{"id":"https://openalex.org/W4281298076","doi":"https://doi.org/10.3389/fendo.2022.893854","title":"Ablation of the miR-465 Cluster Causes a Skewed Sex Ratio in Mice","display_name":"Ablation of the miR-465 Cluster Causes a Skewed Sex Ratio in Mice","publication_year":2022,"publication_date":"2022-05-23","ids":{"openalex":"https://openalex.org/W4281298076","doi":"https://doi.org/10.3389/fendo.2022.893854","pmid":"https://pubmed.ncbi.nlm.nih.gov/35677715","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9167928"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2022.893854","doi":"https://doi.org/10.3389/fendo.2022.893854","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.893854","pdf_url":null,"source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fendo.2022.893854","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054920721","display_name":"Zhuqing Wang","orcid":"https://orcid.org/0000-0002-3988-0733","observed_orcids":["https://orcid.org/0000-0002-3988-0733"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuqing Wang","raw_affiliation_strings":["Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","institution_ids":["https://openalex.org/I134113660"]},{"raw_affiliation_string":"The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019509284","display_name":"Nan Meng","orcid":"https://orcid.org/0000-0001-9795-9282","observed_orcids":["https://orcid.org/0000-0001-9795-9282"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Meng","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine Xiamen University, Xiamen, China","Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100372136","display_name":"Yue Wang","orcid":"https://orcid.org/0009-0001-4220-0479","observed_orcids":["https://orcid.org/0009-0001-4220-0479"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","institution_ids":["https://openalex.org/I134113660"]},{"raw_affiliation_string":"The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055436613","display_name":"Tong Zhou","orcid":"https://orcid.org/0000-0003-2361-1931","observed_orcids":["https://orcid.org/0000-0003-2361-1931","https://orcid.org/0000-0003-0572-9610"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Zhou","raw_affiliation_strings":["Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023236942","display_name":"Musheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Musheng Li","raw_affiliation_strings":["Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035814710","display_name":"Shawn Wang","orcid":"https://orcid.org/0000-0001-5122-0132","observed_orcids":["https://orcid.org/0000-0001-5122-0132"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn Wang","raw_affiliation_strings":["Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320995","display_name":"Sheng Chen","orcid":"https://orcid.org/0000-0002-5238-3432","observed_orcids":["https://orcid.org/0000-0002-5238-3432"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheng Chen","raw_affiliation_strings":["Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","institution_ids":["https://openalex.org/I134113660"]},{"raw_affiliation_string":"The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102730931","display_name":"Huili Zheng","orcid":"https://orcid.org/0000-0003-3030-2950","observed_orcids":["https://orcid.org/0000-0003-3030-2950"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huili Zheng","raw_affiliation_strings":["Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","institution_ids":["https://openalex.org/I134113660"]},{"raw_affiliation_string":"The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000235097","display_name":"Shuangbo Kong","orcid":"https://orcid.org/0000-0002-7513-4041","observed_orcids":["https://orcid.org/0000-0002-7513-4041"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuangbo Kong","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine Xiamen University, Xiamen, China","Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408836","display_name":"Haibin Wang","orcid":"https://orcid.org/0000-0002-9865-324X","observed_orcids":["https://orcid.org/0000-0002-9865-324X"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haibin Wang","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine Xiamen University, Xiamen, China","Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086210898","display_name":"Wei Yan","orcid":"https://orcid.org/0000-0001-9569-9026","observed_orcids":["https://orcid.org/0000-0001-9569-9026"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Yan","raw_affiliation_strings":["Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States","Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, United States","institution_ids":["https://openalex.org/I134113660"]},{"raw_affiliation_string":"The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5086210898"],"corresponding_institution_ids":["https://openalex.org/I134113660","https://openalex.org/I161318765","https://openalex.org/I177607063","https://openalex.org/I4210165985"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.0514,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.73345769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"893854","last_page":"893854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.14839999377727509,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.03869999945163727,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-ratio","display_name":"sex ratio","score":0.6019999980926514},{"id":"https://openalex.org/keywords/placental-development","display_name":"placental development","score":0.8539999723434448},{"id":"https://openalex.org/keywords/alkbh1","display_name":"ALKBH1","score":0.7929999828338623},{"id":"https://openalex.org/keywords/embryo-resorption","display_name":"embryo resorption","score":0.6240000128746033},{"id":"https://openalex.org/keywords/extraembryonic-tissues","display_name":"extraembryonic tissues","score":0.722000002861023},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7942012548446655},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.665062427520752},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5767547488212585},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.570480227470398},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5287144780158997},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.49816465377807617},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.4602670967578888},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4170933961868286},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.416043221950531},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4087413251399994},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3766076862812042},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.32906970381736755},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30797863006591797},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.23570969700813293},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.19874292612075806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10128259658813477}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012744","descriptor_name":"Sex Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2022.893854","doi":"https://doi.org/10.3389/fendo.2022.893854","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.893854","pdf_url":null,"source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9167928","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9167928","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:35677715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35677715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8e0908c5d90241768ec2e3ce3fa1b581","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8e0908c5d90241768ec2e3ce3fa1b581","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2022.893854","doi":"https://doi.org/10.3389/fendo.2022.893854","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.893854","pdf_url":null,"source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2226464521","display_name":"COBRE: Smooth Muscle Plasticity","funder_award_id":"P30GM110767","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3352468854","display_name":"Center for Male Reproductive Epigenomics","funder_award_id":"P50HD098593","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G52429490","display_name":"Epitranscriptomic regulation of spermatogenesis and male fertility","funder_award_id":"R01HD099924","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6591070839","display_name":"Messenger RNA Fate Control in Spermatogenesis","funder_award_id":"R01HD085506","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7503282099","display_name":"Epigenetic Diagnostics for Preventative Medicine","funder_award_id":"61174","funder_id":"https://openalex.org/F4320306193","funder_display_name":"John Templeton Foundation"},{"id":"https://openalex.org/G8228164556","display_name":null,"funder_award_id":"HD0085506","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000070311","display_name":null,"funder_award_id":"HD098593","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000134444","display_name":null,"funder_award_id":"HD098593, HD0085506, HD099924","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306193","display_name":"John Templeton Foundation","ror":"https://ror.org/035tnyy05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1963680147","https://openalex.org/W1964631913","https://openalex.org/W1979515401","https://openalex.org/W1980909719","https://openalex.org/W2003207389","https://openalex.org/W2006247279","https://openalex.org/W2009859786","https://openalex.org/W2036961190","https://openalex.org/W2061556094","https://openalex.org/W2065128082","https://openalex.org/W2068771737","https://openalex.org/W2089001645","https://openalex.org/W2090169148","https://openalex.org/W2104600481","https://openalex.org/W2105549148","https://openalex.org/W2107898461","https://openalex.org/W2123612204","https://openalex.org/W2141857263","https://openalex.org/W2147185833","https://openalex.org/W2147507101","https://openalex.org/W2148995065","https://openalex.org/W2149366307","https://openalex.org/W2170304007","https://openalex.org/W2189571558","https://openalex.org/W2206657302","https://openalex.org/W2294562574","https://openalex.org/W2314750298","https://openalex.org/W2326098901","https://openalex.org/W2425262592","https://openalex.org/W2531303593","https://openalex.org/W2671308999","https://openalex.org/W2750218245","https://openalex.org/W2765518343","https://openalex.org/W2789302016","https://openalex.org/W2908682015","https://openalex.org/W2910261752","https://openalex.org/W2917567846","https://openalex.org/W2947031495","https://openalex.org/W2949042941","https://openalex.org/W2949181076","https://openalex.org/W2950215920","https://openalex.org/W2993072683","https://openalex.org/W2998149943","https://openalex.org/W2999441936","https://openalex.org/W3025229225","https://openalex.org/W3171653527","https://openalex.org/W3209790292"],"related_works":["https://openalex.org/W3123285648","https://openalex.org/W4396692571","https://openalex.org/W2101681543","https://openalex.org/W2782558136","https://openalex.org/W2274840461","https://openalex.org/W2995229033","https://openalex.org/W2803684700","https://openalex.org/W2906611848","https://openalex.org/W4380625275","https://openalex.org/W2390083104"],"abstract_inverted_index":{"The":[0],"X-linked":[1],"miR-465":[2,28,43,57,79,115,155,168],"cluster":[3,29,44,59,116,156,169],"is":[4,30,157],"highly":[5],"expressed":[6],"in":[7,18,45,51,104,142],"the":[8,23,27,39,42,52,56,86,110,114,121,133,143,154,167,187],"testis,":[9,53],"sperm,":[10],"newborn":[11],"ovary,":[12],"and":[13,103,164,184],"blastocysts":[14],"as":[15,17,91,93],"well":[16],"8-16":[19],"cell":[20],"embryos.":[21],"However,":[22],"physiological":[24],"role":[25,40],"of":[26,41,55,135,166,186],"still":[31],"largely":[32],"unknown.":[33],"This":[34],"study":[35,151],"aims":[36],"to":[37,120,171,181],"dissect":[38],"murine":[46],"development.":[47],"Despite":[48],"abundant":[49],"expression":[50],"ablation":[54,165],"miRNA":[58],"using":[60],"CRISPR-Cas9":[61],"did":[62],"not":[63],"cause":[64],"infertility.":[65],"Instead,":[66],"a":[67,172],"skewed":[68,173],"sex":[69,174],"ratio":[70,175],"biased":[71],"toward":[72],"males":[73,178],"(60%":[74],"males)":[75],"was":[76],"observed":[77],"among":[78],"KO":[80,144],"mice.":[81],"Further":[82],"analyses":[83,107,126],"revealed":[84,108],"that":[85,109,153],"female":[87,161,188],"conceptuses":[88,145],"selectively":[89],"degenerated":[90],"early":[92],"embryonic":[94],"day":[95],"8.5":[96],"(E8.5).":[97],"Small":[98],"RNA":[99],"deep":[100],"sequencing,":[101],"qPCR,":[102],"situ":[105],"hybridization":[106],"miRNAs":[111],"encoded":[112],"by":[113,132],"were":[117],"mainly":[118],"localized":[119],"extraembryonic":[122],"tissue/developing":[123],"placenta.":[124],"RNA-seq":[125],"identified":[127],"altered":[128],"mRNA":[129],"transcriptome":[130],"characterized":[131],"dysregulation":[134],"numerous":[136],"critical":[137],"placental":[138,162],"genes,":[139],"e.g.,":[140],"Alkbh1,":[141],"at":[146],"E7.5.":[147],"Taken":[148],"together,":[149],"this":[150],"showed":[152],"required":[158],"for":[159],"normal":[160],"development,":[163],"leads":[170],"with":[176],"more":[177],"(~60%)":[179],"due":[180],"selective":[182],"degeneration":[183],"resorption":[185],"conceptuses.":[189]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-24T00:00:00"}