{"id":"https://openalex.org/W4280536633","doi":"https://doi.org/10.7754/clin.lab.2021.210731","title":"Angelica Sinensis Polysaccharide Suppresses the Aging of Hematopoietic Stem Cells Through Sirt1/FoxO1 Signaling","display_name":"Angelica Sinensis Polysaccharide Suppresses the Aging of Hematopoietic Stem Cells Through Sirt1/FoxO1 Signaling","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4280536633","doi":"https://doi.org/10.7754/clin.lab.2021.210731","pmid":"https://pubmed.ncbi.nlm.nih.gov/35536062"},"language":"en","primary_location":{"id":"doi:10.7754/clin.lab.2021.210731","doi":"https://doi.org/10.7754/clin.lab.2021.210731","is_oa":false,"landing_page_url":"https://doi.org/10.7754/clin.lab.2021.210731","pdf_url":null,"source":{"id":"https://openalex.org/S36748825","display_name":"Clinical Laboratory","issn_l":"1433-6510","issn":["1433-6510"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4323283984","host_organization_name":"Clinical Laboratory Publications","host_organization_lineage":["https://openalex.org/P4323283984"],"host_organization_lineage_names":["Clinical Laboratory Publications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Laboratory","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004872385","display_name":"Peng L\u00fc","orcid":"https://orcid.org/0000-0002-4366-8807","observed_orcids":["https://orcid.org/0000-0002-4366-8807","https://orcid.org/0000-0002-3263-7765","https://orcid.org/0009-0000-5996-1197","https://orcid.org/0009-0007-1951-1491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lu Peng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039578103","display_name":"Shihuan Tang","orcid":"https://orcid.org/0000-0003-0589-4499","observed_orcids":["https://orcid.org/0000-0003-0589-4499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shihuan Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Honghui Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Honghui Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023190577","display_name":"Qianxing Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qianxing Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100697961","display_name":"Ting Long","orcid":"https://orcid.org/0000-0001-5580-1487","observed_orcids":["https://orcid.org/0000-0001-5580-1487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting Long","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323483","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0002-7038-5407","observed_orcids":["https://orcid.org/0000-0002-7038-5407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109205163","display_name":"Qinyuan Wu","orcid":"https://orcid.org/0000-0002-1453-9643","observed_orcids":["https://orcid.org/0000-0002-1453-9643"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qinyuan Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455028","display_name":"Yaping Wang","orcid":"https://orcid.org/0000-0003-0526-0744","observed_orcids":["https://orcid.org/0000-0003-0526-0744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaping Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101529634","display_name":"Ling Liu","orcid":"https://orcid.org/0000-0003-0927-6372","observed_orcids":["https://orcid.org/0000-0003-0927-6372","https://orcid.org/0000-0001-7588-6086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xian Tang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xian Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zhuomin Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhuomin Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Xianping Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xianping Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3537,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.89794646,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"68","issue":"05/2022","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angelica-sinensis-polysaccharide","display_name":"Angelica sinensis polysaccharide","score":1.0},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/stem-cell-aging","display_name":"stem cell aging","score":0.7689999938011169},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8399999737739563},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8190000057220459},{"id":"https://openalex.org/keywords/radiation-induced-aging","display_name":"radiation-induced aging","score":0.6679999828338623},{"id":"https://openalex.org/keywords/mitochondrial-morphology","display_name":"mitochondrial morphology","score":0.5529999732971191},{"id":"https://openalex.org/keywords/sa-beta-galactosidase","display_name":"SA-\u03b2-galactosidase","score":0.75},{"id":"https://openalex.org/keywords/anti-aging","display_name":"anti-aging","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C140149449","wikidata":"https://www.wikidata.org/wiki/Q17928793","display_name":"FOXO1","level":4,"score":0.7820059061050415},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6678495407104492},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6310624480247498},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5966544151306152},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5777285099029541},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5117177963256836},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.48895084857940674},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.48642754554748535},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4655369818210602},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.4542331397533417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4439394176006317},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40937596559524536},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3923950493335724},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3783251941204071},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3523935079574585},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2909016013145447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27921852469444275},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18299800157546997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11430278420448303},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.09076830744743347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071161","descriptor_name":"Forkhead Box Protein O1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029971","descriptor_name":"Angelica sinensis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029971","descriptor_name":"Angelica sinensis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.7754/clin.lab.2021.210731","doi":"https://doi.org/10.7754/clin.lab.2021.210731","is_oa":false,"landing_page_url":"https://doi.org/10.7754/clin.lab.2021.210731","pdf_url":null,"source":{"id":"https://openalex.org/S36748825","display_name":"Clinical Laboratory","issn_l":"1433-6510","issn":["1433-6510"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4323283984","host_organization_name":"Clinical Laboratory Publications","host_organization_lineage":["https://openalex.org/P4323283984"],"host_organization_lineage_names":["Clinical Laboratory Publications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Laboratory","raw_type":"journal-article"},{"id":"pmid:35536062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35536062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical laboratory","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2382271373","https://openalex.org/W3210958529","https://openalex.org/W4200562766","https://openalex.org/W2607232593","https://openalex.org/W2394426564","https://openalex.org/W4307771700","https://openalex.org/W2766887719","https://openalex.org/W2362935866","https://openalex.org/W3030202865","https://openalex.org/W2411123053"],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1],"study":[2],"investigated":[3],"the":[4,29,52,83,94,103,115,130,142,150,158,172,192,237],"anti-aging":[5],"effects":[6],"of":[7,55,118,184,202,229,243],"Angelica":[8],"sinensis":[9],"polysaccharide":[10],"(ASP)":[11],"on":[12],"mouse":[13],"hematopoietic":[14],"stem":[15],"cells":[16],"(HSCs)":[17],"and":[18,57,108,122,138,152,154,167,188,204,227],"related":[19],"mechanisms.":[20],"METHODS:":[21],"Seventy-two":[22],"C57BL/6J":[23],"mice":[24,44,62],"were":[25,45,63,71,212],"randomly":[26],"divided":[27],"into":[28],"following":[30],"three":[31],"groups":[32],"(n":[33],"=":[34],"24":[35],"per":[36],"group):":[37],"control":[38,131,193],"group;":[39],"aging":[40,53,95,143,173,176,228,242],"group,":[41,59,144,160],"in":[42,60,86,129,149,233,245],"which":[43,61],"irradiated":[46],"with":[47,171],"X-ray":[48],"uniformly":[49],"to":[50,81,92,101,113],"establish":[51],"model":[54],"HSCs;":[56],"ASP":[58,67,159,215,222],"given":[64],"200":[65],"mg/kg":[66],"during":[68],"irradiation.":[69],"HSCs":[70,128,145,161,185,230,244],"collected":[72],"by":[73,214,235],"immunomagnetic":[74],"beads,":[75],"transmission":[76],"electron":[77],"microscopy":[78],"was":[79,90,99,111],"used":[80,91,100,112],"examine":[82],"morphological":[84],"changes":[85,211],"HSCs,":[87],"SA-\u03b2-Gal":[88,186],"staining":[89,98,187],"detect":[93,102],"cells,":[96],"immunofluorescence":[97],"reactive":[104],"oxygen":[105],"species":[106],"(ROS),":[107],"western":[109],"blotting":[110],"evaluate":[114],"expression":[116,201],"levels":[117],"sirtuin":[119],"1":[120],"(Sirt1)":[121],"forkhead":[123],"box":[124],"O1":[125],"(FoxO1).":[126],"RESULTS:":[127],"group":[132,177,194],"had":[133,146,162,178,199],"an":[134],"intact":[135],"cytoplasmic":[136,165],"structure":[137,166],"many":[139,147],"mitochondria.":[140,156],"In":[141,157],"vacuoles":[148],"cytoplasm,":[151],"few":[153],"irregular":[155],"a":[163,179],"normal":[164],"more":[168],"mitochondria":[169],"compared":[170],"group.":[174],"The":[175],"significantly":[180],"higher":[181],"positive":[182],"rate":[183],"ROS":[189],"production":[190],"than":[191],"(p":[195,206],"<":[196,207,219],"0.05),":[197],"but":[198],"lower":[200],"Sirt1":[203],"FoxO1":[205],"0.05).":[208,220],"These":[209],"patho(physio)logical":[210],"ameliorated":[213],"treatment":[216],"(all":[217],"p":[218],"CONCLUSIONS:":[221],"inhibits":[223],"irradiation-induced":[224],"oxidative":[225],"stress":[226],"at":[231],"least":[232],"part":[234],"regulating":[236],"Sirt1/FoxO1":[238],"pathway,":[239],"thereby":[240],"delaying":[241],"mice.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-05-22T00:00:00"}