{"id":"https://openalex.org/W4281293535","doi":"https://doi.org/10.3389/fimmu.2022.899161","title":"The Efficacy of Cancer Immunotherapies Is Compromised by Helicobacter pylori Infection","display_name":"The Efficacy of Cancer Immunotherapies Is Compromised by Helicobacter pylori Infection","publication_year":2022,"publication_date":"2022-05-23","ids":{"openalex":"https://openalex.org/W4281293535","doi":"https://doi.org/10.3389/fimmu.2022.899161","pmid":"https://pubmed.ncbi.nlm.nih.gov/35677057","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9168074"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.899161","doi":"https://doi.org/10.3389/fimmu.2022.899161","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.899161","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.899161/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.899161/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043599475","display_name":"P Oster","orcid":"https://orcid.org/0000-0002-6448-7503","observed_orcids":["https://orcid.org/0000-0002-6448-7503"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Paul Oster","raw_affiliation_strings":["Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006599712","display_name":"Laurie Vaillant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Laurie Vaillant","raw_affiliation_strings":["Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087570752","display_name":"Brynn McMillan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Brynn McMillan","raw_affiliation_strings":["Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000260036","display_name":"Dominique Velin","orcid":"https://orcid.org/0000-0001-6033-5871","observed_orcids":["https://orcid.org/0000-0001-6033-5871"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Dominique Velin","raw_affiliation_strings":["Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000260036"],"corresponding_institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2486,"currency":"EUR","value_usd":2681},"fwci":1.0734,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.7241206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"899161","last_page":"899161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.906000018119812},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.5059999823570251},{"id":"https://openalex.org/keywords/malt-lymphoma","display_name":"MALT lymphoma","score":0.859000027179718},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.7350000143051147},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.8339999914169312},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.8073442578315735},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7001585364341736},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6585336923599243},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6582744121551514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.646192729473114},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5320848822593689},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.45641544461250305},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.42633816599845886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17722204327583313}],"mesh":[{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D018442","descriptor_name":"Lymphoma, B-Cell, Marginal Zone","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.3389/fimmu.2022.899161","doi":"https://doi.org/10.3389/fimmu.2022.899161","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.899161","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.899161/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:35677057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35677057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9168074","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9168074/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:serval.unil.ch:BIB_A0B0F20EDD09","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_A0B0F20EDD09","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology, vol. 13, pp. 899161","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:iris.unil.ch:iris/190704","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/190704","pdf_url":"https://iris.unil.ch/bitstreams/92f10581-e6a2-4de1-893d-e84a879c9b3b/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"review article"},{"id":"pmh:oai:doaj.org/article:bfd84d6a54654fbcab4fffc7b0e4a620","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bfd84d6a54654fbcab4fffc7b0e4a620","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.899161","doi":"https://doi.org/10.3389/fimmu.2022.899161","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.899161","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.899161/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7116055627","display_name":null,"funder_award_id":"KFS-4452-02-2018","funder_id":"https://openalex.org/F4320327941","funder_display_name":"Swiss Cancer Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320323831","display_name":"Universit\u00e9 de Lausanne","ror":"https://ror.org/019whta54"},{"id":"https://openalex.org/F4320327941","display_name":"Swiss Cancer Research Foundation","ror":"https://ror.org/022wnsy59"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281293535.pdf","grobid_xml":"https://content.openalex.org/works/W4281293535.grobid-xml"},"referenced_works_count":166,"referenced_works":["https://openalex.org/W1539897961","https://openalex.org/W1558456773","https://openalex.org/W1649651531","https://openalex.org/W1699918302","https://openalex.org/W1750136822","https://openalex.org/W1843693004","https://openalex.org/W1888120829","https://openalex.org/W1928006163","https://openalex.org/W1933740900","https://openalex.org/W1962130714","https://openalex.org/W1969505329","https://openalex.org/W1971115798","https://openalex.org/W1972345745","https://openalex.org/W1974616640","https://openalex.org/W1978969638","https://openalex.org/W1985539406","https://openalex.org/W1987863757","https://openalex.org/W1992945893","https://openalex.org/W1994975655","https://openalex.org/W1994993231","https://openalex.org/W1995018598","https://openalex.org/W1998846885","https://openalex.org/W2001142268","https://openalex.org/W2001717792","https://openalex.org/W2003059653","https://openalex.org/W2005904261","https://openalex.org/W2012264087","https://openalex.org/W2032056606","https://openalex.org/W2032148614","https://openalex.org/W2033109379","https://openalex.org/W2035831689","https://openalex.org/W2037638312","https://openalex.org/W2039155608","https://openalex.org/W2039875876","https://openalex.org/W2040693077","https://openalex.org/W2044124936","https://openalex.org/W2047043794","https://openalex.org/W2048403514","https://openalex.org/W2048469790","https://openalex.org/W2059781799","https://openalex.org/W2061613081","https://openalex.org/W2062347907","https://openalex.org/W2064522355","https://openalex.org/W2066427200","https://openalex.org/W2066452478","https://openalex.org/W2066926516","https://openalex.org/W2067187611","https://openalex.org/W2071962822","https://openalex.org/W2078336838","https://openalex.org/W2081081618","https://openalex.org/W2084198623","https://openalex.org/W2085264719","https://openalex.org/W2097112399","https://openalex.org/W2097643518","https://openalex.org/W2102675454","https://openalex.org/W2103264839","https://openalex.org/W2105755414","https://openalex.org/W2107369528","https://openalex.org/W2107926181","https://openalex.org/W2108650847","https://openalex.org/W2109566059","https://openalex.org/W2112108652","https://openalex.org/W2113173540","https://openalex.org/W2114581080","https://openalex.org/W2115122569","https://openalex.org/W2116192373","https://openalex.org/W2117698323","https://openalex.org/W2119102884","https://openalex.org/W2121216309","https://openalex.org/W2121516672","https://openalex.org/W2123960655","https://openalex.org/W2126553133","https://openalex.org/W2133343738","https://openalex.org/W2133422786","https://openalex.org/W2135191287","https://openalex.org/W2137961256","https://openalex.org/W2140552166","https://openalex.org/W2141983035","https://openalex.org/W2142100540","https://openalex.org/W2149042360","https://openalex.org/W2149980799","https://openalex.org/W2150903402","https://openalex.org/W2151626967","https://openalex.org/W2153354382","https://openalex.org/W2154048440","https://openalex.org/W2155454428","https://openalex.org/W2155605596","https://openalex.org/W2156009988","https://openalex.org/W2157531541","https://openalex.org/W2160014515","https://openalex.org/W2162488370","https://openalex.org/W2164838962","https://openalex.org/W2165456770","https://openalex.org/W2168838268","https://openalex.org/W2185075416","https://openalex.org/W2229794099","https://openalex.org/W2232570276","https://openalex.org/W2254794399","https://openalex.org/W2260606606","https://openalex.org/W2273066997","https://openalex.org/W2315018741","https://openalex.org/W2341372633","https://openalex.org/W2412773516","https://openalex.org/W2550084345","https://openalex.org/W2566205732","https://openalex.org/W2572551054","https://openalex.org/W2601055810","https://openalex.org/W2616825195","https://openalex.org/W2618592868","https://openalex.org/W2742763599","https://openalex.org/W2756448133","https://openalex.org/W2758170246","https://openalex.org/W2765314233","https://openalex.org/W2766903152","https://openalex.org/W2767624281","https://openalex.org/W2772225910","https://openalex.org/W2782333299","https://openalex.org/W2783159800","https://openalex.org/W2783565259","https://openalex.org/W2788846482","https://openalex.org/W2789825114","https://openalex.org/W2792256546","https://openalex.org/W2795720999","https://openalex.org/W2797443945","https://openalex.org/W2803417520","https://openalex.org/W2807577801","https://openalex.org/W2884301716","https://openalex.org/W2885474386","https://openalex.org/W2887026479","https://openalex.org/W2892039698","https://openalex.org/W2896023509","https://openalex.org/W2896728499","https://openalex.org/W2909301717","https://openalex.org/W2915010259","https://openalex.org/W2921477085","https://openalex.org/W2924644564","https://openalex.org/W2930202795","https://openalex.org/W2937358637","https://openalex.org/W2955224282","https://openalex.org/W2955757810","https://openalex.org/W2976924121","https://openalex.org/W2985134017","https://openalex.org/W3023692543","https://openalex.org/W3025158964","https://openalex.org/W3028293850","https://openalex.org/W3041520229","https://openalex.org/W3047455092","https://openalex.org/W3049052172","https://openalex.org/W3111836013","https://openalex.org/W3126208996","https://openalex.org/W3130159011","https://openalex.org/W3138104526","https://openalex.org/W3159363972","https://openalex.org/W3159850003","https://openalex.org/W3162058804","https://openalex.org/W3173553906","https://openalex.org/W3179559990","https://openalex.org/W3184950993","https://openalex.org/W3195863089","https://openalex.org/W3216394039","https://openalex.org/W4200296315","https://openalex.org/W4207055527","https://openalex.org/W4210658708","https://openalex.org/W4210902065","https://openalex.org/W4210913993","https://openalex.org/W4243273332"],"related_works":["https://openalex.org/W4403202031","https://openalex.org/W4392861032","https://openalex.org/W4408487607","https://openalex.org/W4386407113","https://openalex.org/W7124243705","https://openalex.org/W3179559990","https://openalex.org/W4403636567","https://openalex.org/W4416662782","https://openalex.org/W4390667416","https://openalex.org/W4322009654"],"abstract_inverted_index":{"Helicobacter":[0],"pylori":[1,21,45,75,122,135],"infects":[2],"the":[3,15,26,48,51,96,117,130,138],"gastric":[4,31],"mucosa":[5],"of":[6,10,18,28,42,50,82,93,98,106,133,140],"a":[7,40,103],"large":[8],"number":[9],"humans.":[11],"Although":[12],"asymptomatic":[13],"in":[14,64,95],"vast":[16],"majority":[17],"cases,":[19],"H":[20,44,74,107,121,134],"infection":[22,76,136],"can":[23],"lead":[24],"to":[25,55],"development":[27],"peptic":[29],"ulcers":[30],"adenocarcinoma":[32],"and":[33,67,88,123,126],"mucosa-associated":[34],"lymphoid":[35],"tissue":[36],"(MALT)":[37],"lymphoma.":[38],"Using":[39],"variety":[41],"mechanisms,":[43],"locally":[46],"suppresses":[47],"function":[49],"host":[52],"immune":[53,109],"system":[54],"establish":[56],"chronic":[57],"infection.":[58],"Systemic":[59],"immunomodulation":[60],"has":[61,101],"been":[62],"observed":[63],"both":[65],"clinical":[66],"pre-clinical":[68],"studies,":[69],"which":[70],"have":[71],"demonstrated":[72],"that":[73],"is":[77],"associated":[78],"with":[79],"reduced":[80],"incidence":[81],"inflammatory":[83],"diseases,":[84],"such":[85],"as":[86],"asthma":[87],"Crohn\u2019s":[89],"disease.":[90],"The":[91],"introduction":[92],"immunotherapies":[94],"arsenal":[97],"anti-cancer":[99],"drugs":[100],"revealed":[102],"new":[104],"facet":[105],"pylori-induced":[108],"suppression.":[110],"In":[111],"this":[112],"review,":[113],"we":[114],"will":[115],"describe":[116],"intimate":[118],"interactions":[119],"between":[120],"its":[124],"host,":[125],"formulate":[127],"hypothtyeses":[128],"describing":[129],"detrimental":[131],"impact":[132],"on":[137],"efficacy":[139],"cancer":[141],"immunotherapies.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-05-24T00:00:00"}