{"id":"https://openalex.org/W4280501948","doi":"https://doi.org/10.1364/boe.455783","title":"In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids","display_name":"In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids","publication_year":2022,"publication_date":"2022-05-12","ids":{"openalex":"https://openalex.org/W4280501948","doi":"https://doi.org/10.1364/boe.455783","pmid":"https://pubmed.ncbi.nlm.nih.gov/35781966","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9208582"},"language":"en","primary_location":{"id":"doi:10.1364/boe.455783","doi":"https://doi.org/10.1364/boe.455783","is_oa":true,"landing_page_url":"https://doi.org/10.1364/boe.455783","pdf_url":null,"source":{"id":"https://openalex.org/S104118869","display_name":"Biomedical Optics Express","issn_l":"2156-7085","issn":["2156-7085"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Optics Express","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1364/boe.455783","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073401098","display_name":"Kayvan Samimi","orcid":"https://orcid.org/0000-0002-2566-612X","observed_orcids":["https://orcid.org/0000-0002-2566-612X"]},"institutions":[{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayvan Samimi","raw_affiliation_strings":["Morgridge Institute for Research"],"raw_orcid":"https://orcid.org/0000-0002-2566-612X","affiliations":[{"raw_affiliation_string":"Morgridge Institute for Research","institution_ids":["https://openalex.org/I29680605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034234543","display_name":"Bikash Ranjan Pattnaik","orcid":"https://orcid.org/0000-0002-5385-358X","observed_orcids":["https://orcid.org/0000-0002-5385-358X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bikash R. Pattnaik","raw_affiliation_strings":["McPherson Eye Research Institute, University of Wisconsin-Madison","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McPherson Eye Research Institute, University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089958612","display_name":"Elizabeth E. Capowski","orcid":"https://orcid.org/0000-0002-8204-5434","observed_orcids":["https://orcid.org/0000-0002-8204-5434"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth E. Capowski","raw_affiliation_strings":["University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087358894","display_name":"Krishanu Saha","orcid":"https://orcid.org/0000-0003-2837-0858","observed_orcids":["https://orcid.org/0000-0003-2837-0858"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2802999273","display_name":"Wisconsin Institutes for Discovery","ror":"https://ror.org/05gbven85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802999273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishanu Saha","raw_affiliation_strings":["McPherson Eye Research Institute, University of Wisconsin-Madison","University of Wisconsin-Madison","Wisconsin Institute for Discovery, University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McPherson Eye Research Institute, University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2802999273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063963894","display_name":"David M. Gamm","orcid":"https://orcid.org/0000-0002-8152-613X","observed_orcids":["https://orcid.org/0000-0002-8152-613X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Gamm","raw_affiliation_strings":["McPherson Eye Research Institute, University of Wisconsin-Madison","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McPherson Eye Research Institute, University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084628898","display_name":"Melissa C. Skala","orcid":"https://orcid.org/0000-0002-6320-7637","observed_orcids":["https://orcid.org/0000-0002-6320-7637"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa C. Skala","raw_affiliation_strings":["McPherson Eye Research Institute, University of Wisconsin-Madison","Morgridge Institute for Research","University of Wisconsin-Madison"],"raw_orcid":"https://orcid.org/0000-0002-6320-7637","affiliations":[{"raw_affiliation_string":"McPherson Eye Research Institute, University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Morgridge Institute for Research","institution_ids":["https://openalex.org/I29680605"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1913,"currency":"USD","value_usd":1913},"apc_paid":{"value":1913,"currency":"USD","value_usd":1913},"fwci":0.5712,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56919661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"6","first_page":"3476","last_page":"3476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photoreceptors","display_name":"photoreceptors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/visual-cycle","display_name":"visual cycle","score":0.871999979019165},{"id":"https://openalex.org/keywords/retinoids","display_name":"retinoids","score":0.9430000185966492},{"id":"https://openalex.org/keywords/autofluorescence-lifetime","display_name":"autofluorescence lifetime","score":0.7889999747276306},{"id":"https://openalex.org/keywords/retinal-organoids","display_name":"retinal organoids","score":0.843999981880188},{"id":"https://openalex.org/keywords/phototransduction","display_name":"phototransduction","score":0.8659999966621399},{"id":"https://openalex.org/keywords/multiphoton-excitation","display_name":"multiphoton excitation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/two-photon-imaging","display_name":"two-photon imaging","score":0.6460000276565552},{"id":"https://openalex.org/keywords/retinal-explants","display_name":"retinal explants","score":0.6899999976158142},{"id":"https://openalex.org/keywords/functional-screening","display_name":"functional screening","score":0.4390000104904175},{"id":"https://openalex.org/keywords/mouse-retina","display_name":"mouse retina","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C131667965","wikidata":"https://www.wikidata.org/wiki/Q445081","display_name":"Visual phototransduction","level":3,"score":0.8865068554878235},{"id":"https://openalex.org/C179687394","wikidata":"https://www.wikidata.org/wiki/Q4826281","display_name":"Autofluorescence","level":3,"score":0.7982367277145386},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.7228213548660278},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6484135389328003},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.5978145003318787},{"id":"https://openalex.org/C2779113765","wikidata":"https://www.wikidata.org/wiki/Q681562","display_name":"Electroretinography","level":3,"score":0.5588250160217285},{"id":"https://openalex.org/C2908832724","wikidata":"https://www.wikidata.org/wiki/Q7187600","display_name":"Photic Stimulation","level":4,"score":0.45402130484580994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35354068875312805},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3040348291397095},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.16621020436286926},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.13717392086982727},{"id":"https://openalex.org/C178253425","wikidata":"https://www.wikidata.org/wiki/Q162668","display_name":"Visual perception","level":3,"score":0.11619144678115845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09563612937927246},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05804750323295593},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1364/boe.455783","doi":"https://doi.org/10.1364/boe.455783","is_oa":true,"landing_page_url":"https://doi.org/10.1364/boe.455783","pdf_url":null,"source":{"id":"https://openalex.org/S104118869","display_name":"Biomedical Optics Express","issn_l":"2156-7085","issn":["2156-7085"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Optics Express","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9208582","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9208582","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Opt Express","raw_type":"Text"},{"id":"pmid:35781966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35781966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical optics express","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1364/boe.455783","doi":"https://doi.org/10.1364/boe.455783","is_oa":true,"landing_page_url":"https://doi.org/10.1364/boe.455783","pdf_url":null,"source":{"id":"https://openalex.org/S104118869","display_name":"Biomedical Optics Express","issn_l":"2156-7085","issn":["2156-7085"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Optics Express","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2174714203","display_name":"Single Cell Profiling To Define Biomarkers Of Photoreceptor Dysfunction After Gene Editing Within PSC-Derived Organoids","funder_award_id":"U01EB029371","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G2268260240","display_name":"Mechanisms of Retinogenesis in Human Stem Cells","funder_award_id":"R01EY021218","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2682194152","display_name":"Waisman Intellectual and Developmental Disabilities Research Center","funder_award_id":"U54HD090256","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G270397074","display_name":"Optical imaging of pancreas cancer organoids for drug development and personalized treatment","funder_award_id":"R01CA211082","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3244917574","display_name":"Cellular level optical metabolic imaging to predict drug response in cancer","funder_award_id":"R01CA185747","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3264309901","display_name":"(PQ7) Quantitative in vivo optical imaging of tumor heterogeneity","funder_award_id":"R01CA205101","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8182736654","display_name":"Single Cell Profiling To Define Biomarkers Of Photoreceptor Dysfunction After Gene Editing Within PSC-Derived Organoids","funder_award_id":"U01HL145792","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8676937187","display_name":"Single Cell Profiling To Define Biomarkers Of Photoreceptor Dysfunction After Gene Editing Within PSC-Derived Organoids","funder_award_id":"U01EY032333","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320307022","display_name":"Muskingum County Community Foundation","ror":"https://ror.org/047a10n20"},{"id":"https://openalex.org/F4320312237","display_name":"Carl Marshall and Mildred Almen Reeves Foundation","ror":"https://ror.org/03s3fx919"},{"id":"https://openalex.org/F4320314525","display_name":"Retina Research Foundation","ror":"https://ror.org/05n2ytn05"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W100965007","https://openalex.org/W207933033","https://openalex.org/W1531084823","https://openalex.org/W1532411511","https://openalex.org/W1587435244","https://openalex.org/W1965219715","https://openalex.org/W1975082016","https://openalex.org/W1975250798","https://openalex.org/W1986668976","https://openalex.org/W1997137305","https://openalex.org/W1999695626","https://openalex.org/W2019731198","https://openalex.org/W2023215494","https://openalex.org/W2031487394","https://openalex.org/W2044439880","https://openalex.org/W2052361452","https://openalex.org/W2069838246","https://openalex.org/W2072010374","https://openalex.org/W2075365540","https://openalex.org/W2086546231","https://openalex.org/W2090093046","https://openalex.org/W2103344716","https://openalex.org/W2127763168","https://openalex.org/W2133281894","https://openalex.org/W2153411657","https://openalex.org/W2153478200","https://openalex.org/W2161797751","https://openalex.org/W2162264610","https://openalex.org/W2214193457","https://openalex.org/W2364913486","https://openalex.org/W2745315781","https://openalex.org/W2904334833","https://openalex.org/W2908873329","https://openalex.org/W2915976408","https://openalex.org/W2935260107","https://openalex.org/W2976053079","https://openalex.org/W3041543461","https://openalex.org/W3044730717","https://openalex.org/W3081420496","https://openalex.org/W3083943664","https://openalex.org/W3087102910","https://openalex.org/W3135263581","https://openalex.org/W3139826906","https://openalex.org/W3195792392","https://openalex.org/W3212579199"],"related_works":["https://openalex.org/W4220938210","https://openalex.org/W2413531146","https://openalex.org/W4392950242","https://openalex.org/W2396919516","https://openalex.org/W4320084943","https://openalex.org/W4200436890","https://openalex.org/W1972150994","https://openalex.org/W3134312317","https://openalex.org/W3116119661","https://openalex.org/W4412872206"],"abstract_inverted_index":{"Photoreceptors":[0],"are":[1],"the":[2,9,14,32,41,64,111],"key":[3],"functional":[4,38,122],"cell":[5],"types":[6],"responsible":[7],"for":[8,96],"initiation":[10],"of":[11,21,40,63,99,114,124],"vision":[12],"in":[13,44,61],"retina.":[15],"Phototransduction":[16],"involves":[17],"isomerization":[18],"and":[19,28,51,58,81,89,102,118,127],"conversion":[20,103],"vitamin":[22],"A":[23],"compounds,":[24],"known":[25],"as":[26],"retinoids,":[27,94],"their":[29,100],"recycling":[30],"through":[31],"visual":[33,42,65,115],"cycle.":[34],"We":[35,75],"demonstrate":[36],"a":[37,78],"readout":[39],"cycle":[43,66,116],"photoreceptors":[45],"within":[46,104],"stem":[47],"cell-derived":[48],"retinal":[49,53,125],"organoids":[50],"mouse":[52],"explants":[54],"based":[55],"on":[56],"spectral":[57],"lifetime":[59],"changes":[60],"autofluorescence":[62],"retinoids":[67],"after":[68],"exposure":[69],"to":[70],"light":[71],"or":[72],"chemical":[73],"stimuli.":[74],"also":[76],"apply":[77],"simultaneous":[79],"two-":[80],"three-photon":[82],"excitation":[83],"method":[84],"that":[85],"provides":[86],"specific":[87],"signals":[88],"increases":[90],"contrast":[91],"between":[92],"these":[93],"allowing":[95],"reliable":[97],"detection":[98],"presence":[101],"photoreceptors.":[105],"This":[106],"multiphoton":[107],"imaging":[108],"technique":[109],"resolves":[110],"slow":[112],"dynamics":[113],"reactions":[117],"can":[119],"enable":[120],"high-throughput":[121],"screening":[123],"tissues":[126],"organoid":[128],"cultures":[129],"with":[130],"single-cell":[131],"resolution.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-22T00:00:00"}