{"id":"https://openalex.org/W4280531007","doi":"https://doi.org/10.1007/s00520-022-07121-3","title":"An exploratory study of factors associated with long-term, high-dose opioid prescription in cancer patients in Japan based on a medical claims database","display_name":"An exploratory study of factors associated with long-term, high-dose opioid prescription in cancer patients in Japan based on a medical claims database","publication_year":2022,"publication_date":"2022-05-11","ids":{"openalex":"https://openalex.org/W4280531007","doi":"https://doi.org/10.1007/s00520-022-07121-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/35543815","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9213265"},"language":"en","primary_location":{"id":"doi:10.1007/s00520-022-07121-3","doi":"https://doi.org/10.1007/s00520-022-07121-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00520-022-07121-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00520-022-07121-3.pdf","source":{"id":"https://openalex.org/S50055314","display_name":"Supportive Care in Cancer","issn_l":"0941-4355","issn":["0941-4355","1433-7339"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Supportive Care in Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00520-022-07121-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077440505","display_name":"Tatsuya Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tatsuya Hashimoto","raw_affiliation_strings":["Department of Anesthesiology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane, Japan. hashit@med.shimane-u.ac.jp","Department of Anesthesiology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane, Japan. hashit@med.shimane-u.ac.jp","institution_ids":["https://openalex.org/I169016828"]},{"raw_affiliation_string":"Department of Anesthesiology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane, Japan","institution_ids":["https://openalex.org/I169016828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028437386","display_name":"Hirokazu Mishima","orcid":"https://orcid.org/0000-0003-3227-5116","observed_orcids":["https://orcid.org/0000-0003-3227-5116"]},"institutions":[{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Mishima","raw_affiliation_strings":["Medical Affairs Department, Shionogi & Co. Ltd., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Department, Shionogi & Co. Ltd., Osaka, Japan","institution_ids":["https://openalex.org/I4210118477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103868158","display_name":"Chika Sakai","orcid":"https://orcid.org/0000-0003-3686-6669","observed_orcids":["https://orcid.org/0000-0003-3686-6669"]},"institutions":[{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chika Sakai","raw_affiliation_strings":["Medical Affairs Department, Shionogi & Co. Ltd., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Department, Shionogi & Co. Ltd., Osaka, Japan","institution_ids":["https://openalex.org/I4210118477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030303937","display_name":"Yuichi Koretaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Koretaka","raw_affiliation_strings":["Data Science Department, Shionogi & Co. Ltd., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Science Department, Shionogi & Co. Ltd., Osaka, Japan","institution_ids":["https://openalex.org/I4210118477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032729131","display_name":"Yoji Saito","orcid":"https://orcid.org/0000-0002-4497-1381","observed_orcids":["https://orcid.org/0000-0002-4497-1381"]},"institutions":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoji Saito","raw_affiliation_strings":["Department of Anesthesiology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane, Japan","institution_ids":["https://openalex.org/I169016828"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077440505"],"corresponding_institution_ids":["https://openalex.org/I169016828"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":0.5234,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.58297196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"30","issue":"8","first_page":"6879","last_page":"6888"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.08980000019073486,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-dose-opioids","display_name":"high-dose opioids","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cancer-pain","display_name":"cancer pain","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.7540000081062317},{"id":"https://openalex.org/keywords/morphine-milligram-equivalents","display_name":"morphine milligram equivalents","score":0.6859999895095825},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/back-pain","display_name":"back pain","score":0.9819999933242798},{"id":"https://openalex.org/keywords/non-opioid-analgesics","display_name":"non-opioid analgesics","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9491087794303894},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.7979879379272461},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.7462875843048096},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4547426700592041},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44335445761680603},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.4227473735809326},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.417512446641922},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40380263328552246},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.33833542466163635},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11838480830192566},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010818","descriptor_name":"Practice Patterns, Physicians'","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00520-022-07121-3","doi":"https://doi.org/10.1007/s00520-022-07121-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00520-022-07121-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00520-022-07121-3.pdf","source":{"id":"https://openalex.org/S50055314","display_name":"Supportive Care in Cancer","issn_l":"0941-4355","issn":["0941-4355","1433-7339"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Supportive Care in Cancer","raw_type":"journal-article"},{"id":"pmid:35543815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35543815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9213265","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9213265/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Support Care Cancer","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:00994:0006614210","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.shimane-u.ac.jp/55325","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1007/s00520-022-07121-3","doi":"https://doi.org/10.1007/s00520-022-07121-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00520-022-07121-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00520-022-07121-3.pdf","source":{"id":"https://openalex.org/S50055314","display_name":"Supportive Care in Cancer","issn_l":"0941-4355","issn":["0941-4355","1433-7339"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Supportive Care in Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323316","display_name":"Shionogi","ror":"https://ror.org/01v3bqg10"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4280531007.pdf","grobid_xml":"https://content.openalex.org/works/W4280531007.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1976669937","https://openalex.org/W2140469792","https://openalex.org/W2203090015","https://openalex.org/W2758599742","https://openalex.org/W2786883050","https://openalex.org/W2796960888","https://openalex.org/W2917504199","https://openalex.org/W2963873198","https://openalex.org/W2982655667","https://openalex.org/W3071140377","https://openalex.org/W3109618435"],"related_works":["https://openalex.org/W2904032863","https://openalex.org/W3181188200","https://openalex.org/W4408403721","https://openalex.org/W4205100477","https://openalex.org/W3109354414","https://openalex.org/W4402965747","https://openalex.org/W4415940705","https://openalex.org/W2629129812","https://openalex.org/W2901180600","https://openalex.org/W2443709040"],"abstract_inverted_index":{"PURPOSE:":[0],"As":[1],"the":[2,16,26,79,106,117,159,164,171,191,206,240],"cancer":[3,59],"survivors":[4],"increase,":[5],"patients":[6,82],"using":[7,48],"long-term":[8],"and":[9,34,60,81,126,167,188,214,217,244,249],"high-dose":[10,40,140,199,212],"opioids":[11,63,247],"are":[12],"also":[13,228],"increasing.":[14],"Therefore,":[15],"promotion":[17],"of":[18,29,58,62,94,119,154,183,205,242],"appropriate":[19],"use":[20,246],"is":[21,235],"important.":[22],"This":[23],"study":[24,47,207],"investigated":[25],"actual":[27],"status":[28],"opioid":[30,70,86,141,192,200],"prescriptions":[31,61,193],"in":[32,158,163,170],"Japan":[33],"identified":[35,221],"factors":[36,135],"associated":[37,137,196,223],"with":[38,55,116,138,197],"long-term,":[39,139,198,211],"prescription.":[41,201],"METHODS:":[42],"We":[43,150],"conducted":[44],"a":[45,49,56],"case-control":[46],"hospital-based":[50],"administrative":[51],"claims":[52],"database.":[53],"Patients":[54,66],"diagnosis":[57],"were":[64,76,103,157,162,169,194,209,220],"included.":[65],"who":[67,83],"received":[68,84],"continuous":[69,85],"for":[71,98,230],"less":[72,120],"than":[73,121],"183":[74,99],"days":[75,100,123,128],"defined":[77,104],"as":[78,105,222],"\"control,\"":[80],"at":[87],"higher":[88],"dose":[89,182],"levels":[90],"(\u2265":[91],"120":[92],"mg/day":[93],"oral":[95],"morphine":[96],"equivalent)":[97],"or":[101,129],"more":[102,130],"\"case.\"":[107],"The":[108,174],"case":[109,165,172],"was":[110,147],"subdivided":[111],"into":[112],"two":[113],"groups:":[114],"those":[115],"duration":[118],"730":[122,127],"(case":[124,131],"I)":[125],"II).":[132],"After":[133],"describing":[134],"possibly":[136],"prescription,":[142,187],"ordinal":[143],"logistic":[144],"regression":[145],"analysis":[146,175],"conducted.":[148],"RESULTS:":[149],"included":[151],"19,176":[152],"patients;":[153],"these,":[155],"13,517":[156],"control,":[160],"111":[161],"I,":[166],"682":[168],"II.":[173],"showed":[176],"that":[177],"distant":[178],"metastasis,":[179],"back":[180],"pain,":[181],"opioids,":[184,213],"non-opioid":[185],"analgesics,":[186],"chemotherapy":[189],"during":[190],"significantly":[195],"CONCLUSION:":[202],"Four":[203],"percent":[204],"population":[208],"prescribed":[210,229],"several":[215],"comorbidities":[216],"concomitant":[218],"medications":[219],"factors.":[224],"Opioids":[225],"might":[226],"be":[227],"non-cancer":[231],"chronic":[232],"pain.":[233],"It":[234],"necessary":[236],"to":[237,245],"properly":[238],"distinguish":[239],"type":[241],"pain":[243],"safely":[248],"appropriately.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-05-22T00:00:00"}
