{"id":"https://openalex.org/W4281249486","doi":"https://doi.org/10.3390/ijms23105779","title":"Proteomics and Phosphoproteomics of Circulating Extracellular Vesicles Provide New Insights into Diabetes Pathobiology","display_name":"Proteomics and Phosphoproteomics of Circulating Extracellular Vesicles Provide New Insights into Diabetes Pathobiology","publication_year":2022,"publication_date":"2022-05-21","ids":{"openalex":"https://openalex.org/W4281249486","doi":"https://doi.org/10.3390/ijms23105779","pmid":"https://pubmed.ncbi.nlm.nih.gov/35628588","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9147902"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23105779","doi":"https://doi.org/10.3390/ijms23105779","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23105779","pdf_url":"https://www.mdpi.com/1422-0067/23/10/5779/pdf?version=1653445944","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/10/5779/pdf?version=1653445944","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013515661","display_name":"Yury O. N\u00fa\u00f1ez L\u00f3pez","orcid":"https://orcid.org/0000-0003-0382-9124","observed_orcids":["https://orcid.org/0000-0003-0382-9124"]},"institutions":[{"id":"https://openalex.org/I2799648416","display_name":"AdventHealth Orlando","ror":"https://ror.org/02n1cyj49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799648416"]},{"id":"https://openalex.org/I4210135360","display_name":"Translational Research Institute for Metabolism and Diabetes","ror":"https://ror.org/03gj9g134","country_code":"US","type":"facility","lineage":["https://openalex.org/I188891513","https://openalex.org/I2799648416","https://openalex.org/I4210135360"]},{"id":"https://openalex.org/I4405270336","display_name":"AdventHealth","ror":"https://ror.org/00gqase94","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405270336"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yury O. Nunez Lopez","raw_affiliation_strings":["AdventHealth, Translational Research Institute (TRI), Orlando, FL 32828, USA"],"raw_orcid":"https://orcid.org/0000-0003-0382-9124","affiliations":[{"raw_affiliation_string":"AdventHealth, Translational Research Institute (TRI), Orlando, FL 32828, USA","institution_ids":["https://openalex.org/I2799648416","https://openalex.org/I4210135360","https://openalex.org/I4405270336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018259425","display_name":"Anton B. Iliuk","orcid":"https://orcid.org/0000-0002-2914-1363","observed_orcids":["https://orcid.org/0000-0002-2914-1363"]},"institutions":[{"id":"https://openalex.org/I4210154637","display_name":"Tymora Analytical Operations (United States)","ror":"https://ror.org/04dd14e02","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154637"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anton Iliuk","raw_affiliation_strings":["Tymora Analytical Operations, West Lafayette, IN 47906, USA"],"raw_orcid":"https://orcid.org/0000-0002-2914-1363","affiliations":[{"raw_affiliation_string":"Tymora Analytical Operations, West Lafayette, IN 47906, USA","institution_ids":["https://openalex.org/I4210154637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014697482","display_name":"Alejandra M. Petrilli","orcid":"https://orcid.org/0000-0002-3090-9325","observed_orcids":["https://orcid.org/0000-0002-3090-9325"]},"institutions":[{"id":"https://openalex.org/I2799648416","display_name":"AdventHealth Orlando","ror":"https://ror.org/02n1cyj49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799648416"]},{"id":"https://openalex.org/I4210135360","display_name":"Translational Research Institute for Metabolism and Diabetes","ror":"https://ror.org/03gj9g134","country_code":"US","type":"facility","lineage":["https://openalex.org/I188891513","https://openalex.org/I2799648416","https://openalex.org/I4210135360"]},{"id":"https://openalex.org/I4405270336","display_name":"AdventHealth","ror":"https://ror.org/00gqase94","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405270336"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandra Petrilli","raw_affiliation_strings":["AdventHealth, Translational Research Institute (TRI), Orlando, FL 32828, USA"],"raw_orcid":"https://orcid.org/0000-0002-3090-9325","affiliations":[{"raw_affiliation_string":"AdventHealth, Translational Research Institute (TRI), Orlando, FL 32828, USA","institution_ids":["https://openalex.org/I2799648416","https://openalex.org/I4210135360","https://openalex.org/I4405270336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004107799","display_name":"Carley E. Glass","orcid":"https://orcid.org/0000-0001-9875-1125","observed_orcids":["https://orcid.org/0000-0001-9875-1125"]},"institutions":[{"id":"https://openalex.org/I2799648416","display_name":"AdventHealth Orlando","ror":"https://ror.org/02n1cyj49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799648416"]},{"id":"https://openalex.org/I4210135360","display_name":"Translational Research Institute for Metabolism and Diabetes","ror":"https://ror.org/03gj9g134","country_code":"US","type":"facility","lineage":["https://openalex.org/I188891513","https://openalex.org/I2799648416","https://openalex.org/I4210135360"]},{"id":"https://openalex.org/I4405270336","display_name":"AdventHealth","ror":"https://ror.org/00gqase94","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405270336"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carley Glass","raw_affiliation_strings":["AdventHealth, Translational Research Institute (TRI), Orlando, FL 32828, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AdventHealth, Translational Research Institute (TRI), Orlando, FL 32828, USA","institution_ids":["https://openalex.org/I2799648416","https://openalex.org/I4210135360","https://openalex.org/I4405270336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039861479","display_name":"Anna Casu","orcid":"https://orcid.org/0000-0001-6924-0617","observed_orcids":["https://orcid.org/0000-0001-6924-0617"]},"institutions":[{"id":"https://openalex.org/I2799648416","display_name":"AdventHealth Orlando","ror":"https://ror.org/02n1cyj49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799648416"]},{"id":"https://openalex.org/I4210135360","display_name":"Translational Research Institute for Metabolism and Diabetes","ror":"https://ror.org/03gj9g134","country_code":"US","type":"facility","lineage":["https://openalex.org/I188891513","https://openalex.org/I2799648416","https://openalex.org/I4210135360"]},{"id":"https://openalex.org/I4405270336","display_name":"AdventHealth","ror":"https://ror.org/00gqase94","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405270336"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Casu","raw_affiliation_strings":["AdventHealth, Translational Research Institute (TRI), Orlando, FL 32828, USA"],"raw_orcid":"https://orcid.org/0000-0001-6924-0617","affiliations":[{"raw_affiliation_string":"AdventHealth, Translational Research Institute (TRI), Orlando, FL 32828, USA","institution_ids":["https://openalex.org/I2799648416","https://openalex.org/I4210135360","https://openalex.org/I4405270336"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059098934","display_name":"Richard E. Pratley","orcid":"https://orcid.org/0000-0002-2912-1389","observed_orcids":["https://orcid.org/0000-0002-2912-1389"]},"institutions":[{"id":"https://openalex.org/I2799648416","display_name":"AdventHealth Orlando","ror":"https://ror.org/02n1cyj49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799648416"]},{"id":"https://openalex.org/I4210135360","display_name":"Translational Research Institute for Metabolism and Diabetes","ror":"https://ror.org/03gj9g134","country_code":"US","type":"facility","lineage":["https://openalex.org/I188891513","https://openalex.org/I2799648416","https://openalex.org/I4210135360"]},{"id":"https://openalex.org/I4405270336","display_name":"AdventHealth","ror":"https://ror.org/00gqase94","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405270336"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard E. Pratley","raw_affiliation_strings":["AdventHealth, Translational Research Institute (TRI), Orlando, FL 32828, USA"],"raw_orcid":"https://orcid.org/0000-0002-2912-1389","affiliations":[{"raw_affiliation_string":"AdventHealth, Translational Research Institute (TRI), Orlando, FL 32828, USA","institution_ids":["https://openalex.org/I2799648416","https://openalex.org/I4210135360","https://openalex.org/I4405270336"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018259425","https://openalex.org/A5059098934"],"corresponding_institution_ids":["https://openalex.org/I2799648416","https://openalex.org/I4210135360","https://openalex.org/I4210154637","https://openalex.org/I4405270336"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":3.4223,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.94834508,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"23","issue":"10","first_page":"5779","last_page":"5779"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-extracellular-vesicles","display_name":"circulating extracellular vesicles","score":0.9150000214576721},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.8190000057220459},{"id":"https://openalex.org/keywords/extracellular-vesicle-proteome","display_name":"extracellular vesicle proteome","score":0.8320000171661377},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":1.0},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.6959999799728394},{"id":"https://openalex.org/keywords/pkcdelta","display_name":"PKC\u03b4","score":0.9729999899864197},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.8689159154891968},{"id":"https://openalex.org/C6675166","wikidata":"https://www.wikidata.org/wiki/Q7187538","display_name":"Phosphoproteomics","level":5,"score":0.8671159744262695},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.8013916015625},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.5119057893753052},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48321330547332764},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.47834035754203796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.438627153635025},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3941745460033417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38112643361091614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22336450219154358},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.10621896386146545},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.0876401960849762},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.0},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms23105779","doi":"https://doi.org/10.3390/ijms23105779","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23105779","pdf_url":"https://www.mdpi.com/1422-0067/23/10/5779/pdf?version=1653445944","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/2021.10.31.21265724","doi":"https://doi.org/10.1101/2021.10.31.21265724","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.31.21265724","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2021/11/01/2021.10.31.21265724.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9147902","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9147902","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:35628588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35628588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:fc026d98cfeb49bfb83962e728a70183","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fc026d98cfeb49bfb83962e728a70183","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 5779, p 5779 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms23105779","doi":"https://doi.org/10.3390/ijms23105779","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23105779","pdf_url":"https://www.mdpi.com/1422-0067/23/10/5779/pdf?version=1653445944","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F2615479001","display_name":"AdventHealth","ror":"https://ror.org/00gqase94"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281249486.pdf","grobid_xml":"https://content.openalex.org/works/W4281249486.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W1904254775","https://openalex.org/W1950118853","https://openalex.org/W1967594212","https://openalex.org/W1967933031","https://openalex.org/W1979510466","https://openalex.org/W1983286754","https://openalex.org/W1987504685","https://openalex.org/W1992187671","https://openalex.org/W1993409946","https://openalex.org/W1996919353","https://openalex.org/W2002952985","https://openalex.org/W2006900120","https://openalex.org/W2012034410","https://openalex.org/W2014752437","https://openalex.org/W2015391533","https://openalex.org/W2017507172","https://openalex.org/W2017983668","https://openalex.org/W2027107711","https://openalex.org/W2027445170","https://openalex.org/W2034646931","https://openalex.org/W2049025878","https://openalex.org/W2051042078","https://openalex.org/W2051785784","https://openalex.org/W2052882363","https://openalex.org/W2055382292","https://openalex.org/W2064015939","https://openalex.org/W2064384823","https://openalex.org/W2076229019","https://openalex.org/W2080352379","https://openalex.org/W2081098333","https://openalex.org/W2105898083","https://openalex.org/W2112830170","https://openalex.org/W2114211654","https://openalex.org/W2116717483","https://openalex.org/W2123106337","https://openalex.org/W2131419387","https://openalex.org/W2131492087","https://openalex.org/W2146512944","https://openalex.org/W2146957741","https://openalex.org/W2147524926","https://openalex.org/W2149098481","https://openalex.org/W2151186330","https://openalex.org/W2152849583","https://openalex.org/W2154876324","https://openalex.org/W2156941462","https://openalex.org/W2162143298","https://openalex.org/W2162151881","https://openalex.org/W2170852633","https://openalex.org/W2171000684","https://openalex.org/W2171081396","https://openalex.org/W2259481044","https://openalex.org/W2342473733","https://openalex.org/W2346152485","https://openalex.org/W2346694641","https://openalex.org/W2400762618","https://openalex.org/W2401966128","https://openalex.org/W2417487626","https://openalex.org/W2554139951","https://openalex.org/W2594408608","https://openalex.org/W2603189578","https://openalex.org/W2615714795","https://openalex.org/W2752920244","https://openalex.org/W2766187962","https://openalex.org/W2767767370","https://openalex.org/W2786262376","https://openalex.org/W2800208504","https://openalex.org/W2806375940","https://openalex.org/W2808808322","https://openalex.org/W2810368020","https://openalex.org/W2886022119","https://openalex.org/W2886504687","https://openalex.org/W2900059354","https://openalex.org/W2901496107","https://openalex.org/W2914579308","https://openalex.org/W2931418311","https://openalex.org/W2943261504","https://openalex.org/W2948262697","https://openalex.org/W2963543751","https://openalex.org/W2966085154","https://openalex.org/W2972869264","https://openalex.org/W2996274474","https://openalex.org/W3012261844","https://openalex.org/W3017836124","https://openalex.org/W3021143415","https://openalex.org/W3025557718","https://openalex.org/W3028622214","https://openalex.org/W3039215336","https://openalex.org/W3094209855","https://openalex.org/W3095414730","https://openalex.org/W3120209173","https://openalex.org/W3125755970","https://openalex.org/W3131480669","https://openalex.org/W3131729522","https://openalex.org/W3131989051","https://openalex.org/W3132267651","https://openalex.org/W3138482198","https://openalex.org/W3167670931","https://openalex.org/W3175752499","https://openalex.org/W3177080725","https://openalex.org/W3184395450","https://openalex.org/W3193618072","https://openalex.org/W3204789385","https://openalex.org/W4200400903","https://openalex.org/W4205466154","https://openalex.org/W4213144883","https://openalex.org/W4231637220","https://openalex.org/W4242364069","https://openalex.org/W6752579131","https://openalex.org/W6797786779"],"related_works":["https://openalex.org/W4385340989","https://openalex.org/W4220922186","https://openalex.org/W4416338448","https://openalex.org/W7000479364","https://openalex.org/W4297995900","https://openalex.org/W3130378681","https://openalex.org/W2996274474","https://openalex.org/W4391540699","https://openalex.org/W2800208504","https://openalex.org/W7163656895"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,13,94,111,151,164,232,239,245,301],"this":[3],"study":[4,281],"was":[5,261],"to":[6,57,140,195,207],"define":[7,147],"the":[8,59,112,133,148,187,237,249,299],"proteomic":[9,284],"and":[10,27,63,71,88,99,137,153,174,176,189,222,253,258,285,292,294],"phosphoproteomic":[11,149,286],"landscape":[12],"circulating":[14],"extracellular":[15],"vesicles":[16],"(EVs)":[17],"in":[18,186,202,210,213,218,255,269,278,288],"people":[19,158,289],"with":[20,159,290],"normal":[21],"glucose":[22],"tolerance":[23],"(NGT),":[24],"prediabetes":[25,291],"(PDM),":[26],"diabetes":[28,160],"(T2DM).":[29],"Archived":[30],"serum":[31],"samples":[32],"from":[33,157,220],"30":[34],"human":[35],"subjects":[36],"(n":[37],"=":[38],"10":[39],"per":[40],"group,":[41],"ORIGINS":[42],"study,":[43],"NCT02226640)":[44],"were":[45,48,55,76,84,104,215],"used.":[46],"EVs":[47,156,219],"isolated":[49],"using":[50,78,86],"EVtrap\u00ae.":[51],"Mass":[52],"spectrometry-based":[53],"methods":[54],"used":[56],"detect":[58],"global":[60],"EV":[61,97,102,251,271,283],"proteome":[62],"phosphoproteome.":[64],"Differentially":[65],"expressed":[66,114],"features,":[67],"correlation,":[68],"enriched":[69,72,243],"pathways,":[70],"tissue-specific":[73],"protein":[74],"sets":[75],"identified":[77,105,282],"custom":[79],"R":[80],"scripts.":[81],"Phosphosite-centric":[82],"analyses":[83],"conducted":[85],"directPA":[87],"PhosR":[89],"software":[90],"packages.":[91],"A":[92,241],"total":[93],"2372":[95],"unique":[96,101],"proteins":[98,125,252],"716":[100],"phosphoproteins":[103,128,254],"among":[106,132,248],"all":[107],"samples.":[108],"Unsupervised":[109],"clustering":[110],"differentially":[113],"(fold":[115],"change":[116],"\u2265":[117],"2,":[118],"p":[119],"<":[120,123],"0.05,":[121],"FDR":[122],"0.05)":[124],"and,":[126],"particularly,":[127],"showed":[129],"excellent":[130],"discrimination":[131],"three":[134],"groups.":[135],"CDK1":[136],"PKC\u03b4":[138],"appear":[139],"drive":[141],"key":[142],"upstream":[143],"phosphorylation":[144,204],"events":[145],"that":[146,226,266],"signatures":[150,287],"PDM":[152,188,221,257],"T2DM.":[154],"Circulating":[155],"carry":[161],"increased":[162,217],"levels":[163],"specific":[165],"phosphorylated":[166],"kinases":[167,181],"(i.e.,":[168],"AKT1,":[169],"GSK3B,":[170],"LYN,":[171],"MAP2K2,":[172],"MYLK,":[173],"PRKCD)":[175],"could":[177],"potentially":[178],"distribute":[179],"activated":[180],"systemically.":[182],"Among":[183],"characteristic":[184],"changes":[185],"T2DM":[190,259,293],"EVs,":[191],"\u201cintegrin":[192],"switching\u201d":[193],"appeared":[194],"be":[196,208],"a":[197],"central":[198],"feature.":[199],"Proteins":[200],"involved":[201],"oxidative":[203],"(OXPHOS),":[205],"known":[206],"reduced":[209],"various":[211],"tissues":[212],"diabetes,":[214],"significantly":[216],"T2DM,":[223],"which":[224],"suggests":[225,265],"an":[227,267],"abnormally":[228],"elevated":[229],"EV-mediated":[230],"secretion":[231,274],"OXPHOS":[233],"components":[234],"may":[235,275],"underlie":[236],"development":[238],"diabetes.":[240,302],"highly":[242],"signature":[244],"liver-specific":[246],"markers":[247],"downregulated":[250],"both":[256],"groups":[260],"also":[262],"detected.":[263],"This":[264,280],"alteration":[268],"liver":[270],"composition":[272],"and/or":[273],"occur":[276],"early":[277],"prediabetes.":[279],"provides":[295],"novel":[296],"insight":[297],"into":[298],"pathobiology":[300]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-23T00:00:00"}
