{"id":"https://openalex.org/W4280604366","doi":"https://doi.org/10.3390/ph15050613","title":"Machine-Learning Guided Discovery of Bioactive Inhibitors of PD1-PDL1 Interaction","display_name":"Machine-Learning Guided Discovery of Bioactive Inhibitors of PD1-PDL1 Interaction","publication_year":2022,"publication_date":"2022-05-16","ids":{"openalex":"https://openalex.org/W4280604366","doi":"https://doi.org/10.3390/ph15050613","pmid":"https://pubmed.ncbi.nlm.nih.gov/35631439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9145945"},"language":"en","primary_location":{"id":"doi:10.3390/ph15050613","doi":"https://doi.org/10.3390/ph15050613","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph15050613","pdf_url":"https://www.mdpi.com/1424-8247/15/5/613/pdf?version=1652757062","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8247/15/5/613/pdf?version=1652757062","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031702923","display_name":"Sachin P. Patil","orcid":"https://orcid.org/0000-0002-1354-0386","observed_orcids":["https://orcid.org/0000-0002-1354-0386"]},"institutions":[{"id":"https://openalex.org/I138659443","display_name":"Widener University","ror":"https://ror.org/00nsyd297","country_code":"US","type":"education","lineage":["https://openalex.org/I138659443"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sachin P. Patil","raw_affiliation_strings":["Department of Chemical Engineering, Widener University, Chester, PA 19013, USA","NanoBio Lab, School of Engineering, Widener University, Chester, PA 19013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Widener University, Chester, PA 19013, USA","institution_ids":["https://openalex.org/I138659443"]},{"raw_affiliation_string":"NanoBio Lab, School of Engineering, Widener University, Chester, PA 19013, USA","institution_ids":["https://openalex.org/I138659443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025336100","display_name":"Elena Fattakhova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138659443","display_name":"Widener University","ror":"https://ror.org/00nsyd297","country_code":"US","type":"education","lineage":["https://openalex.org/I138659443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Fattakhova","raw_affiliation_strings":["Department of Chemical Engineering, Widener University, Chester, PA 19013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Widener University, Chester, PA 19013, USA","institution_ids":["https://openalex.org/I138659443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033962825","display_name":"Jeremy Hofer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138659443","display_name":"Widener University","ror":"https://ror.org/00nsyd297","country_code":"US","type":"education","lineage":["https://openalex.org/I138659443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Hofer","raw_affiliation_strings":["Department of Computer Science, Widener University, Chester, PA 19013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Widener University, Chester, PA 19013, USA","institution_ids":["https://openalex.org/I138659443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085185466","display_name":"Michael Oravic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138659443","display_name":"Widener University","ror":"https://ror.org/00nsyd297","country_code":"US","type":"education","lineage":["https://openalex.org/I138659443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Oravic","raw_affiliation_strings":["Department of Biomedical Engineering, Widener University, Chester, PA 19013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Widener University, Chester, PA 19013, USA","institution_ids":["https://openalex.org/I138659443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030690785","display_name":"Autumn Bender","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138659443","display_name":"Widener University","ror":"https://ror.org/00nsyd297","country_code":"US","type":"education","lineage":["https://openalex.org/I138659443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Autumn Bender","raw_affiliation_strings":["Department of Chemical Engineering, Widener University, Chester, PA 19013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Widener University, Chester, PA 19013, USA","institution_ids":["https://openalex.org/I138659443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009167823","display_name":"Jason Brearey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138659443","display_name":"Widener University","ror":"https://ror.org/00nsyd297","country_code":"US","type":"education","lineage":["https://openalex.org/I138659443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Brearey","raw_affiliation_strings":["Department of Chemical Engineering, Widener University, Chester, PA 19013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Widener University, Chester, PA 19013, USA","institution_ids":["https://openalex.org/I138659443"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel Parker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138659443","display_name":"Widener University","ror":"https://ror.org/00nsyd297","country_code":"US","type":"education","lineage":["https://openalex.org/I138659443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Parker","raw_affiliation_strings":["Department of Chemical Engineering, Widener University, Chester, PA 19013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Widener University, Chester, PA 19013, USA","institution_ids":["https://openalex.org/I138659443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020412757","display_name":"Madison Radnoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138659443","display_name":"Widener University","ror":"https://ror.org/00nsyd297","country_code":"US","type":"education","lineage":["https://openalex.org/I138659443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madison Radnoff","raw_affiliation_strings":["Department of Chemical Engineering, Widener University, Chester, PA 19013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Widener University, Chester, PA 19013, USA","institution_ids":["https://openalex.org/I138659443"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020071782","display_name":"Zackary Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138659443","display_name":"Widener University","ror":"https://ror.org/00nsyd297","country_code":"US","type":"education","lineage":["https://openalex.org/I138659443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zackary Smith","raw_affiliation_strings":["Department of Chemical Engineering, Widener University, Chester, PA 19013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Widener University, Chester, PA 19013, USA","institution_ids":["https://openalex.org/I138659443"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031702923"],"corresponding_institution_ids":["https://openalex.org/I138659443"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2094},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2094},"fwci":1.3548,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.79396092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"5","first_page":"613","last_page":"613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-1-pd-l1-interaction","display_name":"PD-1/PD-L1 interaction","score":0.8610000014305115},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.9079999923706055},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8650000095367432},{"id":"https://openalex.org/keywords/machine-learning-screening","display_name":"machine learning screening","score":0.5619999766349792},{"id":"https://openalex.org/keywords/random-forest-classification","display_name":"random forest classification","score":0.7620000243186951},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bioactive-compound-discovery","display_name":"bioactive compound discovery","score":0.49300000071525574},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.6541399359703064},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5723815560340881},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5072550177574158},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.468142569065094},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44779467582702637},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4404502213001251},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3296818733215332},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3261953592300415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29147517681121826},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.25502774119377136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21862736344337463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12097543478012085},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0894450843334198},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/ph15050613","doi":"https://doi.org/10.3390/ph15050613","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph15050613","pdf_url":"https://www.mdpi.com/1424-8247/15/5/613/pdf?version=1652757062","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},{"id":"pmid:35631439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35631439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9145945","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9145945/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b22a3f01d1e441d484a22c77e0d183c3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b22a3f01d1e441d484a22c77e0d183c3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, Vol 15, Iss 5, p 613 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ph15050613","doi":"https://doi.org/10.3390/ph15050613","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph15050613","pdf_url":"https://www.mdpi.com/1424-8247/15/5/613/pdf?version=1652757062","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2573181045","display_name":null,"funder_award_id":"C1807","funder_id":"https://openalex.org/F4320306513","funder_display_name":"W. W. Smith Charitable Trust"}],"funders":[{"id":"https://openalex.org/F1675959181","display_name":"Gordon Charter Foundation","ror":null},{"id":"https://openalex.org/F4320306513","display_name":"W. W. Smith Charitable Trust","ror":"https://ror.org/04nv2ya05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4280604366.pdf","grobid_xml":"https://content.openalex.org/works/W4280604366.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1749548564","https://openalex.org/W1852608922","https://openalex.org/W1968319881","https://openalex.org/W1993591356","https://openalex.org/W2034354062","https://openalex.org/W2039473152","https://openalex.org/W2078374001","https://openalex.org/W2090983338","https://openalex.org/W2105668062","https://openalex.org/W2128983966","https://openalex.org/W2130479394","https://openalex.org/W2134967712","https://openalex.org/W2143482176","https://openalex.org/W2156786194","https://openalex.org/W2338150527","https://openalex.org/W2791191184","https://openalex.org/W2792030365","https://openalex.org/W2885871437","https://openalex.org/W2886462153","https://openalex.org/W2902968854","https://openalex.org/W2946931705","https://openalex.org/W2967658120","https://openalex.org/W2970405984","https://openalex.org/W2972212968","https://openalex.org/W2974137438","https://openalex.org/W2977648831","https://openalex.org/W3041306552","https://openalex.org/W3168254371","https://openalex.org/W6638841920"],"related_works":["https://openalex.org/W4415775080","https://openalex.org/W4384820909","https://openalex.org/W4413329192","https://openalex.org/W4391256965","https://openalex.org/W7213435957","https://openalex.org/W4319986615","https://openalex.org/W2995382150","https://openalex.org/W7212311802","https://openalex.org/W4386638813","https://openalex.org/W4413787692"],"abstract_inverted_index":{"The":[0,149],"selective":[1,208],"activation":[2],"of":[3,10,21,37,56,101,120,169,180],"the":[4,35,76,145,167,177,216],"innate":[5],"immune":[6,11],"system":[7],"through":[8,72],"blockade":[9],"checkpoint":[12],"PD1-PDL1":[13,39,70,162,209,229],"interaction":[14],"has":[15,62],"proven":[16],"effective":[17,69],"against":[18],"a":[19,53],"variety":[20],"cancers.":[22],"In":[23,75],"contrast":[24],"to":[25,93,118,131,135,166,187,204],"six":[26,94],"antibody":[27],"therapies":[28],"approved":[29,50,107],"and":[30,108,174,182,207,215],"several":[31],"under":[32],"clinical":[33],"investigation,":[34],"development":[36],"small-molecule":[38],"inhibitors":[40],"is":[41],"still":[42],"in":[43],"its":[44],"infancy":[45],"with":[46,153,176],"no":[47],"such":[48],"drugs":[49],"yet.":[51],"Nevertheless,":[52],"promising":[54],"series":[55],"small":[57],"molecules":[58,122,152,194],"inducing":[59],"PDL1":[60,73,146],"dimerization":[61],"revealed":[63],"important":[64],"spatio-chemical":[65],"features":[66,82],"required":[67],"for":[68,83,198,223,227],"inhibition":[71],"sequestration.":[74],"present":[77],"study,":[78],"we":[79],"utilized":[80],"these":[81,114],"developing":[84],"machine-learning":[85],"(ML)":[86],"classifiers":[87],"by":[88],"fitting":[89],"Random":[90],"Forest":[91],"models":[92,214],"2D":[95],"fingerprint":[96],"descriptors.":[97],"A":[98],"focused":[99],"database":[100],"~16":[102],"K":[103],"bioactive":[104,189],"molecules,":[105,172],"including":[106],"experimental":[109],"drugs,":[110],"was":[111],"screened":[112],"using":[113,159],"ML":[115,127,213],"models,":[116],"leading":[117,165,203],"classification":[119],"361":[121],"as":[123],"potentially":[124],"active.":[125],"These":[126],"hits":[128],"were":[129,156],"subjected":[130],"molecular":[132],"docking":[133],"studies":[134],"further":[136,199],"shortlist":[137],"them":[138],"based":[139],"on":[140],"their":[141,188],"binding":[142,163],"interactions":[143,155],"within":[144],"dimer":[147],"pocket.":[148],"top":[150],"20":[151],"favorable":[154],"experimentally":[157],"tested":[158],"HTRF":[160],"human":[161],"assays,":[164],"identification":[168],"two":[170],"active":[171],"CRT5":[173],"P053,":[175],"IC50":[178],"values":[179],"22.35":[181],"33.65":[183],"\u00b5M,":[184],"respectively.":[185],"Owing":[186],"nature,":[190],"our":[191,212],"newly":[192],"discovered":[193],"may":[195,220],"prove":[196,221],"suitable":[197],"medicinal":[200],"chemistry":[201],"optimization,":[202],"more":[205],"potent":[206],"inhibitors.":[210,230],"Finally,":[211],"integrated":[217],"screening":[218,224],"protocol":[219],"useful":[222],"larger":[225],"libraries":[226],"novel":[228]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-05-22T00:00:00"}
