{"id":"https://openalex.org/W4280638801","doi":"https://doi.org/10.1016/j.ejpb.2022.05.007","title":"Application of physiologically based absorption and pharmacokinetic modeling in the development process of oral modified release generic products","display_name":"Application of physiologically based absorption and pharmacokinetic modeling in the development process of oral modified release generic products","publication_year":2022,"publication_date":"2022-05-19","ids":{"openalex":"https://openalex.org/W4280638801","doi":"https://doi.org/10.1016/j.ejpb.2022.05.007","pmid":"https://pubmed.ncbi.nlm.nih.gov/35598768"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejpb.2022.05.007","doi":"https://doi.org/10.1016/j.ejpb.2022.05.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejpb.2022.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S122302516","display_name":"European Journal of Pharmaceutics and Biopharmaceutics","issn_l":"0939-6411","issn":["0939-6411","1873-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutics and Biopharmaceutics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069634129","display_name":"Saima Subhani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saima Subhani","raw_affiliation_strings":["Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056467877","display_name":"Chaejin Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaejin Kim","raw_affiliation_strings":["Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paula Muniz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula Muniz","raw_affiliation_strings":["Model Informed Development (MID), Dynakin, SLU., a CTI company, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Model Informed Development (MID), Dynakin, SLU., a CTI company, Bilbao, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044977738","display_name":"M\u00f3nica Rodr\u00edguez","orcid":"https://orcid.org/0000-0003-0403-9810","observed_orcids":["https://orcid.org/0000-0003-0403-9810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monica Rodriguez","raw_affiliation_strings":["Model Informed Development (MID), Dynakin, SLU., a CTI company, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Model Informed Development (MID), Dynakin, SLU., a CTI company, Bilbao, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sandra van Os","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103972","display_name":"Synthon (Netherlands)","ror":"https://ror.org/01gswc231","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210103972"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sandra van Os","raw_affiliation_strings":["Synthon BV, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthon BV, the Netherlands","institution_ids":["https://openalex.org/I4210103972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032661583","display_name":"Elena Su\u00e1rez","orcid":"https://orcid.org/0000-0002-6683-4847","observed_orcids":["https://orcid.org/0000-0002-6683-4847"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210089430","display_name":"BioCruces Health research Institute","ror":"https://ror.org/0061s4v88","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210089430"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Suarez","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine and Nursery, University of Basque Country UPV/EHU, Biocruces Health Research Institute, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine and Nursery, University of Basque Country UPV/EHU, Biocruces Health Research Institute, Spain","institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210089430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073938156","display_name":"Rodrigo Cristofoletti","orcid":"https://orcid.org/0000-0003-2619-0343","observed_orcids":["https://orcid.org/0000-0003-2619-0343"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodrigo Cristofoletti","raw_affiliation_strings":["Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062673118","display_name":"Stephan Schmidt","orcid":"https://orcid.org/0000-0002-4998-1167","observed_orcids":["https://orcid.org/0000-0002-4998-1167"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan Schmidt","raw_affiliation_strings":["Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000391786","display_name":"Valvanera Vozmediano","orcid":"https://orcid.org/0000-0002-2636-1889","observed_orcids":["https://orcid.org/0000-0002-2636-1889"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Valvanera Vozmediano","raw_affiliation_strings":["Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA. Electronic address: valva@cop.ufl.edu","Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA. Electronic address: valva@cop.ufl.edu","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000391786"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":null,"fwci":0.1312,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.09461426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"176","issue":null,"first_page":"87","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-model","display_name":"physiologically based pharmacokinetic modeling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/generic-drug-development","display_name":"generic drug development","score":0.8450000286102295},{"id":"https://openalex.org/keywords/gastrointestinal-drug-absorption","display_name":"gastrointestinal drug absorption","score":0.7200000286102295},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-correlation","display_name":"in vitro-in vivo correlation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/oral-bioavailability-prediction","display_name":"oral bioavailability prediction","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pharmaceutical-formulation-development","display_name":"drug formulation development","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.9205055236816406},{"id":"https://openalex.org/C2910701995","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutics","level":5,"score":0.7347429990768433},{"id":"https://openalex.org/C2779484521","wikidata":"https://www.wikidata.org/wiki/Q5975478","display_name":"IVIVC","level":5,"score":0.6732994914054871},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.637098491191864},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5988032817840576},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.49831295013427734},{"id":"https://openalex.org/C2781430271","wikidata":"https://www.wikidata.org/wiki/Q278760","display_name":"Biopharmaceutics Classification System","level":3,"score":0.4527592062950134},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4237542152404785},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.41592735052108765},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.3970780372619629},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39025434851646423},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3572372496128082},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3516925871372223},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3411691188812256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25480854511260986},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1674865484237671},{"id":"https://openalex.org/C14029885","wikidata":"https://www.wikidata.org/wiki/Q5282807","display_name":"Dissolution testing","level":4,"score":0.10127261281013489},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.0},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001702","descriptor_name":"Biopharmaceutics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejpb.2022.05.007","doi":"https://doi.org/10.1016/j.ejpb.2022.05.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejpb.2022.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S122302516","display_name":"European Journal of Pharmaceutics and Biopharmaceutics","issn_l":"0939-6411","issn":["0939-6411","1873-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutics and Biopharmaceutics","raw_type":"journal-article"},{"id":"pmid:35598768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35598768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W176229142","https://openalex.org/W1535421419","https://openalex.org/W1576144270","https://openalex.org/W1593241028","https://openalex.org/W1603855465","https://openalex.org/W1615135251","https://openalex.org/W1641607484","https://openalex.org/W1906682217","https://openalex.org/W1922027594","https://openalex.org/W1929292775","https://openalex.org/W1979784444","https://openalex.org/W1982801384","https://openalex.org/W2001536171","https://openalex.org/W2011891393","https://openalex.org/W2015075381","https://openalex.org/W2016053698","https://openalex.org/W2018986030","https://openalex.org/W2024245738","https://openalex.org/W2027143209","https://openalex.org/W2029590089","https://openalex.org/W2040472157","https://openalex.org/W2047614775","https://openalex.org/W2058738094","https://openalex.org/W2062761938","https://openalex.org/W2067302812","https://openalex.org/W2079261283","https://openalex.org/W2090769267","https://openalex.org/W2090917011","https://openalex.org/W2094688990","https://openalex.org/W2109499209","https://openalex.org/W2114183363","https://openalex.org/W2140661985","https://openalex.org/W2471373044","https://openalex.org/W2508043529","https://openalex.org/W2557877458","https://openalex.org/W2587352275","https://openalex.org/W2593007632","https://openalex.org/W2621175742","https://openalex.org/W2742371482","https://openalex.org/W2758156076","https://openalex.org/W2767094705","https://openalex.org/W2794956428","https://openalex.org/W2796519768","https://openalex.org/W2903058058","https://openalex.org/W2904923971","https://openalex.org/W2914645825","https://openalex.org/W2946721242","https://openalex.org/W2967653042","https://openalex.org/W2974768556","https://openalex.org/W2990882447","https://openalex.org/W3023695469","https://openalex.org/W3024793343","https://openalex.org/W3030199526","https://openalex.org/W3118336291","https://openalex.org/W6640278148"],"related_works":["https://openalex.org/W4210511873","https://openalex.org/W2894424090","https://openalex.org/W2115848859","https://openalex.org/W4408997612","https://openalex.org/W2758156076","https://openalex.org/W2075009832","https://openalex.org/W2993827462","https://openalex.org/W7125888609","https://openalex.org/W2768920139","https://openalex.org/W4391164935"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-22T00:00:00"}