{"id":"https://openalex.org/W4280558175","doi":"https://doi.org/10.1016/j.stemcr.2022.04.015","title":"FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes","display_name":"FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes","publication_year":2022,"publication_date":"2022-05-19","ids":{"openalex":"https://openalex.org/W4280558175","doi":"https://doi.org/10.1016/j.stemcr.2022.04.015","pmid":"https://pubmed.ncbi.nlm.nih.gov/35594860","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9214056"},"language":"en","primary_location":{"id":"doi:10.1016/j.stemcr.2022.04.015","doi":"https://doi.org/10.1016/j.stemcr.2022.04.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2022.04.015","pdf_url":"http://www.cell.com/article/S2213671122002041/pdf","source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2213671122002041/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082889882","display_name":"Tsotne Chitiashvili","orcid":"https://orcid.org/0000-0002-4887-1097","observed_orcids":["https://orcid.org/0000-0002-4887-1097"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsotne Chitiashvili","raw_affiliation_strings":["Molecular Cell and Developmental Biology Department, University of California Los Angeles, Los Angeles, CA, USA; Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA","Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA","Molecular Cell and Developmental Biology Department, University of California Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell and Developmental Biology Department, University of California Los Angeles, Los Angeles, CA, USA; Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Cell and Developmental Biology Department, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033311345","display_name":"Fei\u2010Man Hsu","orcid":"https://orcid.org/0000-0002-9901-7464","observed_orcids":["https://orcid.org/0000-0002-9901-7464"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei-man Hsu","raw_affiliation_strings":["Molecular Cell and Developmental Biology Department, University of California Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell and Developmental Biology Department, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012753791","display_name":"Iris Dror","orcid":"https://orcid.org/0000-0001-7144-2250","observed_orcids":["https://orcid.org/0000-0001-7144-2250"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iris Dror","raw_affiliation_strings":["Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017513011","display_name":"Kathrin Plath","orcid":"https://orcid.org/0000-0001-7796-3372","observed_orcids":["https://orcid.org/0000-0001-7796-3372"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210150380","display_name":"Broad Center","ror":"https://ror.org/04tbrah05","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150380"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathrin Plath","raw_affiliation_strings":["Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA","Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA","Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA","Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210150380"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073685964","display_name":"Amander T. Clark","orcid":"https://orcid.org/0000-0003-2483-3982","observed_orcids":["https://orcid.org/0000-0003-2483-3982"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210150380","display_name":"Broad Center","ror":"https://ror.org/04tbrah05","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150380"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amander Clark","raw_affiliation_strings":["Molecular Cell and Developmental Biology Department, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: clarka@ucla.edu","Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA","Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA","Molecular Cell and Developmental Biology Department, University of California Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell and Developmental Biology Department, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: clarka@ucla.edu","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210150380"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Cell and Developmental Biology Department, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073685964"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210150380","https://openalex.org/I4390039293"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":2.207,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.86531246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"17","issue":"6","first_page":"1268","last_page":"1278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgfr3","display_name":"FGFR3","score":0.996999979019165},{"id":"https://openalex.org/keywords/primordial-germ-cells","display_name":"primordial germ cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/meiosis-initiation","display_name":"meiosis initiation","score":0.824999988079071},{"id":"https://openalex.org/keywords/germ-cell-development","display_name":"germ cell development","score":0.7129999995231628},{"id":"https://openalex.org/keywords/oocyte-maturation","display_name":"oocyte maturation","score":0.640999972820282},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.7799999713897705},{"id":"https://openalex.org/keywords/human-embryo","display_name":"human embryo","score":0.4860000014305115},{"id":"https://openalex.org/keywords/fgf-signaling","display_name":"FGF signaling","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9363120198249817},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.7406386733055115},{"id":"https://openalex.org/C190446060","wikidata":"https://www.wikidata.org/wiki/Q5550959","display_name":"Germ line development","level":4,"score":0.47250211238861084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46669891476631165},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46422478556632996},{"id":"https://openalex.org/C39297687","wikidata":"https://www.wikidata.org/wiki/Q1410510","display_name":"Gametogenesis","level":4,"score":0.4279100298881531},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3818039894104004},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.19153183698654175}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.stemcr.2022.04.015","doi":"https://doi.org/10.1016/j.stemcr.2022.04.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2022.04.015","pdf_url":"http://www.cell.com/article/S2213671122002041/pdf","source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9214056","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9214056","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"Text"},{"id":"pmid:35594860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35594860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8366p589","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8366p589","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Reports, vol 17, iss 6","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.stemcr.2022.04.015","doi":"https://doi.org/10.1016/j.stemcr.2022.04.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2022.04.015","pdf_url":"http://www.cell.com/article/S2213671122002041/pdf","source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3903355757","display_name":"Reprogramming Genetic Networks to a Pluripotent State","funder_award_id":"P01GM099134","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4277381368","display_name":"Epigenetic control of the human X chromosome","funder_award_id":"R01HD098387","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5402058235","display_name":null,"funder_award_id":"5R24HD000836-53","funder_id":"https://openalex.org/F4320306082","funder_display_name":"Howard Hughes Medical Institute"},{"id":"https://openalex.org/G8398908806","display_name":"Cellular and Molecular Basis of Human Primordial Germ Cell Specification","funder_award_id":"R01HD079546","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000865766","display_name":"Laboratory of Developmental Biology","funder_award_id":"R24HD000836","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000898870","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016042","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306257","display_name":"Boehringer Ingelheim","ror":"https://ror.org/05kffp613"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332502","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337550","display_name":"Jonsson Comprehensive Cancer Center","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320337596","display_name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337666","display_name":"David Geffen School of Medicine, University of California, Los Angeles","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4280558175.pdf","grobid_xml":"https://content.openalex.org/works/W4280558175.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W146475322","https://openalex.org/W1528685733","https://openalex.org/W1973939670","https://openalex.org/W1977828694","https://openalex.org/W1988391018","https://openalex.org/W1994206956","https://openalex.org/W1998763321","https://openalex.org/W2010786205","https://openalex.org/W2037720356","https://openalex.org/W2048650610","https://openalex.org/W2059145054","https://openalex.org/W2098711385","https://openalex.org/W2110804359","https://openalex.org/W2111602711","https://openalex.org/W2118017182","https://openalex.org/W2138720929","https://openalex.org/W2145182226","https://openalex.org/W2159129772","https://openalex.org/W2270369744","https://openalex.org/W2509837331","https://openalex.org/W2607948634","https://openalex.org/W2763109317","https://openalex.org/W2765511682","https://openalex.org/W2790107757","https://openalex.org/W2800392236","https://openalex.org/W2801831908","https://openalex.org/W2906273947","https://openalex.org/W2995043840","https://openalex.org/W2997947233","https://openalex.org/W3108530058","https://openalex.org/W3119224759","https://openalex.org/W3134111171","https://openalex.org/W3157353881","https://openalex.org/W3163737793","https://openalex.org/W3164692211","https://openalex.org/W4243178088"],"related_works":["https://openalex.org/W2984242671","https://openalex.org/W2163710935","https://openalex.org/W7099324879","https://openalex.org/W2087400892","https://openalex.org/W2091385966","https://openalex.org/W1985422392","https://openalex.org/W1973939670","https://openalex.org/W4408804930","https://openalex.org/W2387905827","https://openalex.org/W2096940239"],"abstract_inverted_index":{"Human":[0],"germ":[1,19],"cell":[2,62],"development":[3],"is":[4,41],"a":[5,95],"highly":[6],"regulated":[7],"process":[8],"beginning":[9],"soon":[10],"after":[11],"embryo":[12],"implantation":[13],"with":[14,26,65],"the":[15,27,47],"specification":[16],"of":[17,29],"primordial":[18,58],"cells":[20,80],"(PGCs)":[21],"and":[22,49],"ending":[23],"in":[24,91,101],"adulthood":[25],"differentiation":[28],"gametes.":[30],"Here,":[31],"we":[32,75],"show":[33,76],"that":[34,67,77],"fibroblast":[35],"growth":[36],"factor":[37],"receptor":[38],"3":[39],"(FGFR3)":[40],"expressed":[42],"by":[43,71],"human":[44,83],"PGCs":[45,55,100],"during":[46],"first":[48],"second":[50],"trimester,":[51],"becoming":[52],"repressed":[53],"as":[54,94],"differentiate":[56],"into":[57],"oocytes.":[59],"Using":[60],"fluorescence-activated":[61],"sorting":[63],"(FACS)":[64],"antibodies":[66],"recognize":[68],"FGFR3":[69,87],"followed":[70],"single-cell":[72],"RNA":[73],"sequencing,":[74],"isolating":[78],"FGFR3-positive":[79],"enriches":[81],"for":[82],"PGCs.":[84],"Taken":[85],"together,":[86],"could":[88],"be":[89],"used":[90],"future":[92],"studies":[93],"strategy":[96],"to":[97],"identify":[98],"maturing":[99],"vitro.":[102]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-22T00:00:00"}
