{"id":"https://openalex.org/W4280628607","doi":"https://doi.org/10.53846/goediss-9250","title":"Detecting the Undetectable: Functional Protein Motions in the Hidden Timescale Window Revealed by NMR Relaxation Measurements","display_name":"Detecting the Undetectable: Functional Protein Motions in the Hidden Timescale Window Revealed by NMR Relaxation Measurements","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4280628607","doi":"https://doi.org/10.53846/goediss-9250"},"language":"en","primary_location":{"id":"doi:10.53846/goediss-9250","doi":"https://doi.org/10.53846/goediss-9250","is_oa":true,"landing_page_url":"https://doi.org/10.53846/goediss-9250","pdf_url":"https://ediss.uni-goettingen.de/bitstream/11858/14057/1/PhD_thesis_supriya.pdf","source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Georg-August-University G\u00f6ttingen","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ediss.uni-goettingen.de/bitstream/11858/14057/1/PhD_thesis_supriya.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072275874","display_name":"Supriya Pratihar","orcid":"https://orcid.org/0000-0001-6779-1490","observed_orcids":["https://orcid.org/0000-0001-6779-1490"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pratihar, Supriya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072275874"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.5609999895095825,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.5609999895095825,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4302000105381012,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.7720000147819519},{"id":"https://openalex.org/keywords/relaxation-dispersion","display_name":"relaxation dispersion","score":0.9179999828338623},{"id":"https://openalex.org/keywords/protein-backbone-dynamics","display_name":"backbone dynamics","score":0.5389999747276306},{"id":"https://openalex.org/keywords/activation-energy","display_name":"activation energy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/antibody-binding","display_name":"antibody binding","score":0.4180000126361847},{"id":"https://openalex.org/keywords/molecular-recognition","display_name":"molecular recognition","score":0.5699999928474426},{"id":"https://openalex.org/keywords/rdc","display_name":"RDC","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.6840818524360657},{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.6320573091506958},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6199461817741394},{"id":"https://openalex.org/C132459708","wikidata":"https://www.wikidata.org/wiki/Q744069","display_name":"Extrapolation","level":2,"score":0.5801994204521179},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5768907070159912},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4834240674972534},{"id":"https://openalex.org/C86183883","wikidata":"https://www.wikidata.org/wiki/Q507505","display_name":"Arrhenius equation","level":3,"score":0.48167121410369873},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.4792361557483673},{"id":"https://openalex.org/C112964491","wikidata":"https://www.wikidata.org/wiki/Q213659","display_name":"Supercooling","level":2,"score":0.47126078605651855},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.43750476837158203},{"id":"https://openalex.org/C95121573","wikidata":"https://www.wikidata.org/wiki/Q190474","display_name":"Activation energy","level":2,"score":0.41922783851623535},{"id":"https://openalex.org/C168110828","wikidata":"https://www.wikidata.org/wiki/Q1331626","display_name":"Spectral density","level":2,"score":0.4145713150501251},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4078870117664337},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3961167633533478},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3765467703342438},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.341330349445343},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3214995265007019},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.29925817251205444},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.18971160054206848},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.17646843194961548},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1532057523727417},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09575867652893066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09137594699859619},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.53846/goediss-9250","doi":"https://doi.org/10.53846/goediss-9250","is_oa":true,"landing_page_url":"https://doi.org/10.53846/goediss-9250","pdf_url":"https://ediss.uni-goettingen.de/bitstream/11858/14057/1/PhD_thesis_supriya.pdf","source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Georg-August-University G\u00f6ttingen","raw_type":"dissertation"},{"id":"pmh:oai:ediss.uni-goettingen.de:11858/14057","doi":null,"is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400625","display_name":"eDiss (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralThesis"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/174048","doi":null,"is_oa":false,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/174048","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"doi:10.53846/goediss-9250","doi":"https://doi.org/10.53846/goediss-9250","is_oa":true,"landing_page_url":"https://doi.org/10.53846/goediss-9250","pdf_url":"https://ediss.uni-goettingen.de/bitstream/11858/14057/1/PhD_thesis_supriya.pdf","source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Georg-August-University G\u00f6ttingen","raw_type":"dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4280628607.pdf","grobid_xml":"https://content.openalex.org/works/W4280628607.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W30334872","https://openalex.org/W49665239","https://openalex.org/W68685419","https://openalex.org/W90721141","https://openalex.org/W240415867","https://openalex.org/W1504943018","https://openalex.org/W1559673007","https://openalex.org/W1974253337","https://openalex.org/W1974637570","https://openalex.org/W1976261939","https://openalex.org/W1976560973","https://openalex.org/W1977179882","https://openalex.org/W1977462247","https://openalex.org/W1977558457","https://openalex.org/W1978120371","https://openalex.org/W1978598430","https://openalex.org/W1979408355","https://openalex.org/W1979826536","https://openalex.org/W1980139576","https://openalex.org/W1981024715","https://openalex.org/W1981596913","https://openalex.org/W1982186905","https://openalex.org/W1985490516","https://openalex.org/W1986379760","https://openalex.org/W1988565419","https://openalex.org/W1989186646","https://openalex.org/W1991917686","https://openalex.org/W1992577725","https://openalex.org/W1994762261","https://openalex.org/W1997477098","https://openalex.org/W1997760180","https://openalex.org/W2001575435","https://openalex.org/W2004370807","https://openalex.org/W2004577830","https://openalex.org/W2008609697","https://openalex.org/W2008693523","https://openalex.org/W2009239521","https://openalex.org/W2010892677","https://openalex.org/W2011658408","https://openalex.org/W2019577939","https://openalex.org/W2020716464","https://openalex.org/W2025717854","https://openalex.org/W2028968631","https://openalex.org/W2029313276","https://openalex.org/W2030384127","https://openalex.org/W2034339666","https://openalex.org/W2035531864","https://openalex.org/W2038470880","https://openalex.org/W2041856011","https://openalex.org/W2046120655","https://openalex.org/W2047695660","https://openalex.org/W2050043175","https://openalex.org/W2051514595","https://openalex.org/W2052045126","https://openalex.org/W2053590485","https://openalex.org/W2054191418","https://openalex.org/W2055497972","https://openalex.org/W2055557864","https://openalex.org/W2058947924","https://openalex.org/W2064655213","https://openalex.org/W2070820417","https://openalex.org/W2074856155","https://openalex.org/W2074970710","https://openalex.org/W2076283593","https://openalex.org/W2081184407","https://openalex.org/W2084273798","https://openalex.org/W2084295374","https://openalex.org/W2091352656","https://openalex.org/W2095379955","https://openalex.org/W2097985410","https://openalex.org/W2103639723","https://openalex.org/W2108067304","https://openalex.org/W2119749713","https://openalex.org/W2135867920","https://openalex.org/W2144731691","https://openalex.org/W2146933476","https://openalex.org/W2149860949","https://openalex.org/W2150123812","https://openalex.org/W2150815156","https://openalex.org/W2153745204","https://openalex.org/W2153970368","https://openalex.org/W2156012420","https://openalex.org/W2156771958","https://openalex.org/W2157182791","https://openalex.org/W2159013987","https://openalex.org/W2169821755","https://openalex.org/W2170756255","https://openalex.org/W2253387945","https://openalex.org/W2282370358","https://openalex.org/W2294044832","https://openalex.org/W2319226565","https://openalex.org/W2334161820","https://openalex.org/W2335368293","https://openalex.org/W2335891899","https://openalex.org/W2407195738","https://openalex.org/W2433404105","https://openalex.org/W2469104722","https://openalex.org/W2470665661","https://openalex.org/W2619313165","https://openalex.org/W2753992776","https://openalex.org/W2769189202","https://openalex.org/W2920878173","https://openalex.org/W2921323684","https://openalex.org/W2978977982","https://openalex.org/W3004830535","https://openalex.org/W3018137979","https://openalex.org/W3195050999","https://openalex.org/W4230269630","https://openalex.org/W4239462853","https://openalex.org/W4248477811","https://openalex.org/W4255201988","https://openalex.org/W4299530233"],"related_works":["https://openalex.org/W2149860949","https://openalex.org/W2469104722","https://openalex.org/W839306994","https://openalex.org/W770658349","https://openalex.org/W4296337360","https://openalex.org/W1965598721","https://openalex.org/W2389594087","https://openalex.org/W2131823126","https://openalex.org/W2968981376","https://openalex.org/W2382009254"],"abstract_inverted_index":{"About":[0],"50":[1],"years":[2],"ago,":[3],"even":[4,52,434],"before":[5],"NMR":[6,35,57],"was":[7,79,147,174,323,357,485,497,562,595,607,632,664],"ready":[8],"to":[9,61,83,93,176,244,248,395,458,500,502,511,540,611,623],"determine":[10,62],"structure":[11],"of":[12,33,72,113,153,161,191,197,214,251,259,277,283,289,307,320,340,362,383,482,507,569,583,604,680,713],"proteins,":[13],"it":[14],"could":[15,405,443,465,675],"unveil":[16],"a":[17,95,119,143,189,240,249,263,286,352,396,419,459,520,546,618],"surprising":[18],"motion":[19,63,146,162,236,254,266,344,365,449,472,484,496,556,674,705],"in":[20,47,98,108,130,149,224,239,267,269,280,296,335,366,422,435,450,455,477,515,529,535,542,545,565,590,629,634,692,708,721,728],"aromatic":[21,657],"side-chain":[22,343,364],"(Wuthrich":[23],"&":[24],"Wagner,":[25],"1975)":[26],"from":[27,87,211,326,426,487,571,617,638,677],"1D":[28],"1H":[29],"spectra.":[30],"With":[31],"decades":[32],"development,":[34],"is":[36,91,229,431,552,686,706],"now":[37],"the":[38,65,73,106,150,154,159,168,172,185,201,225,232,252,256,275,281,303,315,341,360,363,381,392,427,445,468,474,480,503,553,566,579,584,598,602,605,653,670,681,689,693,729],"most":[39],"powerful":[40],"technique":[41],"for":[42,171,380,473],"studying":[43],"atomic":[44],"resolution":[45],"dynamics":[46,67,75,129,210,276,349,525],"proteins":[48],"at":[49,164,194,526,601],"biological":[50],"conditions,":[51],"inside":[53],"live":[54],"cells.":[55],"Although":[56],"offers":[58],"relaxation-based":[59],"methods":[60],"on":[64],"entire":[66],"timescale":[68,89,160,190,305,317,336],"spectrum,":[69],"accurate":[70],"characterization":[71],"supra-\u03c4c":[74,145,221,235,483,704],"(4":[76,523],"ns-40":[77],"\u00b5s)":[78,524],"not":[80],"possible":[81],"due":[82],"technical":[84],"limitations.":[85],"Dynamics":[86],"this":[88,131,137,440,551,635,696],"window":[90],"indicated":[92],"play":[94],"decisive":[96],"role":[97],"molecular":[99,723],"recognition":[100,258,724],"and":[101,311,318,337,373,378,417,490,648,711,715,725],"binding":[102,510],"events.":[103],"By":[104,135],"combining":[105],"advancement":[107],"hardware":[109],"with":[110,188,255,285,329,345,399,410,557,578,656],"smart":[111],"design":[112],"pulse":[114],"programs,":[115],"we":[116,207,272,389,404,442,464,518],"have":[117,273,390],"developed":[118,139,295],"high-power":[120,140,700],"RD":[121,228,290,423],"(relaxation":[122],"dispersion)":[123],"method,":[124],"which":[125,242,322,375,430,537,685],"can":[126,301],"accurately":[127],"detect":[128,444,467],"previously":[132,324,346],"inaccessible":[133],"window.":[134],"applying":[136,699],"newly":[138,233,494],"R1\u03c1":[141,327],"RD,":[142,701],"hidden":[144],"found":[148,208,325,347,416,519,539,596,622,633],"first":[151,475],"loop":[152,186],"well-known":[155],"protein":[156,533],"GB3.":[157,260],"From":[158],"measured":[163],"several":[165],"supercooled":[166],"temperatures,":[167],"activation":[169,338],"energy":[170,339],"loop-motion":[173],"estimated":[175],"be":[177,541],"65.6":[178],"kJ":[179],"mol-1.":[180],"Arrhenius":[181],"extrapolation":[182],"showed":[183],"that":[184,669],"moves":[187],"~400":[192],"ns":[193],"physiological":[195],"temperature":[196],"308":[198],"K.":[199],"Analyzing":[200],"640-membered":[202],"ERMD":[203],"(Ensemble-Restrained-Molecular-Dynamics)":[204],"RDC":[205,489],"ensemble,":[206],"elevated":[209],"higher":[212,400,407],"fluctuation":[213],"backbone":[215,265,348,384,710],"atoms":[216],"as":[217,219,452],"well":[218],"lower":[220],"order":[222],"parameters":[223],"region":[226],"where":[227,403,479,652],"detected.":[230,665],"Interestingly,":[231],"observed":[234,253],"takes":[237],"place":[238],"region,":[241],"binds":[243],"antibodies.":[245],"This":[246,299,355,493],"hints":[247,350],"link":[250],"antibody":[257],"After":[261],"unveiling":[262],"functional":[264],"GB3,":[268],"chapter":[270,387,516],"2":[271],"studied":[274,730],"methyl":[278],"groups":[279],"side-chains":[282,658,712],"ubiquitin,":[284],"new":[287],"type":[288],"method;":[291],"13C":[292],"Extreme-CPMG":[293],"(E-CPMG),":[294],"our":[297],"group.":[298],"method":[300],"cover":[302],"detectable":[304],"range":[306],"both":[308,488,709],"conventional":[309,436],"CPMG":[310,437],"R1\u03c1.":[312],"E-CPMG":[313,393],"reported":[314],"same":[316,567],"amplitude":[319,470],"motion,":[321],"measurements":[328,332],"much":[330],"longer":[331],"time.":[333],"Similarity":[334],"detected":[342,495,555],"towards":[351],"common":[353],"mechanism.":[354],"hypothesis":[356],"proven":[358],"by":[359,688,698],"absence":[361],"two":[367,643],"different":[368],"single":[369],"point":[370],"mutants":[371,645],"(E24A":[372],"G53A),":[374],"were":[376,621,659],"designed":[377],"tested":[379],"quenching":[382],"dynamics.":[385],"In":[386,462,609,642,695],"3,":[388],"extended":[391],"approach":[394],"nucleus":[397],"(1H)":[398],"gyromagnetic":[401],"ratio,":[402],"generate":[406],"B1":[408],"field":[409],"less":[411],"applied":[412],"RF":[413],"power.":[414],"We":[415],"corrected":[418],"linear":[420],"decay":[421],"profiles,":[424],"arising":[425],"phase":[428],"cycle,":[429],"widely":[432],"used":[433],"measurements.":[438],"Using":[439],"approach,":[441],"peptide-flip":[446],"induced":[447],"breathing":[448],"twice":[451],"many":[453],"residues":[454,536,570,655],"ubiquitin":[456,508],"compared":[457],"previous":[460],"report.":[461],"addition,":[463],"directly":[466],"large":[469],"pincer-mode":[471],"time,":[476],"segments":[478],"existence":[481],"predicted":[486,499,564],"MD":[491],"simulations.":[492],"already":[498],"contribute":[501],"conformational":[504,625,662],"adaption":[505],"power":[506],"while":[509],"other":[512,644],"proteins.":[513,717,731],"Finally,":[514],"4,":[517],"very":[521],"fast":[522,678],"263":[527],"K":[528],"an":[530],"intrinsically":[531],"disordered":[532,716],"p53-TAD,":[534],"are":[538],"helical":[543,560,630],"conformation":[544],"bound":[547],"complex.":[548],"So":[549],"far,":[550],"fastest":[554],"RD.":[558],"The":[559],"propensity":[561,631],"also":[563],"stretch":[568],"SSP":[572,639],"(secondary":[573],"structural":[574],"propensity)":[575],"score":[576,640],"calculation":[577],"experimental":[580],"chemical":[581],"shifts":[582],"free":[585],"protein.":[586],"A":[587,627],"great":[588],"reduction":[589],"exchange":[591,663],"rate":[592],"(~100":[593],"times)":[594],"when":[597],"proline":[599],"residue":[600],"C-terminal":[603],"helix":[606,684],"removed.":[608],"addition":[610],"that,":[612],"more":[613],"residues,":[614],"including":[615],"some":[616],"second":[619],"helix,":[620],"undergo":[624],"exchange.":[626],"doubling":[628],"mutant":[636],"(P27A)":[637],"calculations.":[641],"(W23A;":[646],"F19A":[647],"W23A;":[649],"F19A;":[650],"P27A)":[651],"hydrophobic":[654,690],"removed,":[660],"no":[661],"These":[666,718],"finding":[667],"suggests":[668],"RD-observed":[671],"4":[672],"\u00b5s":[673],"originate":[676],"folding":[679,726],"transiently":[682],"formed":[683],"assisted":[687],"core":[691],"center.":[694],"thesis,":[697],"functionally":[702],"relevant":[703],"discovered":[707],"well-folded":[714],"findings":[719],"helped":[720],"understanding":[722],"processes":[727]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-05-22T00:00:00"}