{"id":"https://openalex.org/W4280540831","doi":"https://doi.org/10.1021/acs.jnatprod.2c00054","title":"Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral Duva florida , Displays Inhibition of the SARS-CoV-2 3CLpro Enzyme","display_name":"Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral Duva florida , Displays Inhibition of the SARS-CoV-2 3CLpro Enzyme","publication_year":2022,"publication_date":"2022-05-12","ids":{"openalex":"https://openalex.org/W4280540831","doi":"https://doi.org/10.1021/acs.jnatprod.2c00054","pmid":"https://pubmed.ncbi.nlm.nih.gov/35549259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9127705"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jnatprod.2c00054","doi":"https://doi.org/10.1021/acs.jnatprod.2c00054","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.2c00054","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.jnatprod.2c00054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077072391","display_name":"Nicole E. Avalon","orcid":"https://orcid.org/0000-0003-3588-892X","observed_orcids":["https://orcid.org/0000-0003-3588-892X"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole E. Avalon","raw_affiliation_strings":["Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States"],"raw_orcid":"https://orcid.org/0000-0003-3588-892X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024408975","display_name":"Jordan Nafie","orcid":"https://orcid.org/0000-0003-1986-0302","observed_orcids":["https://orcid.org/0000-0003-1986-0302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan Nafie","raw_affiliation_strings":["BioTools, Inc., Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTools, Inc., Jupiter, Florida 33458, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044242248","display_name":"Carolina De Marco Ver\u00edssimo","orcid":"https://orcid.org/0000-0003-1762-6387","observed_orcids":["https://orcid.org/0000-0003-1762-6387"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Carolina De Marco Verissimo","raw_affiliation_strings":["Molecular Parasitology Laboratory (MPL), Centre for One Health and Ryan Institute, School of Natural Science, National University of Ireland Galway, H91 TK33 Galway, Republic of Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Parasitology Laboratory (MPL), Centre for One Health and Ryan Institute, School of Natural Science, National University of Ireland Galway, H91 TK33 Galway, Republic of Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010878401","display_name":"Luke C. Warrensford","orcid":"https://orcid.org/0000-0002-9206-5121","observed_orcids":["https://orcid.org/0000-0002-9206-5121"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke C. Warrensford","raw_affiliation_strings":["Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States"],"raw_orcid":"https://orcid.org/0000-0002-9206-5121","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017484452","display_name":"Sarah G. Dietrick","orcid":"https://orcid.org/0000-0002-1566-1958","observed_orcids":["https://orcid.org/0000-0002-1566-1958"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah G. Dietrick","raw_affiliation_strings":["Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025661865","display_name":"Amanda R. Pittman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda R. Pittman","raw_affiliation_strings":["Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069453413","display_name":"Ryan M. Young","orcid":"https://orcid.org/0000-0002-1219-9665","observed_orcids":["https://orcid.org/0000-0002-1219-9665"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Ryan M. Young","raw_affiliation_strings":["School of Natural Sciences and Ryan Institute, National University of Ireland Galway, H91 TK33 Galway, Republic of Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Natural Sciences and Ryan Institute, National University of Ireland Galway, H91 TK33 Galway, Republic of Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080498765","display_name":"Fiona L. Kearns","orcid":"https://orcid.org/0000-0002-5469-9035","observed_orcids":["https://orcid.org/0000-0002-5469-9035"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fiona L. Kearns","raw_affiliation_strings":["Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068045885","display_name":"Tracess B. Smalley","orcid":"https://orcid.org/0000-0002-3295-7443","observed_orcids":["https://orcid.org/0000-0002-3295-7443"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracess Smalley","raw_affiliation_strings":["Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, United States","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003937372","display_name":"Jennifer M. Binning","orcid":"https://orcid.org/0000-0001-5871-686X","observed_orcids":["https://orcid.org/0000-0001-5871-686X"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Binning","raw_affiliation_strings":["Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, United States","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068367604","display_name":"John P. Dalton","orcid":"https://orcid.org/0000-0003-3829-9186","observed_orcids":["https://orcid.org/0000-0003-3829-9186"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"John P. Dalton","raw_affiliation_strings":["Molecular Parasitology Laboratory (MPL), Centre for One Health and Ryan Institute, School of Natural Science, National University of Ireland Galway, H91 TK33 Galway, Republic of Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Parasitology Laboratory (MPL), Centre for One Health and Ryan Institute, School of Natural Science, National University of Ireland Galway, H91 TK33 Galway, Republic of Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036428674","display_name":"Mark Paul Johnson","orcid":"https://orcid.org/0000-0002-5078-1410","observed_orcids":["https://orcid.org/0000-0002-5078-1410"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Mark P. Johnson","raw_affiliation_strings":["School of Natural Sciences and Ryan Institute, National University of Ireland Galway, H91 TK33 Galway, Republic of Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Natural Sciences and Ryan Institute, National University of Ireland Galway, H91 TK33 Galway, Republic of Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037901921","display_name":"H. Lee Woodcock","orcid":"https://orcid.org/0000-0003-3539-273X","observed_orcids":["https://orcid.org/0000-0003-3539-273X"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Lee Woodcock","raw_affiliation_strings":["Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States"],"raw_orcid":"https://orcid.org/0000-0003-3539-273X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082462001","display_name":"A. Louise Allcock","orcid":"https://orcid.org/0000-0002-4806-0040","observed_orcids":["https://orcid.org/0000-0002-4806-0040"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"A. Louise Allcock","raw_affiliation_strings":["School of Natural Sciences and Ryan Institute, National University of Ireland Galway, H91 TK33 Galway, Republic of Ireland"],"raw_orcid":"https://orcid.org/0000-0002-4806-0040","affiliations":[{"raw_affiliation_string":"School of Natural Sciences and Ryan Institute, National University of Ireland Galway, H91 TK33 Galway, Republic of Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053554880","display_name":"Bill J. Baker","orcid":"https://orcid.org/0000-0003-3033-5779","observed_orcids":["https://orcid.org/0000-0003-3033-5779"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bill J. Baker","raw_affiliation_strings":["Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053554880","https://openalex.org/A5082462001"],"corresponding_institution_ids":["https://openalex.org/I188760350","https://openalex.org/I2613432"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":0.3873,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.29100529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"85","issue":"5","first_page":"1315","last_page":"1323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meroterpenoids","display_name":"meroterpenoids","score":0.7789999842643738},{"id":"https://openalex.org/keywords/chromenes","display_name":"chromenes","score":0.6930000185966492},{"id":"https://openalex.org/keywords/main-protease-inhibition","display_name":"main protease inhibition","score":0.9290000200271606},{"id":"https://openalex.org/keywords/antiviral-natural-products","display_name":"antiviral natural products","score":0.8130000233650208},{"id":"https://openalex.org/keywords/vibrational-circular-dichroism","display_name":"vibrational circular dichroism","score":0.8989999890327454},{"id":"https://openalex.org/keywords/absolute-configuration","display_name":"absolute configuration","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C143020374","wikidata":"https://www.wikidata.org/wiki/Q2411228","display_name":"Coral","level":2,"score":0.7420438528060913},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6176177859306335},{"id":"https://openalex.org/C2778849931","wikidata":"https://www.wikidata.org/wiki/Q18960","display_name":"Sponge","level":2,"score":0.5848874449729919},{"id":"https://openalex.org/C2777538117","wikidata":"https://www.wikidata.org/wiki/Q425196","display_name":"Neuraminidase inhibitor","level":5,"score":0.5753421783447266},{"id":"https://openalex.org/C83042747","wikidata":"https://www.wikidata.org/wiki/Q686881","display_name":"Benthic zone","level":2,"score":0.5521284341812134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49247321486473083},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4424781799316406},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4337523877620697},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4009981155395508},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3194389343261719},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.19509398937225342},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.17528867721557617},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.15541526675224304},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.11483100056648254},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07717123627662659},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005431","descriptor_name":"Florida","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D037421","descriptor_name":"Anthozoa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/acs.jnatprod.2c00054","doi":"https://doi.org/10.1021/acs.jnatprod.2c00054","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.2c00054","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv-2022-bjcfb-v3","doi":"https://doi.org/10.26434/chemrxiv-2022-bjcfb-v3","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2022-bjcfb-v3","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/627bb14387d01fb6f8e16425/original/tuaimenal-a-a-meroterpene-from-the-irish-deep-sea-soft-coral-duva-florida-displays-inhibition-of-the-sars-co-v-2-3c-lpro-enzyme.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9127705","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9127705","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Nat Prod","raw_type":"Text"},{"id":"pmid:35549259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35549259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6gc2n3xq","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6gc2n3xq","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Natural Products, vol 85, iss 5","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acs.jnatprod.2c00054","doi":"https://doi.org/10.1021/acs.jnatprod.2c00054","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.2c00054","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1483802566","display_name":null,"funder_award_id":"R56 AI154922","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1888088267","display_name":null,"funder_award_id":"2014-2020\u2019","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G297749360","display_name":null,"funder_award_id":"COVID-19 Rapid Response","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G5514976981","display_name":null,"funder_award_id":"COVID-19","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5881380420","display_name":null,"funder_award_id":"SFI/15/1A/3100","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G6696452430","display_name":"Rapid ELISA test for SARS-CoV-2 (coronavirus) disease detection and surveillance","funder_award_id":"20/COV/0023","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G7712668395","display_name":null,"funder_award_id":"PBA/MB/16/01","funder_id":"https://openalex.org/F4320320861","funder_display_name":"University of Galway"},{"id":"https://openalex.org/G8645602608","display_name":"Natural Product Derived Inhibitors of ESKAPE Pathogens","funder_award_id":"R56AI154922","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000896088","display_name":"Design and application ofrobust and efficient QM/MM free energy simulation methods for biomolecular systems","funder_award_id":"R01GM129519","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310847","display_name":"University of South Florida","ror":"https://ror.org/032db5x82"},{"id":"https://openalex.org/F4320311521","display_name":"National University of Ireland","ror":"https://ror.org/00shsf120"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320320861","display_name":"University of Galway","ror":"https://ror.org/03bea9k73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4280540831.pdf","grobid_xml":"https://content.openalex.org/works/W4280540831.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1915787054","https://openalex.org/W1985588649","https://openalex.org/W2014462946","https://openalex.org/W2015377151","https://openalex.org/W2018235432","https://openalex.org/W2019701333","https://openalex.org/W2027423337","https://openalex.org/W2027484375","https://openalex.org/W2039781258","https://openalex.org/W2060809301","https://openalex.org/W2070753604","https://openalex.org/W2076790509","https://openalex.org/W2091586720","https://openalex.org/W2096477691","https://openalex.org/W2102377211","https://openalex.org/W2108567906","https://openalex.org/W2111139603","https://openalex.org/W2112828889","https://openalex.org/W2129467565","https://openalex.org/W2136414263","https://openalex.org/W2140830298","https://openalex.org/W2147238518","https://openalex.org/W2154753571","https://openalex.org/W2161356478","https://openalex.org/W2169678694","https://openalex.org/W2943716765","https://openalex.org/W2951283070","https://openalex.org/W3008443627","https://openalex.org/W3009912996","https://openalex.org/W3011701533","https://openalex.org/W3012320055","https://openalex.org/W3013306614","https://openalex.org/W3015060795","https://openalex.org/W3015608194","https://openalex.org/W3027630905","https://openalex.org/W3035876959","https://openalex.org/W3038184555","https://openalex.org/W3039588085","https://openalex.org/W3092990052","https://openalex.org/W3093805839","https://openalex.org/W3129818081","https://openalex.org/W3130163626","https://openalex.org/W3130320451","https://openalex.org/W3133499696","https://openalex.org/W3200348940","https://openalex.org/W3209921099","https://openalex.org/W3214271933","https://openalex.org/W4205709855","https://openalex.org/W4211115512","https://openalex.org/W4240553488","https://openalex.org/W4300941182"],"related_works":["https://openalex.org/W4205849121","https://openalex.org/W3154526829","https://openalex.org/W6976854293","https://openalex.org/W4388079766","https://openalex.org/W3203035766","https://openalex.org/W3140736263","https://openalex.org/W4410489082","https://openalex.org/W4416594725","https://openalex.org/W4361005685","https://openalex.org/W4250206574"],"abstract_inverted_index":{"Cold":[0],"water":[1],"benthic":[2],"environments":[3],"are":[4],"a":[5,13,22,33,50,54,59],"prolific":[6],"source":[7],"of":[8,15,21,68,104],"structurally":[9],"diverse":[10],"molecules":[11],"with":[12,58],"range":[14],"bioactivities":[16],"against":[17],"human":[18],"disease.":[19],"Specimens":[20],"previously":[23],"chemically":[24],"unexplored":[25],"soft":[26,70],"coral,":[27],"Duva":[28],"florida,":[29],"were":[30],"collected":[31],"during":[32],"deep-sea":[34],"cruise":[35],"that":[36],"sampled":[37],"marine":[38],"invertebrates":[39],"along":[40],"the":[41,69,99],"Irish":[42],"continental":[43],"margin":[44],"in":[45,90],"2018.":[46],"Tuaimenal":[47],"A":[48,96],"(1),":[49],"cyclized":[51],"merosesquiterpenoid":[52],"representing":[53],"new":[55],"carbon":[56],"scaffold":[57],"highly":[60],"substituted":[61],"chromene":[62],"core,":[63],"was":[64,80],"discovered":[65],"through":[66,82],"exploration":[67],"coral":[71],"secondary":[72],"metabolome":[73],"via":[74],"NMR-guided":[75],"fractionation.":[76],"The":[77],"absolute":[78],"configuration":[79],"determined":[81],"vibrational":[83],"circular":[84],"dichroism.":[85],"Functional":[86],"biochemical":[87],"assays":[88],"and":[89],"silico":[91],"docking":[92],"experiments":[93],"found":[94],"tuaimenal":[95],"selectively":[97],"inhibits":[98],"viral":[100],"main":[101],"protease":[102],"(3CLpro)":[103],"SARS-CoV-2.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-05-22T00:00:00"}
