex.org/W2105459360","https://openalex.org/W2107598346","https://openalex.org/W2108064918","https://openalex.org/W2109550365","https://openalex.org/W2111656053","https://openalex.org/W2111877246","https://openalex.org/W2112123471","https://openalex.org/W2113806491","https://openalex.org/W2116086384","https://openalex.org/W2117115065","https://openalex.org/W2118613671","https://openalex.org/W2118982164","https://openalex.org/W2119146367","https://openalex.org/W2119896120","https://openalex.org/W2120813964","https://openalex.org/W2120993577","https://openalex.org/W2121080857","https://openalex.org/W2123761806","https://openalex.org/W2127063807","https://openalex.org/W2127807231","https://openalex.org/W2130351191","https://openalex.org/W2130473166","https://openalex.org/W2131103696","https://openalex.org/W2132923173","https://openalex.org/W2137467818","https://openalex.org/W2139591061","https://openalex.org/W2141182631","https://openalex.org/W2141363604","https://openalex.org/W2141649011","https://openalex.org/W2142263069","https://openalex.org/W2143163879","https://openalex.org/W2144887013","https://openalex.org/W2146646005","https://openalex.org/W2147350757","https://openalex.org/W2147652122","https://openalex.org/W2148226248","https://openalex.org/W2148911309","https://openalex.org/W2149244682","https://openalex.org/W2149360266","https://openalex.org/W2149915530","https://openalex.org/W2150678612","https://openalex.org/W2155464214","https://openalex.org/W2156657486","https://openalex.org/W2157669002","https://openalex.org/W2159124392","https://openalex.org/W2160834915","https://openalex.org/W2160932925","https://openalex.org/W2161691927","https://openalex.org/W2163895585","https://openalex.org/W2164992400","https://openalex.org/W2322553446","https://openalex.org/W2499376400","https://openalex.org/W2560367415","https://openalex.org/W2572174216","https://openalex.org/W2592935721","https://openalex.org/W2737785069","https://openalex.org/W4205811845","https://openalex.org/W4285719527","https://openalex.org/W6675361852","https://openalex.org/W6682156754"],"related_works":["https://openalex.org/W2245685754","https://openalex.org/W1532823403","https://openalex.org/W7047398057","https://openalex.org/W4415706691","https://openalex.org/W2891683357","https://openalex.org/W8803558","https://openalex.org/W2064876347","https://openalex.org/W2138455645","https://openalex.org/W133627563","https://openalex.org/W1968183881"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}