{"id":"https://openalex.org/W4281286664","doi":"https://doi.org/10.1097/md9.0000000000000196","title":"Randomized controlled trial of the significance of combined use with Ninjin\u2019yoeito in CapeOX + Bmab therapy for patients with unresectable advanced/recurrent colorectal cancer: A protocol for study on efficacy, safety, and interaction (NYX study)","display_name":"Randomized controlled trial of the significance of combined use with Ninjin\u2019yoeito in CapeOX + Bmab therapy for patients with unresectable advanced/recurrent colorectal cancer: A protocol for study on efficacy, safety, and interaction (NYX study)","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4281286664","doi":"https://doi.org/10.1097/md9.0000000000000196"},"language":"en","primary_location":{"id":"doi:10.1097/md9.0000000000000196","doi":"https://doi.org/10.1097/md9.0000000000000196","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md9.0000000000000196","pdf_url":null,"source":{"id":"https://openalex.org/S4210177383","display_name":"Medicine Case Reports and Study Protocols","issn_l":"2691-3895","issn":["2691-3895"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine: Case Reports and Study Protocols","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/md9.0000000000000196","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008116561","display_name":"Yoshiharu Motoo","orcid":"https://orcid.org/0000-0002-0776-6434","observed_orcids":["https://orcid.org/0000-0002-0776-6434"]},"institutions":[{"id":"https://openalex.org/I882656400","display_name":"Komatsu (Japan)","ror":"https://ror.org/03s23ay81","country_code":"JP","type":"company","lineage":["https://openalex.org/I882656400"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiharu Motoo","raw_affiliation_strings":["Department of Medical Oncology, Komatsu Sophia Hospital, 478 Oki-machi, Komatsu, Ishikawa"],"raw_orcid":"https://orcid.org/0000-0002-0776-6434","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Komatsu Sophia Hospital, 478 Oki-machi, Komatsu, Ishikawa","institution_ids":["https://openalex.org/I882656400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101589150","display_name":"Katsunori Shinozaki","orcid":"https://orcid.org/0000-0003-0596-3423","observed_orcids":["https://orcid.org/0000-0003-0596-3423"]},"institutions":[{"id":"https://openalex.org/I4210107840","display_name":"Hiroshima Prefectural Hospital","ror":"https://ror.org/01rrd4612","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107840","https://openalex.org/I4405284852"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsunori Shinozaki","raw_affiliation_strings":["Division of Clinical Oncology, Hiroshima Prefectural Hospital, 1-5-54 Ujina-Kanda, Minami-ku, Hiroshima"],"raw_orcid":"https://orcid.org/0000-0003-0596-3423","affiliations":[{"raw_affiliation_string":"Division of Clinical Oncology, Hiroshima Prefectural Hospital, 1-5-54 Ujina-Kanda, Minami-ku, Hiroshima","institution_ids":["https://openalex.org/I4210107840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016459174","display_name":"Tsuyoshi Takagi","orcid":"https://orcid.org/0000-0003-4716-323X","observed_orcids":["https://orcid.org/0000-0003-4716-323X"]},"institutions":[{"id":"https://openalex.org/I4210155849","display_name":"Nishijin Hospital","ror":"https://ror.org/0525j6d32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155849"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Takagi","raw_affiliation_strings":["Department of Surgery, Nishijin Hospital, 1035 Mizomae-cho, Nishi-Hairu, Rokken-machi, Itsutsuji-cho, Kamigyo-ku, Kyoto"],"raw_orcid":"https://orcid.org/0000-0003-4716-323X","affiliations":[{"raw_affiliation_string":"Department of Surgery, Nishijin Hospital, 1035 Mizomae-cho, Nishi-Hairu, Rokken-machi, Itsutsuji-cho, Kamigyo-ku, Kyoto","institution_ids":["https://openalex.org/I4210155849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101965739","display_name":"Shingo Ito","orcid":"https://orcid.org/0000-0002-1064-7591","observed_orcids":["https://orcid.org/0000-0002-1064-7591"]},"institutions":[{"id":"https://openalex.org/I4405253942","display_name":"Kawasaki Saiwai Hospital","ror":"https://ror.org/017s8ee04","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253942"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Ito","raw_affiliation_strings":["Department of Gastrointestinal Surgery, the Second Kawasaki Saiwai Clinic, 39-1 Miyako-cho, Saiwai-ku, Kawasaki, Kanagawa"],"raw_orcid":"https://orcid.org/0000-0002-1064-7591","affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, the Second Kawasaki Saiwai Clinic, 39-1 Miyako-cho, Saiwai-ku, Kawasaki, Kanagawa","institution_ids":["https://openalex.org/I4405253942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091529471","display_name":"Hideto Fujita","orcid":"https://orcid.org/0000-0002-6702-8011","observed_orcids":["https://orcid.org/0000-0002-6702-8011"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideto Fujita","raw_affiliation_strings":["Department of General and Gastroenterological Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa"],"raw_orcid":"https://orcid.org/0000-0002-6702-8011","affiliations":[{"raw_affiliation_string":"Department of General and Gastroenterological Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026639791","display_name":"Yoshinori Munemoto","orcid":"https://orcid.org/0000-0002-0893-6706","observed_orcids":["https://orcid.org/0000-0002-0893-6706"]},"institutions":[{"id":"https://openalex.org/I4210122864","display_name":"Fukui-ken Saiseikai Hospital","ror":"https://ror.org/032rtvf56","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210122864"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Munemoto","raw_affiliation_strings":["Department of Surgery, Fukuiken Saikseikai Hospital, 7-1 Funabashi, Wadanaka-cho, Fukui"],"raw_orcid":"https://orcid.org/0000-0002-0893-6706","affiliations":[{"raw_affiliation_string":"Department of Surgery, Fukuiken Saikseikai Hospital, 7-1 Funabashi, Wadanaka-cho, Fukui","institution_ids":["https://openalex.org/I4210122864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055130191","display_name":"Naohisa Yoshida","orcid":"https://orcid.org/0000-0001-6167-9705","observed_orcids":["https://orcid.org/0000-0001-6167-9705"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naohisa Yoshida","raw_affiliation_strings":["Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kawaramachi-Hirokoji, Kajii-cho, Kamigyo-ku, Kyoto"],"raw_orcid":"https://orcid.org/0000-0001-6167-9705","affiliations":[{"raw_affiliation_string":"Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kawaramachi-Hirokoji, Kajii-cho, Kamigyo-ku, Kyoto","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072512404","display_name":"Eishi Baba","orcid":"https://orcid.org/0000-0001-9428-6772","observed_orcids":["https://orcid.org/0000-0001-9428-6772"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eishi Baba","raw_affiliation_strings":["Department of Oncology and Social Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka"],"raw_orcid":"https://orcid.org/0000-0001-9428-6772","affiliations":[{"raw_affiliation_string":"Department of Oncology and Social Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102810917","display_name":"Yoshiaki Shindo","orcid":"https://orcid.org/0000-0002-4931-2545","observed_orcids":["https://orcid.org/0000-0002-4931-2545"]},"institutions":[{"id":"https://openalex.org/I4210105519","display_name":"Nakad\u014dri General Hospital","ror":"https://ror.org/010kthv55","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105519"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Shindo","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Nakadori General Hospital, 3-15 Misono-cho, Minamidori, Akita"],"raw_orcid":"https://orcid.org/0000-0002-4931-2545","affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Nakadori General Hospital, 3-15 Misono-cho, Minamidori, Akita","institution_ids":["https://openalex.org/I4210105519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042489088","display_name":"Takamasa Nishiuchi","orcid":"https://orcid.org/0000-0002-3187-7273","observed_orcids":["https://orcid.org/0000-0002-3187-7273"]},"institutions":[{"id":"https://openalex.org/I4210093795","display_name":"Takamatsu Red Cross Hospital","ror":"https://ror.org/00n3egs77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210093795"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takamasa Nishiuchi","raw_affiliation_strings":["Department of Medical Oncology, Takamatsu Red Cross Hospital, 4-1-3 Ban-Cho, Takamatsu, Kagawa 760-0017, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3187-7273","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Takamatsu Red Cross Hospital, 4-1-3 Ban-Cho, Takamatsu, Kagawa 760-0017, Japan","institution_ids":["https://openalex.org/I4210093795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086680208","display_name":"Masatomo Miura","orcid":"https://orcid.org/0000-0001-7120-2425","observed_orcids":["https://orcid.org/0000-0001-7120-2425"]},"institutions":[{"id":"https://openalex.org/I4210132405","display_name":"Akita University Hospital","ror":"https://ror.org/02szmmq82","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132405"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatomo Miura","raw_affiliation_strings":["Department of Pharmacy, Akita University Hospital, 44-2 Hasunuma, Hiroomote, Akita"],"raw_orcid":"https://orcid.org/0000-0001-7120-2425","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Akita University Hospital, 44-2 Hasunuma, Hiroomote, Akita","institution_ids":["https://openalex.org/I4210132405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101885138","display_name":"Satoshi Morita","orcid":"https://orcid.org/0000-0002-4344-3317","observed_orcids":["https://orcid.org/0000-0002-4344-3317"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Morita","raw_affiliation_strings":["Deapartment of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto"],"raw_orcid":"https://orcid.org/0000-0002-4344-3317","affiliations":[{"raw_affiliation_string":"Deapartment of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062868734","display_name":"Akihito Tsuji","orcid":"https://orcid.org/0000-0003-4034-1945","observed_orcids":["https://orcid.org/0000-0003-4034-1945"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]},{"id":"https://openalex.org/I4210135297","display_name":"Kagawa University Hospital","ror":"https://ror.org/033sspj46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I201933988","https://openalex.org/I4210135297"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihito Tsuji","raw_affiliation_strings":["Department of Clinical Oncology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4034-1945","affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, Japan","institution_ids":["https://openalex.org/I201933988","https://openalex.org/I4210135297"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5008116561"],"corresponding_institution_ids":["https://openalex.org/I882656400"],"apc_list":null,"apc_paid":null,"fwci":0.2214,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.44746356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"3","issue":"5","first_page":"e0196","last_page":"e0196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.10809999704360962,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ninjin-yoeito","display_name":"Ninjin'yoeito","score":0.9369999766349792},{"id":"https://openalex.org/keywords/kampo-medicine","display_name":"Kampo medicine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7900000214576721},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/colorectal-cancer-recurrence","display_name":"recurrent colorectal cancer","score":0.984000027179718},{"id":"https://openalex.org/keywords/capeox","display_name":"CapeOX","score":0.7910000085830688},{"id":"https://openalex.org/keywords/capecitabine","display_name":"capecitabine","score":0.9089999794960022},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":1.0},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.9369999766349792},{"id":"https://openalex.org/keywords/conut-score","display_name":"CONUT score","score":0.6430000066757202},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9259999990463257},{"id":"https://openalex.org/keywords/neurofilament-heavy-chain","display_name":"neurofilament heavy chain","score":0.8399999737739563},{"id":"https://openalex.org/keywords/supportive-therapy","display_name":"supportive therapy","score":0.5260000228881836},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7969380617141724},{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.7945951819419861},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.7546521425247192},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.7354395985603333},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7006075978279114},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6257097125053406},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47714942693710327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.468932181596756},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4291326403617859},{"id":"https://openalex.org/C2777793932","wikidata":"https://www.wikidata.org/wiki/Q1116229","display_name":"Common Terminology Criteria for Adverse Events","level":3,"score":0.41319432854652405},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2535856366157532}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/md9.0000000000000196","doi":"https://doi.org/10.1097/md9.0000000000000196","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md9.0000000000000196","pdf_url":null,"source":{"id":"https://openalex.org/S4210177383","display_name":"Medicine Case Reports and Study Protocols","issn_l":"2691-3895","issn":["2691-3895"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine: Case Reports and Study Protocols","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1097/md9.0000000000000196","doi":"https://doi.org/10.1097/md9.0000000000000196","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md9.0000000000000196","pdf_url":null,"source":{"id":"https://openalex.org/S4210177383","display_name":"Medicine Case Reports and Study Protocols","issn_l":"2691-3895","issn":["2691-3895"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine: Case Reports and Study Protocols","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W77244783","https://openalex.org/W2088205781","https://openalex.org/W2103735966","https://openalex.org/W2121368761","https://openalex.org/W2141688840","https://openalex.org/W2166023752","https://openalex.org/W2170802167","https://openalex.org/W2481029616","https://openalex.org/W2618908006","https://openalex.org/W2794639115","https://openalex.org/W2848717028","https://openalex.org/W2904824013","https://openalex.org/W2972273476","https://openalex.org/W3013605775","https://openalex.org/W4211168195"],"related_works":["https://openalex.org/W7155492186","https://openalex.org/W3013605775","https://openalex.org/W2605222400","https://openalex.org/W2368540191","https://openalex.org/W2601576175","https://openalex.org/W3021178495","https://openalex.org/W2800514002","https://openalex.org/W2890345059","https://openalex.org/W2395954151","https://openalex.org/W7097927847"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"This":[2,187,248],"randomized":[3],"controlled":[4],"trial":[5,188],"is":[6,178],"aimed":[7],"at":[8],"clarifying":[9],"the":[10,81,90,116,129,140,174,190,197,209,253],"benefit":[11],"of":[12,15,136,147,152,160,194,199,213,256],"an":[13],"extract":[14],"ninjin\u2019yoeito":[16],"(NYT,":[17],"traditional":[18],"Japanese":[19],"herbal":[20],"medicine,":[21],"Kampo)":[22],"when":[23],"combined":[24],"with":[25,36,42,50,104,220,240],"capecitabine":[26],"plus":[27,30],"oxaliplatin":[28],"(CapeOX)":[29],"bevacizumab":[31],"(Bmab)":[32],"in":[33,196,238,252],"150":[34],"patients":[35,171,219,239],"metastatic":[37],"or":[38,53,89,222],"recurrent":[39,54,223],"colorectal":[40,55,224,241],"cancer":[41,56,242],"special":[43],"reference":[44],"to":[45,59,80,182,218],"nutritional":[46,101,202],"status.":[47],"Methods/Design:":[48],"Patients":[49],"unresectable,":[51],"metastatic,":[52],"who":[57,71],"plan":[58],"receive":[60],"CapeOX":[61,86,214],"+":[62,85,87,94,215],"Bmab":[63,216],"will":[64,76,99,127,168],"be":[65,77,100,233],"recruited.":[66],"Of":[67],"these":[68],"patients,":[69],"those":[70],"provide":[72],"written":[73],"informed":[74],"consent":[75],"randomly":[78],"allocated":[79],"NYT":[82,132,195,231],"group":[83,92],"(NYT":[84],"Bmab)":[88],"control":[91],"(CapeOX":[93],"Bmab).":[95],"The":[96,124,165,226],"co-primary":[97],"endpoints":[98,126],"status,":[102],"evaluated":[103,138],"CONtrolling":[105],"NUTritional":[106],"Status":[107],"scores,":[108],"and":[109,133,145,155,157,173,192,204],"severe":[110],"non-hematological":[111],"adverse":[112,206],"events,":[113],"assessed":[114],"using":[115,139],"Common":[117],"Terminology":[118],"Criteria":[119],"for":[120,143],"Adverse":[121],"Events":[122],"v5.0.":[123],"secondary":[125],"include":[128,169,229],"interaction":[130],"between":[131],"capecitabine;":[134],"quality":[135],"life":[137],"European":[141],"Organization":[142],"Research":[144],"Treatment":[146],"Cancer-QLQ-C30;":[148],"relative":[149],"dose":[150],"intensity":[151],"oxaliplatin,":[153],"capecitabine,":[154],"bevacizumab;":[156],"plasma":[158],"levels":[159],"phosphorylated":[161],"neurofilament":[162],"heavy":[163],"chain.":[164],"two":[166],"groups":[167],"75":[170],"each,":[172],"patient":[175],"recruitment":[176],"period":[177],"January":[179],"1st,":[180],"2020":[181],"December":[183],"31st,":[184],"2022.":[185],"Discussion:":[186],"evaluates":[189],"efficacy":[191],"safety":[193],"maintenance":[198],"a":[200,234],"better":[201],"status":[203],"fewer":[205],"events":[207],"during":[208],"standard":[210],"chemotherapeutic":[211],"regimen":[212],"administered":[217],"advanced":[221],"cancer.":[225],"potential":[227],"implications":[228],"that":[230],"could":[232],"strong":[235],"supportive":[236],"therapy":[237],"receiving":[243],"chemotherapy.":[244],"Trial":[245],"registration":[246],"number:":[247,260],"study":[249],"was":[250],"registered":[251],"Japan":[254],"Registry":[255],"Clinical":[257],"Trials":[258],"(registration":[259],"jRCTs041190071)":[261],"on":[262],"October":[263],"2,":[264],"2019.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-05-24T00:00:00"}