{"id":"https://openalex.org/W4281297686","doi":"https://doi.org/10.52711/0974-360x.2022.00281","title":"Method Development and Validation of Simultaneous Determination of Assay of Quinapril and Tolcapone","display_name":"Method Development and Validation of Simultaneous Determination of Assay of Quinapril and Tolcapone","publication_year":2022,"publication_date":"2022-04-23","ids":{"openalex":"https://openalex.org/W4281297686","doi":"https://doi.org/10.52711/0974-360x.2022.00281"},"language":"en","primary_location":{"id":"doi:10.52711/0974-360x.2022.00281","doi":"https://doi.org/10.52711/0974-360x.2022.00281","is_oa":false,"landing_page_url":"https://doi.org/10.52711/0974-360x.2022.00281","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013267142","display_name":"O.S.S. Chandana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262389","display_name":"Aditya University","ror":"https://ror.org/03127q162","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405262389"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"O.S.S. Chandana","raw_affiliation_strings":["Aditya Engineering College, Surampalem, India - 533 437"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aditya Engineering College, Surampalem, India - 533 437","institution_ids":["https://openalex.org/I4405262389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013267142"],"corresponding_institution_ids":["https://openalex.org/I4405262389"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1680","last_page":"1682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quinapril","display_name":"quinapril","score":1.0},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.9539999961853027},{"id":"https://openalex.org/keywords/stability-indicating-method","display_name":"stability-indicating assay","score":0.7799999713897705},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/hplc-analysis","display_name":"HPLC assay","score":0.656000018119812},{"id":"https://openalex.org/keywords/drug-quantification","display_name":"pharmaceutical analysis","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2776992270","wikidata":"https://www.wikidata.org/wiki/Q596022","display_name":"Quinapril","level":5,"score":0.9907002449035645},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7677985429763794},{"id":"https://openalex.org/C96616956","wikidata":"https://www.wikidata.org/wiki/Q285100","display_name":"Phosphate buffered saline","level":2,"score":0.5877471566200256},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5014803409576416},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.49577221274375916},{"id":"https://openalex.org/C2777463227","wikidata":"https://www.wikidata.org/wiki/Q408047","display_name":"Acetonitrile","level":2,"score":0.46190956234931946},{"id":"https://openalex.org/C2992520659","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatographic separation","level":3,"score":0.446821391582489},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4379507303237915},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.41924363374710083},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38675713539123535},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3097791373729706},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.18516802787780762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14218443632125854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0907059907913208},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.0},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52711/0974-360x.2022.00281","doi":"https://doi.org/10.52711/0974-360x.2022.00281","is_oa":false,"landing_page_url":"https://doi.org/10.52711/0974-360x.2022.00281","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1971635938","https://openalex.org/W1980026499","https://openalex.org/W2063028213","https://openalex.org/W2129832544","https://openalex.org/W2150191905","https://openalex.org/W2911317752","https://openalex.org/W4235760589"],"related_works":["https://openalex.org/W4400879472","https://openalex.org/W2884666075","https://openalex.org/W2051036822","https://openalex.org/W2956235270","https://openalex.org/W2031854734","https://openalex.org/W2077204961","https://openalex.org/W2087462168","https://openalex.org/W7097761135","https://openalex.org/W6997232375","https://openalex.org/W7219231587"],"abstract_inverted_index":{"A":[0],"simple":[1],"and":[2,14,44,71,93,97,105,109,122,124],"selective":[3],"HPLC":[4,127],"method":[5,59,114,131],"is":[6,95,107],"developed":[7],"for":[8,62,80,88,135],"the":[9],"simultaneous":[10],"determination":[11],"of":[12,34,37,40,47,54,56,91,103],"quinapril":[13],"tolcopone.":[15],"The":[16,58,77,99,112],"chromatographic":[17],"separation":[18],"was":[19,60,115],"achieved":[20],"on":[21],"a":[22,35,52],"inertsil":[23],"column,":[24],"C18(150":[25],"X":[26],"4.6":[27],"ID)":[28],"5\u00b5m":[29],"with":[30,51],"mobile":[31],"phase":[32],"consisting":[33],"mixture":[36],"40":[38],"volumes":[39,46],"mixed":[41],"phosphate":[42],"buffer":[43],"60":[45],"acetonitrile":[48],"were":[49],"prepared":[50],"detection":[53],"wavelength":[55],"239nm.":[57],"validated":[61],"analytical":[63],"parameters":[64],"such":[65],"as":[66,73],"specificity,":[67],"accuracy,":[68],"precision,":[69],"robustness":[70],"ruggedness":[72],"per":[74],"ICH":[75],"guidelines.":[76],"correlation":[78],"coefficient":[79],"linear":[81],"curve":[82],"obtained":[83],"between":[84],"concentration":[85],"vs.":[86],"Area":[87],"standard":[89],"preparations":[90],"Quinapril":[92,104],"Tolcapone":[94,106],"0.995":[96],"0.999.":[98],"percentage":[100],"mean":[101],"recovery":[102],"101.02%":[108],"99.55%":[110],"respectively.":[111],"proposed":[113],"found":[116],"to":[117],"be":[118,133],"simple,":[119],"accurate,":[120],"precise,":[121],"robust":[123],"stability":[125],"indicating":[126],"method.":[128],"Hence":[129],"this":[130],"can":[132],"used":[134],"routine":[136],"analysis.":[137]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2022-05-24T00:00:00"}