{"id":"https://openalex.org/W4280519085","doi":"https://doi.org/10.1016/j.sciaf.2022.e01225","title":"Annona muricata mitigates glycerol-induced nephrotoxicities in male albino rats through signaling pathways of angiotensin conversion enzyme, kidney injury molecule-1, and antioxidant properties","display_name":"Annona muricata mitigates glycerol-induced nephrotoxicities in male albino rats through signaling pathways of angiotensin conversion enzyme, kidney injury molecule-1, and antioxidant properties","publication_year":2022,"publication_date":"2022-05-18","ids":{"openalex":"https://openalex.org/W4280519085","doi":"https://doi.org/10.1016/j.sciaf.2022.e01225"},"language":"en","primary_location":{"id":"doi:10.1016/j.sciaf.2022.e01225","doi":"https://doi.org/10.1016/j.sciaf.2022.e01225","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sciaf.2022.e01225","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2468227622001326/pdf","source":{"id":"https://openalex.org/S4210198261","display_name":"Scientific African","issn_l":"2468-2276","issn":["2468-2276"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific African","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2468227622001326/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043078523","display_name":"Adeolu Alex Adedapo","orcid":"https://orcid.org/0000-0003-3003-7579","observed_orcids":["https://orcid.org/0000-0003-3003-7579"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"Adeolu Alex Adedapo","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria"],"raw_orcid":"https://orcid.org/0000-0003-3003-7579","affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031395781","display_name":"Oluwaseun Abiodun Oni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Oluwaseun Abiodun Oni","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043843590","display_name":"Olufunke Olubunmi Falayi","orcid":"https://orcid.org/0000-0002-3387-2097","observed_orcids":["https://orcid.org/0000-0002-3387-2097"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Olufunke Olubunmi Falayi","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037710042","display_name":"Iyanuoluwa Omolola Ogunmiluyi","orcid":"https://orcid.org/0000-0002-0457-754X","observed_orcids":["https://orcid.org/0000-0002-0457-754X"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Iyanuoluwa Omolola Ogunmiluyi","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110130066","display_name":"Blessing Seun Ogunpolu","orcid":"https://orcid.org/0000-0001-5876-225X","observed_orcids":["https://orcid.org/0000-0001-5876-225X"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Blessing Seun Ogunpolu","raw_affiliation_strings":["Department of Veterinary Medicine, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017250336","display_name":"Temidayo Olutayo Om\u00f3b\u00f2w\u00e1l\u00e9","orcid":"https://orcid.org/0000-0002-9486-2861","observed_orcids":["https://orcid.org/0000-0002-9486-2861"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Temidayo Olutayo Omobowale","raw_affiliation_strings":["Department of Veterinary Medicine, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043404389","display_name":"Ademola Adetokunbo Oyagbemi","orcid":"https://orcid.org/0000-0002-8996-8610","observed_orcids":["https://orcid.org/0000-0002-8996-8610"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ademola Adetokunbo Oyagbemi","raw_affiliation_strings":["Department of Veterinary Physiology and Biochemistry, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology and Biochemistry, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075584246","display_name":"Oluwafemi Omoniyi Oguntibeju","orcid":"https://orcid.org/0000-0002-7299-1128","observed_orcids":["https://orcid.org/0000-0002-7299-1128"]},"institutions":[{"id":"https://openalex.org/I159253421","display_name":"Cape Peninsula University of Technology","ror":"https://ror.org/056e9h402","country_code":"ZA","type":"education","lineage":["https://openalex.org/I159253421"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Oluwafemi Omoniyi Oguntibeju","raw_affiliation_strings":["Department of Biomedical Sciences, Cape Peninsula University of Technology, Bellsville, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Cape Peninsula University of Technology, Bellsville, South Africa","institution_ids":["https://openalex.org/I159253421"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074800822","display_name":"Momoh Audu Yakubu","orcid":"https://orcid.org/0000-0002-6072-2473","observed_orcids":["https://orcid.org/0000-0002-6072-2473"]},"institutions":[{"id":"https://openalex.org/I48205209","display_name":"Texas Southern University","ror":"https://ror.org/05ch0aw77","country_code":"US","type":"education","lineage":["https://openalex.org/I48205209"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Momoh Audu Yakubu","raw_affiliation_strings":["Department of Environmental and Interdisciplinary Sciences, Texas Southern University, Houston, TX 77074 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Interdisciplinary Sciences, Texas Southern University, Houston, TX 77074 USA","institution_ids":["https://openalex.org/I48205209"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043078523"],"corresponding_institution_ids":["https://openalex.org/I181631907"],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":0.3178,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.37778855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"16","issue":null,"first_page":"e01225","last_page":"e01225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12497","display_name":"Traditional and Medicinal Uses of Annonaceae","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12497","display_name":"Traditional and Medicinal Uses of Annonaceae","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.07999999821186066,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/annona-muricata","display_name":"Annona muricata","score":1.0},{"id":"https://openalex.org/keywords/glycerol-induced-nephrotoxicity","display_name":"glycerol-induced nephrotoxicity","score":0.9229999780654907},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.8270000219345093},{"id":"https://openalex.org/keywords/kim-1","display_name":"KIM-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.828000009059906},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/antihypertensive-effect","display_name":"antihypertensive effect","score":0.7620000243186951},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/enalapril","display_name":"enalapril","score":0.7620000243186951},{"id":"https://openalex.org/keywords/methanolic-leaf-extract","display_name":"methanolic leaf extract","score":0.8230000138282776},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.7450000047683716},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.7728800773620605},{"id":"https://openalex.org/C2775940317","wikidata":"https://www.wikidata.org/wiki/Q422185","display_name":"Enalapril","level":4,"score":0.7509387731552124},{"id":"https://openalex.org/C2779565439","wikidata":"https://www.wikidata.org/wiki/Q1709343","display_name":"Annona muricata","level":2,"score":0.7243459820747375},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.641771674156189},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5184661746025085},{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.49505773186683655},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.48549985885620117},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48531264066696167},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.4594363570213318},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4337877333164215},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4217069447040558},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4101821184158325},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.397030770778656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3050750494003296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.303550124168396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24094602465629578},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.20498642325401306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2007961869239807},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.1493135690689087},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.sciaf.2022.e01225","doi":"https://doi.org/10.1016/j.sciaf.2022.e01225","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sciaf.2022.e01225","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2468227622001326/pdf","source":{"id":"https://openalex.org/S4210198261","display_name":"Scientific African","issn_l":"2468-2276","issn":["2468-2276"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific African","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b3c83bb18f3a43828ec07e45d08e70eb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b3c83bb18f3a43828ec07e45d08e70eb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific African, Vol 16, Iss , Pp e01225- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.sciaf.2022.e01225","doi":"https://doi.org/10.1016/j.sciaf.2022.e01225","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sciaf.2022.e01225","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2468227622001326/pdf","source":{"id":"https://openalex.org/S4210198261","display_name":"Scientific African","issn_l":"2468-2276","issn":["2468-2276"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific African","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4280519085.pdf","grobid_xml":"https://content.openalex.org/works/W4280519085.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W64395378","https://openalex.org/W238270000","https://openalex.org/W339039077","https://openalex.org/W1564024272","https://openalex.org/W1963734181","https://openalex.org/W1965234101","https://openalex.org/W1968659654","https://openalex.org/W1976616659","https://openalex.org/W1981426346","https://openalex.org/W1982100697","https://openalex.org/W1985120487","https://openalex.org/W1989383588","https://openalex.org/W1994606929","https://openalex.org/W1999517476","https://openalex.org/W2017106369","https://openalex.org/W2021213904","https://openalex.org/W2025639892","https://openalex.org/W2028850203","https://openalex.org/W2033024401","https://openalex.org/W2042641359","https://openalex.org/W2050994990","https://openalex.org/W2057522312","https://openalex.org/W2063137485","https://openalex.org/W2064378798","https://openalex.org/W2069348249","https://openalex.org/W2072796605","https://openalex.org/W2088316894","https://openalex.org/W2094746732","https://openalex.org/W2109062904","https://openalex.org/W2109216149","https://openalex.org/W2118879965","https://openalex.org/W2126949664","https://openalex.org/W2130157109","https://openalex.org/W2146552067","https://openalex.org/W2155431333","https://openalex.org/W2164469730","https://openalex.org/W2164819474","https://openalex.org/W2166339066","https://openalex.org/W2283370633","https://openalex.org/W2327269495","https://openalex.org/W2400851843","https://openalex.org/W2464219105","https://openalex.org/W2580188336","https://openalex.org/W2599562088","https://openalex.org/W2617003155","https://openalex.org/W2624022898","https://openalex.org/W2731967770","https://openalex.org/W2741005915","https://openalex.org/W2755720653","https://openalex.org/W2760569565","https://openalex.org/W2766417677","https://openalex.org/W2770579776","https://openalex.org/W2772272740","https://openalex.org/W2785787964","https://openalex.org/W2790896371","https://openalex.org/W2795337376","https://openalex.org/W2804180697","https://openalex.org/W2804648738","https://openalex.org/W2885160809","https://openalex.org/W2892324208","https://openalex.org/W2892913735","https://openalex.org/W2908295316","https://openalex.org/W2943216514","https://openalex.org/W2954638309","https://openalex.org/W2968875770","https://openalex.org/W2970285468","https://openalex.org/W2982666137","https://openalex.org/W3000090182","https://openalex.org/W3014023943","https://openalex.org/W3015054508","https://openalex.org/W3016228847","https://openalex.org/W3091774312","https://openalex.org/W3112856165","https://openalex.org/W3115356508","https://openalex.org/W4211223405","https://openalex.org/W4245616408","https://openalex.org/W4251627164","https://openalex.org/W7167354735"],"related_works":["https://openalex.org/W7213427652","https://openalex.org/W3157272460","https://openalex.org/W4386257585","https://openalex.org/W4394738394","https://openalex.org/W7093331519","https://openalex.org/W2949621214","https://openalex.org/W4411214548","https://openalex.org/W3046646192","https://openalex.org/W7166344462","https://openalex.org/W7131354466"],"abstract_inverted_index":{"The":[0,31,61,198],"ameliorative":[1],"effect":[2],"of":[3,26,71,79,110,126,145,152,162,177,187,200,213,231,241],"Annona":[4,72,242],"muricata":[5,73,243],"in":[6,11,105,142,174,207,216],"glycerol-induced":[7],"acute":[8],"kidney":[9,176,192,204,209,250],"injury":[10,205],"laboratory":[12],"rats":[13,18,28],"was":[14,35,52],"evaluated.":[15],"Thirty":[16],"albino":[17],"were":[19,22,108,172],"used":[20],"and":[21,64,82,90,103,149,155,165,203,225,256],"divided":[23],"into":[24],"five":[25],"six":[27],"per":[29],"group.":[30,219],"first":[32],"(control)":[33],"group":[34,51,137],"given":[36,53],"distilled":[37],"water":[38],"(2":[39],"ml/kg)":[40,57],"for":[41,87],"seven":[42,88],"days,":[43,89],"while":[44],"the":[45,80,113,127,135,143,163,168,175,178,188,208,217,221,226,249],"second":[46],"(toxicant":[47],"or":[48],"glycerol":[49,55,96],"alone)":[50],"only":[54],"(10":[56,84,97],"on":[58,91,248],"day":[59,92],"8.":[60],"third,":[62],"fourth,":[63],"fifth":[65],"groups":[66],"received":[67,95],"methanol":[68],"leaf":[69,128],"extract":[70,129,164,189,227,240],"(100":[74],"mg/kg),":[75],"200":[76,124,160,185,237],"mg/kg":[77,125,161,186,238],"dose":[78,239],"extract,":[81],"enalapril":[83,166,224],"mg/kg)":[85],"respectively":[86],"eight":[93],"all":[94],"ml/kg).":[98],"Serum":[99],"chemistry,":[100],"histopathology,":[101],"immunohistochemistry,":[102],"changes":[104,171],"blood":[106,116],"pressure":[107,117],"indices":[109],"toxicity.":[111],"In":[112,132],"toxicant":[114,136,179,218],"group,":[115,180],"increased":[118],"significantly":[119],"(p<0.05),":[120],"but":[121,181],"treatment":[122],"with":[123,159,184,194],"reversed":[130,167],"this.":[131],"biochemical":[133],"analysis,":[134],"had":[138],"a":[139],"significant":[140,229],"increase":[141],"levels":[144,151],"oxidative":[146],"stress":[147],"markers":[148],"decreased":[150],"some":[153],"enzymatic":[154],"non-enzymatic":[156],"antioxidants.":[157],"Treatment":[158],"trend.":[169],"Histopathological":[170],"seen":[173],"those":[182],"treated":[183],"showed":[190,210,235],"normal":[191],"histology":[193],"no":[195],"observable":[196],"lesion.":[197],"immunolocalization":[199],"angiotensin-converting":[201],"enzyme":[202],"molecule-1":[206],"high":[211],"expression":[212],"these":[214],"proteins":[215],"At":[220],"same":[222],"time,":[223],"caused":[228],"downregulation":[230],"their":[232],"expressions.":[233],"Results":[234],"that":[236],"could":[244],"confer":[245],"effective":[246],"protection":[247],"due":[251],"to":[252],"its":[253],"anti-inflammatory,":[254],"anti-hypertensive":[255],"antioxidant":[257],"properties.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-22T00:00:00"}